{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:08:20Z","timestamp":1788826100605,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T00:00:00Z","timestamp":1516406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The development of the gastric lesion is complex and the result of the imbalance between aggressive and protective factors, involving the generation of free radicals and disturbance in nitric oxide (NO) production. Sulphated polysaccharides (SP), from marine algae, are widely used in biotechnological and pharmaceutical areas. In this study, we evaluated the effects of SP from the green marine alga Caulerpa mexicana (Cm-SP) in ethanol-induced gastric damage models in mice. Cm-SP (2, 20, or 200 mg\/kg), administered p.o., significantly reduced gastric damage, and these effects were inhibited through pretreatment with indomethacin. Cm-SP (200 mg\/kg) prevented the ethanol-induced decline in glutathione and restored its normal level. Moreover, it was able to normalize the elevated thiobarbituric acid reactive substance levels. However, Cm-SP did not show any significant effects on NO2\/NO3 level, when compared to the ethanol group. The pretreatment with L- NAME induced gastric mucosal damage and did not inhibit the gastroprotective effect of Cm-SP (200 mg\/kg). In conclusion, the gastroprotective effects of Cm-SP in mice involve prostaglandins and reduction in the oxidative stress and are independent of NO.<\/jats:p>","DOI":"10.3390\/ph11010006","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T04:51:13Z","timestamp":1516596673000},"page":"6","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage"],"prefix":"10.3390","volume":"11","author":[{"given":"Jos\u00e9","family":"Carneiro","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Federal University of Cear\u00e1, s\/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil"},{"name":"Federal Institute of Education, Science and Technology of Cear\u00e1, Armando Sales Louzada Street, 62580-000 Acara\u00fa, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ticiana","family":"Holanda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Federal University of Cear\u00e1, s\/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Quinder\u00e9","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Federal University of Cear\u00e1, s\/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annyta","family":"Frota","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Federal University of Cear\u00e1, s\/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vit\u00f3ria","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Federal University of Cear\u00e1, s\/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayane","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Federal University of Cear\u00e1, s\/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Federal University of Cear\u00e1, s\/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dainesy","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Morphoology, Faculty of Medicine, Federal University of Cear\u00e1, s\/n Delmiro de Farias Street, Porangabu\u00e7u Campus, 60416-030 Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoniella","family":"Gomes Duarte","sequence":"additional","affiliation":[{"name":"Department of Morphoology, Faculty of Medicine, Federal University of Cear\u00e1, s\/n Delmiro de Farias Street, Porangabu\u00e7u Campus, 60416-030 Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Benevides","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Federal University of Cear\u00e1, s\/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,20]]},"reference":[{"key":"ref_1","first-page":"34","article-title":"Peptic ulcer: A review on etiology and pathogenesis","volume":"3","author":"Amandeep","year":"2012","journal-title":"Int. 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