{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:10:09Z","timestamp":1785190209935,"version":"3.55.0"},"reference-count":34,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathogens"],"abstract":"<jats:p>Cyperus articulatus L. is popularly known as priprioca. Its rhizomes are used as a medicine in the treatment of malaria in traditional medicine. Since priprioca oil is extracted for commercial purpose, we evaluated if the components from the priprioca residue can be a source of antiplasmodial active molecules. This study aimed to determine the in vitro antiplasmodial and cytotoxicity activities of the ethanolic extract of C. articulatus as an in vitro antiplasmodial agent. From the solid residue of the plant rhizomes, 40 g samples were removed and subjected to hot extraction using a Soxhlet extractor. The in vitro antiplasmodial activity was determined using the W2 and 3D7 strains of P. falciparum. The phytochemical study identified the following main compounds: corymbolone (14.25%), cyclocolorenone (9.75%), and cadalene (8.36%). The extract exhibited moderate IC50 (inhibitory concentration) against the two strains of P. falciparum: 1.21 \u00b1 0.01 against the W2 strain and 1.10 \u00b1 0.06 \u00b5g\/mL against the 3D7 strain. Our results show the therapeutic potential of priprioca residue as a low-cost antiplasmodial agent.<\/jats:p>","DOI":"10.3390\/pathogens9110889","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T09:22:45Z","timestamp":1603790565000},"page":"889","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Chemical Composition and In Vitro Antiplasmodial Activity of the Ethanolic Extract of Cyperus articulatus var. nodosus Residue"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-6271","authenticated-orcid":false,"given":"Francisco Fl\u00e1vio Vieira de","family":"Assis","sequence":"first","affiliation":[{"name":"Laboratory of Animal Health, LARSANA, Federal University of Western Par\u00e1, UFOPA, Santar\u00e9m, Par\u00e1 68040-255, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazar\u00e9 Carneiro da","family":"Silva","sequence":"additional","affiliation":[{"name":"Pharmacology Laboratory, Federal University of Western Par\u00e1, Santar\u00e9m, Par\u00e1 68040-255, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldiney Pires","family":"Moraes","sequence":"additional","affiliation":[{"name":"Pharmacology Laboratory, Federal University of Western Par\u00e1, Santar\u00e9m, Par\u00e1 68040-255, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-769X","authenticated-orcid":false,"given":"Lauro Euclides Soares","family":"Barata","sequence":"additional","affiliation":[{"name":"Laboratory for Research &amp; Development of Bioactive Products, Federal University of Western Par\u00e1, Santar\u00e9m, Par\u00e1 68040-255, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-3652","authenticated-orcid":false,"given":"Antonio Humberto Hamad","family":"Minervino","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Health, LARSANA, Federal University of Western Par\u00e1, UFOPA, Santar\u00e9m, Par\u00e1 68040-255, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"ref_1","first-page":"158","article-title":"Un nouveau parasite trouv\u00e9 dans le sang de malades atteints de fi\u00e8vre palustre. 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