{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:53:18Z","timestamp":1774936398739,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016156","name":"US Army Medical Research and Development Command","doi-asserted-by":"crossref","award":["W81XWH-17-C-0184"],"award-info":[{"award-number":["W81XWH-17-C-0184"]}],"id":[{"id":"10.13039\/100016156","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science Foundation EPSCOR","award":["NSF-EPS-0903787"],"award-info":[{"award-number":["NSF-EPS-0903787"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathophysiology"],"abstract":"<jats:p>Background\/Objectives: No effective intervention currently exists for non-compressible pulmonary injury, especially in a prehospital setting. Visco-liquids like trisilanol i-octyl POSS could remedy this. POSS resists hemorrhage and activates clotting; this can be augmented with kaolin (22.5%; PK) or chitin (10%; PC). Methods: We tested the efficacy of POSS, PK, and PC in treating incisional lung wounds in swine (39 \u00b1 1 kg; n = 10). An incisional wound was made in the lung via a left thoracotomy, allowed to bleed freely for 30 s, and then no treatment (UNT), gauze with compression (GC), or POSS, PK, or PC was applied (1.5 mL). Each treatment was applied once per animal for a total of 5 wounds. Wounds were observed for 10 min for hemostasis and pneumostasis; GC treatments were assessed at 3 min intervals. Results: POSS and PC produced hemostasis in 8 of 10 wounds; GC: 7 (all significant from UNT); PK: 5 and UNT: 1. PK was not different from any group. POSS (2 \u00b1 0.3 min) and PC (1.4 \u00b1 0.4 min) clotted more quickly than GC (8 \u00b1 3 min); PK was intermediate (3.8 \u00b1 2 min) and not different from any other group. Pneumostasis was achieved in all POSS, PC, and PK, and only after hemostasis in the GC group. Conclusions: Because both POSS and PC provided quick and lasting hemorrhage and pneumatic control in this model, without need for compression, these results support the concept that these types of liquid POSS compounds could prove to be efficacious in prehospital treatment of non-compressible trauma wounds.<\/jats:p>","DOI":"10.3390\/pathophysiology33010001","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T07:01:33Z","timestamp":1766386893000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Liquid Trisilanol i-Octyl POSS Achieves Rapid Hemostasis and Pneumostasis in Experimental Lung Injury"],"prefix":"10.3390","volume":"33","author":[{"given":"Michelle","family":"Tucci","sequence":"first","affiliation":[{"name":"Anesthesiology, University of Mississippi Medical Center (UMMC), Jackson, MS 39216, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3611-1648","authenticated-orcid":false,"given":"Robert C.","family":"O\u2032Brien","sequence":"additional","affiliation":[{"name":"Ophthalmology, Miller School of Medicine, University of Miami, Miami, FL 33146, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Lichtenhan","sequence":"additional","affiliation":[{"name":"Hybrid Plastics, Inc., Hattiesburg, MS 39401, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Benghuzzi","sequence":"additional","affiliation":[{"name":"Biology, Jackson State University, Jackson, MS 39217, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drew","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Surgery, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S431","DOI":"10.1097\/TA.0b013e3182755dcc","article-title":"Death on the battlefield (2001\u20132011): Implications for the future of combat casualty care","volume":"73","author":"Eastridge","year":"2012","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.sopen.2022.01.006","article-title":"Lung hemorrhage in trauma: Technical tricks and tips","volume":"8","author":"Barber","year":"2022","journal-title":"Surg. Open Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13049-016-0301-9","article-title":"Prehospital control of life-threatening truncal and junctional haemorrhage is the ultimate challenge in optimizing trauma care; a review of treatment options and their applicability in the civilian trauma setting","volume":"24","author":"Tan","year":"2016","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_4","unstructured":"Oldsmar, F.L. (2021). Advanced Ranger First Responder Handbook, Breakaway Media, LLC."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Loman-Cortes, P., Binte Huq, T., and Vivero-Escoto, J.L. (2021). Use of Polyhedral Oligomeric Silsesquioxane (POSS) in Drug Delivery, Photodynamic Therapy and Bioimaging. Molecules, 26.","DOI":"10.3390\/molecules26216453"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.biomaterials.2016.01.005","article-title":"Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold","volume":"83","author":"Crowley","year":"2016","journal-title":"Biomaterials"},{"key":"ref_7","first-page":"746","article-title":"Polyhedral oligomeric silsesquioxane\u2013polymer nanocomposites","volume":"14","author":"Waddon","year":"2002","journal-title":"Adv. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1039\/C7DT00487G","article-title":"The thrombogenic activity of POSS silanols","volume":"46","author":"Lichtenhan","year":"2017","journal-title":"Dalton Trans."},{"key":"ref_9","first-page":"100111","article-title":"Arterial junctional hemostasis without compression: Evaluation of visco-liquid hemostats in male swine","volume":"18","author":"Tucci","year":"2025","journal-title":"Biomater. Biosyst."},{"key":"ref_10","unstructured":"National Research Council of the National Academies (2011). Guide for the Care and Use of Laboratory Animals, National Academies Press. [8th ed.]."},{"key":"ref_11","first-page":"S110","article-title":"Blood pressure at which rebleeding occurs after resuscitation in swine with aortic injury","volume":"54","author":"Sondeen","year":"2003","journal-title":"J. Trauma"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1700859","DOI":"10.1002\/adma.201700859","article-title":"Biomaterials and advanced technologies for hemostatic management of bleeding","volume":"30","author":"Hickman","year":"2018","journal-title":"Adv. Mater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13019-016-0563-3","article-title":"Prospective evaluation of biodegradable polymeric sealant for intraoperative air leaks","volume":"11","author":"Park","year":"2016","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111740","DOI":"10.1016\/j.msec.2020.111740","article-title":"Hemostatic performance and biocompatibility of chitosan-based agents in experimental parenchymal bleeding","volume":"120","author":"Deineka","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Quan, W.Y., Hu, Z., Liu, H.Z., Ouyang, Q.Q., Zhang, D.-Y., Li, S.-D., Li, P.-W., and Yang, Z.-M. (2019). Mussel-inspired catechol-functionalized hydrogels and their medical applications. Molecules, 24.","DOI":"10.3390\/molecules24142586"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e2301551","DOI":"10.1002\/adhm.202301551","article-title":"Injectable, Antibacterial, and Hemostatic Tissue Sealant Hydrogels","volume":"12","author":"Haghniaz","year":"2023","journal-title":"Adv. Health Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e1901722","DOI":"10.1002\/adhm.201901722","article-title":"Engineering tough, injectable, naturally derived, bioadhesive composite hydrogels","volume":"9","author":"Tavafoghi","year":"2020","journal-title":"Adv. Health Mater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7972","DOI":"10.1016\/j.biomaterials.2012.07.055","article-title":"Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure","volume":"33","author":"Mehdizadeh","year":"2012","journal-title":"Biomaterials"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1039\/C9CS00285E","article-title":"Catechol-functionalized hydrogels: Biomimetic design, adhesion mechanism, and biomedical applications","volume":"49","author":"Zhang","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1750-1164-6-12","article-title":"TissuePatch\u2122 as a novel synthetic sealant for repair of superficial lung defect: In vitro tests results","volume":"6","author":"Zhang","year":"2012","journal-title":"Ann. Surg. Innov. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1749-8090-8-90","article-title":"Reduction of intraoperative air leaks with Progel in pulmonary resection: A comprehensive review","volume":"8","author":"Fuller","year":"2013","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"011504","DOI":"10.1063\/5.0038364","article-title":"Recent advances on polymeric hydrogels as wound dressings","volume":"5","author":"Pan","year":"2021","journal-title":"APL Bioeng."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"34008","DOI":"10.1021\/acsomega.4c04577","article-title":"Development and characterization of biodegradable polyurethane-urea-based hydrogels for the prevention of postoperative peritoneal adhesions","volume":"9","author":"Kortenbrede","year":"2024","journal-title":"ACS Omega"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3390\/pathophysiology31030034","article-title":"Evaluation of full thickness wounds following application of a visco-liquid hemostat in a swine model","volume":"31","author":"Tucci","year":"2024","journal-title":"Pathophysiology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102006","DOI":"10.1016\/j.toxrep.2025.102006","article-title":"Histopathological evaluation of viscoelastic POSS administered subcutaneously using a rat model","volume":"14","author":"Benghuzzi","year":"2025","journal-title":"Toxicol. Rep"},{"key":"ref_26","first-page":"26","article-title":"Histopathological evaluation: POSS gel polymer and the proliferation of cellular components needed for repair","volume":"60","author":"Benghuzzi","year":"2024","journal-title":"Biomed. Sci. Instrum."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1177\/00031348221087905","article-title":"Thromboelastography-Based Evaluation of Gender-Associated Hypercoagulability","volume":"88","author":"Rodgers","year":"2022","journal-title":"Am. Surg."}],"container-title":["Pathophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1873-149X\/33\/1\/1\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T05:16:53Z","timestamp":1766553413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1873-149X\/33\/1\/1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["pathophysiology33010001"],"URL":"https:\/\/doi.org\/10.3390\/pathophysiology33010001","relation":{},"ISSN":["1873-149X"],"issn-type":[{"value":"1873-149X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]}}}