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Emerging evidence, however, suggests that the virus also has the potential to cause infections in Europe, where autochtonous transmission of the virus has been identified. This review focuses on evolving ZIKV epidemiology, modes of transmission and host-virus interactions. The clinical manifestations, diagnostic issues relating to cross-reactivity to the dengue flavivirus and concerns surrounding ZIKV infection in pregnancy are discussed. In the last section, current challenges in treatment and prevention are outlined.<\/jats:p>","DOI":"10.3390\/pathogens9110898","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T11:43:06Z","timestamp":1603885386000},"page":"898","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Zika Virus"],"prefix":"10.3390","volume":"9","author":[{"given":"Sophie","family":"Masmejan","sequence":"first","affiliation":[{"name":"Maternofetal and Obstetrics Research Unit, Department \u201cWoman-Mother-Child\u201d, University Hospital, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Musso","sequence":"additional","affiliation":[{"name":"Laboratoire Eurofins Labazur Guyane, 97300 Cayenne, French Guiana"},{"name":"Aix Marseille University, IRD, AP-HM, SSA, VITROME, IHU-M\u00e9diterran\u00e9e Infection, 13007 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Vouga","sequence":"additional","affiliation":[{"name":"Maternofetal and Obstetrics Research Unit, Department \u201cWoman-Mother-Child\u201d, University Hospital, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-8129","authenticated-orcid":false,"given":"Leo","family":"Pomar","sequence":"additional","affiliation":[{"name":"Maternofetal and Obstetrics Research Unit, Department \u201cWoman-Mother-Child\u201d, University Hospital, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradip","family":"Dashraath","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, National University Hospital, Singapore 119074, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5166-5841","authenticated-orcid":false,"given":"Milos","family":"Stojanov","sequence":"additional","affiliation":[{"name":"Maternofetal and Obstetrics Research Unit, Department \u201cWoman-Mother-Child\u201d, University Hospital, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Panchaud","sequence":"additional","affiliation":[{"name":"Service of Pharmacy, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"},{"name":"Institute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9914-6496","authenticated-orcid":false,"given":"David","family":"Baud","sequence":"additional","affiliation":[{"name":"Maternofetal and Obstetrics Research Unit, Department \u201cWoman-Mother-Child\u201d, University Hospital, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika Virus (I). 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