{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:00:53Z","timestamp":1791986453382,"version":"4.4.0"},"reference-count":107,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of General Medical Sciences","award":["GM121307"],"award-info":[{"award-number":["GM121307"]}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL149264"],"award-info":[{"award-number":["HL149264"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathophysiology"],"abstract":"<jats:p>Hydrogen sulfide (H2S) is a gasotransmitter that exerts a multitude of functions in both physiologic and pathophysiologic processes. H2S-synthesizing enzymes are increased in a variety of human malignancies, including colon, prostate, breast, renal, urothelial, ovarian, oral squamous cell, and thyroid cancers. In cancer, H2S promotes tumor growth, cellular and mitochondrial bioenergetics, migration, invasion, angiogenesis, tumor blood flow, metastasis, epithelia\u2013mesenchymal transition, DNA repair, protein sulfhydration, and chemotherapy resistance Additionally, in some malignancies, increased H2S-synthesizing enzyme expression correlates with a worse prognosis and a higher tumor stage. Here we review the role of H2S in cancer, with an emphasis on the molecular mechanisms by which H2S promotes cancer development, progression, dedifferentiation, and metastasis.<\/jats:p>","DOI":"10.3390\/pathophysiology28030028","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T22:35:20Z","timestamp":1632263720000},"page":"437-456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Molecular Functions of Hydrogen Sulfide in Cancer"],"prefix":"10.3390","volume":"28","author":[{"given":"Rodney E.","family":"Shackelford","sequence":"first","affiliation":[{"name":"Department of Pathology & Translational Pathobiology, LSU Health Sciences Center Shreveport, Shreveport, LA 71130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam Z.","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Pathology & Translational Pathobiology, LSU Health Sciences Center Shreveport, Shreveport, LA 71130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Meram","sequence":"additional","affiliation":[{"name":"Head & Neck Oncologic\/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial\/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kim","sequence":"additional","affiliation":[{"name":"Head & Neck Oncologic\/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial\/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawaz","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Head & Neck Oncologic\/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial\/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavan","family":"Patel","sequence":"additional","affiliation":[{"name":"Head & Neck Oncologic\/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial\/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghali E.","family":"Ghali","sequence":"additional","affiliation":[{"name":"Head & Neck Oncologic\/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial\/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Kevil","sequence":"additional","affiliation":[{"name":"Department of Pathology & Translational Pathobiology, LSU Health Sciences Center Shreveport, Shreveport, LA 71130, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev.pa.32.040192.000545","article-title":"Toxicology of hydrogen sulfide","volume":"32","author":"Reiffenstein","year":"1992","journal-title":"Annu. 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