{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:38:40Z","timestamp":1776127120716,"version":"3.50.1"},"reference-count":72,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Innovation and Technological Development of the Republic of Serbia","award":["200110"],"award-info":[{"award-number":["200110"]}]},{"DOI":"10.13039\/501100004410","name":"MNTR","doi-asserted-by":"publisher","award":["FA4Lin"],"award-info":[{"award-number":["FA4Lin"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Erasmus mobility grant"},{"name":"EU COST","award":["20135"],"award-info":[{"award-number":["20135"]}]},{"name":"EU COST","award":["20119"],"award-info":[{"award-number":["20119"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Pathophysiology"],"abstract":"<jats:p>Current standard treatments for chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS), a urological disorder with anxiety as a major comorbidity, are limited in success rates. Recent findings revealed the anti-inflammatory and neuroprotective effects of CO-releasing molecules (CO-RMs), but there is a gap in the knowledge on its effects in CP\/CPPS. Therefore, the objective of our study was to investigate the potential therapeutic effects of CORM-A1 on the scrotal pain threshold and anxiety-related behaviors in experimental model of CP\/CPPS. Adult Wistar albino male rats were randomized to Sham (intraprostatic saline) or CP\/CPPS (intraprostatic \u03bb-carrageenan) groups (n = 12). Half received CORM-A1 (2 mg\/kg\/day, i.p., days 1\u20137), others PBS, forming four subgroups (n = 6). The pain threshold (by an electronic von Frey esthesiometer) and anxiety-like behavior (by an open field, elevated plus maze and light\/dark test) were assessed; prostates were histologically examined. Carrageenan-induced CP\/CPPS caused significant mechanical pain hypersensitivity (p &lt; 0.001), anxiety-like behaviors (p &lt; 0.001\u20130.05), and histological prostate damage when compared to corresponding Sham groups. CORM-A1 treatment increased pain thresholds (p &lt; 0.001) and improved behavioral outcomes (p &lt; 0.001\u20130.01) in all ethological tests. These findings indicate that CORM-A1 exerts analgesic and anxiolytic effects in an experimental model of CP\/CPPS in rats.<\/jats:p>","DOI":"10.3390\/pathophysiology32040053","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:37:21Z","timestamp":1759311441000},"page":"53","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Carbon Monoxide in an Experimental Model of Chronic Pelvic Pain Syndrome: The Effects of CORM-A1 on Pain and Anxiety-Related Behaviors"],"prefix":"10.3390","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9499-3247","authenticated-orcid":false,"given":"Nikola","family":"\u0160utulovi\u0107","sequence":"first","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neriman","family":"Ezgin","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"},{"name":"Department of Biotechnology, Institute of Natural and Applied Sciences, Cukurova University, Adana 01330, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5921-974X","authenticated-orcid":false,"given":"Nela","family":"Pu\u0161ka\u0161","sequence":"additional","affiliation":[{"name":"Institute of Histology and Embryology \u201cAleksandar \u0110. Kosti\u0107\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilija","family":"\u0110uri\u0107","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0812-2438","authenticated-orcid":false,"given":"\u017deljko","family":"Gruba\u010d","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-4819","authenticated-orcid":false,"given":"Daniel","family":"\u0160krijelj","sequence":"additional","affiliation":[{"name":"Clinic of Urology, University Clinical Center of Serbia, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-5466","authenticated-orcid":false,"given":"Milena","family":"Veskovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology \u201cLjubodrag Buba Mihailovic\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-6232","authenticated-orcid":false,"given":"Du\u0161an","family":"Mladenovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology \u201cLjubodrag Buba Mihailovic\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidora","family":"Savi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-8596","authenticated-orcid":false,"given":"Djuro","family":"Macut","sequence":"additional","affiliation":[{"name":"Clinic of Endocrinology, Diabetes and Metabolic Disease, University Clinical Centre of Serbia, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yavuz","family":"Dodurga","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, University of Pamukkale, Denizli 20160, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Ra\u0161i\u0107-Markovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivera","family":"Stanojlovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0806-444X","authenticated-orcid":false,"given":"Dragan","family":"Hrn\u010di\u0107","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4103\/aja202434","article-title":"Chronic prostatitis\/chronic pelvic pain syndrome induces metabolomic changes in expressed prostatic secretions and plasma","volume":"27","author":"Zhang","year":"2025","journal-title":"Asian J. 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