{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:23:12Z","timestamp":1782523392046,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DBT BUILDER","award":["BT\/INF\/22\/SP41415\/2021"],"award-info":[{"award-number":["BT\/INF\/22\/SP41415\/2021"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Pathophysiology"],"abstract":"<jats:p>The present study aims to evaluate the effect of Sepia pharaonis ink on insulin resistance in PCOS-induced mice. Treatment with sepia ink in dehydroepiandrosterone (DHEA)-induced PCOS mice at various doses of 50 mg\/kg, 100\u2009mg\/kg, and 200\u2009mg\/kg body weight mitigated the insulin resistance in the study groups with decreased concentration of testosterone and increased concentrations of estrogen and progesterone compared to the PCOS group tested by ELISA. The histopathological analysis and restoration of glucose analysis showed a significant reduction in treatment groups. Reduced expression of insulin resistance genes like androgen receptor (AR), insulin receptor substrate 1 (IRS-1), and insulin-like growth factor1 (IGF-1) by qRT-PCR indicate a positive impact of sepia ink in alleviating the symptoms associated with PCOS. Taken together, the results of this study indicate sepia ink as a promising therapeutic intervention and a possible drug target for insulin resistance in diabetes and gynecological disorders like PCOS.<\/jats:p>","DOI":"10.3390\/pathophysiology31030031","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T09:15:41Z","timestamp":1723799741000},"page":"408-419","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sepia pharaonis Ink Mitigates Dehydroepiandrosterone-Induced Insulin Resistance in Mouse Model of Polycystic Ovarian Syndrome"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2204-4453","authenticated-orcid":false,"given":"Prathyusha","family":"Yamarthi","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Osmania University, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama Satyasri","family":"Kotipalli","sequence":"additional","affiliation":[{"name":"Applied Biology, CSIR\u2014Indian Institute of Chemical Technology, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samatasai","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Applied Biology, CSIR\u2014Indian Institute of Chemical Technology, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1189-7944","authenticated-orcid":false,"given":"Kv","family":"Veena","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Osmania University, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muralidharan","family":"Kathirvel","sequence":"additional","affiliation":[{"name":"Applied Biology, CSIR\u2014Indian Institute of Chemical Technology, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7890-9471","authenticated-orcid":false,"given":"Rajkumar","family":"Vutukuri","sequence":"additional","affiliation":[{"name":"Institute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjula","family":"Bhanoori","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Osmania University, Hyderabad 500007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","article-title":"Role of insulin resistance in human disease","volume":"37","author":"Reaven","year":"1988","journal-title":"Diabetes"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2174\/1570161112999140217095038","article-title":"Omentin: Linking metabolic syndrome and cardiovascular disease","volume":"12","author":"Zhou","year":"2014","journal-title":"Curr. 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