{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:18:29Z","timestamp":1790032709367,"version":"4.0.1"},"reference-count":41,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Irinotecan, an anticancer drug, induces diarrhea and intestinal inflammation, resulting in an increase in the cost of care and in treatment delays. In this study, we investigated whether alpha-lipoic acid (\u03b1-LA) could improve irinotecan-mediated intestinal inflammation, diarrhea and dysmotility. Intestinal mucositis was induced by irinotecan injection (75 mg\/kg, i.p., for 4 days) in Swiss mice. \u03b1-LA (50, 100 or 200 mg\/kg, gavage) was administered daily 1 h before the injection of irinotecan. Duodenum tissues were obtained for inflammation and proliferation analysis. The outcomes: diarrhea, intestinal dysmotility, weight body loss and survival were evaluated. Compared with the control condition, irinotecan diminished (p &lt; 0.05) intestinal villus height, caused a loss of crypt integrity and intense inflammatory cell infiltration, increased myeloperoxidase (MPO), IL-6 and IL-1\u03b2 levels and decreased reduced glutathione (GSH) levels in duodenum segments and increased gastric retention and decreased liquid retention in the medial intestinal segment, resulting in increased intestinal transit, severe diarrhea and reduced survival (approximately 72%). Furthermore, \u03b1-LA (200 mg\/kg) pretreatment ameliorated (p &lt; 0.05) these irinotecan-induced effects. Our findings show that \u03b1-LA reduced irinotecan-induced inflammation, intestinal dysmotility and diarrhea, resulting in improved survival. \u03b1-LA may be a useful therapeutic agent for the treatment of gut dysmotility in patients with intestinal mucositis associated with irinotecan treatment.<\/jats:p>","DOI":"10.3390\/ph13110361","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T09:09:32Z","timestamp":1604394572000},"page":"361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Alpha-Lipoic Acid Improves Survival and Prevents Irinotecan-Induced Inflammation and Intestinal Dysmotility in Mice"],"prefix":"10.3390","volume":"13","author":[{"given":"Daniely V. S.","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Morphology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deiziane V. S.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Morphology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-170, Brazil"},{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-275, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren N. S.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-275, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeline M. H. P.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Morphology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingridy S.","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-275, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dainesy S.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-275, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concei\u00e7\u00e3o S.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Morphology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1658-9281","authenticated-orcid":false,"given":"Ana L. V.","family":"Pequeno","sequence":"additional","affiliation":[{"name":"Department of Morphology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7033-655X","authenticated-orcid":false,"given":"Roberto C. P.","family":"Lima-J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-275, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro M. G.","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Morphology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-170, Brazil"},{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-275, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silv\u00e2nia M. M.","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE 60430-275, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8214-4379","authenticated-orcid":false,"given":"Gerly A. 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