{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T22:00:42Z","timestamp":1786399242163,"version":"build-2736575974"},"reference-count":61,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:00:00Z","timestamp":1608336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Thymus mastichina has the appearance of a semishrub and can be found in jungles and rocky lands of the Iberian Peninsula. This work aimed to review and gather available scientific information on the composition and biological properties of T. mastichina. The main constituents of T. mastichina essential oil are 1,8-cineole (or eucalyptol) and linalool, while the extracts are characterized by the presence of flavonoids, phenolic acids, and terpenes. The essential oil and extracts of T. mastichina have demonstrated a wide diversity of biological activities. They showed antibacterial activity against several bacteria such as Escherichia coli, Proteus mirabilis, Salmonella subsp., methicillin-resistant and methicillin-sensitive Staphylococcus aureus, Listeria monocytogenes EGD, Bacillus cereus, and Pseudomonas, among others, and antifungal activity against Candida spp. and Fusarium spp. Additionally, it has antioxidant activity, which has been evaluated through different methods. Furthermore, other activities have also been studied, such as anticancer, antiviral, insecticidal, repellent, anti-Alzheimer, and anti-inflammatory activity. In conclusion, considering the biological activities reported for the essential oil and extracts of T. mastichina, its potential as a preservative agent could be explored to be used in the food, cosmetic, or pharmaceutical industries.<\/jats:p>","DOI":"10.3390\/ph13120479","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T01:01:08Z","timestamp":1608512468000},"page":"479","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Thymus mastichina: Composition and Biological Properties with a Focus on Antimicrobial Activity"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7010-0619","authenticated-orcid":false,"given":"M\u00e1rcio","family":"Rodrigues","sequence":"first","affiliation":[{"name":"School of Health Sciences, Polytechnic Institute of Guarda, Rua da Cadeia, 6300-035 Guarda, Portugal"},{"name":"Research Unit for Inland Development (UDI), Polytechnic Institute of Guarda, Av. Dr. Francisco S\u00e1 Carneiro, 50, 6300-559 Guarda, Portugal"},{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Clara","family":"Lopes","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Polytechnic Institute of Guarda, Rua da Cadeia, 6300-035 Guarda, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa","family":"Vaz","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Polytechnic Institute of Guarda, Rua da Cadeia, 6300-035 Guarda, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Filipe","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Polytechnic Institute of Guarda, Rua da Cadeia, 6300-035 Guarda, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-0714","authenticated-orcid":false,"given":"Gilberto","family":"Alves","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-8115","authenticated-orcid":false,"given":"Maximiano P.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Polytechnic Institute of Guarda, Rua da Cadeia, 6300-035 Guarda, Portugal"},{"name":"Research Unit for Inland Development (UDI), Polytechnic Institute of Guarda, Av. Dr. Francisco S\u00e1 Carneiro, 50, 6300-559 Guarda, Portugal"},{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6832-3082","authenticated-orcid":false,"given":"Paula","family":"Coutinho","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Polytechnic Institute of Guarda, Rua da Cadeia, 6300-035 Guarda, Portugal"},{"name":"Research Unit for Inland Development (UDI), Polytechnic Institute of Guarda, Av. Dr. Francisco S\u00e1 Carneiro, 50, 6300-559 Guarda, Portugal"},{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 R. T. S.","family":"Araujo","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Polytechnic Institute of Guarda, Rua da Cadeia, 6300-035 Guarda, Portugal"},{"name":"Research Unit for Inland Development (UDI), Polytechnic Institute of Guarda, Av. Dr. Francisco S\u00e1 Carneiro, 50, 6300-559 Guarda, Portugal"},{"name":"LAQV\/REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,19]]},"reference":[{"key":"ref_1","unstructured":"Utad, J.B. (2020, July 23). Ficha da Esp\u00e9cie Thymus mastichina. 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