{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:44:13Z","timestamp":1792442653423,"version":"4.5.0"},"reference-count":38,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014417","name":"Pa\u0144stwowy Instytut Weterynaryjny - Pa\u0144stwowy Instytut Badawczy","doi-asserted-by":"publisher","award":["The study was supported by the subsidy on maintenance of the research potential S\/385: \u201cDevelopment and improvement of the methodology for testing the virucidal activity of disinfectants against the African swine fever virus (ASFV)\u201d"],"award-info":[{"award-number":["The study was supported by the subsidy on maintenance of the research potential S\/385: \u201cDevelopment and improvement of the methodology for testing the virucidal activity of disinfectants against the African swine fever virus (ASFV)\u201d"]}],"id":[{"id":"10.13039\/501100014417","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>African swine fever (ASF) causes huge economic losses and is one of most dangerous diseases of pigs. The disease is known for almost 100 years, an effective vaccine or treatment is still unavailable, only proper biosecurity measures, including disinfection, are being applied, in order to prevent disease outbreaks. Eight active substances, i.e., formaldehyde, sodium hypochlorite, caustic soda, glutaraldehyde, phenol, benzalkonium chloride, potassium peroxymonosulfate and acetic acid, were tested, in order to confirm their effectiveness against African swine fever virus (ASFV). This specific selection was done based on the World Organisation for Animal Health (OIE)\u2019s recommendation and previous disinfectant studies on surfaces. The result of our study shows that most of them inactivate the virus, in recommended concentrations. In order to reduce the cytotoxicity of the four substances, Microspin S-400 HR columns were applied, therefore making it possible to demonstrate four logarithms virus titer reduction. Sodium hypochlorite, glutaraldehyde, caustic soda and potassium peroxymonosulfate showed the best ASFV inactivation rates, achieving titer reductions over 5 logs. Despite microfiltration, the virucidal activity of formaldehyde was not assessable, due to its high cytotoxicity. Our results showed that cleaning is particularly important, because removal of the soiling provides improved effectiveness of the tested chemical compounds.<\/jats:p>","DOI":"10.3390\/pathogens9110878","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T02:34:54Z","timestamp":1603679694000},"page":"878","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Effectiveness of Chemical Compounds Used against African Swine Fever Virus in Commercial Available Disinfectants"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5705-4099","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Juszkiewicz","sequence":"first","affiliation":[{"name":"Department of Swine Diseases, National Veterinary Research Institute, Partyzant\u00f3w 57 Avenue, 24-100 Pu\u0142awy, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2991-9964","authenticated-orcid":false,"given":"Marek","family":"Walczak","sequence":"additional","affiliation":[{"name":"Department of Swine Diseases, National Veterinary Research Institute, Partyzant\u00f3w 57 Avenue, 24-100 Pu\u0142awy, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Mazur-Panasiuk","sequence":"additional","affiliation":[{"name":"Department of Swine Diseases, National Veterinary Research Institute, Partyzant\u00f3w 57 Avenue, 24-100 Pu\u0142awy, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1333-4275","authenticated-orcid":false,"given":"Grzegorz","family":"Wo\u017aniakowski","sequence":"additional","affiliation":[{"name":"Department of Swine Diseases, National Veterinary Research Institute, Partyzant\u00f3w 57 Avenue, 24-100 Pu\u0142awy, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.vaccine.2018.03.040","article-title":"African swine fever virus (ASFV) protection mediated by NH\/P68 and NH\/P68 recombinant live-attenuated viruses","volume":"36","author":"Gallardo","year":"2018","journal-title":"Vaccine"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Arias, M., De La Torre, A., Dixon, L.K., Gallardo, C., Jori, F., Laddomada, A., Martins, C., Parkhouse, R.M., Revilla, Y., and Rodriguez, F.A.J.-M. 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