{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:37:15Z","timestamp":1760402235381,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Medical University of Bia\u0142ystok","doi-asserted-by":"publisher","award":["SUB\/1\/DN\/21\/004\/1143"],"award-info":[{"award-number":["SUB\/1\/DN\/21\/004\/1143"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>Extraintestinal manifestations (EIMs) are observed in 15\u201320% of patients with inflammatory bowel disease (IBD). One of the rare EIMs is myocarditis, the incidence of which is estimated at around 1%. The main cause of myocarditis is a viral infection. Other causes include autoimmune diseases and drug complications (sulfasalazine, mesalazine). We present the case of an 11-year-old girl with Crohn\u2019s disease (CD) with EIMs, manifested as hip joint inflammation and erythema nodosum. At the same time, the symptoms of myopericarditis appeared with changes in electrocardiogram (ECG), echocardiography and high troponin I concentration. Therapy with corticosteroids resulted in the resolution of skin lesions and cardiological symptoms. Systemic connective tissue diseases, viral and bacterial infections were excluded in the differential diagnosis. The suspicion of mesalazine-induced EIMs was also ruled out as the symptoms resolved despite continued therapy with mesalazine. No further recurrences of myopericarditis were observed.<\/jats:p>","DOI":"10.3390\/pediatric14010005","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T20:33:04Z","timestamp":1641933184000},"page":"26-31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful Treatment with Corticosteroids in an 11-Year-Old Patient with Crohn\u2019s Disease and Myopericarditis\u2014Case Report"],"prefix":"10.3390","volume":"14","author":[{"given":"Joanna","family":"Ryzko","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Waszyngtona St. 17, 15-274 Bia\u0142ystok, Poland"},{"name":"Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children\u2019s Memorial Health Institute, 04-730 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0755-911X","authenticated-orcid":false,"given":"Katarzyna","family":"Zdanowicz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Waszyngtona St. 17, 15-274 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz Marek","family":"Lebensztejn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Waszyngtona St. 17, 15-274 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-6578","authenticated-orcid":false,"given":"Urszula","family":"Daniluk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Waszyngtona St. 17, 15-274 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jacc.2011.09.074","article-title":"Update on myocarditis","volume":"59","author":"Kindermann","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1161\/CIRCULATIONAHA.105.584532","article-title":"Myocarditis current trends in diagnosis and treatment","volume":"113","author":"Magnani","year":"2006","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/MPG.0b013e318093f4b0","article-title":"Extraintestinal Manifestations of Inflammatory Bowel Disease","volume":"46","author":"Jose","year":"2008","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_4","first-page":"964","article-title":"Myocarditis in Children with Inflammatory Bowel Disease","volume":"5","author":"Frid","year":"1986","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1001\/archinte.1983.00350010098017","article-title":"Pleuropericarditis: An Extraintestinal Complication of Inflammatory Bowel Disease","volume":"143","author":"Patwardhan","year":"1983","journal-title":"Arch. Intern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0140-6736(89)92407-0","article-title":"Cardiac Hypersensitivity to 5-Aminosalicylic Acid","volume":"333","author":"Agnholt","year":"1989","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/BF02282352","article-title":"Pleuropericarditis related to the use of mesalamine","volume":"41","author":"Gujral","year":"1996","journal-title":"Dig. Dis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.repc.2012.12.018","article-title":"Mesalamine-induced myocarditis following diagnosis of Crohn\u2019s disease: A case report","volume":"32","author":"Martins","year":"2013","journal-title":"Rev. Port. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1017\/S1047951114001048","article-title":"Mesalamine-induced myopericarditis in a paediatric patient with Crohn\u2019s disease","volume":"25","author":"Nair","year":"2015","journal-title":"Cardiol. Young"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4318\/tjg.2012.0357","article-title":"Myocarditis due to mesalamine treatment in a patient with Crohn\u2019s disease in China","volume":"23","author":"Liu","year":"2012","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.3748\/wjg.v9.i10.2300","article-title":"Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: Results of 25-year follow-up study","volume":"9","author":"Lakatos","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.14503\/THIJ-16-5859","article-title":"Eosinophilia and ulcerative colitis associated with eosinophilis myocarditis","volume":"44","author":"Murphy","year":"2017","journal-title":"Tex. Heart Inst. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1093\/eurheartj\/ehm456","article-title":"The role of endomyocardial biopsy in the management of cardiovascular disease: A Scientific Statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology","volume":"28","author":"Cooper","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1056\/NEJMra0800028","article-title":"Myocarditis","volume":"360","author":"Leslie","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_15","first-page":"1","article-title":"Myocarditis in Crohn\u2019s disease: A case report","volume":"4","author":"Bart","year":"2020","journal-title":"Eur. Heart J. Case Rep."},{"key":"ref_16","first-page":"e4248","article-title":"Acute Myopericarditis with Crohn\u2019s Disease Flare-up","volume":"11","author":"Kumar","year":"2019","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0828-282X(10)70470-0","article-title":"Recurrent myopericarditis with extensive ulcerative colitis","volume":"26","author":"Freeman","year":"2010","journal-title":"Can. J. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"bcr2014204818","DOI":"10.1136\/bcr-2014-204818","article-title":"Ulcerative colitis-induced myocarditis","volume":"2014","author":"Gruenhagen","year":"2014","journal-title":"BMJ Case Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/ccr3.1562","article-title":"Recurrent pericarditis as an extra-intestinal manifestation of ulcerative colitis in 14-year old girl","volume":"6","author":"Taminiau","year":"2018","journal-title":"Clin. Case Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9813893","DOI":"10.1155\/2018\/9813893","article-title":"Myocarditis secondary to mesalamine- induced cardiotoxicity in a patient with ulcerative colitis","volume":"2018","author":"Okoro","year":"2018","journal-title":"Case Rep. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"512","DOI":"10.5009\/gnl.2012.6.4.512","article-title":"A case of acute myocarditis as the initial presentation of Crohn\u2019s disease","volume":"6","author":"Oh","year":"2012","journal-title":"Gut Liver"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00431-002-0925-9","article-title":"Possibile activation of an intramyocardial inflammatory process (Staphylococcus ureus) after treatment with infliximab in a boy with Crohn disease","volume":"161","author":"Reichardt","year":"2002","journal-title":"Eur. J. Pediatr."},{"key":"ref_23","first-page":"249","article-title":"Hypersensitivity perimyocarditis after the first dose of infliximab","volume":"107","year":"2015","journal-title":"Rev. Esp. Enferm. Dig."}],"container-title":["Pediatric Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2036-7503\/14\/1\/5\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:27:10Z","timestamp":1760362030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7503\/14\/1\/5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,11]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["pediatric14010005"],"URL":"https:\/\/doi.org\/10.3390\/pediatric14010005","relation":{},"ISSN":["2036-7503"],"issn-type":[{"type":"electronic","value":"2036-7503"}],"subject":[],"published":{"date-parts":[[2022,1,11]]}}}