{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:30:44Z","timestamp":1790652644061,"version":"4.1.0"},"reference-count":81,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["AGL2014-56518-JIN"],"award-info":[{"award-number":["AGL2014-56518-JIN"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The Zika virus (ZIKV) is a mosquito-borne flavivirus that can lead to birth defects (microcephaly), ocular lesions and neurological disorders (Guillain-Barr\u00e9 syndrome). There is no licensed vaccine or antiviral treatment against ZIKV infection. The effort to understand the complex interactions of ZIKV with cellular networks contributes to the identification of novel host-directed antiviral (HDA) candidates. Among the cellular pathways involved in infection, lipid metabolism gains attention. In ZIKV-infected cells lipid metabolism attributed to intracellular membrane remodeling, virion morphogenesis, autophagy modulation, innate immunity and inflammation. The key roles played by the cellular structures associated with lipid metabolism, such as peroxisomes and lipid droplets, are starting to be deciphered. Consequently, there is a wide variety of lipid-related antiviral strategies that are currently under consideration, which include an inhibition of sterol regulatory element-binding proteins (SREBP), the activation of adenosine-monophosphate activated kinase (AMPK), an inhibition of acetyl-Coenzyme A carboxylase (ACC), interference with sphingolipid metabolism, blockage of intracellular cholesterol trafficking, or a treatment with cholesterol derivatives. Remarkably, most of the HDAs identified in these studies are also effective against flaviviruses other than ZIKV (West Nile virus and dengue virus), supporting their broad-spectrum effect. Considering that lipid metabolism is one of the main cellular pathways suitable for pharmacological intervention, the idea of repositioning drugs targeting lipid metabolism as antiviral candidates is gaining force.<\/jats:p>","DOI":"10.3390\/ph12020097","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T11:54:31Z","timestamp":1561118071000},"page":"97","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-3613","authenticated-orcid":false,"given":"Miguel A.","family":"Mart\u00edn-Acebes","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria (INIA), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3129-813X","authenticated-orcid":false,"given":"Nereida","family":"Jim\u00e9nez de Oya","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria (INIA), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8269-5544","authenticated-orcid":false,"given":"Juan-Carlos","family":"Saiz","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria (INIA), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Martin-Acebes, M.A., and Saiz, J.C. (2019). The Scientific Response to Zika Virus. J. Clin. Med., 8.","DOI":"10.3390\/jcm8030369"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/S0140-6736(17)31450-2","article-title":"An update on Zika virus infection","volume":"390","author":"Baud","year":"2017","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3389\/fmicb.2017.01554","article-title":"Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?","volume":"8","author":"Saiz","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Diamond, M.S., Ledgerwood, J.E., and Pierson, T.C. (2018). Zika Virus Vaccine Development: Progress in the Face of New Challenges. Annu. Rev. Med.","DOI":"10.1146\/annurev-med-040717-051127"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Saiz, J.C., and Martin-Acebes, M.A. (2017). The Race to Find Antivirals for Zika Virus. Antimicrob. Agents Chemother., 61.","DOI":"10.1128\/AAC.00411-17"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.antiviral.2017.06.001","article-title":"Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network","volume":"144","author":"Aliota","year":"2017","journal-title":"Antivir. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrd.2017.33","article-title":"Broad-spectrum agents for flaviviral infections: Dengue, Zika and beyond","volume":"16","author":"Boldescu","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.coviro.2016.09.003","article-title":"The quest for host targets to combat dengue virus infections","volume":"20","author":"Acosta","year":"2016","journal-title":"Curr. Opin. Virol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Saiz, J.C., Oya, N.J., Blazquez, A.B., Escribano-Romero, E., and Martin-Acebes, M.A. (2018). Host-Directed Antivirals: A Realistic Alternative to Fight Zika Virus. Viruses, 10.","DOI":"10.20944\/preprints201807.0359.v1"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.plipres.2016.09.005","article-title":"Lipids and flaviviruses, present and future perspectives for the control of dengue, Zika, and West Nile viruses","volume":"64","author":"Saiz","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"ref_11","first-page":"125","article-title":"Rewiring cellular networks by members of the Flaviviridae family","volume":"16","author":"Neufeldt","year":"2018","journal-title":"Nat. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Byers, N.M., Fleshman, A.C., Perera, R., and Molins, C.R. (2019). Metabolomic Insights into Human Arboviral Infections: Dengue, Chikungunya, and Zika Viruses. Viruses, 11.","DOI":"10.3390\/v11030225"},{"key":"ref_13","unstructured":"ICTV (2019, January 22). Virus Taxonomy: 2018 Release. Available online: https:\/\/talk.ictvonline.org\/ictv-reports\/ictv_online_report\/positive-sense-rna-viruses\/w\/flaviviridae\/360\/genus-flavivirus."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1021\/acs.chemrev.7b00719","article-title":"Biochemistry and Molecular Biology of Flaviviruses","volume":"118","author":"Barrows","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nsmb.3268","article-title":"Extended surface for membrane association in Zika virus NS1 structure","volume":"23","author":"Brown","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Perera, R., Riley, C., Isaac, G., Hopf-Jannasch, A.S., Moore, R.J., Weitz, K.W., Pasa-Tolic, L., Metz, T.O., Adamec, J., and Kuhn, R.J. (2012). Dengue virus infection perturbs lipid homeostasis in infected mosquito cells. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002584"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"12041","DOI":"10.1128\/JVI.02061-14","article-title":"The composition of West Nile virus lipid envelope unveils a role of sphingolipid metabolism in flavivirus biogenesis","volume":"88","author":"Blazquez","year":"2014","journal-title":"J. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Liebscher, S., Ambrose, R.L., Aktepe, T.E., Mikulasova, A., Prier, J.E., Gillespie, L.K., Lopez-Denman, A.J., Rupasinghe, T.W.T., Tull, D., and McConville, M.J. (2018). Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1007029"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Chotiwan, N., Andre, B.G., Sanchez-Vargas, I., Islam, M.N., Grabowski, J.M., Hopf-Jannasch, A., Gough, E., Nakayasu, E., Blair, C.D., and Belisle, J.T. (2018). Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1006853"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Melo, C.F., de Oliveira, D.N., Lima, E.O., Guerreiro, T.M., Esteves, C.Z., Beck, R.M., Padilla, M.A., Milanez, G.P., Arns, C.W., and Proenca-Modena, J.L. (2016). A Lipidomics Approach in the Characterization of Zika-Infected Mosquito Cells: Potential Targets for Breaking the Transmission Cycle. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164377"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Diop, F., Vial, T., Ferraris, P., Wichit, S., Bengue, M., Hamel, R., Talignani, L., Liegeois, F., Pompon, J., and Yssel, H. (2018). Zika virus infection modulates the metabolomic profile of microglial cells. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0206093"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"11209","DOI":"10.1038\/s41598-018-29329-2","article-title":"Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium","volume":"8","author":"Singh","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3389\/fmicb.2019.00753","article-title":"Lipidomic Analysis Reveals Serum Alteration of Plasmalogens in Patients Infected With ZIKA Virus","volume":"10","author":"Queiroz","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.str.2015.12.011","article-title":"The Role of the Membrane in the Structure and Biophysical Robustness of the Dengue Virion Envelope","volume":"24","author":"Reddy","year":"2016","journal-title":"Structure"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.celrep.2017.02.014","article-title":"Ultrastructural Characterization of Zika Virus Replication Factories","volume":"18","author":"Cortese","year":"2017","journal-title":"Cell Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.virol.2016.11.002","article-title":"Cytoarchitecture of Zika virus infection in human neuroblastoma and Aedes albopictus cell lines","volume":"501","author":"Offerdahl","year":"2017","journal-title":"Virology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Martin-Acebes, M.A., Blazquez, A.B., Jimenez de Oya, N., Escribano-Romero, E., and Saiz, J.C. (2011). West nile virus replication requires Fatty Acid synthesis but is independent on phosphatidylinositol-4-phosphate lipids. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024970"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.chom.2009.03.007","article-title":"Composition and three-dimensional architecture of the dengue virus replication and assembly sites","volume":"5","author":"Welsch","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.celrep.2019.04.051","article-title":"The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection","volume":"27","author":"Lin","year":"2019","journal-title":"Cell Rep."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Majerova, T., Novotny, P., Krysova, E., and Konvalinka, J. (2019). Exploiting the unique features of Zika and Dengue proteases for inhibitor design. Biochimie.","DOI":"10.1016\/j.biochi.2019.05.004"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.15252\/embj.201695290","article-title":"Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure","volume":"35","author":"Xu","year":"2016","journal-title":"EMBO J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1074\/mcp.TIR118.000800","article-title":"Global Interactomics Uncovers Extensive Organellar Targeting by Zika Virus","volume":"17","author":"Coyaud","year":"2018","journal-title":"Mol. Cell. Proteom."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1194\/jlr.M049148","article-title":"Lipidomics identifies a requirement for peroxisomal function during influenza virus replication","volume":"55","author":"Tanner","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.chom.2018.09.002","article-title":"Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication","volume":"24","author":"Cook","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.gene.2017.07.049","article-title":"Molecular cloning and characterization of the genes encoding the proteins of Zika virus","volume":"628","author":"Hou","year":"2017","journal-title":"Gene"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jmb.2018.02.006","article-title":"Crystal Structure of the Capsid Protein from Zika Virus","volume":"430","author":"Shang","year":"2018","journal-title":"J. Mol. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Samsa, M.M., Mondotte, J.A., Iglesias, N.G., Assuncao-Miranda, I., Barbosa-Lima, G., Da Poian, A.T., Bozza, P.T., and Gamarnik, A.V. (2009). Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000632"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.stem.2016.07.019","article-title":"Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy","volume":"19","author":"Liang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1128\/JVI.00354-15","article-title":"Biology of Zika Virus Infection in Human Skin Cells","volume":"89","author":"Hamel","year":"2015","journal-title":"J. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/15548627.2016.1265192","article-title":"Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B","volume":"13","author":"Lennemann","year":"2017","journal-title":"Autophagy"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Gratton, R., Agrelli, A., Tricarico, P.M., Brandao, L., and Crovella, S. (2019). Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051048"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Ke, P.Y. (2018). The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19123940"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Willard, K.A., Elling, C.L., Stice, S.L., and Brindley, M.A. (2018). The Oxysterol 7-Ketocholesterol Reduces Zika Virus Titers in Vero Cells and Human Neurons. Viruses, 11.","DOI":"10.3390\/v11010020"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.chom.2010.10.006","article-title":"Dengue virus-induced autophagy regulates lipid metabolism","volume":"8","author":"Heaton","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.chom.2018.05.005","article-title":"Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production","volume":"23","author":"Zhang","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Merino-Ramos, T., Jimenez de Oya, N., Saiz, J.C., and Martin-Acebes, M.A. (2017). Antiviral Activity of Nordihydroguaiaretic Acid and Its Derivative Tetra-O-Methyl Nordihydroguaiaretic Acid against West Nile Virus and Zika Virus. Antimicrob. Agents Chemother., 61.","DOI":"10.1128\/AAC.00376-17"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1002\/hep.24619","article-title":"Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus","volume":"54","author":"Syed","year":"2011","journal-title":"Hepatology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.antiviral.2014.07.002","article-title":"Nordihydroguaiaretic acid (NDGA) inhibits replication and viral morphogenesis of dengue virus","volume":"109","author":"Syed","year":"2014","journal-title":"Antivir. Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Uchida, L., Urata, S., Ulanday, G.E., Takamatsu, Y., Yasuda, J., Morita, K., and Hayasaka, D. (2016). Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses, 8.","DOI":"10.3390\/v8020046"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41467-018-08015-x","article-title":"SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target","volume":"10","author":"Yuan","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Jimenez de Oya, N., Blazquez, A.B., Casas, J., Saiz, J.C., and Martin-Acebes, M.A. (2018). Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection through Modification of Host Cell Lipid Metabolism. Antimicrob. Agents Chemother., 62.","DOI":"10.1128\/AAC.00360-18"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Cheng, F., Ramos da Silva, S., Huang, I.C., Jung, J.U., and Gao, S.J. (2018). Suppression of Zika Virus Infection and Replication in Endothelial Cells and Astrocytes by PKA Inhibitor PKI 14-22. J. Virol., 92.","DOI":"10.1128\/JVI.02019-17"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Soto-Acosta, R., Bautista-Carbajal, P., Cervantes-Salazar, M., Angel-Ambrocio, A.H., and Del Angel, R.M. (2017). DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006257"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1080\/22221751.2019.1604084","article-title":"Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models","volume":"8","author":"Esler","year":"2019","journal-title":"Emerg. Microbes Infect."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"22162","DOI":"10.1016\/S0021-9258(17)31770-2","article-title":"Critical phosphorylation sites for acetyl-CoA carboxylase activity","volume":"269","author":"Ha","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41421-018-0017-2","article-title":"Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869","volume":"4","author":"Huang","year":"2018","journal-title":"Cell Discov."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1038\/s41598-017-03316-5","article-title":"Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking","volume":"7","author":"Wichit","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.immuni.2017.02.012","article-title":"25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model","volume":"46","author":"Li","year":"2017","journal-title":"Immunity"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Tricarico, P.M., Caracciolo, I., Gratton, R., D\u2019Agaro, P., and Crovella, S. (2018). 25-hydroxycholesterol reduces inflammation, viral load and cell death in ZIKV-infected U-87 MG glial cell line. Inflammopharmacology.","DOI":"10.1007\/s10787-018-0517-6"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.chom.2016.07.004","article-title":"A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection","volume":"20","author":"Barrows","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"10856","DOI":"10.1038\/s41598-018-29183-2","article-title":"Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface","volume":"8","author":"Clain","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.antiviral.2018.02.003","article-title":"The molecular tweezer CLR01 inhibits Ebola and Zika virus infection","volume":"152","author":"Rocker","year":"2018","journal-title":"Antivir. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/s41563-018-0194-2","article-title":"Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide","volume":"17","author":"Jackman","year":"2018","journal-title":"Nat. Mater."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4419-6741-1_1","article-title":"An overview of sphingolipid metabolism: From synthesis to breakdown","volume":"688","author":"Gault","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1194\/jlr.M064212","article-title":"Host sphingomyelin increases West Nile virus infection in vivo","volume":"57","author":"Sanchez","year":"2016","journal-title":"J. Lipid Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.virol.2015.06.015","article-title":"Differential utilisation of ceramide during replication of the flaviviruses West Nile and dengue virus","volume":"484","author":"Aktepe","year":"2015","journal-title":"Virology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"37829","DOI":"10.1038\/srep37829","article-title":"Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus","volume":"6","author":"Taniguchi","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fcimb.2018.00388","article-title":"The Role of Host Cholesterol during Flavivirus Infection","volume":"8","year":"2018","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.pt.2017.10.007","article-title":"Lipids and Pathogen Blocking by Wolbachia","volume":"33","author":"Frentiu","year":"2017","journal-title":"Trends Parasitol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41467-017-00610-8","article-title":"Perturbed cholesterol and vesicular trafficking associated with dengue blocking in Wolbachia-infected Aedes aegypti cells","volume":"8","author":"Geoghegan","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Schultz, M.J., Isern, S., Michael, S.F., Corley, R.B., Connor, J.H., and Frydman, H.M. (2017). Variable Inhibition of Zika Virus Replication by Different Wolbachia Strains in Mosquito Cell Cultures. J. Virol., 91.","DOI":"10.1128\/JVI.00339-17"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Schultz, M.J., Tan, A.L., Gray, C.N., Isern, S., Michael, S.F., Frydman, H.M., and Connor, J.H. (2018). Wolbachia wStri Blocks Zika Virus Growth at Two Independent Stages of Viral Replication. MBio, 9.","DOI":"10.1128\/mBio.00738-18"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.12688\/f1000research.9648.1","article-title":"Zika antiviral chemotherapy: Identification of drugs and promising starting points for drug discovery from an FDA-approved library","volume":"5","author":"Pascoalino","year":"2016","journal-title":"F1000Research"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.tips.2015.04.010","article-title":"Targeting SREBPs for treatment of the metabolic syndrome","volume":"36","author":"Soyal","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"484","DOI":"10.2174\/1568026618666180523104541","article-title":"SCAP\/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy","volume":"18","author":"Cheng","year":"2018","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Hardie, D.G. (2018). Keeping the home fires burning: AMP-activated protein kinase. J. R. Soc. Interface, 15.","DOI":"10.1098\/rsif.2017.0774"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.chembiol.2012.08.019","article-title":"AMP-activated protein kinase: A target for drugs both ancient and modern","volume":"19","author":"Hardie","year":"2012","journal-title":"Chem. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Shanbhogue, P., and Hannun, Y.A. (2018). Exploring the Therapeutic Landscape of Sphingomyelinases. Handbook of Experimental Pharmacology, Springer.","DOI":"10.1007\/164_2018_179"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1161\/ATV.0000000000000073","article-title":"Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association","volume":"39","author":"Newman","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Lima, W.G., Souza, N.A., Fernandes, S.O.A., Cardoso, V.N., and Godoi, I.P. (2019). Serum lipid profile as a predictor of dengue severity: A systematic review and meta-analysis. Rev. Med. Virol., e2056.","DOI":"10.1002\/rmv.2056"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/12\/2\/97\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:00:15Z","timestamp":1760187615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/12\/2\/97"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,21]]},"references-count":81,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["ph12020097"],"URL":"https:\/\/doi.org\/10.3390\/ph12020097","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,21]]}}}