{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:06:05Z","timestamp":1771005965794,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathophysiology"],"abstract":"<jats:p>Hashimoto\u2019s thyroiditis and psoriasis are inflammatory disorders that significantly impact patients\u2019 quality of life, stressing the need for novel biomarkers of early diagnosis. This randomized clinical trial (NCT04693936) aims to identify Hashimoto\u2019s thyroiditis\u2019 and psoriasis\u2019 metabolic biomarkers and to investigate the effect of environmental factors on the disease-related metabolic imprint and quality of life. Patients with Hashimoto\u2019s thyroiditis, patients with psoriasis, and healthy individuals aged 18\u201360 will be recruited, enrolled according to eligibility criteria (medical history, clinical thyroid markers and the PASI score) and randomized to two groups. The intervention group will receive a combination of nutraceuticals for 6 months as part of a Mediterranean diet, and the control group will follow their usual diet. Data will be collected at baseline and the end of the study, including metabolite levels, lifestyle and anthropometric measurements, adherence to the Mediterranean diet (through the Mediterranean Diet Score) and disease-specific quality of life (through the Thyroid Patient Report Outcome for Hashimoto\u2019s group, and the Dermatology Life Quality Index for the psoriasis group). This study will investigate metabolic biomarkers and related changes in Hashimoto\u2019s thyroiditis and psoriasis and evaluate the association of metabolic changes with dietary factors and quality of life.<\/jats:p>","DOI":"10.3390\/pathophysiology28020019","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T22:26:01Z","timestamp":1623709561000},"page":"291-306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Clinical Trial for the Identification of Metabolic Biomarkers in Hashimoto\u2019s Thyroiditis and in Psoriasis: Study Protocol"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3058-429X","authenticated-orcid":false,"given":"Evangelia","family":"Sarandi","sequence":"first","affiliation":[{"name":"Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003 Heraklion, Greece"},{"name":"Metabolomic Medicine, Health Clinics for Autoimmune and Chronic Diseases, 10674 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Kruger Krasagakis","sequence":"additional","affiliation":[{"name":"Dermatology Department, University Hospital of Heraklion, 71500 Heraklion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6885-6209","authenticated-orcid":false,"given":"Dimitris","family":"Tsoukalas","sequence":"additional","affiliation":[{"name":"Metabolomic Medicine, Health Clinics for Autoimmune and Chronic Diseases, 10674 Athens, Greece"},{"name":"European Institute of Nutritional Medicine, 00198 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gottfried","family":"Rudofsky","sequence":"additional","affiliation":[{"name":"Clinic of Endocrinology and Metabolic Disorders, Cantonal Hospital Olten, Baslerstrasse 150, 4600 Olten, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-2462","authenticated-orcid":false,"given":"Aristides","family":"Tsatsakis","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003 Heraklion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Margin\u0103, D., Ungurianu, A., Purdel, C., Tsoukalas, D., Sarandi, E., Thanasoula, M., Tekos, F., Mesnage, R., Kouretas, D., and Tsatsakis, A. 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