{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T17:34:00Z","timestamp":1775928840842,"version":"3.50.1"},"reference-count":16,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>Fish roe are not yet described as triggers of allergic reactions in Italy, especially during the pediatric age; they are more frequently involved in anaphylaxis in Eastern countries, such as Japan. For this report, we reported a case of anaphylaxis in a 2-year-old boy admitted to our Hospital Pediatric Emergency Room with a suspected allergic reaction. 15 min after the meal, he presented generalized urticaria, angioedema, wheezing, sneezing, and two vomiting episodes. The meal was smoked salmon, butter, mayonnaise, anchovies, and fish roe (salmon and lumpfish roe). Tryptase serum levels presented as elevated in the acute phase and normal after 24 h. Serum food-specific IgE tested negative for salmon and other fish, such as skin prick tests. Serum food-specific IgE showed that the patient was sensitized to cow\u2019s milk and eggs, but he doesn\u2019t have a food allergy. He had regularly consumed milk and eggs before and after the allergic reaction without clinical problems. A prick-by-prick test resulted positive for fish roe (salmon and lumpfish roe). Based on patient\u2019s history, allergy test results in vivo, and tryptase serum levels, the diagnosis of anaphylaxis induced by fish roe was confirmed. In conclusion, to the best of our knowledge, this is the first pediatric case of fish roe-induced anaphylaxis reported in Italy.<\/jats:p>","DOI":"10.3390\/pediatric14020023","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T05:13:08Z","timestamp":1649481188000},"page":"170-174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fish Roe-Induced Anaphylaxis in Italy: A Pediatric Case Report"],"prefix":"10.3390","volume":"14","author":[{"given":"Nicoletta","family":"De Paulis","sequence":"first","affiliation":[{"name":"Pediatrics and Neonatology Unit, Department of Maternal and Child Health, Guglielmo da Saliceto Hospital, Azienda USL di Piacenza, 29121 Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8985-770X","authenticated-orcid":false,"given":"Margherita","family":"Di Costanzo","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Department of Maternal and Child Health, Guglielmo da Saliceto Hospital, Azienda USL di Piacenza, 29121 Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Capra","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Department of Maternal and Child Health, Guglielmo da Saliceto Hospital, Azienda USL di Piacenza, 29121 Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Peveri","sequence":"additional","affiliation":[{"name":"Department of Allergology, Guglielmo da Saliceto Hospital, Azienda USL di Piacenza, 29121 Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Montagni","sequence":"additional","affiliation":[{"name":"Department of Allergology, Guglielmo da Saliceto Hospital, Azienda USL di Piacenza, 29121 Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7441-9248","authenticated-orcid":false,"given":"Giacomo","family":"Biasucci","sequence":"additional","affiliation":[{"name":"Pediatrics and Neonatology Unit, Department of Maternal and Child Health, Guglielmo da Saliceto Hospital, Azienda USL di Piacenza, 29121 Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.alit.2017.02.001","article-title":"Committee for Japanese Pediatric Guideline for Food Allergy, The Japanese Society of Pediatric Allergy and Clinical Immunology, The Japanese Society of Allergology. Japanese Guidelines for Food Allergy 2017","volume":"66","author":"Ebisawa","year":"2017","journal-title":"Allergol. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1021\/jf8031759","article-title":"Major allergen and its IgE cross-reactivity among salmonid fish roe allergy","volume":"57","author":"Shimizu","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/ped.12168","article-title":"Intussusception secondary to anaphylactic reaction to salmon roe (ikura)","volume":"55","author":"Takeuchi","year":"2013","journal-title":"Pediatr. Int."},{"key":"ref_4","first-page":"301","article-title":"Allergy to salmon eggs without concomitant fish allergies, three pediatric cases","volume":"44","author":"Pages","year":"2015","journal-title":"Rev. French Allergol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.anai.2016.11.020","article-title":"Salmon roe (ikura) induced anaphylaxis in a child","volume":"118","author":"Minhas","year":"2017","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_6","first-page":"233","article-title":"Salmon caviar-induced anaphylactic shock","volume":"24","author":"Flais","year":"2004","journal-title":"Allergy Asthma Proc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.18176\/jiaci.0347","article-title":"Salmon Roe as an Emerging Allergen in Western Countries","volume":"29","author":"Cosme","year":"2019","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/all.12437","article-title":"EAACI Food Allergy and Anaphylaxis Guidelines Group. Anaphylaxis: Guidelines from the European Academy of Allergy and Clinical Immunology","volume":"69","author":"Muraro","year":"2014","journal-title":"Allergy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.jaci.2015.11.015","article-title":"Anaphylaxis in children and adolescents: The European Anaphylaxis Registry","volume":"137","author":"Grabenhenrich","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.pcl.2015.07.008","article-title":"Signs and Symptoms of Food Allergy and Food-Induced Anaphylaxis","volume":"62","author":"Sharma","year":"2015","journal-title":"Pediatr Clin. N. Am."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s12016-020-08777-7","article-title":"Using Baseline and Peak serum tryptase levels to diagnose anaphylaxis: A Review","volume":"58","author":"Passia","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1398-9995.2007.01614.x","article-title":"Identification of vitellogenin as an allergen in Beluga caviar allergy","volume":"63","author":"Cases","year":"2008","journal-title":"Allergy"},{"key":"ref_13","first-page":"732178","article-title":"Fish Allergy Around the World-Precise Diagnosis to Facilitate Patient Management. Front","volume":"2","author":"Kalic","year":"2021","journal-title":"Allergy"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2332\/allergolint.54.317","article-title":"IgE Cross-reactivity between fish roe (salmon, herring and pollock) and chicken egg in patients anaphylactic to salmon roe","volume":"54","author":"Kondo","year":"2005","journal-title":"Allergol. Int."},{"key":"ref_15","first-page":"625","article-title":"Allergen in fish roe","volume":"28","author":"Saeki","year":"2008","journal-title":"Allergy Pract."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.alit.2019.09.007","article-title":"Type-I-hypersensitivity to 15 kDa, 28 kDa and 54 kDa proteins in vitellogenin specific to Gadus chalcogrammus roe","volume":"69","author":"Hanaoka","year":"2020","journal-title":"Allergol. Int."}],"container-title":["Pediatric Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2036-7503\/14\/2\/23\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:50:11Z","timestamp":1760136611000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7503\/14\/2\/23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,8]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["pediatric14020023"],"URL":"https:\/\/doi.org\/10.3390\/pediatric14020023","relation":{},"ISSN":["2036-7503"],"issn-type":[{"value":"2036-7503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,8]]}}}