{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:29:20Z","timestamp":1790998160142,"version":"4.1.0"},"reference-count":426,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T00:00:00Z","timestamp":1527638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1052\/A7"],"award-info":[{"award-number":["CRC1052\/A7"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Maintenance of body weight is fundamental to maintain one\u2019s health and to promote longevity. Nevertheless, it appears that the global obesity epidemic is still constantly increasing. Endocannabinoids (eCBs) are lipid messengers that are involved in overall body weight control by interfering with manifold central and peripheral regulatory circuits that orchestrate energy homeostasis. Initially, blocking of eCB signaling by first generation cannabinoid type 1 receptor (CB1) inverse agonists such as rimonabant revealed body weight-reducing effects in laboratory animals and men. Unfortunately, rimonabant also induced severe psychiatric side effects. At this point, it became clear that future cannabinoid research has to decipher more precisely the underlying central and peripheral mechanisms behind eCB-driven control of feeding behavior and whole body energy metabolism. Here, we will summarize the most recent advances in understanding how central eCBs interfere with circuits in the brain that control food intake and energy expenditure. Next, we will focus on how peripheral eCBs affect food digestion, nutrient transformation and energy expenditure by interfering with signaling cascades in the gastrointestinal tract, liver, pancreas, fat depots and endocrine glands. To finally outline the safe future potential of cannabinoids as medicines, our overall goal is to address the molecular, cellular and pharmacological logic behind central and peripheral eCB-mediated body weight control, and to figure out how these precise mechanistic insights are currently transferred into the development of next generation cannabinoid medicines displaying clearly improved safety profiles, such as significantly reduced side effects.<\/jats:p>","DOI":"10.3390\/ph11020055","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T03:07:42Z","timestamp":1527736062000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Endocannabinoids in Body Weight Control"],"prefix":"10.3390","volume":"11","author":[{"given":"Henrike","family":"Horn","sequence":"first","affiliation":[{"name":"Institute of Anatomy, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"B\u00f6hme","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Koch","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.neuro.30.051606.094324","article-title":"Neurobiology of feeding and energy expenditure","volume":"30","author":"Gao","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0140-6736(13)60103-8","article-title":"Associations of linear growth and relative weight gain during early life with adult health and human capital in countries of low and middle income: Findings from five birth cohort studies","volume":"382","author":"Adair","year":"2013","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1016\/S0140-6736(17)32129-3","article-title":"NCD Risk Factor Collaboration (NCD-RisC) Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: A pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults","volume":"390","author":"Smolen","year":"2017","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1038\/ijo.2008.246","article-title":"Energy metabolism, fuel selection and body weight regulation","volume":"32","author":"Galgani","year":"2008","journal-title":"Int. J. Obes. (Lond.)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/mp.2014.30","article-title":"Molecular and cellular regulation of hypothalamic melanocortin neurons controlling food intake and energy metabolism","volume":"19","author":"Koch","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1242\/dmm.009613","article-title":"The evolution of human adiposity and obesity: Where did it all go wrong?","volume":"5","author":"Wells","year":"2012","journal-title":"Dis. Models Mech."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tins.2012.12.005","article-title":"Hypothalamic control of energy balance: Insights into the role of synaptic plasticity","volume":"36","author":"Dietrich","year":"2013","journal-title":"Trends Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"jeb167254","DOI":"10.1242\/jeb.167254","article-title":"The evolution of body fatness: Trading off disease and predation risk","volume":"221","author":"Speakman","year":"2018","journal-title":"J. Exp. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fnins.2017.00293","article-title":"Cannabinoid receptor signaling in central regulation of feeding behavior: A mini-review","volume":"11","author":"Koch","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/BF02862859","article-title":"An archaeological and historical account of cannabis in China","volume":"28","author":"Li","year":"1973","journal-title":"Econ. Bot."},{"key":"ref_11","first-page":"80","article-title":"Physical evidence for the antiquity of Cannabis sativa L.","volume":"5","author":"Fleming","year":"1998","journal-title":"J. Int. Hemp Assoc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fphar.2017.00108","article-title":"Cannabis in Chinese medicine: Are some traditional indications referenced in ancient literature related to cannabinoids?","volume":"8","author":"Brand","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/0040-4020(63)85022-X","article-title":"Hashish\u2014I. The structure of cannabidiol","volume":"19","author":"Mechoulam","year":"1963","journal-title":"Tetrahedron"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1021\/ja01062a046","article-title":"Isolation, structure, and partial synthesis of an active constituent of hashish","volume":"86","author":"Gaoni","year":"1964","journal-title":"J. Am. Chem. Soc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/0040-4020(65)80064-3","article-title":"Hashish\u2014IV. The isolation and structure of cannabinolic cannabidiolic and cannabigerolic acids","volume":"21","author":"Mechoulam","year":"1965","journal-title":"Tetrahedron"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrn3811","article-title":"Early phytocannabinoid chemistry to endocannabinoids and beyond","volume":"15","author":"Mechoulam","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1360-0443.2007.01795.x","article-title":"Conversation with raphael mechoulam","volume":"102","author":"Mechoulam","year":"2007","journal-title":"Addiction"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0026-895X(25)09876-1","article-title":"Determination and characterization of a cannabinoid receptor in rat brain","volume":"34","author":"Devane","year":"1988","journal-title":"Mol. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/365061a0","article-title":"Molecular characterization of a peripheral receptor for cannabinoids","volume":"365","author":"Munro","year":"1993","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1432-1033.1995.tb20780.x","article-title":"Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations","volume":"232","author":"Galiegue","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","article-title":"Isolation and structure of a brain constituent that binds to the cannabinoid receptor","volume":"258","author":"Devane","year":"1992","journal-title":"Science (N.Y.)"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","article-title":"Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors","volume":"50","author":"Mechoulam","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tips.2015.02.008","article-title":"Endocannabinoid signaling at the periphery: 50 years after thc","volume":"36","author":"Maccarrone","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"E625","DOI":"10.1208\/aapsj070364","article-title":"The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids","volume":"7","author":"Pertwee","year":"2005","journal-title":"AAPS J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1124\/pr.112.006387","article-title":"Chemical probes of endocannabinoid metabolism","volume":"65","author":"Blankman","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.tins.2011.03.003","article-title":"Supply and demand for endocannabinoids","volume":"34","author":"Alger","year":"2011","journal-title":"Trends Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mce.2011.10.011","article-title":"Regulation of endocannabinoid release by G proteins: A paracrine mechanism of G protein-coupled receptor action","volume":"353","author":"Gyombolai","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropharm.2007.05.020","article-title":"Multiple pathways involved in the biosynthesis of anandamide","volume":"54","author":"Liu","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref_29","first-page":"491","article-title":"Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain","volume":"1861","author":"Leishman","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1073\/pnas.0730816100","article-title":"Evidence against the presence of an anandamide transporter","volume":"100","author":"Glaser","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"34660","DOI":"10.1074\/jbc.M112.373241","article-title":"Evidence for bidirectional endocannabinoid transport across cell membranes","volume":"287","author":"Chicca","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropharm.2017.11.032","article-title":"The cannabinoid transporter inhibitor omdm-2 reduces social interaction: Further evidence for transporter-mediated endocannabinoid release","volume":"130","author":"Seillier","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/febs.12212","article-title":"Transport of endocannabinoids across the plasma membrane and within the cell","volume":"280","author":"Fowler","year":"2013","journal-title":"FEBS J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1194\/jlr.M300170-JLR200","article-title":"Binding of anandamide to bovine serum albumin","volume":"44","author":"Bojesen","year":"2003","journal-title":"J. Lipid Res."},{"key":"ref_35","first-page":"309","article-title":"Endocannabinoid-mediated control of synaptic transmission","volume":"89","author":"Kano","year":"2009","journal-title":"Phys. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1677\/JME-08-0190","article-title":"Signal transduction of the CB1 cannabinoid receptor","volume":"44","author":"Turu","year":"2010","journal-title":"J. Mol. Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1073\/pnas.1521304113","article-title":"Orexin-a represses satiety-inducing pomc neurons and contributes to obesity via stimulation of endocannabinoid signaling","volume":"113","author":"Morello","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/npp.2017.206","article-title":"CB1 receptor signaling in the brain: Extracting specificity from ubiquity","volume":"43","author":"Bains","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nature02913","article-title":"Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids","volume":"431","author":"Bacci","year":"2004","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/pr.110.003004","article-title":"International union of basic and clinical pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond CB1 and CB2","volume":"62","author":"Pertwee","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nn.3053","article-title":"Mitochondrial CB(1) receptors regulate neuronal energy metabolism","volume":"15","author":"Benard","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.celrep.2015.06.075","article-title":"Metabolic interplay between astrocytes and neurons regulates endocannabinoid action","volume":"12","author":"Viader","year":"2015","journal-title":"Cell Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.neuron.2008.01.029","article-title":"Endocannabinoids mediate neuron-astrocyte communication","volume":"57","author":"Navarrete","year":"2008","journal-title":"Neuron"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnint.2016.00024","article-title":"Endocannabinoids and heterogeneity of glial cells in brain function","volume":"10","author":"Scheller","year":"2016","journal-title":"Front. Integr. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbi.2015.06.002","article-title":"Endocannabinoids drive the acquisition of an alternative phenotype in microglia","volume":"49","author":"Mecha","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1093\/cercor\/bhu231","article-title":"Endocannabinoids induce lateral long-term potentiation of transmitter release by stimulation of gliotransmission","volume":"25","author":"Navarrete","year":"2015","journal-title":"Cereb. Cortex"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuropharm.2017.06.017","article-title":"Synaptic functions of endocannabinoid signaling in health and disease","volume":"124","author":"Araque","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature14260","article-title":"Hypothalamic pomc neurons promote cannabinoid-induced feeding","volume":"519","author":"Koch","year":"2015","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1038\/nn.4392","article-title":"Dynamic GABAergic afferent modulation of AgRP neurons","volume":"19","author":"Garfield","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cmet.2017.09.021","article-title":"Overlapping brain circuits for homeostatic and hedonic feeding","volume":"27","author":"Rossi","year":"2018","journal-title":"Cell Metab."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Novelle, M.G., and Dieguez, C. (2018). Food addiction and binge eating: Lessons learned from animal models. Nutrients, 10.","DOI":"10.3390\/nu10010071"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1017\/S0954422414000080","article-title":"The endocannabinoid system and appetite: Relevance for food reward","volume":"27","author":"Jager","year":"2014","journal-title":"Nutr. Res. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/sj.ijo.0803274","article-title":"Endocannabinoids, feeding and suckling\u2014From our perspective","volume":"30","author":"Mechoulam","year":"2006","journal-title":"Int. J. Obes."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0014-2999(01)00953-0","article-title":"Critical role of the endogenous cannabinoid system in mouse pup suckling and growth","volume":"419","author":"Fride","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0014-2999(03)01295-0","article-title":"Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: Evidence for a \u201cCB3\u201d receptor","volume":"461","author":"Fride","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1758-5996-4-35","article-title":"Excess of the endocannabinoid anandamide during lactation induces overweight, fat accumulation and insulin resistance in adult mice","volume":"4","author":"Aguirre","year":"2012","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1038\/nutd.2015.17","article-title":"The endocannabinoid anandamide during lactation increases body fat content and CB1 receptor levels in mice adipose tissue","volume":"5","author":"Aguirre","year":"2015","journal-title":"Nutr. Diabetes"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2945010","DOI":"10.1155\/2017\/2945010","article-title":"Oral administration of the endocannabinoid anandamide during lactation: Effects on hypothalamic cannabinoid type 1 receptor and food intake in adult mice","volume":"2017","author":"Aguirre","year":"2017","journal-title":"J. Nutr. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"596149","DOI":"10.1155\/2009\/596149","article-title":"Cannabis and breastfeeding","volume":"2009","author":"Garry","year":"2009","journal-title":"J. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/sj.ijo.0802583","article-title":"CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity","volume":"28","author":"Delgorge","year":"2004","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6273","DOI":"10.1523\/JNEUROSCI.2648-09.2010","article-title":"Alterations in the hippocampal endocannabinoid system in diet-induced obese mice","volume":"30","author":"Massa","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1073\/pnas.96.10.5780","article-title":"Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice","volume":"96","author":"Zimmer","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/bies.201500046","article-title":"Dissecting the cannabinergic control of behavior: The where matters","volume":"37","author":"Desprez","year":"2015","journal-title":"BioEssays News Rev. Mol. Cell. Dev. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"R1111","DOI":"10.1016\/j.cub.2014.10.023","article-title":"The hypothalamus","volume":"24","author":"Saper","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1210\/en.2013-1831","article-title":"The temporal pattern of cfos activation in hypothalamic, cortical, and brainstem nuclei in response to fasting and refeeding in male mice","volume":"155","author":"Wu","year":"2014","journal-title":"Endocrinology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cmet.2006.09.004","article-title":"Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus","volume":"4","author":"Date","year":"2006","journal-title":"Cell Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35078085","article-title":"Leptin activates anorexigenic pomc neurons through a neural network in the arcuate nucleus","volume":"411","author":"Cowley","year":"2001","journal-title":"Nature"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.neuron.2017.06.014","article-title":"Toward a wiring diagram understanding of appetite control","volume":"95","author":"Andermann","year":"2017","journal-title":"Neuron"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.molmet.2017.01.004","article-title":"Cannabinoid type 1 receptor-containing axons innervate NPY\/AgRP neurons in the mouse arcuate nucleus","volume":"6","author":"Morozov","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/nn.4372","article-title":"Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis","volume":"19","author":"Zhang","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nn.4495","article-title":"A molecular census of arcuate hypothalamus and median eminence cell types","volume":"20","author":"Campbell","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.celrep.2015.08.070","article-title":"Agrp neurons regulate bone mass","volume":"13","author":"Kim","year":"2015","journal-title":"Cell Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1073\/pnas.1210644110","article-title":"Hunger-promoting hypothalamic neurons modulate effector and regulatory t-cell responses","volume":"110","author":"Matarese","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0166-4328(86)90071-9","article-title":"Effect of paraventricular nucleus lesions on body weight, food intake and insulin levels","volume":"22","author":"Sims","year":"1986","journal-title":"Behav. Brain Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/(SICI)1096-9861(19980914)399:1<101::AID-CNE8>3.0.CO;2-5","article-title":"Oxytocinergic inputs to the nucleus of the solitary tract and dorsal motor nucleus of the vagus in neonatal rats","volume":"399","author":"Rinaman","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0031-9384(90)90234-U","article-title":"Oxytocin inhibits food and fluid intake in rats","volume":"48","author":"Arletti","year":"1990","journal-title":"Physiol. Behav."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.physbeh.2017.03.007","article-title":"Current findings on the role of oxytocin in the regulation of food intake","volume":"176","author":"Spetter","year":"2017","journal-title":"Physiol. Behav."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fphar.2015.00137","article-title":"Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: Different lipid signals?","volume":"6","author":"Romano","year":"2015","journal-title":"Front. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"E1266","DOI":"10.1152\/ajpendo.00411.2013","article-title":"Hindbrain noradrenergic input to the hypothalamic PVN mediates the activation of oxytocinergic neurons induced by the satiety factor oleoylethanolamide","volume":"305","author":"Romano","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"8096","DOI":"10.1523\/JNEUROSCI.0036-10.2010","article-title":"The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin","volume":"30","author":"Gaetani","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1113\/JP271946","article-title":"Hubs and spokes of the lateral hypothalamus: Cell types, circuits and behaviour","volume":"594","author":"Bonnavion","year":"2016","journal-title":"J. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/380243a0","article-title":"A role for melanin-concentrating hormone in the central regulation of feeding behaviour","volume":"380","author":"Qu","year":"1996","journal-title":"Nature"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/25341","article-title":"Mice lacking melanin-concentrating hormone are hypophagic and lean","volume":"396","author":"Shaimada","year":"1998","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2009.09.106","article-title":"Lateral hypothalamic orexin\/hypocretin neurons: A role in reward-seeking and addiction","volume":"1314","author":"Smith","year":"2010","journal-title":"Brain Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation","volume":"98","author":"Chemelli","year":"1999","journal-title":"Cell"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1523\/JNEUROSCI.0732-07.2007","article-title":"Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin\/orexin neurons: Implications for cannabinoid actions on food intake and cognitive arousal","volume":"27","author":"Huang","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cmet.2005.03.003","article-title":"Input organization and plasticity of hypocretin neurons: Possible clues to obesity\u2019s association with insomnia","volume":"1","author":"Horvath","year":"2005","journal-title":"Cell Metab."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"E2229","DOI":"10.1073\/pnas.1219485110","article-title":"Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons","volume":"110","author":"Cristino","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"9625","DOI":"10.1073\/pnas.1307389110","article-title":"Orexin neurons use endocannabinoids to break obesity-induced inhibition","volume":"110","author":"Alpar","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.molmet.2017.04.005","article-title":"Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese mice","volume":"6","author":"Becker","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/npp.2017.12","article-title":"Singular location and signaling profile of adenosine A2A-cannabinoid CB1receptor heteromers in the dorsal striatum","volume":"43","author":"Moreno","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.neuron.2005.10.021","article-title":"Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit","volume":"48","author":"Jo","year":"2005","journal-title":"Neuron"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature04071","article-title":"A role for lateral hypothalamic orexin neurons in reward seeking","volume":"437","author":"Harris","year":"2005","journal-title":"Nature"},{"key":"ref_95","first-page":"1","article-title":"Distribution of the orexin-1 receptor (OX1R) in the mouse forebrain and rostral brainstem: A characterisation of OX1R-eGFP mice","volume":"66\u201367","author":"Lawrence","year":"2015","journal-title":"J. Chem. Neuroanat."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"R1692","DOI":"10.1152\/ajpregu.00044.2011","article-title":"Evidence for the role of hindbrain orexin-1 receptors in the control of meal size","volume":"301","author":"Parise","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"12199","DOI":"10.1038\/ncomms12199","article-title":"Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons","volume":"7","author":"Tung","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1210\/endo.141.11.7757","article-title":"Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans","volume":"141","author":"Date","year":"2000","journal-title":"Endocrinology"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Alen, F., Crespo, I., Ramirez-Lopez, M.T., Jagerovic, N., Goya, P., de Fonseca, F.R., de Heras, R.G., and Orio, L. (2013). Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral cb1 receptor antagonism. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0060918"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Hashiguchi, H., Sheng, Z., Routh, V., Gerzanich, V., Simard, J.M., and Bryan, J. (2017). Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184261"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Kola, B., Farkas, I., Christ-Crain, M., Wittmann, G., Lolli, F., Amin, F., Harvey-White, J., Liposits, Z., Kunos, G., and Grossman, A.B. (2008). The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001797"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.physbeh.2017.12.005","article-title":"A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice","volume":"184","author":"Kalafateli","year":"2018","journal-title":"Physiol. Behav."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.tem.2010.08.002","article-title":"Obesity and leptin resistance: Distinguishing cause from effect","volume":"21","author":"Myers","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1113\/jphysiol.2009.173328","article-title":"Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status","volume":"587","author":"Mitchell","year":"2009","journal-title":"J. Physiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejphar.2003.09.047","article-title":"Basal and feeding-evoked dopamine release in the rat nucleus accumbens is depressed by leptin","volume":"482","author":"Krugel","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1530\/JOE-13-0455","article-title":"Targeted leptin receptor blockade: Role of ventral tegmental area and nucleus of the solitary tract leptin receptors in body weight homeostasis","volume":"222","author":"Matheny","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ijo.2017.231","article-title":"Triglycerides cross the blood-brain barrier and induce central leptin and insulin receptor resistance","volume":"42","author":"Banks","year":"2018","journal-title":"Int. J. Obes. (Lond.)"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/35071088","article-title":"Leptin-regulated endocannabinoids are involved in maintaining food intake","volume":"410","author":"Goparaju","year":"2001","journal-title":"Nature"},{"key":"ref_109","first-page":"457","article-title":"The inhibitory effect of combination treatment with leptin and cannabinoid cb1 receptor agonist on food intake and body weight gain is mediated by serotonin 1b and 2c receptors","volume":"67","author":"Wolak","year":"2016","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.molmet.2017.06.010","article-title":"Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling","volume":"6","author":"Tam","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fendo.2017.00047","article-title":"Cholecystokinin-from local gut hormone to ubiquitous messenger","volume":"8","author":"Rehfeld","year":"2017","journal-title":"Front. Endocrinol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1037\/h0077040","article-title":"Cholecystokinin elicits the complete behavioral sequence of satiety in rats","volume":"89","author":"Antin","year":"1975","journal-title":"J. Comp. Physiol. Psychol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0006-8993(84)90124-0","article-title":"Bilateral midbrain transections block the behavioral effects of cholecystokinin on feeding and exploration in rats","volume":"322","author":"Crawley","year":"1984","journal-title":"Brain Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"11905","DOI":"10.1038\/ncomms11905","article-title":"Genetically and functionally defined NTS to PBN brain circuits mediating anorexia","volume":"7","author":"Roman","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/npp.2008.97","article-title":"Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning","volume":"34","author":"Chhatwal","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1038\/npp.2011.59","article-title":"Cholecystokinin exerts an effect via the endocannabinoid system to inhibit gabaergic transmission in midbrain periaqueductal gray","volume":"36","author":"Mitchell","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1113\/JP273484","article-title":"Nutritional status-dependent endocannabinoid signalling regulates the integration of rat visceral information","volume":"595","author":"Khlaifia","year":"2017","journal-title":"J. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.6986652","article-title":"Insulin binding sites localized to nerve terminals in rat median eminence and arcuate nucleus","volume":"207","author":"Posner","year":"1980","journal-title":"Science"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2337\/diab.44.2.147","article-title":"Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression","volume":"44","author":"Sipols","year":"1995","journal-title":"Diabetes"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1523\/JNEUROSCI.3118-09.2010","article-title":"Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons","volume":"30","author":"Williams","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.molmet.2017.03.013","article-title":"Insulin controls food intake and energy balance via npy neurons","volume":"6","author":"Loh","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0306-4522(96)00434-4","article-title":"Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem","volume":"77","author":"Larsen","year":"1997","journal-title":"Neuroscience"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.molmet.2015.07.008","article-title":"Distribution and characterisation of glucagon-like peptide-1 receptor expressing cells in the mouse brain","volume":"4","author":"Cork","year":"2015","journal-title":"Mol. Metab."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.coph.2013.09.006","article-title":"The gut hormone glucagon-like peptide-1 produced in brain: Is this physiologically relevant?","volume":"13","author":"Trapp","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1152\/ajpregu.1998.274.1.R23","article-title":"Pvn infusion of GLP-1-(7\u201436) amide suppresses feeding but does not induce aversion or alter locomotion in rats","volume":"274","author":"McMahon","year":"1998","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"897.e895","DOI":"10.1016\/j.neuron.2017.09.042","article-title":"Enhanced AMPA receptor trafficking mediates the anorexigenic effect of endogenous glucagon-like peptide-1 in the paraventricular hypothalamus","volume":"96","author":"Liu","year":"2017","journal-title":"Neuron"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"14302","DOI":"10.1074\/jbc.M115.655662","article-title":"Modulation of glucagon-like peptide-1 (GLP-1) potency by endocannabinoid-like lipids represents a novel mode of regulating GLP-1 receptor signaling","volume":"290","author":"Cheng","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Witkamp, R.F. (2018). The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite. Mol. Asp. Med., in press.","DOI":"10.1016\/j.mam.2018.01.002"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuropharm.2015.05.013","article-title":"The role of polyunsaturated fatty acids and GPR40 receptor in brain","volume":"113","author":"Khan","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nn.2736","article-title":"Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions","volume":"14","author":"Lafourcade","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"218s","DOI":"10.1093\/jn\/136.1.218S","article-title":"Structure of the blood-brain barrier and its role in the transport of amino acids","volume":"136","author":"Hawkins","year":"2006","journal-title":"J. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev.nutr.27.061406.093726","article-title":"Mechanisms of food intake repression in indispensable amino acid deficiency","volume":"27","author":"Gietzen","year":"2007","journal-title":"Annu. Rev. Nutr."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fendo.2016.00148","article-title":"Central amino acid sensing in the control of feeding behavior","volume":"7","author":"Heeley","year":"2016","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/978-3-642-24716-3_12","article-title":"Sensing of glucose in the brain","volume":"209","author":"Thorens","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1113\/jphysiol.2009.182147","article-title":"Electrophysiological identification of glucose-sensing neurons in rat nodose ganglia","volume":"588","author":"Grabauskas","year":"2010","journal-title":"J. Physiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1152\/ajpregu.00527.2010","article-title":"Multiple hypothalamic circuits sense and regulate glucose levels","volume":"300","author":"Karnani","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature06098","article-title":"Glucose sensing by pomc neurons regulates glucose homeostasis and is impaired in obesity","volume":"449","author":"Parton","year":"2007","journal-title":"Nature"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"C746","DOI":"10.1152\/ajpcell.00641.2008","article-title":"Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose","volume":"296","author":"Murphy","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1074\/jbc.RA117.000838","article-title":"Leptin enhances hypothalamic lactate dehydrogenase A (LDHA)-dependent glucose sensing to lower glucose production in high-fat-fed rats","volume":"293","author":"Abraham","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.2337\/db11-0120","article-title":"Glucose transporter-1 in the hypothalamic glial cells mediates glucose sensing to regulate glucose production in vivo","volume":"60","author":"Chari","year":"2011","journal-title":"Diabetes"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/jcbfm.2013.206","article-title":"Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion","volume":"34","author":"Allard","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1172\/JCI64102","article-title":"Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes","volume":"122","author":"Granado","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molmet.2013.08.001","article-title":"Astroglial cb1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes","volume":"2","author":"Bosier","year":"2013","journal-title":"Mol. Metab."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1113\/jphysiol.2010.202051","article-title":"Atp-mediated glucosensing by hypothalamic tanycytes","volume":"589","author":"Frayling","year":"2011","journal-title":"J. Physiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/jcmm.12590","article-title":"The role of tanycytes in hypothalamic glucosensing","volume":"19","author":"Barahona","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/physrev.00023.2014","article-title":"Neuronal reward and decision signals: From theories to data","volume":"95","author":"Schultz","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Montmayeur, J.P., and le Coutre, J. (2010). Evolutionary perspectives on fat ingestion and metabolism in humans. Fat Detection: Taste, Texture, and Post Ingestive Effects, CRC Press.","DOI":"10.1201\/9781420067767"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0149-7634(95)00033-B","article-title":"Food reward: Brain substrates of wanting and liking","volume":"20","author":"Berridge","year":"1996","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0195-6663(90)90083-K","article-title":"Why a palatability construct is needed","volume":"14","author":"Rogers","year":"1990","journal-title":"Appetite"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuropharm.2017.04.033","article-title":"Endocannabinoid modulation of dopamine neurotransmission","volume":"124","author":"Covey","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.pbb.2005.01.032","article-title":"Endocannabinoid signaling system and brain reward: Emphasis on dopamine","volume":"81","author":"Gardner","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0306-4522(03)00070-8","article-title":"Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia","volume":"119","author":"Julian","year":"2003","journal-title":"Neuroscience"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0028-3908(03)00029-7","article-title":"Differential cannabinoid-induced electrophysiological effects in rat ventral tegmentum","volume":"44","author":"Cheer","year":"2003","journal-title":"Neuropharmacology"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Turner, B.D., Kashima, D.T., Manz, K.M., Grueter, C.A., and Grueter, B.A. (2018). Synaptic plasticity in the nucleus accumbens: Lessons learned from experience. ACS Chem. Neurosci.","DOI":"10.1021\/acschemneuro.7b00420"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0301-0082(80)90018-0","article-title":"From motivation to action: Functional interface between the limbic system and the motor system","volume":"14","author":"Mogenson","year":"1980","journal-title":"Prog. Neurobiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/sj.bjp.0704767","article-title":"Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: Stimulation of eating by 2-arachidonoyl glycerol","volume":"136","author":"Kirkham","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"8384","DOI":"10.1073\/pnas.122149199","article-title":"Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens","volume":"99","author":"Robbe","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1037\/xan0000090","article-title":"\u201cWanting,\u201d \u201cliking,\u201d and their relation to consciousness","volume":"42","author":"Anselme","year":"2016","journal-title":"J. Exp. Psychol. Anim. Learn. Cogn."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1073\/pnas.1503550112","article-title":"Identity-specific coding of future rewards in the human orbitofrontal cortex","volume":"112","author":"Howard","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1038\/s41593-017-0008-x","article-title":"Elucidating the underlying components of food valuation in the human orbitofrontal cortex","volume":"20","author":"Suzuki","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1038\/ncomms4926","article-title":"Orbitofrontal neurons infer the value and identity of predicted outcomes","volume":"5","author":"Stalnaker","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1038\/nn.4136","article-title":"Neural mechanisms supporting maladaptive food choices in anorexia nervosa","volume":"18","author":"Foerde","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fnins.2018.00040","article-title":"Limited access to a high fat diet alters endocannabinoid tone in female rats","volume":"12","author":"Satta","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s002130050326","article-title":"Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors","volume":"132","author":"Arnone","year":"1997","journal-title":"Psychopharmacology (Berl.)"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/231260b0","article-title":"Effects of marihuana on the solution of anagrams, memory and appetite","volume":"231","author":"Abel","year":"1971","journal-title":"Nature"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0031-9384(98)00170-X","article-title":"Hyperphagia in pre-fed rats following oral delta9-THC","volume":"65","author":"Williams","year":"1998","journal-title":"Phys. Behav."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0091-3057(76)90202-1","article-title":"Comparative effects of various naturally occurring cannabinoids on food, sucrose and water consumption by rats","volume":"4","author":"Sofia","year":"1976","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/bs.irn.2015.09.003","article-title":"Endocannabinoid regulation of neuroendocrine systems","volume":"125","author":"Tasker","year":"2015","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3758\/BF03336548","article-title":"Increased and decreased eating following THC administration","volume":"29","author":"Glick","year":"1972","journal-title":"Psychon. Sci."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0014-2999(00)00059-5","article-title":"Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice","volume":"392","author":"Hao","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s002130050953","article-title":"Anandamide induces overeating: Mediation by central cannabinoid (CB1) receptors","volume":"143","author":"Williams","year":"1999","journal-title":"Psychopharmacology"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuropharm.2011.10.018","article-title":"Cannabinoid facilitation of behavioral and biochemical hedonic taste responses","volume":"63","author":"Solinas","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nn.3647","article-title":"The endocannabinoid system controls food intake via olfactory processes","volume":"17","author":"Bellocchio","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/chemse\/bjx062","article-title":"Role of endocannabinoids on sweet taste perception, food preference, and obesity-related disorders","volume":"43","author":"Tarragon","year":"2017","journal-title":"Chem. Senses"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/nn.4639","article-title":"Yummy or yucky? Ask your central amygdala","volume":"20","author":"Livneh","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0006-8993(80)91117-8","article-title":"Efferent connections of the parabrachial nucleus in the rat","volume":"197","author":"Saper","year":"1980","journal-title":"Brain Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"9702","DOI":"10.1523\/JNEUROSCI.1171-08.2008","article-title":"Activating parabrachial cannabinoid cb1 receptors selectively stimulates feeding of palatable foods in rats","volume":"28","author":"DiPatrizio","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.physbeh.2006.05.024","article-title":"Gustatory reward and the nucleus accumbens","volume":"89","author":"Norgren","year":"2006","journal-title":"Physiol. Behav."},{"key":"ref_179","first-page":"6","article-title":"Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies","volume":"6","author":"Befort","year":"2015","journal-title":"Front. Pharmacol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"e34955","DOI":"10.7554\/eLife.34955","article-title":"Endogenous opioids in the nucleus accumbens promote approach to high-fat food in the absense of caloric need","volume":"7","author":"Caref","year":"2018","journal-title":"eLife"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1046\/j.1460-9568.1999.00847.x","article-title":"Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain","volume":"11","author":"Marsicano","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"E2717","DOI":"10.1073\/pnas.1206303109","article-title":"Cannabinoid receptor 1-expressing neurons in the nucleus accumbens","volume":"109","author":"Winters","year":"2012","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrendo.2017.61","article-title":"Food addiction and obesity: Unnecessary medicalization of hedonic overeating","volume":"13","author":"Finlayson","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pneurobio.2015.03.002","article-title":"Taste, olfactory, and food reward value processing in the brain","volume":"127\u2013128","author":"Rolls","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nature22375","article-title":"Homeostatic circuits selectively gate food cue responses in insular cortex","volume":"546","author":"Livneh","year":"2017","journal-title":"Nature"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.biopsych.2011.05.010","article-title":"Brain type 1 cannabinoid receptor availability in patients with anorexia and bulimia nervosa","volume":"70","author":"Gerard","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"12627","DOI":"10.1523\/JNEUROSCI.1028-13.2013","article-title":"Anandamide, cannabinoid type 1 receptor, and nmda receptor activation mediate non-hebbian presynaptically expressed long-term depression at the first central synapse for visceral afferent fibers","volume":"33","author":"Khlaifia","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/jdi.12492","article-title":"Mechanistic relationship between the vagal afferent pathway, central nervous system and peripheral organs in appetite regulation","volume":"7","author":"Ueno","year":"2016","journal-title":"J. Diabetes Investig."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"R1623","DOI":"10.1152\/ajpregu.1999.276.6.R1623","article-title":"Gut vagal afferent lesions increase meal size but do not block gastric preload-induced feeding suppression","volume":"276","author":"Schwartz","year":"1999","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.coph.2007.10.008","article-title":"A potential role for the hippocampus in energy intake and body weight regulation","volume":"7","author":"Davidson","year":"2007","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ejphar.2013.09.068","article-title":"Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system","volume":"722","author":"Sharkey","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/1756283X15618131","article-title":"Nausea: A review of pathophysiology and therapeutics","volume":"9","author":"Singh","year":"2016","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2165\/00003495-198300251-00006","article-title":"Review of cannabinoids and their antiemetic effectiveness","volume":"25","author":"Vincent","year":"1983","journal-title":"Drugs"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1136\/gut.2003.036350","article-title":"Cannabinoid hyperemesis: Cyclical hyperemesis in association with chronic cannabis abuse","volume":"53","author":"Allen","year":"2004","journal-title":"Gut"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1017\/S1740925X06000202","article-title":"Astroglial heterogeneity closely reflects the neuronal-defined anatomy of the adult murine CNS","volume":"2","author":"Emsley","year":"2006","journal-title":"Neuron Glia Biol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.brainresrev.2009.12.001","article-title":"Heterogeneity in astrocyte morphology and physiology","volume":"63","author":"Matyash","year":"2010","journal-title":"Brain Res. Rev."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-1-61779-452-0_3","article-title":"Heterogeneity of astrocytic form and function","volume":"814","author":"Oberheim","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.cell.2011.07.022","article-title":"Astrocytes are endogenous regulators of basal transmission at central synapses","volume":"146","author":"Panatier","year":"2011","journal-title":"Cell"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1113\/jphysiol.2010.203224","article-title":"Astrocytes control gabaergic inhibition of neurons in the mouse barrel cortex","volume":"589","author":"Benedetti","year":"2011","journal-title":"J. Physiol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/3684","article-title":"Astrocyte-mediated potentiation of inhibitory synaptic transmission","volume":"1","author":"Kang","year":"1998","journal-title":"Nat. Neurosci."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0166-2236(98)01349-6","article-title":"Tripartite synapses: Glia, the unacknowledged partner","volume":"22","author":"Araque","year":"1999","journal-title":"Trends Neurosci."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature08673","article-title":"Long-term potentiation depends on release of D-serine from astrocytes","volume":"463","author":"Henneberger","year":"2010","journal-title":"Nature"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.neuron.2014.02.007","article-title":"Gliotransmitters travel in time and space","volume":"81","author":"Araque","year":"2014","journal-title":"Neuron"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1038\/sj.npp.1301375","article-title":"Striatal adenosine A2a and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids","volume":"32","author":"Carriba","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.celrep.2015.04.002","article-title":"Astrocytes control food intake by inhibiting agrp neuron activity via adenosine a1 receptors","volume":"11","author":"Yang","year":"2015","journal-title":"Cell Rep."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.cell.2016.07.028","article-title":"Astrocytic insulin signaling couples brain glucose uptake with nutrient availability","volume":"166","author":"Quarta","year":"2016","journal-title":"Cell"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuroscience.2015.06.007","article-title":"Glucose and hypothalamic astrocytes: More than a fueling role?","volume":"323","author":"Leloup","year":"2016","journal-title":"Neuroscience"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.molmet.2015.08.005","article-title":"Leptin potentiates astrogenesis in the developing hypothalamus","volume":"4","author":"Rottkamp","year":"2015","journal-title":"Mol. Metab."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nn.3725","article-title":"Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding","volume":"17","author":"Kim","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pneurobio.2016.03.001","article-title":"The role of astrocytes in the hypothalamic response and adaptation to metabolic signals","volume":"144","author":"Chowen","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0074-7696(05)47003-5","article-title":"Hypothalamic tanycytes: A key component of brain-endocrine interaction","volume":"247","author":"Rodriguez","year":"2005","journal-title":"Int. Rev. Cytol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.molmet.2017.08.015","article-title":"Amino acid sensing in hypothalamic tanycytes via umami taste receptors","volume":"6","author":"Lazutkaite","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cmet.2013.12.015","article-title":"Hypothalamic tanycytes are an erk-gated conduit for leptin into the brain","volume":"19","author":"Balland","year":"2014","journal-title":"Cell Metab."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1002\/cne.22382","article-title":"Endocannabinoid system in the adult rat circumventricular areas: An immunohistochemical study","volume":"518","author":"Suarez","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3389\/fnins.2015.00387","article-title":"Hypothalamic tanycytes-masters and servants of metabolic, neuroendocrine, and neurogenic functions","volume":"9","author":"Goodman","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1210\/en.2004-1520","article-title":"Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus","volume":"146","author":"Araujo","year":"2005","journal-title":"Endocrinology"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"908","DOI":"10.2337\/db16-0586","article-title":"Inhibiting microglia expansion prevents diet-induced hypothalamic and peripheral inflammation","volume":"66","author":"Andre","year":"2017","journal-title":"Diabetes"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"29424","DOI":"10.1038\/srep29424","article-title":"Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis","volume":"6","author":"Jin","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-2999(00)00211-9","article-title":"Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor","volume":"396","author":"Buckley","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/syn.20050","article-title":"Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: An immunohistochemical study","volume":"53","author":"Nunez","year":"2004","journal-title":"Synapse"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1567-5769(01)00147-3","article-title":"Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation","volume":"2","author":"Carlisle","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1124\/mol.65.4.999","article-title":"Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism","volume":"65","author":"Carrier","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroscience.2017.08.053","article-title":"Distinct roles of neuronal and microglial CB2 cannabinoid receptors in the mouse hippocampus","volume":"363","author":"Li","year":"2017","journal-title":"Neuroscience"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1093\/brain\/awp239","article-title":"Microglial CB2 cannabinoid receptors are neuroprotective in huntington\u2019s disease excitotoxicity","volume":"132","author":"Palazuelos","year":"2009","journal-title":"Brain J. Neurol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1471-4159.2005.03380.x","article-title":"Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli","volume":"95","author":"Maresz","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neuroscience.2015.10.041","article-title":"Neuronal expression of CB2 cannabinoid receptor mrnas in the mouse hippocampus","volume":"311","author":"Li","year":"2015","journal-title":"Neuroscience"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cmet.2010.02.015","article-title":"CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance","volume":"11","author":"Quarta","year":"2010","journal-title":"Cell Metab."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Deveaux, V., Cadoudal, T., Ichigotani, Y., Teixeira-Clerc, F., Louvet, A., Manin, S., Nhieu, J.T., Belot, M.P., Zimmer, A., and Even, P. (2009). Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005844"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.2337\/db10-1809","article-title":"Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy","volume":"60","author":"Barutta","year":"2011","journal-title":"Diabetes"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/bph.13226","article-title":"Role of the endocannabinoid system in diabetes and diabetic complications","volume":"173","author":"Gruden","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1172\/JCI17725","article-title":"The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis","volume":"112","author":"Cota","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI200523057","article-title":"Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity","volume":"115","author":"DePetrillo","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"926","DOI":"10.2337\/db09-1482","article-title":"CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice","volume":"59","author":"Jourdan","year":"2010","journal-title":"Diabetes"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1172\/JCI34827","article-title":"Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice","volume":"118","author":"Liu","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1073\/pnas.152334899","article-title":"Brain monoglyceride lipase participating in endocannabinoid inactivation","volume":"99","author":"Dinh","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"27218","DOI":"10.1074\/jbc.272.43.27218","article-title":"Cdna cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases","volume":"272","author":"Karlsson","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1194\/jlr.M065227","article-title":"Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation","volume":"57","author":"Krott","year":"2016","journal-title":"J. Lipid Res."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.2337\/diabetes.54.10.2838","article-title":"Activation of the peripheral endocannabinoid system in human obesity","volume":"54","author":"Engeli","year":"2005","journal-title":"Diabetes"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/dom.12646","article-title":"Endocannabinoid regulation of beta-cell functions: Implications for glycaemic control and diabetes","volume":"18","author":"Jourdan","year":"2016","journal-title":"Diabetes Obes. Metab."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"33021","DOI":"10.1074\/jbc.R800012200","article-title":"Endocannabinoids and the control of energy homeostasis","volume":"283","author":"Kunos","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"R2185","DOI":"10.1152\/ajpregu.00663.2007","article-title":"A neutral CB1 receptor antagonist reduces weight gain in rat","volume":"293","author":"Chambers","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_242","first-page":"430","article-title":"Rimonabant sanofi-synthelabo","volume":"5","author":"Fernandez","year":"2004","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"432607","DOI":"10.1155\/2011\/432607","article-title":"Rimonabant: From rio to ban","volume":"2011","author":"Sam","year":"2011","journal-title":"J. Obes."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1038\/oby.2011.69","article-title":"Rimonabant redux and strategies to improve the future outlook of CB1 receptor neutral-antagonist\/inverse-agonist therapies","volume":"19","author":"Ward","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1073\/pnas.0912048107","article-title":"Endocannabinoids selectively enhance sweet taste","volume":"107","author":"Yoshida","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1172\/JCI25299","article-title":"Cd36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions","volume":"115","author":"Laugerette","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"R1823","DOI":"10.1152\/ajpregu.00211.2007","article-title":"CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice","volume":"293","author":"Sclafani","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1113\/JP270295","article-title":"Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice","volume":"593","author":"Niki","year":"2015","journal-title":"J. Physiol."},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Matias, I., Gatta-Cherifi, B., Tabarin, A., Clark, S., Leste-Lasserre, T., Marsicano, G., Piazza, P.V., and Cota, D. (2012). Endocannabinoids measurement in human saliva as potential biomarker of obesity. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042399"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.5604\/17322693.1176778","article-title":"Saliva of obese patients\u2014Is it different?","volume":"69","author":"Choromanska","year":"2015","journal-title":"Postepy Hig. Med. Dosw. (Online)"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1096\/fj.13-227587","article-title":"Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats","volume":"27","author":"DiPatrizio","year":"2013","journal-title":"FASEB J."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.biochi.2013.07.029","article-title":"Is the taste of fat regulated?","volume":"96","author":"Chevrot","year":"2014","journal-title":"Biochimie"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.physbeh.2011.02.016","article-title":"Oral fatty acid signaling and intestinal lipid processing: Support and supposition","volume":"105","author":"Mattes","year":"2011","journal-title":"Physiol. Behav."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.plipres.2011.02.002","article-title":"Fatty acid detection during food consumption and digestion: Associations with ingestive behavior and obesity","volume":"50","author":"Stewart","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Simopoulos, A.P. (2016). An increase in the omega-6\/omega-3 fatty acid ratio increases the risk for obesity. Nutrients, 8.","DOI":"10.3390\/nu8030128"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbalip.2008.01.006","article-title":"Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine","volume":"1781","author":"Artmann","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00213-002-1263-3","article-title":"Cannabinoid influences on palatability: Microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and sr141716","volume":"165","author":"Higgs","year":"2003","journal-title":"Psychopharmacology (Berl.)"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/chemse\/bjj065","article-title":"Variation in the human tas1r taste receptor genes","volume":"31","author":"Kim","year":"2006","journal-title":"Chem. Senses"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/nutrit\/nuu009","article-title":"Taste perception, associated hormonal modulation, and nutrient intake","volume":"73","author":"Loper","year":"2015","journal-title":"Nutr. Rev."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.semcdb.2012.08.004","article-title":"Modulation of sweet responses of taste receptor cells","volume":"24","author":"Yoshida","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_261","first-page":"1884","article-title":"Cannabinoid receptors in submandibular acinar cells: Functional coupling between saliva fluid and electrolytes secretion and Ca2+ signalling","volume":"125","author":"Kopach","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1177\/153537020623100816","article-title":"Inhibition of salivary secretion by activation of cannabinoid receptors","volume":"231","author":"Prestifilippo","year":"2006","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pharmthera.2009.12.005","article-title":"Cannabinoids and the gut: New developments and emerging concepts","volume":"126","author":"Izzo","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"ref_264","doi-asserted-by":"crossref","unstructured":"Fichna, J., Bawa, M., Thakur, G.A., Tichkule, R., Makriyannis, A., McCafferty, D.M., Sharkey, K.A., and Storr, M. (2014). Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109115"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1124\/jpet.110.175778","article-title":"Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice","volume":"338","author":"Kinsey","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00109-005-0016-2","article-title":"Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis","volume":"84","author":"Massa","year":"2006","journal-title":"J. Mol. Med. (Berl.)"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/sj.bjp.0707423","article-title":"Cannabinoids go nuclear: Evidence for activation of peroxisome proliferator-activated receptors","volume":"152","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0014-5793(03)01196-7","article-title":"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives","volume":"554","author":"Fredriksson","year":"2003","journal-title":"FEBS Lett."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/sj.bjp.0707460","article-title":"The orphan receptor GPR55 is a novel cannabinoid receptor","volume":"152","author":"Ryberg","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature01921","article-title":"Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor ppar-alpha","volume":"425","author":"Fu","year":"2003","journal-title":"Nature"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"30429","DOI":"10.1074\/jbc.M305051200","article-title":"Activation of trpv1 by the satiety factor oleoylethanolamide","volume":"278","author":"Ahern","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.beem.2008.10.003","article-title":"Role of acylethanolamides in the gastrointestinal tract with special reference to food intake and energy balance","volume":"23","author":"Borrelli","year":"2009","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1006\/nbdi.1998.0221","article-title":"Endogenous cannabinoid signaling","volume":"5","author":"Piomelli","year":"1998","journal-title":"Neurobiol. Dis."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"R1407","DOI":"10.1152\/ajpregu.00664.2005","article-title":"Postprandial increase of oleoylethanolamide mobilization in small intestine of the burmese python (python molurus)","volume":"290","author":"Astarita","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/oby.2009.186","article-title":"Basal and fasting\/refeeding-regulated tissue levels of endogenous ppar-alpha ligands in zucker rats","volume":"18","author":"Izzo","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/s00018-004-4494-0","article-title":"Regulation of food intake by oleoylethanolamide","volume":"62","author":"Gaetani","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/35102582","article-title":"An anorexic lipid mediator regulated by feeding","volume":"414","author":"Navarro","year":"2001","journal-title":"Nature"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1096\/fj.201500132","article-title":"Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARalpha","volume":"31","author":"Karwad","year":"2017","journal-title":"FASEB J."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.2337\/db08-1237","article-title":"GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell","volume":"58","author":"Lauffer","year":"2009","journal-title":"Diabetes"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrendo.2015.211","article-title":"Endocannabinoids\u2014At the crossroads between the gut microbiota and host metabolism","volume":"12","author":"Cani","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nn1457","article-title":"Endocannabinoid control of food intake and energy balance","volume":"8","author":"Matias","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1007\/s00109-005-0698-5","article-title":"The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract","volume":"83","author":"Massa","year":"2005","journal-title":"J. Mol. Med. (Berl.)"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1126\/science.1239275","article-title":"A gut lipid messenger links excess dietary fat to dopamine deficiency","volume":"341","author":"Tellez","year":"2013","journal-title":"Science"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/sj.npp.1300695","article-title":"Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa","volume":"30","author":"Monteleone","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.physbeh.2016.12.044","article-title":"Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity","volume":"171","author":"Argueta","year":"2017","journal-title":"Physiol. Behav."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1476-511X-12-78","article-title":"Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men","volume":"12","author":"Berge","year":"2013","journal-title":"Lipids Health Dis."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1073\/pnas.101119098","article-title":"Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets","volume":"98","author":"Berger","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0952-3278(03)00056-5","article-title":"N-3 polyunsaturated fatty acid (PUFA) deficiency elevates and n-3 pufa enrichment reduces brain 2-arachidonoylglycerol level in mice","volume":"69","author":"Watanabe","year":"2003","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/jcp.20678","article-title":"Effect of arachidonic and eicosapentaenoic acid metabolism on raw 264.7 macrophage proliferation","volume":"208","author":"Nieves","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbalip.2005.12.011","article-title":"Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors","volume":"1761","author":"Petersen","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_291","doi-asserted-by":"crossref","unstructured":"Sykaras, A.G., Demenis, C., Case, R.M., McLaughlin, J.T., and Smith, C.P. (2012). Duodenal enteroendocrine i-cells contain mRNA transcripts encoding key endocannabinoid and fatty acid receptors. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042373"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nm1521","article-title":"Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors","volume":"13","author":"Rousseaux","year":"2007","journal-title":"Nat. Med."},{"key":"ref_293","doi-asserted-by":"crossref","unstructured":"Cluny, N.L., Keenan, C.M., Reimer, R.A., Le Foll, B., and Sharkey, K.A. (2015). Prevention of diet-induced obesity effects on body weight and gut microbiota in mice treated chronically with delta9-tetrahydrocannabinol. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144270"},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"12904","DOI":"10.1073\/pnas.1104675108","article-title":"Endocannabinoid signal in the gut controls dietary fat intake","volume":"108","author":"DiPatrizio","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/bcp.12102","article-title":"The hepatic cannabinoid 1 receptor as a modulator of hepatic energy state and food intake","volume":"77","author":"Cooper","year":"2014","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cmet.2007.12.007","article-title":"Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver","volume":"7","author":"Jeong","year":"2008","journal-title":"Cell Metab."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"18832","DOI":"10.1073\/pnas.1309469110","article-title":"Monounsaturated fatty acids generated via stearoyl coa desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase","volume":"110","author":"Liu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_298","doi-asserted-by":"crossref","unstructured":"Chanda, D., Kim, Y.H., Li, T., Misra, J., Kim, D.K., Kim, J.R., Kwon, J., Jeong, W.I., Ahn, S.H., and Park, T.S. (2013). Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via crebh. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068845"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.str.2014.12.018","article-title":"Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: Regulation of fatty acid ethanolamide biosynthesis by bile acids","volume":"23","author":"Magotti","year":"2015","journal-title":"Structure"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1021\/acschembio.6b00624","article-title":"Bile acid recognition by nape-pld","volume":"11","author":"Margheritis","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.phrs.2008.11.002","article-title":"Involvement of cannabinoid CB1- and CB2-receptors in the modulation of exocrine pancreatic secretion","volume":"59","author":"Linari","year":"2009","journal-title":"Pharmacol. Res."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"G181","DOI":"10.1152\/ajpgi.00133.2012","article-title":"Activation of cannabinoid receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms","volume":"304","author":"Michler","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/MED.0b013e32834455a8","article-title":"The role of the endocannabinoid system in islet biology","volume":"18","author":"Doyle","year":"2011","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1463-1326.2012.01563.x","article-title":"Ibipinabant attenuates beta-cell loss in male zucker diabetic fatty rats independently of its effects on body weight","volume":"14","author":"Rohrbach","year":"2012","journal-title":"Diabetes Obes. Metab."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nm.3265","article-title":"Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes","volume":"19","author":"Jourdan","year":"2013","journal-title":"Nat. Med."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ceca.2005.10.005","article-title":"Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell","volume":"39","author":"Fuentes","year":"2006","journal-title":"Cell Calcium"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/oby.2007.106","article-title":"Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet","volume":"16","author":"Starowicz","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ajpath.2011.11.003","article-title":"The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications","volume":"180","author":"Horvath","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"32685","DOI":"10.1074\/jbc.M113.478354","article-title":"CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release","volume":"288","author":"Malenczyk","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"ra23","DOI":"10.1126\/scisignal.2002519","article-title":"Cannabinoids induce pancreatic beta-cell death by directly inhibiting insulin receptor activation","volume":"5","author":"Kim","year":"2012","journal-title":"Sci. Signal."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"E6185","DOI":"10.1073\/pnas.1519040112","article-title":"Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture","volume":"112","author":"Malenczyk","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejphar.2007.02.066","article-title":"Role of cannabinoid CB2 receptors in glucose homeostasis in rats","volume":"565","author":"Suarez","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.plipres.2011.01.001","article-title":"Is lipid signaling through cannabinoid 2 receptors part of a protective system?","volume":"50","author":"Pacher","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mce.2006.12.038","article-title":"Effects of cannabinoid receptors on skeletal muscle oxidative pathways","volume":"267","author":"Cavuoto","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbrc.2007.09.099","article-title":"The expression of receptors for endocannabinoids in human and rodent skeletal muscle","volume":"364","author":"Cavuoto","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/BJ20100751","article-title":"Expression of the cannabinoid system in muscle: Effects of a high-fat diet and CB1 receptor blockade","volume":"433","author":"Crespillo","year":"2011","journal-title":"Biochem. J."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s00125-008-1240-4","article-title":"Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle","volume":"52","author":"Eckardt","year":"2009","journal-title":"Diabetologia"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1124\/mol.108.049205","article-title":"The cannabinoid cb1 receptor antagonist rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating the expression of phosphatidylinositol-3-kinase","volume":"74","author":"Esposito","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2337\/db09-0979","article-title":"Regulation of MAP kinase-directed mitogenic and protein kinase B-mediated signaling by cannabinoid receptor type 1 in skeletal muscle cells","volume":"59","author":"Lipina","year":"2010","journal-title":"Diabetes"},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.2337\/db09-1881","article-title":"Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: The role of enos, p38 mapk, and ampk pathways","volume":"59","author":"Tedesco","year":"2010","journal-title":"Diabetes"},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/cr.2011.205","article-title":"Trpv1 activation improves exercise endurance and energy metabolism through PGC-1alpha upregulation in mice","volume":"22","author":"Luo","year":"2012","journal-title":"Cell Res."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4161\/chan.24583","article-title":"Capsaicin mimics mechanical load-induced intracellular signaling events: Involvement of TRPV1-mediated calcium signaling in induction of skeletal muscle hypertrophy","volume":"7","author":"Ito","year":"2013","journal-title":"Channels (Austin)"},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nm1775","article-title":"Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms","volume":"14","author":"Buettner","year":"2008","journal-title":"Nat. Med."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/ijo.2012.123","article-title":"Endocannabinoids regulate adipokine production and the immune balance of omental adipose tissue in human obesity","volume":"37","author":"Ge","year":"2013","journal-title":"Int. J. Obes. (Lond.)"},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1476-9255-8-33","article-title":"Effect of the cannabinoid receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation","volume":"8","author":"Murumalla","year":"2011","journal-title":"J. Inflamm. (Lond.)"},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s40519-018-0481-6","article-title":"Insulin resistance in obesity: An overview of fundamental alterations","volume":"23","author":"Barazzoni","year":"2018","journal-title":"Eat. Weight Disord."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.4049\/jimmunol.1600476","article-title":"Il-6 regulates m2 polarization and local proliferation of adipose tissue macrophages in obesity","volume":"198","author":"Braune","year":"2017","journal-title":"J. Immunol."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s00125-017-4223-5","article-title":"Hedgehog signalling in myeloid cells impacts on body weight, adipose tissue inflammation and glucose metabolism","volume":"60","author":"Braune","year":"2017","journal-title":"Diabetologia"},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.molmet.2017.05.003","article-title":"ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype","volume":"6","author":"Haim","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/164_2015_8","article-title":"Immune cells and metabolism","volume":"233","author":"Chatzigeorgiou","year":"2016","journal-title":"Handb Exp. Pharmacol."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.2337\/db14-0272","article-title":"Immune cell crosstalk in obesity: A key role for costimulation?","volume":"63","author":"Seijkens","year":"2014","journal-title":"Diabetes"},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1124\/mol.63.4.908","article-title":"The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa\/fa rats and in cultured adipocyte cells","volume":"63","author":"Bensaid","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.2337\/db07-1623","article-title":"Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes","volume":"57","author":"Tedesco","year":"2008","journal-title":"Diabetes"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.cmet.2013.03.001","article-title":"The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders","volume":"17","author":"Silvestri","year":"2013","journal-title":"Cell Metab."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1463-1326.2009.01133.x","article-title":"Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes","volume":"12","author":"Perwitz","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nature07182","article-title":"Prdm16 controls a brown fat\/skeletal muscle switch","volume":"454","author":"Seale","year":"2008","journal-title":"Nature"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1194\/jlr.M018846","article-title":"The adipose organ of obesity-prone C57BL\/6J mice is composed of mixed white and brown adipocytes","volume":"53","author":"Vitali","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/MOL.0b013e328352dcef","article-title":"The holy grail of metabolic disease: Brown adipose tissue","volume":"23","author":"Bartelt","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: Function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1172\/JCI97042","article-title":"Cannabis in fat: High hopes to treat obesity","volume":"127","author":"Hawkins","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1172\/JCI83626","article-title":"Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages","volume":"127","author":"Mancini","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2014.06.007","article-title":"The endocannabinoid system modulates stress, emotionality, and inflammation","volume":"42","author":"Crowe","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuroscience.2011.12.030","article-title":"Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis","volume":"204","author":"Hill","year":"2012","journal-title":"Neuroscience"},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.psyneuen.2017.10.015","article-title":"Pharmacological augmentation of endocannabinoid signaling reduces the neuroendocrine response to stress","volume":"87","author":"Surkin","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/pr.54.2.161","article-title":"International union of pharmacology. XXVII. Classification of cannabinoid receptors","volume":"54","author":"Howlett","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-psych-113011-143739","article-title":"The endocannabinoid system and the brain","volume":"64","author":"Mechoulam","year":"2013","journal-title":"Annu. Rev. Psychol."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1055\/s-0029-1241860","article-title":"Expression and function of endocannabinoid receptors in the human adrenal cortex","volume":"42","author":"Ziegler","year":"2010","journal-title":"Horm. Metab. Res."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1210\/en.2010-0285","article-title":"Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling","volume":"151","author":"Evanson","year":"2010","journal-title":"Endocrinology"},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-20825-1_1","article-title":"Endocannabinoids and their pharmacological actions","volume":"231","author":"Pertwee","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.pnpbp.2009.11.001","article-title":"Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids","volume":"34","author":"Hill","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuroscience.2011.11.043","article-title":"Cannabinoid receptor type 1 antagonism significantly modulates basal and loud noise induced neural and hypothalamic-pituitary-adrenal axis responses in male sprague-dawley rats","volume":"204","author":"Newsom","year":"2012","journal-title":"Neuroscience"},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1210\/en.2004-0638","article-title":"Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis","volume":"145","author":"Patel","year":"2004","journal-title":"Endocrinology"},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000076044","article-title":"Involvement of endogeneous glutamate in the stimulatory effect of norepinephrine and serotonin on the hypothalamo-pituitary-adrenocortical axis","volume":"79","author":"Feldman","year":"2004","journal-title":"Neuroendocrinology"},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.euroneuro.2015.04.026","article-title":"Evidence against a critical role of CB1 receptors in adaptation of the hypothalamic-pituitary-adrenal axis and other consequences of daily repeated stress","volume":"25","author":"Rabasa","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/sj.bjp.0705467","article-title":"Anandamide and vanilloid TRPV1 receptors","volume":"140","author":"Ross","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/j.2040-4603.2016.tb00708.x","article-title":"Hypothalamus-pituitary-thyroid axis","volume":"6","author":"Chiamolera","year":"2016","journal-title":"Comp. Physiol."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2265.2010.03815.x","article-title":"The interaction between growth hormone and the thyroid axis in hypopituitary patients","volume":"74","author":"Behan","year":"2011","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1210\/er.2005-0009","article-title":"The emerging role of the endocannabinoid system in endocrine regulation and energy balance","volume":"27","author":"Pagotto","year":"2006","journal-title":"Endocr. Rev."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0024-3205(74)90223-9","article-title":"Effects of delta 9-THC on growth hormone and ACTH secretion in rats","volume":"15","author":"Kokka","year":"1974","journal-title":"Life Sci."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1210\/endo-125-6-2905","article-title":"Thyroid hormone and growth hormone interact to regulate insulin-like growth factor-i messenger ribonucleic acid and circulating levels in the rat","volume":"125","author":"Wolf","year":"1989","journal-title":"Endocrinology"},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.2337\/db12-0901","article-title":"Developmental role for endocannabinoid signaling in regulating glucose metabolism and growth","volume":"62","author":"Li","year":"2013","journal-title":"Diabetes"},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1677\/JOE-08-0380","article-title":"Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion","volume":"199","author":"Costa","year":"2008","journal-title":"J. Endocrinol."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0091-3057(84)90303-4","article-title":"The effects of delta 9-tetrahydrocannabinol on serum thyrotropin levels in the rat","volume":"20","author":"Hillard","year":"1984","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1530\/eje.0.1470255","article-title":"Evidence for functional cb1 cannabinoid receptor expressed in the rat thyroid","volume":"147","author":"Porcella","year":"2002","journal-title":"Eur. J. Endocrinol."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1210\/en.2008-0330","article-title":"Type 1 cannabinoid receptor-containing axons innervate hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons","volume":"150","author":"Deli","year":"2009","journal-title":"Endocrinology"},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF01968699","article-title":"The effect of marihuana on pituitary-thyroid activity in the rat","volume":"1","author":"Lomax","year":"1970","journal-title":"Agents Actions"},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1523\/JNEUROSCI.23-12-04850.2003","article-title":"Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: A fast feedback mechanism","volume":"23","author":"Di","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_368","first-page":"2687","article-title":"Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: First evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level","volume":"86","author":"Pagotto","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"R309","DOI":"10.1530\/EJE-16-1044","article-title":"Mechanisms in endocrinology: Endocannabinoids and metabolism: Past, present and future","volume":"176","author":"Simon","year":"2017","journal-title":"Eur. J. Endocrinol."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/cpt197112144","article-title":"Hunger and appetite after single doses of marihuana, alcohol, and dextroamphetamine","volume":"12","author":"Hollister","year":"1971","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0195-6663(88)80017-5","article-title":"Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory","volume":"11","author":"Foltin","year":"1988","journal-title":"Appetite"},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00427475","article-title":"Effects of marihuana use on body weight and caloric intake in humans","volume":"49","author":"Greenberg","year":"1976","journal-title":"Psychopharmacology (Berl.)"},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nn.2494","article-title":"Bimodal control of stimulated food intake by the endocannabinoid system","volume":"13","author":"Bellocchio","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/eat.22804","article-title":"The effect of dronabinol in a male patient with anorexia nervosa suffering from severe acute urge to be physically active","volume":"51","author":"Graap","year":"2018","journal-title":"Int. J. Eat. Disord."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1111\/bph.13892","article-title":"Cannabinoid CB1\/CB2 receptor agonists attenuate hyperactivity and body weight loss in a rat model of activity-based anorexia","volume":"174","author":"Scherma","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3322\/canjclin.52.2.72","article-title":"Cancer anorexia-cachexia syndrome: Current issues in research and management","volume":"52","author":"Inui","year":"2002","journal-title":"CA Cancer J. Clin."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/MCO.0b013e3281900ecc","article-title":"Endocannabinoid system in cancer cachexia","volume":"10","year":"2007","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00213-010-1995-4","article-title":"Efficacy and tolerability of high-dose dronabinol maintenance in hiv-positive marijuana smokers: A controlled laboratory study","volume":"212","author":"Bedi","year":"2010","journal-title":"Psychopharmacology (Berl.)"},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/QAI.0b013e31811ed205","article-title":"Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood, and sleep","volume":"45","author":"Haney","year":"2007","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_380","doi-asserted-by":"crossref","unstructured":"Cannabis In-Cachexia-Study-Group, Strasser, F., Luftner, D., Possinger, K., Ernst, G., Ruhstaller, T., Meissner, W., Ko, Y.D., Schnelle, M., and Reif, M. (2006). Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: A multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the cannabis-in-cachexia-study-group. J. Clin. Oncol., 24, 3394\u20133400.","DOI":"10.1200\/JCO.2005.05.1847"},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s40262-015-0363-2","article-title":"Pharmacokinetics of cannabis in cancer cachexia-anorexia syndrome","volume":"55","author":"Reuter","year":"2016","journal-title":"Clin. Pharmacokinet."},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/sj.npp.1301443","article-title":"Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosa","volume":"33","author":"Wagner","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.biopsych.2011.08.018","article-title":"Understanding the neural circuitry of appetitive regulation in eating disorders","volume":"70","author":"Kaye","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.neuroimage.2008.09.044","article-title":"Cortical activation in response to pure taste stimuli during the physiological states of hunger and satiety","volume":"44","author":"Haase","year":"2009","journal-title":"Neuroimage"},{"key":"ref_385","first-page":"51","article-title":"Faah and magl inhibitors: Therapeutic opportunities from regulating endocannabinoid levels","volume":"11","author":"Petrosino","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/FBP.0000000000000023","article-title":"Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats","volume":"25","author":"Kwilasz","year":"2014","journal-title":"Behav. Pharmacol."},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.euroneuro.2015.04.001","article-title":"Inhibition of faah reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice","volume":"25","author":"Nozaki","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.lfs.2012.10.025","article-title":"Therapeutic potential of monoacylglycerol lipase inhibitors","volume":"92","author":"Mulvihill","year":"2013","journal-title":"Life Sci."},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.pain.2012.04.020","article-title":"An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee","volume":"153","author":"Huggins","year":"2012","journal-title":"Pain"},{"key":"ref_390","doi-asserted-by":"crossref","unstructured":"Marco, E.M., Rapino, C., Caprioli, A., Borsini, F., Laviola, G., and Maccarrone, M. (2015). Potential therapeutic value of a novel faah inhibitor for the treatment of anxiety. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0137034"},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.aaf7497","article-title":"Activity-based protein profiling reveals off-target proteins of the faah inhibitor bia 10-2474","volume":"356","author":"Janssen","year":"2017","journal-title":"Science"},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"13958","DOI":"10.1038\/ncomms13958","article-title":"Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity","volume":"8","author":"Soethoudt","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.3390\/ph3082517","article-title":"Brain CB(2) receptors: Implications for neuropsychiatric disorders","volume":"3","author":"Roche","year":"2010","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/syn.20714","article-title":"A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands","volume":"64","author":"Ishiguro","year":"2010","journal-title":"Synapse"},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1196\/annals.1432.035","article-title":"Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption","volume":"1139","author":"Onaivi","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0006-8993(02)04274-9","article-title":"Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in lewis rats","volume":"967","author":"Werner","year":"2003","journal-title":"Brain Res."},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-2826.2008.01683.x","article-title":"Dysregulation of the endocannabinoid system in obesity","volume":"20","author":"Engeli","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/aps.2011.80","article-title":"Novel selective cannabinoid CB(1) receptor antagonist MJ08 with potent in vivo bioactivity and inverse agonistic effects","volume":"32","author":"Chen","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"e6141","DOI":"10.1590\/1414-431x20176141","article-title":"Rimonabant improves metabolic parameters partially attributed to restoration of high voltage-activated Ca2+ channels in skeletal muscle in hfd-fed mice","volume":"50","author":"Chen","year":"2017","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/acel.12438","article-title":"CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction","volume":"15","author":"Lipina","year":"2016","journal-title":"Aging Cell"},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.drudis.2018.01.029","article-title":"Peripheral modulation of the endocannabinoid system in metabolic disease","volume":"23","author":"Shrestha","year":"2018","journal-title":"Drug Discov. Today"},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nrcardio.2017.130","article-title":"Cardiovascular effects of marijuana and synthetic cannabinoids: The good, the bad, and the ugly","volume":"15","author":"Pacher","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_403","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11892-017-0924-x","article-title":"Re-visiting the endocannabinoid system and its therapeutic potential in obesity and associated diseases","volume":"17","author":"Richey","year":"2017","journal-title":"Curr. Diabetes Rep."},{"key":"ref_404","doi-asserted-by":"crossref","first-page":"E747","DOI":"10.1152\/ajpendo.00196.2015","article-title":"Cb1r antagonist increases hepatic insulin clearance in fat-fed dogs likely via upregulation of liver adiponectin receptors","volume":"309","author":"Kabir","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/hep.24077","article-title":"Endocannabinoids in liver disease","volume":"53","author":"Tam","year":"2011","journal-title":"Hepatology"},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.2337\/db08-0161","article-title":"Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats","volume":"57","author":"Nogueiras","year":"2008","journal-title":"Diabetes"},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1073\/pnas.1218573110","article-title":"Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB(1) receptor blockade","volume":"110","author":"Bellocchio","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_408","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0140-6736(07)60033-6","article-title":"Drug treatments for obesity: Orlistat, sibutramine, and rimonabant","volume":"369","author":"Padwal","year":"2007","journal-title":"Lancet"},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/S0140-6736(07)61721-8","article-title":"Efficacy and safety of the weight-loss drug rimonabant: A meta-analysis of randomised trials","volume":"370","author":"Christensen","year":"2007","journal-title":"Lancet"},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"pyw068","DOI":"10.1093\/ijnp\/pyw068","article-title":"The CB1 neutral antagonist AM4113 retains the therapeutic efficacy of the inverse agonist rimonabant for nicotine dependence and weight loss with better psychiatric tolerability","volume":"19","author":"Gueye","year":"2016","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_411","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.pbb.2010.07.021","article-title":"The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior","volume":"97","author":"Randall","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.molmet.2017.07.003","article-title":"The brain strikes back: Hypothalamic targets for peripheral CB1 receptor inverse agonism","volume":"6","author":"Cota","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_413","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.cell.2016.10.004","article-title":"Crystal structure of the human cannabinoid receptor CB1","volume":"167","author":"Hua","year":"2016","journal-title":"Cell"},{"key":"ref_414","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nature20613","article-title":"High-resolution crystal structure of the human CB1 cannabinoid receptor","volume":"540","author":"Shao","year":"2016","journal-title":"Nature"},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nature23272","article-title":"Crystal structures of agonist-bound human cannabinoid receptor CB1","volume":"547","author":"Hua","year":"2017","journal-title":"Nature"},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ijo.2015.169","article-title":"Pro-inflammatory obesity in aged cannabinoid-2 receptor-deficient mice","volume":"40","author":"Schmitz","year":"2016","journal-title":"Int. J. Obes. (Lond.)"},{"key":"ref_417","doi-asserted-by":"crossref","unstructured":"Verty, A.N., Stefanidis, A., McAinch, A.J., Hryciw, D.H., and Oldfield, B. (2015). Anti-obesity effect of the CB2 receptor agonist JWH-015 in diet-induced obese mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0140592"},{"key":"ref_418","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/bab.1589","article-title":"In silico mapping of allosteric ligand binding sites in type-1 cannabinoid receptor","volume":"65","author":"Sabatucci","year":"2018","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_419","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/03602532.2018.1428341","article-title":"The future of type 1 cannabinoid receptor allosteric ligands","volume":"50","author":"Alaverdashvili","year":"2018","journal-title":"Drug Metab. Rev."},{"key":"ref_420","doi-asserted-by":"crossref","first-page":"36944","DOI":"10.1074\/jbc.M112.382481","article-title":"Identification and quantification of a new family of peptide endocannabinoids (pepcans) showing negative allosteric modulation at CB1 receptors","volume":"287","author":"Bauer","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_421","first-page":"137","article-title":"Structure, function, and metabolism of leukotriene constituents of SRS-A","volume":"9","author":"Lewis","year":"1982","journal-title":"Adv. Prostaglandin Thromboxane Leukot. Res."},{"key":"ref_422","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.phrs.2015.07.017","article-title":"Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model","volume":"99","author":"Straiker","year":"2015","journal-title":"Pharmacol. Res."},{"key":"ref_423","doi-asserted-by":"crossref","first-page":"20588","DOI":"10.1073\/pnas.0706980105","article-title":"Hemopressin is an inverse agonist of CB1 cannabinoid receptors","volume":"104","author":"Heimann","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_424","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.2174\/0929866523666161007152435","article-title":"Hemopressin peptides as modulators of the endocannabinoid system and their potential applications as therapeutic tools","volume":"23","author":"Macedonio","year":"2016","journal-title":"Protein Pept. Lett."},{"key":"ref_425","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuropharm.2017.08.008","article-title":"The great divide: Separation between in vitro and in vivo effects of psncbam-based CB1 receptor allosteric modulators","volume":"125","author":"Gamage","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_426","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.phrs.2017.11.019","article-title":"Enantiomer-specific positive allosteric modulation of CB1 signaling in autaptic hippocampal neurons","volume":"129","author":"Mitjavila","year":"2018","journal-title":"Pharmacol. Res."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/11\/2\/55\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:06:35Z","timestamp":1760195195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/11\/2\/55"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,30]]},"references-count":426,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,6]]}},"alternative-id":["ph11020055"],"URL":"https:\/\/doi.org\/10.3390\/ph11020055","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,30]]}}}