{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:28:28Z","timestamp":1760059708523,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathophysiology"],"abstract":"<jats:p>Amyloidosis, often referred to as \u201cthe great imitator\u201d, is a condition characterized by the abnormal deposition of amyloid proteins in various tissues, potentially leading to organ dysfunction. When these deposits localize in the brain, they can disrupt neurological function and present with diverse clinical manifestations, making diagnosis particularly challenging. Cerebral amyloidosis is a rare entity that frequently mimics other neurological disorders, often resulting in significant delays in recognition and management. This case highlights the diagnostic challenge posed by cerebral amyloidosis and underscores its unique presentation. We present the case of a 76-year-old male with a history of rheumatoid arthritis (RA) who developed progressive right-sided weakness over several months. Three years prior, he experienced numbness on the right side of his face and upper limb. Initial imaging identified a small lesion in the left thalamic region, which was originally diagnosed as a glioma. However, due to the worsening of his clinical symptoms, further evaluation was warranted. Subsequent imaging revealed lesion growth, prompting a biopsy that ultimately confirmed the diagnosis of intracerebral amyloidoma. This case underscores the necessity of considering amyloidosis in the differential diagnosis of atypical neurological deficits, particularly in patients with systemic inflammatory conditions such as RA. The initial presentation of hemiparesis resembling a stroke, coupled with non-specific imaging findings and a prior misdiagnosis of glioma, highlights the complexity of cerebral amyloidosis. Only through brain biopsy was the definitive diagnosis established, emphasizing the need for improved diagnostic modalities to facilitate early detection. Further subtyping of amyloidosis, however, requires mass spectrometry-based proteomics or immunohistochemistry to accurately identify the specific amyloid protein involved. Clinicians should maintain a high index of suspicion for cerebral amyloidosis in patients with RA who present with progressive neurological deficits and atypical brain lesions. Early recognition and accurate diagnosis are essential to guiding appropriate management and improving patient outcomes.<\/jats:p>","DOI":"10.3390\/pathophysiology32030031","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T06:56:54Z","timestamp":1751353014000},"page":"31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Cerebral Amyloidoma Mimicking Thalamic Glioma in a Rheumatoid Arthritis Patient"],"prefix":"10.3390","volume":"32","author":[{"given":"Elyaa","family":"Saleh","sequence":"first","affiliation":[{"name":"Laboratory of Pathology, Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia 2408, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia 2408, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malaak","family":"Ramahi","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia 2408, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Loukousia","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, AHEPA General Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodossios","family":"Birbilis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Democritus University of Thrace, 67100 Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-8394","authenticated-orcid":false,"given":"Dimitrios","family":"Kanakis","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia 2408, Cyprus"},{"name":"Centre of Neuroscience and Integrative Brain Research (CENIBRE), University of Nicosia Medical School, Nicosia 1010, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.hfc.2024.02.001","article-title":"Amyloidosis and Amyloidogenesis","volume":"20","author":"Pozzan","year":"2024","journal-title":"Heart Fail. Clin."},{"key":"ref_2","unstructured":"Bustamante, J.G., and Zaidi, S.R.H. (2025, March 13). Amyloidosis, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470285\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.rdc.2018.06.004","article-title":"Secondary, AA, Amyloidosis","volume":"44","author":"Papa","year":"2018","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_4","first-page":"e7245","article-title":"A Rare Case of Cerebral Amyloidoma Mimicking a Hemorrhagic Malignant Central Nervous System Neoplasm","volume":"12","author":"Kapoor","year":"2020","journal-title":"Cureus"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1212\/WNL.0000000000012965","article-title":"CNS Involvement in Hereditary Transthyretin Amyloidosis","volume":"97","author":"Sousa","year":"2021","journal-title":"Neurology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.rcl.2023.01.009","article-title":"Cerebral Amyloid Angiopathy","volume":"61","author":"Szidonya","year":"2023","journal-title":"Radiol. Clin. N. Am."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Landau, D., Avgeropoulos, N., and Ma, J. (2010). Cerebral amyloidoma mimicking intracranial tumor: A case report. J. Med. Case Rep., 4.","DOI":"10.1186\/1752-1947-4-308"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1001\/archneur.63.6.906","article-title":"Intracerebral Amyloidoma Can Mimic High-Grade Glioma on Magnetic Resonance Imaging and Spectroscopy","volume":"63","author":"Ragel","year":"2006","journal-title":"Arch. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/j.radcr.2022.05.038","article-title":"Magnetic resonance imaging of a temporal lobe cerebral amyloidoma","volume":"17","author":"Ogilvie","year":"2022","journal-title":"Radiol. Case Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1159\/000508022","article-title":"Confirming the Diagnosis of Amyloidosis","volume":"143","author":"Wisniowski","year":"2020","journal-title":"Acta Haematol."},{"key":"ref_11","first-page":"369","article-title":"Systemic AA amyloidosis: Epidemiology, diagnosis, and management","volume":"6","author":"Galvan","year":"2014","journal-title":"Clin. Epidemiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1136\/ard.48.8.696","article-title":"Amyloidosis in the rheumatic diseases","volume":"48","author":"Dhillon","year":"1989","journal-title":"Ann. Rheum. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0046-8177(89)90102-0","article-title":"Amyloid protein of vessels in leptomeninges, cortices, choroid plexuses, and pituitary glands from patients with systemic amyloidosis","volume":"20","author":"Ishihara","year":"1989","journal-title":"Hum. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s004280050383","article-title":"Cerebrovascular involvement in systemic AA and AL amyloidosis: A clear haematogenic pattern","volume":"434","author":"Linke","year":"1999","journal-title":"Virchows Arch."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13506129.2019.1693359","article-title":"Causes of AA amyloidosis: A systematic review","volume":"27","author":"Brunger","year":"2019","journal-title":"Amyloid"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cytogfr.2015.12.010","article-title":"The cytokine-serum amyloid A-chemokine network","volume":"30","author":"Gouwy","year":"2016","journal-title":"Cytokine Growth Factor. Rev."},{"key":"ref_17","first-page":"2122","article-title":"AA amyloidosis: Basic knowledge, unmet needs and future treatments","volume":"142","author":"Obici","year":"2012","journal-title":"Swiss Med. Wkly."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kuroda, T., Tanabe, N., Sato, H., Nakatsue, T., Wada, Y., Murakami, S., Nakano, M., and Narita, I. (2013). Distribution of Amyloid Deposits in the Kidneys of a Patient with Reactive Amyloidosis Associated with Rheumatoid Arthritis. BMC Res. Notes, 6.","DOI":"10.1186\/1756-0500-6-231"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.2174\/0929867323666160418114600","article-title":"Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults","volume":"23","author":"Buck","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_20","first-page":"58","article-title":"Serum amyloid A in the assessment of early inflammatory arthritis","volume":"27","author":"Cunnane","year":"2000","journal-title":"J. Rheumatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/ar78","article-title":"Acute-phase Serum Amyloid a Production by Rheumatoid Arthritis Synovial Tissue","volume":"2","author":"Murphy","year":"2000","journal-title":"Arthritis Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.4049\/jimmunol.0902941","article-title":"Acute Serum Amyloid A Induces Migration, Angiogenesis, and Inflammation in Synovial Cells In Vitro and in a Human Rheumatoid Arthritis\/SCID Mouse Chimera Model","volume":"184","author":"Connolly","year":"2010","journal-title":"J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Basile, M.S., Ciurleo, R., Bramanti, A., Petralia, M.C., Fagone, P., Nicoletti, F., and Cavalli, E. (2021). Cognitive Decline in Rheumatoid Arthritis: Insight into the Molecular Pathogenetic Mechanisms. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031185"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00234-001-0728-0","article-title":"Neuroradiological findings in two cases of isolated amyloidoma of the central nervous system","volume":"44","author":"Gallucci","year":"2002","journal-title":"Neuroradiology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1080\/13506120902879939","article-title":"The role of advanced MR methods in the diagnosis of cerebral amyloidoma","volume":"16","author":"Nossek","year":"2009","journal-title":"Amyloid"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/13506120600960585","article-title":"Cerebral AL lambda-amyloidoma: Clinical and pathomorphological characteristics. Review of the literature and of a patient","volume":"14","author":"Fischer","year":"2007","journal-title":"Amyloid"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.mayocp.2020.06.029","article-title":"Amyloid Typing by Mass Spectrometry in Clinical Practice: A Comprehensive Review of 16,175 Samples","volume":"95","author":"Dasari","year":"2020","journal-title":"Mayo Clin. Proc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s40336-014-0098-3","article-title":"Amyloid PET imaging: Applications beyond Alzheimer\u2019s disease","volume":"3","author":"Catafau","year":"2015","journal-title":"Clin. Transl. Imaging"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5414\/NPP29217","article-title":"Intracerebral amyloidoma: Case report and review of the literature","volume":"29","author":"Foreid","year":"2010","journal-title":"Clin. Neuropathol."},{"key":"ref_30","first-page":"850","article-title":"Amyloid A amyloidosis secondary to rheumatoid arthritis: Pathophysiology and treatments","volume":"29","author":"Nakamura","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/14397595.2013.854048","article-title":"Comparison of the clinical utility of tocilizumab and anti-TNF therapy in AA amyloidosis complicating rheumatic diseases","volume":"24","author":"Okuda","year":"2014","journal-title":"Mod. Rheumatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2169\/internalmedicine.41.403","article-title":"Long-term Follow-up of Systemic Reactive AA Amyloidosis Secondary to Rheumatoid Arthritis: Successful Treatment with Intermediate-dose Corticosteroid","volume":"41","author":"Matsuda","year":"2002","journal-title":"Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e1100","DOI":"10.1016\/j.wneu.2024.08.081","article-title":"Long-Term Progression of a Residual Cerebral Amyloidoma: An Illustrative Case and Systematic Review","volume":"190","author":"Romo","year":"2024","journal-title":"World Neurosurg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3171\/2016.7.JNS1690","article-title":"A rare case of central nervous system amyloidoma treated with fractionated radiotherapy","volume":"127","author":"Meier","year":"2017","journal-title":"J. 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