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Complexes with general formula [Ru(\u03b76-p-cymene)(X,Y)(Z)] were prepared, where (X,Y) represents either an O,O-ligand (\u03b2-diketone), N,O-ligand (8-hydroxyquinoline) or O,S-pyrithione-type ligands (pyrithione = 1-hydroxypyridine-2(1H)-thione) with Cl\u2212 or 1,3,5-triaza-7-phosphaadamantane (PTA) as a co-ligand (Z). The tested complexes inhibit the chlamydial growth on HeLa cells, and one of the complexes inhibits the growth of the human herpes simplex virus-2. The chlorido complexes with N,O- and O,S-ligands displayed strong antibacterial activity on Gram-positive strains including the resistant S. aureus (MRSA) and were cytotoxic in adenocarcinoma cell lines. Effect of the structural variation on the biological properties and solution stability was clearly revealed. The decreased bioactivity of the \u03b2-diketone complexes can be related to their lower stability in solution. In contrast, the O,S-pyrithione-type complexes are highly stable in solution and the complexation prevents the oxidation of the O,S-ligands. Comparing the binding of PTA and the chlorido co-ligands, it can be concluded that PTA is generally more strongly coordinated to ruthenium, which at the same time decreased the reactivity of complexes with human serum albumin or 1-methylimidazole as well as diminished their bioactivity.<\/jats:p>","DOI":"10.3390\/ph14060518","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T23:16:46Z","timestamp":1622157406000},"page":"518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of Solution Chemical Properties and Biological Activity of Ruthenium Complexes of Selected \u03b2-Diketone, 8-Hydroxyquinoline and Pyrithione Ligands"],"prefix":"10.3390","volume":"14","author":[{"given":"Tam\u00e1s","family":"Pivarcsik","sequence":"first","affiliation":[{"name":"MTA-SZTE Lend\u00fclet Functional Metal Complexes Research Group, University of Szeged, D\u00f3m T\u00e9r 7, H-6720 Szeged, Hungary"},{"name":"Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, D\u00f3m T\u00e9r 7, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"MTA-SZTE Lend\u00fclet Functional Metal Complexes Research Group, University of Szeged, D\u00f3m T\u00e9r 7, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8638-5815","authenticated-orcid":false,"given":"Nikoletta","family":"Szemer\u00e9di","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Albert Szent-Gy\u00f6rgyi Health Center, Faculty of Medicine, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3067-8835","authenticated-orcid":false,"given":"Anita","family":"Bogdanov","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Albert Szent-Gy\u00f6rgyi Health Center, Faculty of Medicine, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8085-0950","authenticated-orcid":false,"given":"Gabriella","family":"Spengler","sequence":"additional","affiliation":[{"name":"MTA-SZTE Lend\u00fclet Functional Metal Complexes Research Group, University of Szeged, D\u00f3m T\u00e9r 7, H-6720 Szeged, Hungary"},{"name":"Department of Medical Microbiology, Albert Szent-Gy\u00f6rgyi Health Center, Faculty of Medicine, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1986-4840","authenticated-orcid":false,"given":"Jakob","family":"Kljun","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerneja","family":"Kladnik","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-4062","authenticated-orcid":false,"given":"Iztok","family":"Turel","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8058-8128","authenticated-orcid":false,"given":"\u00c9va A.","family":"Enyedy","sequence":"additional","affiliation":[{"name":"MTA-SZTE Lend\u00fclet Functional Metal Complexes Research Group, University of Szeged, D\u00f3m T\u00e9r 7, H-6720 Szeged, Hungary"},{"name":"Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, D\u00f3m T\u00e9r 7, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/ejic.201600986","article-title":"Thirty years of the drug candidate NAMI-A and the myths in the field of ruthenium anticancer compounds: A personal perspective","volume":"12","author":"Alessio","year":"2017","journal-title":"Eur. 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