{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:46:16Z","timestamp":1781819176629,"version":"3.54.5"},"reference-count":53,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathophysiology"],"abstract":"<jats:p>Objectives: This study investigates the effects of resveratrol on systemic inflammatory, oxidative, and metabolic responses in a rat model that combines surgical trauma with prior exposure to Single Prolonged Stress (SPS), an established experimental protocol for modeling post-traumatic stress disorder (PTSD). Methods: Male Wistar rats (n = 21) were randomly assigned to three groups: (I) control (polyvinylpyrrolidone, PVP), (II) SPS + laparotomy + PVP), and (III) SPS + laparotomy + resveratrol. Resveratrol (5 mg\/kg of body weight\/day) or vehicle was administered intragastrically for seven days. Serum concentrations of cortisol, tumor necrosis factor-alpha (TNF-\u03b1), interleukin-6 (IL-6), interleukin-10 (IL-10), glucose, insulin, lipid fractions, and thiobarbituric acid\u2013reactive substances (TBA-RS) were determined by enzyme-linked immunosorbent assay and spectrophotometric methods. Insulin resistance was assessed using the homeostatic model assessment of insulin resistance (HOMA-IR) index. Results: Combined SPS and surgical trauma induced a pronounced systemic inflammatory response characterized by elevated cortisol (+138%), TNF-\u03b1 (+83%), IL-6 (+465%), and ceruloplasmin (+71%), as well as hyperglycemia, hyperinsulinemia, increased HOMA-IR, and atherogenic dyslipidemia with reduced high-density lipoprotein cholesterol (HDL-CH; \u221264%), elevated triglycerides (TGs; +216%), and very low-density lipoprotein cholesterol (VLDL-CH; +218%). Marked activation of lipid peroxidation was observed, as indicated by increased TBA-RS levels before and after incubation. Resveratrol administration significantly decreased cortisol (\u221245%), TNF-\u03b1 (\u221247%), and IL-6 (\u221285%), normalized the IL-10\/IL-6 ratio, and reduced ceruloplasmin levels (\u221213%). The compound improved insulin sensitivity (HOMA-IR \u221250%), elevated HDL-CH (+115%), and lowered TGs and VLDL-CH (\u221244%). It also attenuated both basal and inducible lipid peroxidation (TBA-RS \u221211% and \u221213%), indicating restoration of antioxidant capacity. Conclusions: Thus, resveratrol effectively counteracts the neuroendocrine, inflammatory, and metabolic disturbances induced by combined PTSD-like stress and surgical trauma.<\/jats:p>","DOI":"10.3390\/pathophysiology32040067","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T17:35:17Z","timestamp":1764956117000},"page":"67","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Modulating Role of Resveratrol in Metabolic and Inflammatory Dysregulation Caused by Surgical and Psychoemotional Stress in Rats"],"prefix":"10.3390","volume":"32","author":[{"given":"Roman","family":"Ryabushko","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Poltava State Medical University, 36011 Poltava, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heorhii","family":"Kostenko","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Poltava State Medical University, 36011 Poltava, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4958-3695","authenticated-orcid":false,"given":"Oleh","family":"Akimov","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Poltava State Medical University, 36011 Poltava, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitalii","family":"Kostenko","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Poltava State Medical University, 36011 Poltava, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1017\/S204579602300015X","article-title":"Disability and Post-Traumatic Stress Symptoms in the Ukrainian General Population during the 2022 Russian Invasion","volume":"32","author":"Kang","year":"2023","journal-title":"Epidemiol. 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