{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:34:19Z","timestamp":1786358059035,"version":"build-2736575974"},"reference-count":195,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathophysiology"],"abstract":"<jats:p>The intricate relationship between the heart and the brain has transitioned from historical, cardio-centric theories to a modern, circuit-based, bi-directional framework known as neurocardiology. This review provides a comprehensive anatomical, physiological, and clinical synthesis of the bidirectional heart\u2013brain axis, highlighting how disruptions in one organ systematically impact the other. Structurally, the heart\u2013brain axis operates as a closed-loop feedback network. Vagal parasympathetic control dominates at rest, driven by an asymmetrical fiber distribution where sensory afferents actively supply interoceptive data to the brainstem. Hemodynamically, cerebral blood flow delivery is linked to cardiac output in an age-dependent fashion with the related vascular dysfunction. Clinically, brain-to-heart pathologies like acute brain injury trigger life-threatening catecholamine surges, neuroinflammation, and myocardial stunning, including Takotsubo cardiomyopathy. Conversely, heart-to-brain pathways reveal that atrial fibrillation and heart failure can independently trigger cardioembolic stroke, long-term neuroinflammation, and a profound, progressive burden of cognitive decline. The heart and brain are inexorably linked through complex structural, mechanical, and paracrine pathways. Ameliorating clinical outcomes demands integrated cross-specialty diagnostic screening, digital rhythm monitoring, and holistic neurocardioprotective therapeutic strategies.<\/jats:p>","DOI":"10.3390\/pathophysiology33030058","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:24:53Z","timestamp":1786353893000},"page":"58","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heart Meets Brain: Insights into Neurocardiac Pathophysiology"],"prefix":"10.3390","volume":"33","author":[{"given":"Berk","family":"Rasheed","sequence":"first","affiliation":[{"name":"College of Medicine, University of Illinois Chicago, Rockford, IL 61107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Freed","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Illinois Chicago, Rockford, IL 61107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhi","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, Western University, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, Western University, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6097-8401","authenticated-orcid":false,"given":"Krishna K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, Western University, London, ON N6A 5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"546737","DOI":"10.1155\/2009\/546737","article-title":"The Heart-Brain Connection Begets Cardiovascular Psychiatry and Neurology","volume":"2009","author":"Manev","year":"2009","journal-title":"Cardiovasc. 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