{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:49:30Z","timestamp":1791254970714,"version":"4.1.0"},"reference-count":19,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T00:00:00Z","timestamp":1658620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>Ibuprofen is commonly used for the treatment of hemodynamically significant patent ductus arteriosus (PDA) in preterm infants. It seems that the oral formulation incurs a higher closure rate and has a better safety profile in preterm infants born &gt; 26 weeks\u2019 gestation. There is no consensus across Canadian centers regarding the minimum volume of enteral feeds required prior to starting ibuprofen for the treatment of patent ductus arteriosus, and the current practice is comfort-based depending on the centre and the local prevalence of neonatal morbidities.<\/jats:p>","DOI":"10.3390\/pediatric14030040","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T01:42:13Z","timestamp":1658713333000},"page":"333-337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["What Are the Minimal Feeds Required for Starting Enteral Ibuprofen in Preterm Infants with PDA?"],"prefix":"10.3390","volume":"14","author":[{"given":"Aimann","family":"Surak","sequence":"first","affiliation":[{"name":"Northern Alberta Neonatal Program, Philip C. Etches NICU, Royal Alexandra Hospital Site, DTC 5027, 10240 Kingsway NW, Edmonton, AB T5H 3V9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Hyderi","sequence":"additional","affiliation":[{"name":"Northern Alberta Neonatal Program, Philip C. Etches NICU, Royal Alexandra Hospital Site, DTC 5027, 10240 Kingsway NW, Edmonton, AB T5H 3V9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,24]]},"reference":[{"key":"ref_1","first-page":"CD003481","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants","volume":"2","author":"Ohlsson","year":"2020","journal-title":"Cochrane Database Syst. 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