{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:15:45Z","timestamp":1792610145885,"version":"4.5.0"},"reference-count":71,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016M3A9D3915857, 2019R1I1A3A01061034"],"award-info":[{"award-number":["2016M3A9D3915857, 2019R1I1A3A01061034"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["Intramural grant"],"award-info":[{"award-number":["Intramural grant"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Schisandrol A possesses pharmacological properties and is used to treat various diseases; however, its effects on osteoarthritis (OA) progression remain unclear. Here, we investigated Schisandrol A as a potential therapeutic agent for OA. In vitro, Schisandrol A effects were confirmed based on the levels of expression of catabolic factors (MMPs, ADAMTS5, and Cox2) induced by IL-1\u03b2 or Schisandrol A treatment in chondrocytes. In vivo, experimental OA in mice was induced using a destabilized medial meniscus (DMM) surgical model or oral gavage of Schisandrol A in a dose-dependent manner, and demonstrated using histological analysis. In vitro and in vivo analyses demonstrated that Schisandrol A inhibition attenuated osteoarthritic cartilage destruction via the regulation of Mmp3, Mmp13, Adamts5, and Cox2 expression. In the NF-\u03baB signaling pathway, Schisandrol A suppressed the degradation of I\u03baB and the phosphorylation of p65 induced by IL-1\u03b2. Overall, and Schisandrol A reduced the expression of catabolic factors by blocking NF-\u03baB signaling and prevented cartilage destruction. Therefore, Schisandrol A attenuated OA progression, and can be used to develop novel OA drug therapies.<\/jats:p>","DOI":"10.3390\/ph14030241","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T12:12:18Z","timestamp":1615205538000},"page":"241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Schisandrol A Suppresses Catabolic Factor Expression by Blocking NF-\u03baB Signaling in Osteoarthritis"],"prefix":"10.3390","volume":"14","author":[{"given":"Seong Jae","family":"Han","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Graduate School of Medicine, Ajou University, Suwon 16499, Korea"},{"name":"Department of Pharmacology, School of Medicine, Ajou University, Suwon 16499, Korea"},{"name":"Degenerative InterDiseases Research Center, School of Medicine, Ajou University, Suwon 16499, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimoon","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Life Science, Chung-Ang University, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-1066","authenticated-orcid":false,"given":"Seong-il","family":"Eyun","sequence":"additional","affiliation":[{"name":"Department of Life Science, Chung-Ang University, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-0408","authenticated-orcid":false,"given":"Choong-Gu","family":"Lee","sequence":"additional","affiliation":[{"name":"Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung 25451, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Graduate School of Medicine, Ajou University, Suwon 16499, Korea"},{"name":"Department of Pharmacology, School of Medicine, Ajou University, Suwon 16499, Korea"},{"name":"Degenerative InterDiseases Research Center, School of Medicine, Ajou University, Suwon 16499, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0322-8030","authenticated-orcid":false,"given":"Cheol-Ho","family":"Pan","sequence":"additional","affiliation":[{"name":"Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung 25451, Korea"},{"name":"Division of Bio-Medical Science &amp; Technology, KIST School, Korea University of Science and Technology (UST), Gangneung 02792, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/ni0901-771","article-title":"Pathogenesis of arthritis: Recent research progress","volume":"2","author":"Feldmann","year":"2001","journal-title":"Nat. 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