{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:28:34Z","timestamp":1790299714957,"version":"4.1.0"},"reference-count":197,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Junta de Extremadura, M\u00e9rida, Spain","award":["IB16170"],"award-info":[{"award-number":["IB16170"]}]},{"name":"Junta de Extremadura, M\u00e9rida, Spain","award":["GR18145"],"award-info":[{"award-number":["GR18145"]}]},{"name":"Instituto de Salud Carlos III, Madrid, Spain","award":["RETICS RD16\/0006\/0004 (ARADyAL)"],"award-info":[{"award-number":["RETICS RD16\/0006\/0004 (ARADyAL)"]}]},{"name":"Instituto de Salud Carlos III, Madrid, Spain","award":["PI15\/00303"],"award-info":[{"award-number":["PI15\/00303"]}]},{"name":"Instituto de Salud Carlos III, Madrid, Spain","award":["PI18\/00540"],"award-info":[{"award-number":["PI18\/00540"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>There are many reports suggesting an important role of genetic factors in the etiopathogenesis of essential tremor (ET), encouraging continuing the research for possible genetic markers. Linkage studies in families with ET have identified 4 genes\/loci for familial ET, although the responsible gene(s) have not been identified. Genome-wide association studies (GWAS) described several variants in LINGO1, SLC1A2, STK32B, PPARGC1A, and CTNNA3, related with ET, but none of them have been confirmed in replication studies. In addition, the case-control association studies performed for candidate variants have not convincingly linked any gene with the risk for ET. Exome studies described the association of several genes with familial ET (FUS, HTRA2, TENM4, SORT1, SCN11A, NOTCH2NLC, NOS3, KCNS2, HAPLN4, USP46, CACNA1G, SLIT3, CCDC183, MMP10, and GPR151), but they were found only in singular families and, again, not found in other families or other populations, suggesting that some can be private polymorphisms. The search for responsible genes for ET is still ongoing.<\/jats:p>","DOI":"10.3390\/ph14060516","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T11:07:02Z","timestamp":1622113622000},"page":"516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Genomic Markers for Essential Tremor"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-7323","authenticated-orcid":false,"given":"F\u00e9lix Javier","family":"Jim\u00e9nez-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Section of Neurology, Hospital Universitario del Sureste, E28500 Arganda del Rey, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortensia","family":"Alonso-Navarro","sequence":"additional","affiliation":[{"name":"Section of Neurology, Hospital Universitario del Sureste, E28500 Arganda del Rey, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Garc\u00eda-Mart\u00edn","sequence":"additional","affiliation":[{"name":"ARADyAL Instituto de Salud Carlos III, University Institute of Molecular Pathology Biomarkers, University of Extremadura, E10071 Caceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Department of Neurology, University Hospital M\u00fatua de Terrassa, Fundaci\u00f3 Docencia i Recer\u00e7a M\u00fatua de Terrassa, E08221 Terrassa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Pastor","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit, Department of Neurology, University Hospital M\u00fatua de Terrassa, Fundaci\u00f3 Docencia i Recer\u00e7a M\u00fatua de Terrassa, E08221 Terrassa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A. G.","family":"Ag\u00fandez","sequence":"additional","affiliation":[{"name":"ARADyAL Instituto de Salud Carlos III, University Institute of Molecular Pathology Biomarkers, University of Extremadura, E10071 Caceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1212\/WNL.41.2_Part_1.234","article-title":"Essential tremor, clinical correlates in 350 patients","volume":"41","author":"Lou","year":"1991","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1353-8020(97)00031-X","article-title":"Clinical features of essential tremor seen in neurology practice, a study of 357 patients","volume":"3","author":"Gasalla","year":"1997","journal-title":"Parkinsonism Relat. 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