{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:43:05Z","timestamp":1783568585075,"version":"3.55.0"},"reference-count":43,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FRQNT of Quebec and CONACYT","award":["279380"],"award-info":[{"award-number":["279380"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The conformational study of dendritic platforms containing multiple \u03b2-cyclodextrin (\u03b2CD) units in the periphery is relevant to determine the availability of \u03b2CD cavities for the formation of inclusion complexes in aqueous biological systems. In this work, we performed a detailed conformational analysis in D2O, via 1D and 2D NMR spectroscopy of a novel class of phosphorus dendritic compounds of the type P3N3-[O-C6H4-O-(CH2)n-\u03b2CD]6 (where n = 3 or 4). We unambiguously demonstrated that a functionalized glucopyranose unit of at least one \u03b2CD unit undergoes a 360\u00b0 tumbling process, resulting in a deep inclusion of the spacer that binds the cyclodextrin to the phosphorus core inside the cavity, consequently limiting the availability of the inner cavities. In addition, we confirmed through NMR titrations that this tumbling phenomenon can be reversed for all \u03b2CD host units using a high-affinity guest, namely 1-adamantanecarboxylic acid (AdCOOH). Our findings have demonstrated that it is possible to create a wide variety of multi-functional dendritic platforms.<\/jats:p>","DOI":"10.3390\/ph14060556","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T02:55:28Z","timestamp":1623380128000},"page":"556","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Guest-Mediated Reversal of the Tumbling Process in Phosphorus-Dendritic Compounds Containing \u03b2-Cyclodextrin Units: An NMR Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Kendra","family":"Sorroza-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, M\u00e9xico City CP 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Gonz\u00e1lez-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, M\u00e9xico City CP 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Vonlanthen","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, M\u00e9xico City CP 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-1176","authenticated-orcid":false,"given":"Fabi\u00e1n","family":"Cu\u00e9tara-Guadarrama","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, M\u00e9xico City CP 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4864-3975","authenticated-orcid":false,"given":"Javier","family":"Illescas","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico Nacional de M\u00e9xico\/Instituto Tecnol\u00f3gico de Toluca, Avenida Tecnol\u00f3gico S\/N Col. Agr\u00edcola Bellavista, Metepec CP 52140, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Xia","family":"Zhu","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chimie, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succursale Centre-ville, Montreal, QC H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Rivera","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, M\u00e9xico City CP 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5174","DOI":"10.1039\/C6CS00074F","article-title":"Inorganic dendrimers: Recent advances for catalysis, nanomaterials, and nanomedicine","volume":"45","author":"Caminade","year":"2016","journal-title":"Chem. 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