{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:35:44Z","timestamp":1788546944057,"version":"build-2803163510"},"reference-count":298,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>In recent years, nanoparticles (NPs) have been receiving more attention in dentistry. Their advantageous physicochemical and biological properties can improve the diagnosis, prevention, and treatment of numerous oral diseases, including dental caries, periodontal diseases, pulp and periapical lesions, oral candidiasis, denture stomatitis, hyposalivation, and head, neck, and oral cancer. NPs can also enhance the mechanical and microbiological properties of dental prostheses and implants and can be used to improve drug delivery through the oral mucosa. This paper reviewed studies from 2015 to 2020 and summarized the potential applications of different types of NPs in the many fields of dentistry.<\/jats:p>","DOI":"10.3390\/ph14080752","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T21:44:32Z","timestamp":1627854272000},"page":"752","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Nanoparticles in Dentistry: A Comprehensive Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0777-5012","authenticated-orcid":false,"given":"Gustavo","family":"Moraes","sequence":"first","affiliation":[{"name":"College of Dentistry, University of Saskatchewan, Saskatoon, SK S7N 5E4, Canada"},{"name":"Department of Dentistry, State University of Ponta Grossa, Ponta Grossa 84030-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1835-1186","authenticated-orcid":false,"given":"Carolina","family":"Zambom","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Organic Chemistry, Institute of Chemistry, UNESP\u2014Sao Paulo State University, Araraquara 14800-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-3658","authenticated-orcid":false,"given":"Walter L.","family":"Siqueira","sequence":"additional","affiliation":[{"name":"College of Dentistry, University of Saskatchewan, Saskatoon, SK S7N 5E4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/21691401.2018.1452750","article-title":"Silver nanoparticles Clinacanthus Nutans leaves extract induced apoptosis towards oral squamous cell carcinoma cell lines","volume":"46","author":"Yakop","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00775-018-1600-6","article-title":"Potential applications of engineered nanoparticles in medicine and biology: An update","volume":"23","author":"Rudramurthy","year":"2018","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"032019","DOI":"10.1088\/1757-899X\/263\/3\/032019","article-title":"A review on the classification, characterisation, synthesis of nanoparticles and their application","volume":"263","author":"Saravanakumar","year":"2017","journal-title":"IOP Conf. Ser. Mater. Sci. Eng."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1515\/epoly-2016-0319","article-title":"Comparative investigation of physical, mechanical and thermomechanical characterization of dental composite filled with nanohydroxyapatite and mineral trioxide aggregate","volume":"17","author":"Meena","year":"2017","journal-title":"e-Polymers"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Omidi, M., Fatehinya, A., Farahani, M., Akbari, Z., Shahmoradi, S., Yazdian, F., Tahriri, M., Moharamzadeh, K., Tayebi, L., and Vashaee, D. (2017). Characterization of Biomaterials, Elsevier.","DOI":"10.1016\/B978-0-08-100961-1.00007-4"},{"key":"ref_6","first-page":"ZC05","article-title":"Fabrication and appraisal of poly (Lactic-Co-Glycolic Acid)-moxifloxacin nanoparticles using vitamin E-tpgs: A potential intracanal drug delivery agent","volume":"11","author":"Makkar","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1002\/jbm.b.34320","article-title":"Anticancer effect of novel platinum nanocomposite beads on oral squamous cell carcinoma cells","volume":"107","author":"Tanaka","year":"2019","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ketabat, F., Pundir, M., Mohabatpour, F., Lobanova, L., Koutsopoulos, S., Hadjiiski, L., Chen, X., Papagerakis, P., and Papagerakis, S. (2019). Controlled drug delivery systems for oral cancer treatment-current status and future perspectives. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11070302"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ijpharm.2016.06.052","article-title":"Significance of polymethylmethacrylate (PMMA) modification by zinc oxide nanoparticles for fungal biofilm formation","volume":"510","author":"Cierech","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","article-title":"Dental caries","volume":"369","author":"Selwitz","year":"2007","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.2147\/IJN.S155245","article-title":"Antimicrobial peptide-loaded liquid crystalline precursor bioadhesive system for the prevention of dental caries","volume":"13","author":"Aida","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1208\/s12249-019-1615-5","article-title":"Development and characterization of bioadhesive film embedded with lignocaine and calcium fluoride nanoparticles","volume":"21","author":"Ghafar","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ejps.2017.04.004","article-title":"Fluoride loaded polymeric nanoparticles for dental delivery","volume":"104","author":"Nguyen","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.2147\/IJN.S93105","article-title":"Fungal diseases: Could nanostructured drug delivery systems be a novel paradigm for therapy?","volume":"11","author":"Voltan","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s00253-015-7154-4","article-title":"Calcium fluoride nanoparticles induced suppression of Streptococcus mutans biofilm: An in vitro and in vivo approach","volume":"100","author":"Kulshrestha","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4012\/dmj.2017-195","article-title":"Synthesis of hybrid copper-chitosan nanoparticles with antibacterial activity against cariogenic Streptococcus mutans","volume":"37","author":"Covarrubias","year":"2018","journal-title":"Dent. Mater. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.carbpol.2014.10.026","article-title":"Mucoadhesive electrospun chitosan-based nanofibre mats for dental caries prevention","volume":"117","author":"Samprasit","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.ijbiomac.2017.05.120","article-title":"Nanochitosan modified glass ionomer cement with enhanced mechanical properties and fluoride release","volume":"104","author":"Ravikumar","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/0885328215589672","article-title":"Characterization of antibacterial and adhesion properties of chitosan-modified glass ionomer cement","volume":"30","author":"Ibrahim","year":"2015","journal-title":"J. Biomater. Appl."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/jerd.12282","article-title":"Characterization of chitosan\/TiO(2) nano-powder modified glass-ionomer cement for restorative dental applications","volume":"29","author":"Ibrahim","year":"2017","journal-title":"J. Esthet. Restor. Dent."},{"key":"ref_21","first-page":"93","article-title":"Evaluation of antibacterial efficiency of chitosan and chitosan nanoparticles on cariogenic streptococci: An in vitro study","volume":"8","author":"Aliasghari","year":"2016","journal-title":"Iran. J. Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.carbpol.2019.02.018","article-title":"Mentha piperita essential oils loaded in a chitosan nanogel with inhibitory effect on biofilm formation against S. mutans on the dental surface","volume":"212","author":"Ashrafi","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ikono, R., Vibriani, A., Wibowo, I., Saputro, K.E., Muliawan, W., Bachtiar, B.M., Mardliyati, E., Bachtiar, E.W., Rochman, N.T., and Kagami, H. (2019). Nanochitosan antimicrobial activity against Streptococcus mutans and Candida albicans dual-species biofilms. BMC Res. Notes, 12.","DOI":"10.1186\/s13104-019-4422-x"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.archoralbio.2019.02.004","article-title":"Chitosan hydrogel containing amelogenin-derived peptide: Inhibition of cariogenic bacteria and promotion of remineralization of initial caries lesions","volume":"100","author":"Ren","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1021\/acsnano.6b01370","article-title":"Surface-adaptive, antimicrobially loaded, micellar nanocarriers with enhanced penetration and killing efficiency in staphylococcal biofilms","volume":"10","author":"Liu","year":"2016","journal-title":"ACS Nano"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104586","DOI":"10.1016\/j.archoralbio.2019.104586","article-title":"Anti-acidogenic, anti-biofilm and slow release properties of Dodonaea viscosa var. angustifolia flavone stabilized polymeric nanoparticles","volume":"109","author":"Sebelemetja","year":"2020","journal-title":"Arch. Oral Biol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Trigo Gutierrez, J.K., Zanatta, G.C., Ortega, A.L.M., Balastegui, M.I.C., Sanit\u00e1, P.V., Pavarina, A.C., Barbugli, P.A., and Mima, E.G.O. (2017). Encapsulation of curcumin in polymeric nanoparticles for antimicrobial photodynamic therapy. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187418"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1039\/C8BM01640B","article-title":"pH-Responsive polymeric nanocarriers for efficient killing of cariogenic bacteria in biofilms","volume":"7","author":"Zhao","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8882","DOI":"10.1021\/acsnano.8b04022","article-title":"Polydopamine nanoparticles as efficient scavengers for reactive oxygen species in periodontal disease","volume":"12","author":"Bao","year":"2018","journal-title":"ACS Nano"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.colsurfb.2018.05.015","article-title":"Development of pH-responsive biopolymer-silica composites loaded with Larrea divaricata Cav. extract with antioxidant activity","volume":"169","author":"Olivetti","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.msec.2015.06.033","article-title":"Antimicrobial efficacy of green synthesized drug blended silver nanoparticles against dental caries and periodontal disease causing microorganisms","volume":"56","author":"Emmanuel","year":"2015","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Itohiya, H., Matsushima, Y., Shirakawa, S., Kajiyama, S., Yashima, A., Nagano, T., and Gomi, K. (2019). Organic resolution function and effects of platinum nanoparticles on bacteria and organic matter. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0222634"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"435101","DOI":"10.1088\/1361-6528\/aa8838","article-title":"Bismuth subsalicylate nanoparticles with anaerobic antibacterial activity for dental applications","volume":"28","author":"Camps","year":"2017","journal-title":"Nanotechnology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9605906","DOI":"10.1155\/2016\/9605906","article-title":"Antibacterial activity of partially oxidized Ag\/Au nanoparticles against the oral pathogen porphyromonas gingivalis W83","volume":"2016","author":"Holden","year":"2016","journal-title":"J. Nanomater."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1166\/jbn.2016.2304","article-title":"One-Step fabrication of AgNPs embedded hybrid dual nanofibrous oral wound dressings","volume":"12","author":"Lee","year":"2016","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"He, Y., Jin, Y., Wang, X., Yao, S., Li, Y., Wu, Q., Ma, G., Cui, F., and Liu, H. (2018). An antimicrobial peptide-loaded gelatin\/chitosan nanofibrous membrane fabricated by sequential layer-by-layer electrospinning and electrospraying techniques. Nanomaterials, 8.","DOI":"10.3390\/nano8050327"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3389\/fchem.2019.00926","article-title":"Rapid release polymeric fibers for inhibition of porphyromonas gingivalis adherence to streptococcus gordonii","volume":"7","author":"Mahmoud","year":"2019","journal-title":"Front. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1177\/0022034515589314","article-title":"Kinetic-dependent Killing of Oral Pathogens with Nitric Oxide","volume":"94","author":"Backlund","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pereira, A., Brito, G.A.C., Lima, M.L.S., Silva J\u00fanior, A.A.D., Silva, E.D.S., de Rezende, A.A., Bortolin, R.H., Galvan, M., Pirih, F.Q., and Ara\u00fajo J\u00fanior, R.F. (2018). Metformin hydrochloride-loaded PLGA nanoparticle in periodontal disease experimental model using diabetic rats. Int. J. Mol. Sci., 19.","DOI":"10.20944\/preprints201807.0367.v1"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/10717544.2019.1571121","article-title":"Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: Preparation, characterization and evaluation","volume":"26","author":"Mou","year":"2019","journal-title":"Drug Deliv."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Osorio, R., Alfonso-Rodr\u00edguez, C.A., Medina-Castillo, A.L., Alaminos, M., and Toledano, M. (2016). Bioactive polymeric nanoparticles for periodontal therapy. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166217"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.2147\/IJN.S139178","article-title":"Peptide-modified nanoparticles inhibit formation of Porphyromonas gingivalis biofilms with Streptococcus gordonii","volume":"12","author":"Kalia","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.1038\/s41598-018-24866-2","article-title":"Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease","volume":"8","author":"Zambrano","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"110572","DOI":"10.1016\/j.colsurfb.2019.110572","article-title":"Wheat germ agglutinin liposomes with surface grafted cyclodextrins as bioadhesive dual-drug delivery nanocarriers to treat oral cells","volume":"185","author":"Wijetunge","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e20190025","DOI":"10.1590\/1678-7757-2019-0025","article-title":"Liposomal anesthetic gel for pain control during periodontal therapy in adults: A placebo-controlled RCT","volume":"28","author":"Moraes","year":"2020","journal-title":"J. Appl. Oral Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e12380","DOI":"10.1111\/jicd.12380","article-title":"Development and evaluation of calcium hydroxide-coated, pericardium-based biomembranes for direct pulp capping","volume":"10","author":"Reston","year":"2019","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3389\/fmicb.2018.01371","article-title":"Synergistic effect of newly introduced root canal medicaments; ozonated olive oil and chitosan nanoparticles, against persistent endodontic pathogens","volume":"9","author":"Elshinawy","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4103\/ccd.ccd_225_18","article-title":"Comparative evaluation of antibiofilm efficacy of chitosan nanoparticle- and zinc oxide nanoparticle-incorporated calcium hydroxide-based sealer: An in vitro study","volume":"9","author":"Nair","year":"2018","journal-title":"Contemp. Clin. Dent."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10266-020-00507-x","article-title":"Cytotoxicity and release ions of endodontic sealers incorporated with a silver and vanadium base nanomaterial","volume":"108","author":"Teixeira","year":"2020","journal-title":"Odontology"},{"key":"ref_50","first-page":"e842","article-title":"Spectrophotometric analysis of crown discoloration following the use of silver nanoparticles combined with calcium hydroxide as intracanal medicament","volume":"9","author":"Afkhami","year":"2017","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e20190005","DOI":"10.1590\/1678-7757-2019-0005","article-title":"Comparative effects of final canal irrigation with chitosan and EDTA","volume":"28","author":"Antunes","year":"2020","journal-title":"J. Appl. Oral Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4103\/JCD.JCD_269_16","article-title":"Comparative evaluation of smear layer removal by chitosan and ethylenediaminetetraacetic acid when used as irrigant and its effect on root dentine: An in vitro atomic force microscopic and energy-dispersive X-ray analysis","volume":"20","author":"Mathew","year":"2017","journal-title":"J. Conserv. Dent."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.4103\/njcp.njcp_127_18","article-title":"Effect of chitosan on sealer penetration into the dentinal tubules","volume":"21","author":"Kesim","year":"2018","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1590\/0103-6440202002812","article-title":"Cytotoxicity of chelating agents used in endodontics and their influence on MMPs of cell membranes","volume":"31","author":"Pivatto","year":"2020","journal-title":"Braz. Dent. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/0972-0707.209068","article-title":"Retrievability of calcium hydroxide intracanal medicament with three calcium chelators, ethylenediaminetetraacetic acid, citric acid, and chitosan from root canals: An in vitro cone beam computed tomography volumetric analysis","volume":"20","author":"Raghu","year":"2017","journal-title":"J. Conserv. Dent."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"373","DOI":"10.17796\/1053-4625-42.5.9","article-title":"Tissue engineering of necrotic dental pulp of immature teeth with apical periodontitis in dogs: Radiographic and histological evaluation","volume":"42","author":"Alamoudi","year":"2018","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.nano.2018.01.013","article-title":"Nanomagnetic-mediated drug delivery for the treatment of dental disease","volume":"14","author":"Ji","year":"2018","journal-title":"Nanomedicine"},{"key":"ref_58","first-page":"e119","article-title":"Assessment of toxicity and oxidative DNA damage of sodium hypochlorite, chitosan and propolis on fibroblast cells","volume":"32","author":"Akpinar","year":"2018","journal-title":"Braz. Oral Res."},{"key":"ref_59","first-page":"e361","article-title":"Evaluation of antimicrobial and antifungal efficacy of chitosan as endodontic irrigant against enterococcus faecalis and candida albicans biofilm formed on tooth substrate","volume":"9","author":"Yadav","year":"2017","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4103\/ccd.ccd_745_17","article-title":"Scanning electron microscopic evaluation of efficacy of 17% ethylenediaminetetraacetic acid and chitosan for smear layer removal with ultrasonics: An in vitro study","volume":"8","author":"Kamble","year":"2017","journal-title":"Contemp. Clin. Dent."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.ijbiomac.2017.05.126","article-title":"Comparative evaluation of micron- and nano-sized intracanal medicaments on penetration and fracture resistance of root dentin-An in vitro study","volume":"104","author":"Sireesha","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.joen.2017.03.017","article-title":"Antibacterial roperties of chitosan nanoparticles and propolis associated with calcium hydroxide against single- and multispecies biofilms: An in vitro and in situ study","volume":"43","author":"Kishen","year":"2017","journal-title":"J. Endod."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.msec.2018.07.002","article-title":"Chitosan\/gelatin as a new nano-carrier system for calcium hydroxide delivery in endodontic applications: Development, characterization and process optimization","volume":"92","author":"Farhadian","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4103\/ccd.ccd_114_17","article-title":"Effect of different irrigating solutions on depth of penetration of sealer into dentinal tubules: A confocal microscopic study","volume":"8","author":"Thota","year":"2017","journal-title":"Contemp. Clin. Dent."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00784-019-02916-x","article-title":"A chitosan-based irrigant improves the dislocation resistance of a mineral trioxide aggregate-resin hybrid root canal sealer","volume":"24","author":"Ozlek","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1590\/1807-3107bor-2018.vol32.0121","article-title":"How to improve root canal filling in teeth subjected to radiation therapy for cancer","volume":"32","author":"Paiola","year":"2018","journal-title":"Braz. Oral Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10266-018-0389-7","article-title":"Calcium sustained release, pH changes and cell viability induced by chitosan-based pastes for apexification","volume":"107","year":"2019","journal-title":"Odontology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.sdentj.2019.03.003","article-title":"An in vivo comparative evaluation of antimicrobial efficacy of chitosan, chlorhexidine gluconate gel and their combination as an intracanal medicament against Enterococcus faecalis in failed endodontic cases using real time polymerase chain reaction (qPCR)","volume":"31","author":"Savitha","year":"2019","journal-title":"Saudi Dent. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jdent.2019.01.017","article-title":"Biological properties of modified bioactive glass on dental pulp cells","volume":"83","author":"Zhu","year":"2019","journal-title":"J. Dent."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1515040","DOI":"10.1155\/2019\/1515040","article-title":"Evaluation of chitosan hydrogel for sustained delivery of VEGF for odontogenic differentiation of dental pulp stem cells","volume":"2019","author":"Wu","year":"2019","journal-title":"Stem Cells Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00784-019-02906-z","article-title":"Synergistic potential of 1\u03b1,25-dihydroxyvitamin D3 and calcium-aluminate-chitosan scaffolds with dental pulp cells","volume":"24","author":"Bordini","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2174\/1567201814666170125121735","article-title":"Formulation of saudi propolis into biodegradable chitosan chips for vital pulpotomy","volume":"15","author":"Balata","year":"2018","journal-title":"Curr. Drug Deliv."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"720","DOI":"10.5005\/jp-journals-10024-2586","article-title":"Regenerative evaluation of immature roots using PRF and artificial scaffolds in necrotic permanent teeth: A clinical study","volume":"20","author":"Mittal","year":"2019","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.joen.2017.03.005","article-title":"Histologic evaluation of regenerative endodontic procedures with the Use of chitosan scaffolds in immature dog teeth with apical periodontitis","volume":"43","author":"Palma","year":"2017","journal-title":"J. Endod."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4103\/ijdr.IJDR_634_15","article-title":"Effectiveness of nanoparticles solutions and conventional endodontic irrigants against enterococcus faecalis biofilm","volume":"29","author":"Cechella","year":"2018","journal-title":"Indian J. Dent. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"662","DOI":"10.4103\/JCD.JCD_203_18","article-title":"Antibiofilm efficacy of biosynthesized silver nanoparticles against endodontic-periodontal pathogens: An in vitro study","volume":"21","author":"Halkai","year":"2018","journal-title":"J. Conserv. Dent."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1039\/C7BM00764G","article-title":"A liquid crystalline precursor incorporating chlorhexidine acetate and silver nanoparticles for root canal disinfection","volume":"6","author":"Zheng","year":"2018","journal-title":"Biomater. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1089\/mdr.2018.0228","article-title":"Evaluation of the efficacy of three antimicrobial agents used for regenerative endodontics: An in vitro study","volume":"25","author":"Sadek","year":"2019","journal-title":"Microb. Drug Resist."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4103\/ccd.ccd_828_17","article-title":"Antibacterial efficacy of biosynthesized silver nanoparticles against enterococcus faecalis biofilm: An in vitro study","volume":"9","author":"Halkai","year":"2018","journal-title":"Contemp. Clin. Dent."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.joen.2016.03.014","article-title":"In vitro and in vivo toxicity evaluation of colloidal silver nanoparticles used in endodontic treatments","volume":"42","author":"Takamiya","year":"2016","journal-title":"J. Endod."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.archoralbio.2017.09.028","article-title":"Cytotoxicity, genotoxicity and antibacterial activity of poly(vinyl alcohol)-coated silver nanoparticles and farnesol as irrigating solutions","volume":"84","author":"Rodrigues","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.dental.2019.08.105","article-title":"The synthesis of nano silver-graphene oxide system and its efficacy against endodontic biofilms using a novel tooth model","volume":"35","author":"Ioannidis","year":"2019","journal-title":"Dent. Mater."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Martinez-Andrade, J.M., Avalos-Borja, M., Vilchis-Nestor, A.R., Sanchez-Vargas, L.O., and Castro-Longoria, E. (2018). Dual function of EDTA with silver nanoparticles for root canal treatment-A novel modification. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0190866"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.dental.2019.07.014","article-title":"Novel root canal sealer with dimethylaminohexadecyl methacrylate, nano-silver and nano-calcium phosphate to kill bacteria inside root dentin and increase dentin hardness","volume":"35","author":"Baras","year":"2019","journal-title":"Dent. Mater."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"104481","DOI":"10.1016\/j.archoralbio.2019.104481","article-title":"Antimicrobial and biofilm anti-adhesion activities of silver nanoparticles and farnesol against endodontic microorganisms for possible application in root canal treatment","volume":"107","author":"Faria","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"ref_86","first-page":"280","article-title":"Tooth discoloration induced by imidazolium based silver nanoparticles as an intracanal irrigant","volume":"19","author":"Moazami","year":"2018","journal-title":"J. Dent."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"E9445","DOI":"10.1073\/pnas.1711924114","article-title":"Clinical validation of a nanodiamond-embedded thermoplastic biomaterial","volume":"114","author":"Lee","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"26667","DOI":"10.1038\/srep26667","article-title":"Inhibition of gold nanoparticles (AuNPs) on pathogenic biofilm formation and invasion to host cells","volume":"6","author":"Yu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.joen.2017.12.003","article-title":"Novel endodontic disinfection approach using catalytic nanoparticles","volume":"44","author":"Bukhari","year":"2018","journal-title":"J. Endod."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jdent.2017.02.011","article-title":"Novel bioactive root canal sealer to inhibit endodontic multispecies biofilms with remineralizing calcium phosphate ions","volume":"60","author":"Wang","year":"2017","journal-title":"J. Dent."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.2147\/IJN.S219577","article-title":"Design, evaluation and antimicrobial activity of egyptian propolis-loaded nanoparticles: Intrinsic role as a novel and naturally based root canal nanosealer","volume":"14","author":"Elgendy","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.2147\/IJN.S204550","article-title":"Formulation and characterization of chlorhexidine HCl nanoemulsion as a promising antibacterial root canal irrigant: In-vitro and ex-vivo studies","volume":"14","author":"Abdelmonem","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"713","DOI":"10.4012\/dmj.2018-198","article-title":"Application of hydroxyapatite nanoparticle-assembled powder using basic fibroblast growth factor as a pulp-capping agent","volume":"38","author":"Imura","year":"2019","journal-title":"Dent. Mater. J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.joen.2016.08.029","article-title":"Entrococcus faecalis elimination in root canals using silver nanoparticles, Photodynamic therapy, diode laser, or laser-activated nanoparticles: An in vitro study","volume":"43","author":"Afkhami","year":"2017","journal-title":"J. Endod."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/pho.2016.4148","article-title":"Bactericidal efficacy of photodynamic therapy and chitosan in root canals experimentally infected with enterococcus faecalis: An in vitro study","volume":"35","year":"2017","journal-title":"Photomed. Laser Surg."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e1155","DOI":"10.4317\/jced.55076","article-title":"Comparative evaluation of antibacterial effect of nanoparticles and lasers against endodontic microbiota: An in vitro study","volume":"10","author":"Kushwaha","year":"2018","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/JCD.JCD_337_18","article-title":"Scanning electron microscopic evaluation of smear layer removal at the apical third of root canals using diode laser, endoActivator, and ultrasonics with chitosan: An in vitro study","volume":"22","author":"Abraham","year":"2019","journal-title":"J. Conserv. Dent."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"472","DOI":"10.4103\/0972-0707.190022","article-title":"Effect of chitosan-ethylenediamine tetraacetic acid on Enterococcus faecalis dentinal biofilm and smear layer removal","volume":"19","author":"Geethapriya","year":"2016","journal-title":"J. Conserv. Dent."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.joen.2016.05.018","article-title":"Does liposomal bupivacaine (exparel) significantly reduce postoperative pain\/numbness in symptomatic teeth with a diagnosis of necrosis? A prospective, randomized, double-blind trial","volume":"42","author":"Glenn","year":"2016","journal-title":"J. Endod."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.joen.2016.08.018","article-title":"Pain reduction in untreated symptomatic irreversible pulpitis using liposomal bupivacaine (exparel): A prospective, randomized, double-blind trial","volume":"42","author":"Bultema","year":"2016","journal-title":"J. Endod."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/jbm.b.34170","article-title":"Advanced inorganic nanocomposite for decontaminating titanium dental implants","volume":"107","author":"Laurenti","year":"2019","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"102153","DOI":"10.1016\/j.anaerobe.2020.102153","article-title":"Biofunctionalized zinc peroxide nanoparticles inhibit peri-implantitis associated anaerobes and Aggregatibacter actinomycetemcomitans pH-dependent","volume":"62","author":"Bergs","year":"2020","journal-title":"Anaerobe"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.msec.2018.08.028","article-title":"Phytosynthesis of gold nanoparticles: Characterization, biocompatibility, and evaluation of its osteoinductive potential for application in implant dentistry","volume":"93","author":"Jadhav","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Govindharajulu, J.P., Chen, X., Li, Y., Rodriguez-Cabello, J.C., Battacharya, M., and Aparicio, C. (2017). Chitosan-recombinamer layer-by-layer coatings for multifunctional implants. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020369"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.ijbiomac.2017.10.166","article-title":"Enhanced antimicrobial activity of naturally derived bioactive molecule chitosan conjugated silver nanoparticle against dental implant pathogens","volume":"108","author":"Divakar","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.2147\/IJN.S134843","article-title":"Ti-GO-Ag nanocomposite: The effect of content level on the antimicrobial activity and cytotoxicity","volume":"12","author":"Jin","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1563\/aaid-joi-D-16-00147","article-title":"Antimicrobial effects of three different treatment modalities on dental implant surfaces","volume":"43","author":"Larsen","year":"2017","journal-title":"J. Oral Implantol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s10856-019-6250-x","article-title":"Improvements on biological and antimicrobial properties of titanium modified by AgNPs-loaded chitosan-heparin polyelectrolyte multilayers","volume":"30","author":"Li","year":"2019","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.carbpol.2018.12.039","article-title":"Antibacterial hyaluronic acid\/chitosan multilayers onto smooth and micropatterned titanium surfaces","volume":"207","author":"Valverde","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"17089","DOI":"10.1021\/acsami.8b04045","article-title":"Metal TiO2 nanotube layers for the treatment of dental implant infections","volume":"10","author":"Roguska","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1039\/C6BM00868B","article-title":"Antibacterial properties of nanostructured Cu-TiO2 surfaces for dental implants","volume":"5","author":"Rosenbaum","year":"2017","journal-title":"Biomater. Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"39534","DOI":"10.1021\/acsami.9b13849","article-title":"Bioactive coating on Ti alloy with high osseointegration and antibacterial Ag nanoparticles","volume":"11","author":"Sobolev","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4041\/kjod.2017.47.1.3","article-title":"Incorporation of silver nanoparticles on the surface of orthodontic microimplants to achieve antimicrobial properties","volume":"47","author":"Venugopal","year":"2017","journal-title":"Korean J. Orthod."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/idh.12381","article-title":"Treatment of peri-implant mucositis with a chitosan brush-A pilot randomized clinical trial","volume":"17","author":"Wohlfahrt","year":"2019","journal-title":"Int. J. Dent. Hyg."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40729-017-0098-y","article-title":"A novel non-surgical method for mild peri-implantitis- a multicenter consecutive case series","volume":"3","author":"Wohlfahrt","year":"2017","journal-title":"Int. J. Implant. Dent."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/cid.12738","article-title":"A thermosensitive chitosan-based hydrogel for sealing and lubricating purposes in dental implant system","volume":"21","author":"Cao","year":"2019","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.colsurfb.2017.07.007","article-title":"Liposome-modified titanium surface: A strategy to locally deliver bioactive molecules","volume":"158","author":"Cimmarusti","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"13785","DOI":"10.1021\/acsami.6b03454","article-title":"Electrophoretic deposition of chitosan coatings modified with gelatin nanospheres to tune the release of antibiotics","volume":"8","author":"Song","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.2147\/IJN.S131163","article-title":"In vitro studies of nanosilver-doped titanium implants for oral and maxillofacial surgery","volume":"12","author":"Pokrowiecki","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.2147\/IJN.S197782","article-title":"Investigation of silver nanoparticles on titanium surface created by ion implantation technology","volume":"14","author":"Beke","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_121","first-page":"2280800019847067","article-title":"Enhanced antibacterial activity of titanium by surface modification with polydopamine and silver for dental implant application","volume":"17","author":"Choi","year":"2019","journal-title":"J. Appl. Biomater. Funct. Mater."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/jbm.b.33376","article-title":"Antimicrobial effect and biocompatibility of novel metallic nanocrystalline implant coatings","volume":"104","author":"Gosau","year":"2016","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_123","first-page":"Zc56","article-title":"Comparative evaluation of antifungal effect of titanium, Zirconium and Aluminium nanoparticles coated Titanium plates against C. albicans","volume":"10","author":"Chidambaranathan","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_124","first-page":"37","article-title":"The antibacterial influence of nanotopographic titanium, zirconium, and aluminum nanoparticles against Staphylococcus aureus and porphyromonas gingivalis: An in vitro study","volume":"30","author":"Karthikeyan","year":"2019","journal-title":"Indian J. Dent. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"110210","DOI":"10.1016\/j.msec.2019.110210","article-title":"The biocompatibility of silver and nanohydroxyapatite coatings on titanium dental implants with human primary osteoblast cells","volume":"107","author":"Salaie","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"597","DOI":"10.11607\/jomi.5887","article-title":"Evaluation of a Titanium surface treated with hydroxyapatite nanocrystals on osteoblastic cell behavior: An in vitro study","volume":"33","author":"Martinez","year":"2018","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"de Lima Cavalcanti, J.H., Matos, P.C., Depes de Gouvea, C.V., Carvalho, W., Calvo-Guirado, J.L., Aragoneses, J.M., Perez-Diaz, L., and Gehrke, S.A. (2019). In vitro assessment of the functional dynamics of titanium with surface coating of hydroxyapatite Nanoparticles. Materials, 12.","DOI":"10.3390\/ma12050840"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/jbm.b.34156","article-title":"The enhancement of osseointegration using a graphene oxide\/chitosan\/hydroxyapatite composite coating on titanium fabricated by electrophoretic deposition","volume":"107","author":"Suo","year":"2019","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jcis.2016.02.022","article-title":"Titanium dental implants surface-immobilized with gold nanoparticles as osteoinductive agents for rapid osseointegration","volume":"469","author":"Heo","year":"2016","journal-title":"J. Colloid Interface Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1111\/cid.12665","article-title":"Investigation of surface structure and biocompatibility of chitosan-coated zirconia and alumina dental abutments","volume":"20","author":"Kalyoncuoglu","year":"2018","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Zhong, X., Song, Y., Yang, P., Wang, Y., Jiang, S., Zhang, X., and Li, C. (2016). Titanium surface priming with phase-transited lysozyme to establish a silver nanoparticle-loaded chitosan\/hyaluronic acid antibacterial multilayer via layer-by-layer self-assembly. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146957"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.msec.2019.01.019","article-title":"Deposition of catechol-functionalized chitosan and silver nanoparticles on biomedical titanium surfaces for antibacterial application","volume":"98","author":"Cheng","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"36408","DOI":"10.1038\/srep36408","article-title":"Establishing antibacterial multilayer films on the surface of direct metal laser sintered Titanium primed with phase-transited lysozyme","volume":"6","author":"Guan","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"8090","DOI":"10.1039\/C8TB01918E","article-title":"Surface engineering of titanium implants with enzyme-triggered antibacterial properties and enhanced osseointegration in vivo","volume":"6","author":"Yuan","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1177\/0885328217749963","article-title":"Dopamine self-polymerized along with hydroxyapatite onto the preactivated titanium percutaneous implants surface to promote human gingival fibroblast behavior and antimicrobial activity for biological sealing","volume":"32","author":"Yang","year":"2018","journal-title":"J. Biomater. Appl."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1039\/C9TB01715A","article-title":"Surface modification via plasmid-mediated pLAMA3-CM gene transfection promotes the attachment of gingival epithelial cells to titanium sheets in vitro and improves biological sealing at the transmucosal sites of titanium implants in vivo","volume":"7","author":"Wang","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.carbpol.2018.09.064","article-title":"Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants","volume":"203","author":"Rojo","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.carbpol.2017.03.009","article-title":"Gallium-modified chitosan\/poly(acrylic acid) bilayer coatings for improved titanium implant performances","volume":"166","author":"Bonifacio","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.11607\/jomi.5237","article-title":"Sinus floor elevation and augmentation using synthetic nanocrystalline and nanoporous hydroxyapatite bone substitute materials: Preliminary histologic results","volume":"31","author":"Belouka","year":"2016","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/cid.12859","article-title":"Maxillary sinus floor elevation using hydroxyapatite nano particles vs tenting technique with simultaneous implant placement: A randomized clinical trial","volume":"21","author":"Khaled","year":"2019","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.nano.2017.02.020","article-title":"Nanoparticle mediated PPARgamma gene delivery on dental implants improves osseointegration via mitochondrial biogenesis in diabetes mellitus rat model","volume":"13","author":"Lee","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"S807","DOI":"10.1080\/21691401.2018.1513940","article-title":"Chitosan-gold nanoparticles mediated gene delivery of c-myb facilitates osseointegration of dental implants in ovariectomized rat","volume":"46","author":"Takanche","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.2147\/IJN.S148001","article-title":"Osseointegration of layer-by-layer polyelectrolyte multilayers loaded with IGF1 and coated on titanium implant under osteoporotic condition","volume":"12","author":"Xing","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.11607\/jomi.5938","article-title":"A prospective, randomized, open-label study comparing an opioid-sparing postsurgical pain management protocol with and without liposomal bupivacaine for full-arch implant surgery","volume":"33","author":"Iero","year":"2018","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jdent.2017.02.012","article-title":"Poly(methyl methacrylate) with TiO2 nanoparticles inclusion for stereolitographic complete denture manufacturing-the fututre in dental care for elderly edentulous patients?","volume":"59","author":"Totu","year":"2017","journal-title":"J. Dent."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2842.2009.02039.x","article-title":"The future of complete dentures in oral rehabilitation. A critical review","volume":"37","author":"Carlsson","year":"2010","journal-title":"J. Oral Rehabil."},{"key":"ref_147","first-page":"e417","article-title":"Effect of nanodiamond addition on flexural strength, impact strength, and surface roughness of PMMA denture base","volume":"28","author":"Gad","year":"2019","journal-title":"J. Prosthodont."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/jopr.12573","article-title":"The effect of silica and prepolymer nanoparticles on the mechanical properties of denture base acrylic resin","volume":"27","author":"Cevik","year":"2018","journal-title":"J. Prosthodont."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2489393","DOI":"10.1155\/2019\/2489393","article-title":"Reinforcement of PMMA denture base material with a mixture of ZrO2 nanoparticles and glass fibers","volume":"2019","author":"Gad","year":"2019","journal-title":"Int. J. Dent."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2147\/IJN.S152571","article-title":"Effect of zirconium oxide nanoparticles addition on the optical and tensile properties of polymethyl methacrylate denture base material","volume":"13","author":"Gad","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.4103\/njcp.njcp_388_17","article-title":"Effect of green gold nanoparticles synthesized with plant on the flexural strength of heat-polymerized acrylic resin","volume":"21","author":"Oyar","year":"2018","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/jopr.12974","article-title":"Evaluation of flexural strength of different denture base materials reinforced with different nanoparticles","volume":"28","author":"Karci","year":"2019","journal-title":"J. Prosthodont."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"693","DOI":"10.4012\/dmj.2016-301","article-title":"Antibacterial activity, cytotoxicity and mechanical behavior of nano-enhanced denture base resin with different kinds of inorganic antibacterial agents","volume":"36","author":"Chen","year":"2017","journal-title":"Dent. Mater. J."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1590\/1678-775720160185","article-title":"Silver nanoparticle incorporation effect on mechanical and thermal properties of denture base acrylic resins","volume":"24","author":"Koroglu","year":"2016","journal-title":"J. Appl. Oral Sci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"S365","DOI":"10.4103\/JPBS.JPBS_36_19","article-title":"Impact strength and dimensional accuracy of heat-cure denture base resin reinforced with ZrO2 nanoparticles: An in vitro study","volume":"11","author":"Begum","year":"2019","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"333","DOI":"10.4012\/dmj.2016-243","article-title":"Hydrophilic nano-silica coating agents with platinum and diamond nanoparticles for denture base materials","volume":"36","author":"Yoshizaki","year":"2017","journal-title":"Dent. Mater. J"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.2147\/IJN.S120054","article-title":"Influence of incorporation of ZrO2 nanoparticles on the repair strength of polymethyl methacrylate denture bases","volume":"11","author":"Gad","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"7094056","DOI":"10.1155\/2016\/7094056","article-title":"The reinforcement effect of nano-zirconia on the transverse strength of repaired acrylic denture base","volume":"2016","author":"Gad","year":"2016","journal-title":"Int. J. Dent."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.2147\/IJN.S142857","article-title":"Inhibitory effect of zirconium oxide nanoparticles on Candida albicans adhesion to repaired polymethyl methacrylate denture bases and interim removable prostheses: A new approach for denture stomatitis prevention","volume":"12","author":"Gad","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4012\/dmj.2017-142","article-title":"The synthesis, modification, and application of nanosilica in polymethyl methacrylate denture base","volume":"37","author":"Jiangkongkho","year":"2018","journal-title":"Dent. Mater. J"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"207","DOI":"10.15171\/PS.2017.31","article-title":"Comparison of antifungal properties of acrylic resin reinforced with ZnO and Ag nanoparticles","volume":"23","author":"Anaraki","year":"2017","journal-title":"Pharm. Sci."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Cierech, M., Osica, I., Kolenda, A., Wojnarowicz, J., Szmigiel, D., Lojkowski, W., Kurzydlowski, K., Ariga, K., and Mierzwinska-Nastalska, E. (2018). Mechanical and physicochemical properties of newly formed ZnO-PMMA nanocomposites for denture bases. Nanomaterials, 8.","DOI":"10.3390\/nano8050305"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Salahuddin, N., El-Kemary, M., and Ibrahim, E. (2017). Reinforcement of polymethyl methacrylate denture base resin with ZnO nanostructures. Int. J. Appl. Ceram. Technol., 15.","DOI":"10.1111\/ijac.12802"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"482","DOI":"10.4047\/jap.2017.9.6.482","article-title":"Biofilm formation on denture base resin including ZnO, CaO, and TiO2 nanoparticles","volume":"9","author":"Anwander","year":"2017","journal-title":"J. Adv. Prosthodont."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.2147\/IJN.S132116","article-title":"Antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles","volume":"12","author":"Kamonkhantikul","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4236\/wjnse.2016.63011","article-title":"Effect of Titanium dioxide nano particles incorporation on mechanical and physical properties on two different types of acrylic resin denture base","volume":"06","author":"Ashour","year":"2016","journal-title":"World J. Nano Sci. Eng."},{"key":"ref_167","first-page":"e661","article-title":"Tensile strength and impact strength of color modified acrylic resin reinforced with titanium dioxide nanoparticles","volume":"9","author":"Ghahremani","year":"2017","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_168","first-page":"23","article-title":"The effect of silver nano particles on Candida albicans and streptococcus mutans in denture acrylic resins","volume":"5","author":"Ghahremanloo","year":"2016","journal-title":"J. Dent. Mater. Tech."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/ger.12142","article-title":"Effect of a denture base acrylic resin containing silver nanoparticles on Candida albicans adhesion and biofilm formation","volume":"33","author":"Li","year":"2016","journal-title":"Gerodontology"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.prosdent.2015.09.003","article-title":"In vitro study of the antibacterial properties and impact strength of dental acrylic resins modified with a nanomaterial","volume":"115","author":"Valente","year":"2016","journal-title":"J. Prosthet. Dent."},{"key":"ref_171","first-page":"28","article-title":"The effect of nanochitosans particles on Candida biofilm formation","volume":"2","author":"Falahati","year":"2016","journal-title":"Curr. Med. Mycol."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Bongomin, F., Gago, S., Oladele, R.O., and Denning, D.W. (2017). Global and multi-national prevalence of fungal diseases-estimate precision. J. Fungi, 3.","DOI":"10.3390\/jof3040057"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3109\/10837450.2014.999783","article-title":"Innovative formulation of nystatin particulate systems in toothpaste for candidiasis treatment","volume":"21","author":"Baptista","year":"2016","journal-title":"Pharm. Dev. Technol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2334\/josnusd.16-0295","article-title":"In vivo study of antifungal effects of low-molecular-weight chitosan against Candida albicans","volume":"59","author":"Atai","year":"2017","journal-title":"J. Oral Sci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"E380","DOI":"10.1111\/j.1469-0691.2012.03933.x","article-title":"Comparison of Photodynamic Therapy versus conventional antifungal therapy for the treatment of denture stomatitis: A randomized clinical trial","volume":"18","author":"Mima","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1208\/s12249-019-1496-7","article-title":"Preparation, optimization, and evaluation of hyaluronic acid-based hydrogel loaded with miconazole self-nanoemulsion for the treatment of oral thrush","volume":"20","author":"Hosny","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"055001","DOI":"10.1088\/1748-3190\/aad488","article-title":"Mucoadhesive assessment of different antifungal nanoformulations","volume":"13","author":"Roque","year":"2018","journal-title":"Bioinspir. Biomim."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1038\/s41598-017-04653-1","article-title":"Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13","volume":"7","author":"Niemirowicz","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"109885","DOI":"10.1016\/j.msec.2019.109885","article-title":"Synthesis and characterization of TPP\/chitosan nanoparticles: Colloidal mechanism of reaction and antifungal effect on C. albicans biofilm formation","volume":"104","author":"Magalhaes","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.archoralbio.2018.07.004","article-title":"Effect of chitosan nanoparticles on the inhibition of Candida spp. biofilm on denture base surface","volume":"94","author":"Gondim","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.carbpol.2016.04.101","article-title":"Antibiofilm activity of carboxymethyl chitosan on the biofilms of non-Candida albicans Candida species","volume":"149","author":"Tan","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3109\/10837450.2016.1163391","article-title":"Development and evaluation of N-naphthyl-N,O-succinyl chitosan micelles containing clotrimazole for oral candidiasis treatment","volume":"22","author":"Tonglairoum","year":"2017","journal-title":"Pharm. Dev. Technol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/jop.12435","article-title":"Use of photodynamic therapy and chitosan for inactivacion of Candida albicans in a murine model","volume":"45","author":"Fabio","year":"2016","journal-title":"J. Oral Pathol. Med."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Sakima, V.T., Barbugli, P.A., Cerri, P.S., Chorilli, M., Carmello, J.C., Pavarina, A.C., and Mima, E.G.O. (2018). Antimicrobial photodynamic therapy mediated by curcumin-loaded polymeric nanoparticles in a murine model of oral Candidiasis. Molecules, 23.","DOI":"10.3390\/molecules23082075"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.pdpdt.2019.06.010","article-title":"Antimicrobial photodynamic therapy reduces adhesion capacity and biofilm formation of Candida albicans from induced oral candidiasis in mice","volume":"27","author":"Alves","year":"2019","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_186","first-page":"7020","article-title":"Oral ulcer healing and anti-Candida efficacy of an alcohol-free chitosan-curcumin mouthwash","volume":"22","author":"Mahattanadul","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1089\/acm.2018.0459","article-title":"Effectiveness of an alcohol-free chitosan-curcuminoid mouthwash compared with chlorhexidine mouthwash in denture stomatitis treatment: A randomized trial","volume":"25","author":"Mustafa","year":"2019","journal-title":"J. Altern. Complement. Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.msec.2017.05.034","article-title":"Formulation and in-vitro efficacy of antifungal mucoadhesive polymeric matrices for the delivery of miconazole nitrate","volume":"79","author":"Tejada","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1208\/s12249-017-0720-6","article-title":"Development and evaluation of buccal films based on chitosan for the potential treatment of oral candidiasis","volume":"18","author":"Tejada","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1080\/02652048.2017.1370029","article-title":"Novel solidified reverse micellar solution-based mucoadhesive nano lipid gels encapsulating miconazole nitrate-loaded nanoparticles for improved treatment of oropharyngeal candidiasis","volume":"34","author":"Kenechukwu","year":"2017","journal-title":"J. Microencapsul."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.1007\/s00253-017-8463-6","article-title":"Preparation, characterization and toxicity evaluation of amphotericin B loaded MPEG-PCL micelles and its application for buccal tablets","volume":"101","author":"Zhang","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.2147\/IJN.S103762","article-title":"Development, characterization, and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis","volume":"11","author":"Rencber","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1002\/jbm.b.34510","article-title":"Temperature-dependent mucosal permeation kinetics of stigmasterol microspheres: In vivo mice model antioral candidiasis study","volume":"108","author":"Niyogi","year":"2020","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1080\/08927014.2018.1514391","article-title":"Development of a bioadhesive nanoformulation with Glycyrrhiza glabra L. extract against Candida albicans","volume":"34","author":"Roque","year":"2018","journal-title":"Biofouling"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jds.2017.06.004","article-title":"Antifungal effect of tissue conditioners containing poly(acryloyloxyethyltrimethyl ammonium chloride)-grafted chitosan on Candida albicans growth in vitro","volume":"13","author":"Lee","year":"2018","journal-title":"J. Dent. Sci."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.ijbiomac.2018.06.151","article-title":"Antibacterial and antifungal effects of chitosan nanoparticles on tissue conditioners of complete dentures","volume":"118","author":"Mousavi","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.ijbiomac.2018.12.091","article-title":"In-vitro antifungal efficacy of tissue conditioner-chitosan composites as potential treatment therapy for denture stomatitis","volume":"125","author":"Saeed","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"11","DOI":"10.15171\/joddd.2019.002","article-title":"Evaluation of antibacterial and antifungal properties of a tissue conditioner used in complete dentures after incorporation of ZnOAg nanoparticles","volume":"13","author":"Mousavi","year":"2019","journal-title":"J. Dent. Res. Dent. Clin. Dent. Prospects"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Herla, M., Boening, K., Meissner, H., and Walczak, K. (2019). Mechanical and surface properties of resilient denture liners modified with chitosan salts. Materials, 12.","DOI":"10.3390\/ma12213518"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"181.e1","DOI":"10.1016\/j.prosdent.2019.09.026","article-title":"Activity of chitosan antifungal denture adhesive against common Candida species and Candida albicans adherence on denture base acrylic resin","volume":"123","author":"Namangkalakul","year":"2020","journal-title":"J. Prosthet. Dent."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3389\/fmicb.2019.01667","article-title":"A novel antifungal system with potential for prolonged delivery of histatin 5 to limit growth of Candida albicans","volume":"10","author":"Zambom","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jconrel.2017.04.023","article-title":"Targeting and synergistic action of an antifungal peptide in an antibiotic drug-delivery system","volume":"256","author":"Park","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.ijbiomac.2019.03.031","article-title":"Phloretin loaded chitosan nanoparticles augments the pH-dependent mitochondrial-mediated intrinsic apoptosis in human oral cancer cells","volume":"130","author":"Mariadoss","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/s11671-019-3214-5","article-title":"Using omniscan-loaded nanoparticles as a tumor-targeted MRI contrast agent in oral squamous cell carcinoma by gelatinase-stimuli strategy","volume":"14","author":"Gao","year":"2019","journal-title":"Nanoscale Res. Lett."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2217\/nnm-2019-0290","article-title":"Effects of silver and gold nanoparticles phytosynthesized with Cornus mas extract on oral dysplastic human cells","volume":"15","author":"Baldea","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejpb.2015.11.017","article-title":"Dual drug loaded nanoliposomal chemotherapy: A promising strategy for treatment of head and neck squamous cell carcinoma","volume":"99","author":"Mohan","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2016.04.002","article-title":"Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes","volume":"95","author":"Suliman","year":"2016","journal-title":"Biomaterials"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1166\/jnn.2017.12636","article-title":"Silver nanoparticles as antibacterial and anticancer materials against human breast, cervical and oral cancer cells","volume":"17","author":"Barua","year":"2017","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"110457","DOI":"10.1016\/j.msec.2019.110457","article-title":"Bio-modified TiO(2) nanoparticles with Withania somnifera, Eclipta prostrata and Glycyrrhiza glabra for anticancer and antibacterial applications","volume":"108","author":"Maheswari","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.biopha.2018.05.096","article-title":"Co-encapsulation of dual drug loaded in MLNPs: Implication on sustained drug release and effectively inducing apoptosis in oral carcinoma cells","volume":"104","author":"Mehnath","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jphotobiol.2017.05.012","article-title":"Photothermal therapy using folate conjugated gold nanoparticles enhances the effects of 6MV X-ray on mouth epidermal carcinoma cells","volume":"172","author":"Neshastehriz","year":"2017","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.colsurfb.2016.03.024","article-title":"Intracellular interactions of electrostatically mediated layer-by-layer assembled polyelectrolytes based sorafenib nanoparticles in oral cancer cells","volume":"143","author":"Poojari","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"109876","DOI":"10.1016\/j.msec.2019.109876","article-title":"In vitro antimicrobial and anticancer properties of TiO(2) blow-spun nanofibers containing silver nanoparticles","volume":"104","author":"Bonan","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1080\/15384101.2019.1643658","article-title":"Identification and evaluation of novel drug combinations of Aurora kinase inhibitor CCT137690 for enhanced efficacy in oral cancer cells","volume":"18","author":"Furqan","year":"2019","journal-title":"Cell Cycle"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"285101","DOI":"10.1088\/1361-6528\/aabecc","article-title":"Controlled release of 18-\u03b2-glycyrrhetic acid by nanodelivery systems increases cytotoxicity on oral carcinoma cell line","volume":"29","author":"Cacciotti","year":"2018","journal-title":"Nanotechnology"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Yang, L.X., Wu, Y.N., Wang, P.W., Su, W.C., and Shieh, D.B. (2019). Iron release profile of silica-modified zero-valent iron NPs and their implication in cancer therapy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184336"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ultsonch.2016.02.026","article-title":"Acute effects of sono-activated photocatalytic titanium dioxide nanoparticles on oral squamous cell carcinoma","volume":"32","author":"Takahashi","year":"2016","journal-title":"Ultrason. Sonochem."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jcis.2017.08.030","article-title":"Phloretin-loaded fast dissolving nanofibers for the locoregional therapy of oral squamous cell carcinoma","volume":"508","author":"Nam","year":"2017","journal-title":"J. Colloid. Interface Sci."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"114734","DOI":"10.1016\/j.taap.2019.114734","article-title":"Gefitinib and curcumin-loaded nanoparticles enhance cell apoptosis in human oral cancer SAS cells in vitro and inhibit SAS cell xenografted tumor in vivo","volume":"382","author":"Lai","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.21873\/anticanres.13040","article-title":"Evaluation of a new hydroxyapatite nanoparticle as a drug delivery system to oral squamous cell carcinoma cells","volume":"38","author":"Murata","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_221","first-page":"2541","article-title":"Development and in vitro evaluation of mucoadhesive patches of methotrexate for targeted delivery in oral cancer","volume":"15","author":"Jin","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.2147\/IJN.S156984","article-title":"Antitumor effect of a Pt-loaded nanocomposite based on graphene quantum dots combats hypoxia-induced chemoresistance of oral squamous cell carcinoma","volume":"13","author":"Wei","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Jin, L., Wang, Q., Chen, J., Wang, Z., Xin, H., and Zhang, D. (2019). Efficient delivery of therapeutic siRNA by Fe(3)O(4) magnetic nanoparticles into oral cancer cells. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11110615"},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Lang, L., Lam, T., Chen, A., Jensen, C., Duncan, L., Kong, F.C., Kurago, Z.B., Shay, C., and Teng, Y. (2020). Circumventing AKT-associated radioresistance in oral cancer by novel nanoparticle-encapsulated capivasertib. Cells, 9.","DOI":"10.3390\/cells9030533"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1039\/C7BM00395A","article-title":"Synergistic therapy of chemotherapeutic drugs and MTH1 inhibitors using a pH-sensitive polymeric delivery system for oral squamous cell carcinoma","volume":"5","author":"Li","year":"2017","journal-title":"Biomater. Sci."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.colsurfb.2018.09.076","article-title":"Delivery of MTH1 inhibitor (TH287) and MDR1 siRNA via hyaluronic acid-based mesoporous silica nanoparticles for oral cancers treatment","volume":"173","author":"Shi","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.2147\/IJN.S165699","article-title":"Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1\/Parkin-mediated mitophagy","volume":"13","author":"Wang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/iub.2104","article-title":"Astaxanthin inhibits hallmarks of cancer by targeting the PI3K\/NF-\u03ba\u0392\/STAT3 signalling axis in oral squamous cell carcinoma models","volume":"71","author":"Kowshik","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/jop.12921","article-title":"Targeted magnetic nanoparticle hyperthermia for the treatment of oral cancer","volume":"48","author":"Legge","year":"2019","journal-title":"J. Oral Pathol. Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.taap.2017.07.008","article-title":"Nanoquinacrine caused apoptosis in oral cancer stem cells by disrupting the interaction between GLI1 and \u03b2 catenin through activation of GSK3\u03b2","volume":"330","author":"Nayak","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.nano.2018.01.007","article-title":"Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner","volume":"14","author":"Satapathy","year":"2018","journal-title":"Nanomedicine"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/IJN.S124995","article-title":"Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer","volume":"13","author":"Gupta","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1021\/acs.molpharmaceut.9b00242","article-title":"Comparative and mechanistic study on the anticancer activity of quinacrine-based silver and gold hybrid nanoparticles in head and neck cancer","volume":"16","author":"Hembram","year":"2019","journal-title":"Mol. Pharm."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.ijbiomac.2019.11.001","article-title":"Chitosan nanoparticles loading oxaliplatin as a mucoadhesive topical treatment of oral tumors: Iontophoresis further enhances drug delivery ex vivo","volume":"154","author":"Matos","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Dziedzic, A., Kubina, R., Bu\u0142dak, R.J., Skonieczna, M., and Cholewa, K. (2016). Silver nanoparticles exhibit the dose-dependent anti-proliferative effect against human squamous carcinoma cells attenuated in the presence of berberine. Molecules, 21.","DOI":"10.3390\/molecules21030365"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"480","DOI":"10.4103\/jcrt.JCRT_263_18","article-title":"Development of \u03b1-tocopherol surface-modified targeted delivery of 5-fluorouracil-loaded poly-D, L-lactic-co-glycolic acid nanoparticles against oral squamous cell carcinoma","volume":"15","author":"Srivastava","year":"2019","journal-title":"J. Cancer Res. Ther."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s12663-018-1126-z","article-title":"Co-delivery of 5-fluorouracil and curcumin nanohybrid formulations for improved chemotherapy against oral squamous cell carcinoma","volume":"17","author":"Srivastava","year":"2018","journal-title":"J. Maxillofac. Oral Surg."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s13318-019-00600-9","article-title":"Folate-gold-bilirubin nanoconjugate induces apoptotic death in multidrug-resistant oral carcinoma cells","volume":"45","author":"Rathinaraj","year":"2020","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.archoralbio.2019.05.011","article-title":"Liposome-coated nano doxorubicin induces apoptosis on oral squamous cell carcinoma CAL-27 cells","volume":"103","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1080\/21691401.2019.1573176","article-title":"Combinatorial therapeutic approach for treatment of oral squamous cell carcinoma","volume":"47","author":"Bharadwaj","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijbiomac.2017.12.137","article-title":"Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery","volume":"111","author":"Shtenberg","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.31557\/APJCP.2019.20.7.1973","article-title":"Assessment of the blood parameters, cardiac and liver Enzymes in oral squamous cell carcinoma following treated with injectable doxorubicin-loaded nano-particles","volume":"20","author":"Anvari","year":"2019","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1039\/C6TB01016D","article-title":"Development of a reactive oxygen species (ROS)-responsive nanoplatform for targeted oral cancer therapy","volume":"4","author":"Li","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijpharm.2017.04.027","article-title":"PEGylated doxorubicin nanoparticles mediated by HN-1 peptide for targeted treatment of oral squamous cell carcinoma","volume":"525","author":"Wang","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"29260","DOI":"10.1021\/acsami.8b08269","article-title":"Reactive oxygen species-responsive nanoparticles based on peglated prodrug for targeted treatment of oral tongue squamous cell carcinoma by combining photodynamic therapy and chemotherapy","volume":"10","author":"Shi","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2147\/IJN.S150610","article-title":"Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment","volume":"13","author":"Wang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2018.10.064","article-title":"SDF-1-loaded PLGA nanoparticles for the targeted photoacoustic imaging and photothermal therapy of metastatic lymph nodes in tongue squamous cell carcinoma","volume":"554","author":"Xiong","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2217\/nnm-2019-0415","article-title":"Development of a multifunctional gold nanoplatform for combined chemo-photothermal therapy against oral cancer","volume":"15","author":"Liu","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1021\/acsnano.5b07114","article-title":"Gold nanorods based air scanning electron microscopy and diffusion reflection imaging for mapping tumor margins in squamous cell carcinoma","volume":"10","author":"Ankri","year":"2016","journal-title":"ACS Nano"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cca.2017.09.009","article-title":"A facile gold nanoparticle-based ELISA system for detection of osteopontin in saliva: Towards oral cancer diagnostics","volume":"477","author":"Chakraborty","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40580-018-0134-5","article-title":"Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography","volume":"5","author":"Kim","year":"2018","journal-title":"Nano Converg."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12944-017-0465-y","article-title":"Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for the diagnosis of the oral squamous cell carcinoma","volume":"16","author":"Tan","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.2147\/IJN.S167996","article-title":"Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for tumor stages detection and histologic grades classification of oral squamous cell carcinoma","volume":"13","author":"Xue","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"F\u0103l\u0103ma\u0219, A., Rotaru, H., and Hede\u0219iu, M. (2020). Surface-enhanced Raman spectroscopy (SERS) investigations of saliva for oral cancer diagnosis. Lasers Med. Sci.","DOI":"10.1007\/s10103-020-02988-2"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"27462","DOI":"10.1021\/acsami.7b06839","article-title":"Anti-IL8\/AuNPs-rGO\/ITO as an Immunosensing Platform for Noninvasive Electrochemical Detection of Oral Cancer","volume":"9","author":"Verma","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/00016489.2018.1441544","article-title":"Assessment of lingual sentinel lymph nodes metastases using dual-modal indirect CT\/MR lymphography with gold-gadolinium-based nanoprobes in a tongue VX(2) carcinoma model","volume":"138","author":"Yang","year":"2018","journal-title":"Acta Otolaryngol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bios.2016.01.049","article-title":"MMP2-sensing up-conversion nanoparticle for fluorescence biosensing in head and neck cancer cells","volume":"80","author":"Chan","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.ijom.2019.02.010","article-title":"The use of carbon nanoparticles to track occult lingual lymph nodes in early-stage tongue squamous cell carcinoma","volume":"48","author":"Wu","year":"2019","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.2147\/IJN.S198684","article-title":"SERS-based differential diagnosis between multiple solid malignancies: Breast, colorectal, lung, ovarian and oral cancer","volume":"14","author":"Moisoiu","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bios.2015.11.084","article-title":"Nanostructured zirconia decorated reduced graphene oxide based efficient biosensing platform for non-invasive oral cancer detection","volume":"78","author":"Kumar","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"e1801557","DOI":"10.1002\/adhm.201801557","article-title":"A novel surface enhanced Raman catheter for rapid detection, classification, and grading of oral cancer","volume":"8","author":"Iyer","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Kumar, S., Panwar, S., Kumar, S., Augustine, S., and Malhotra, B.D. (2019). Biofunctionalized nanostructured yttria modified non-invasive impedometric biosensor for efficient detection of oral cancer. Nanomaterials, 9.","DOI":"10.3390\/nano9091190"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13045-019-0827-1","article-title":"Simultaneously inactivating Src and AKT by saracatinib\/capivasertib co-delivery nanoparticles to improve the efficacy of anti-Src therapy in head and neck squamous cell carcinoma","volume":"12","author":"Lang","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"7549","DOI":"10.2147\/IJN.S215087","article-title":"CD44-targeted magnetic nanoparticles kill head and neck squamous cell carcinoma stem cells in an alternating magnetic field","volume":"14","author":"Su","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"14292","DOI":"10.1038\/ncomms14292","article-title":"Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma","volume":"8","author":"Mizrachi","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Damiani, V., Falvo, E., Fracasso, G., Federici, L., Pitea, M., De Laurenzi, V., Sala, G., and Ceci, P. (2017). Therapeutic efficacy of the novel stimuli-sensitive nano-ferritins containing doxorubicin in a head and neck cancer model. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071555"},{"key":"ref_267","first-page":"350","article-title":"Novel drug delivery system based on hollow mesoporous magnetic nanoparticles for head and neck cancers--targeted therapy in vitro and in vivo","volume":"10","author":"Zhang","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13045-018-0623-3","article-title":"Combating head and neck cancer metastases by targeting Src using multifunctional nanoparticle-based saracatinib","volume":"11","author":"Lang","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.colsurfb.2016.07.053","article-title":"Cellular uptake and anticancer activity of salvianolic acid B phospholipid complex loaded nanoparticles in head and neck cancer and precancer cells","volume":"147","author":"Li","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_270","first-page":"415","article-title":"Gold nanoparticles enhance X-ray irradiation-induced apoptosis in head and neck squamous cell carcinoma in vitro","volume":"9","author":"Teraoka","year":"2018","journal-title":"Biomed. Rep."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/mt.2015.169","article-title":"Nanoparticle delivered VEGF-A siRNA enhances photodynamic therapy for head and neck cancer treatment","volume":"24","author":"Lecaros","year":"2016","journal-title":"Mol. Ther."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.colsurfb.2018.04.047","article-title":"Therapeutic efficacy of rebamipide-loaded PLGA nanoparticles coated with chitosan in a mouse model for oral mucositis induced by cancer chemotherapy","volume":"167","author":"Takeuchi","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/jbm.b.33487","article-title":"Buccal adhesive nanofibers containing human growth hormone for oral mucositis","volume":"104","author":"Choi","year":"2016","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.21873\/anticanres.13868","article-title":"Rebamipide-containing film using chitosan and HPMC for oral mucositis induced by cancer chemotherapy","volume":"39","author":"Takeuchi","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.actbio.2019.04.049","article-title":"Synergistic effects of laminin-1 peptides, VEGF and FGF9 on salivary gland regeneration","volume":"91","author":"Nam","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_276","doi-asserted-by":"crossref","unstructured":"Nam, K., Maruyama, C.L., Wang, C.S., Trump, B.G., Lei, P., Andreadis, S.T., and Baker, O.J. (2017). Laminin-111-derived peptide conjugated fibrin hydrogel restores salivary gland function. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187069"},{"key":"ref_277","first-page":"45","article-title":"Diagnosis and management of xerostomia and hyposalivation","volume":"11","author":"Villa","year":"2015","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_278","doi-asserted-by":"crossref","unstructured":"Escobar, A., and Aitken, J. (2019). Xerostomia: An update of causes and treatments. Salivary Glands-New Approaches in Diagnostics and Treatment, IntechOpen.","DOI":"10.5772\/intechopen.72307"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijpharm.2016.04.050","article-title":"Water sorption properties of HM-pectin and liposomes intended to alleviate dry mouth","volume":"506","author":"Adamczak","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijpharm.2015.12.030","article-title":"An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells","volume":"498","author":"Adamczak","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ijpharm.2017.05.032","article-title":"Polymer coated mucoadhesive liposomes intended for the management of xerostomia","volume":"527","author":"Adamczak","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"118697","DOI":"10.1016\/j.ijpharm.2019.118697","article-title":"Recent developments of nanoparticle-delivered dosage forms for buccal delivery","volume":"571","author":"Tran","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3389\/fphar.2019.01328","article-title":"Advances in nanoparticulate drug delivery approaches for sublingual and buccal administration","volume":"10","author":"Hua","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.3109\/10717544.2014.948644","article-title":"Development and evaluation of buccal films impregnated with selegiline-loaded nanospheres","volume":"23","author":"Nair","year":"2016","journal-title":"Drug Deliv."},{"key":"ref_285","first-page":"e126","article-title":"In vitro and in vivo evaluation of nano-based films for buccal delivery of zolpidem","volume":"30","year":"2016","journal-title":"Braz. Oral Res."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ijpharm.2018.05.051","article-title":"Combination of PLGA nanoparticles with mucoadhesive guar-gum films for buccal delivery of antihypertensive peptide","volume":"547","author":"Castro","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijpharm.2015.04.052","article-title":"Liposomal buccal mucoadhesive film for improved delivery and permeation of water-soluble vitamins","volume":"488","author":"Nafee","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jconrel.2016.07.036","article-title":"Multi-layered nanofibrous mucoadhesive films for buccal and sublingual administration of drug-delivery and vaccination nanoparticles-important step towards effective mucosal vaccines","volume":"249","author":"Kulich","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/10837450.2019.1619183","article-title":"Preparation and characterization of insulin chitosan-nanoparticles loaded in buccal films","volume":"24","author":"Alsharif","year":"2019","journal-title":"Pharm. Dev. Technol."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ajps.2017.07.006","article-title":"Buccal administration of mucoadhesive blend films saturated with propranolol loaded nanoparticles","volume":"13","author":"Kraisit","year":"2018","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.colsurfb.2019.05.029","article-title":"Film-nanoparticle composite for enhanced oral delivery of alpha-casozepine","volume":"181","author":"Castro","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejps.2018.05.016","article-title":"Acyclovir lipid nanocapsules gel for oromucosal delivery: A preclinical evidence of efficacy in the chicken pouch membrane model","volume":"121","author":"Abozaid","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ijpharm.2017.04.025","article-title":"Development and characterization of mucoadhesive buccal gels containing lipid nanoparticles of ibuprofen","volume":"533","author":"Marques","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"17972","DOI":"10.1038\/s41598-018-36382-4","article-title":"Hybrid hydrogel composed of polymeric nanocapsules co-loading lidocaine and prilocaine for topical intraoral anesthesia","volume":"8","author":"Muniz","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/02652048.2016.1234513","article-title":"Formulation, in vitro evaluation and kinetic analysis of chitosan-gelatin bilayer muco-adhesive buccal patches of insulin nanoparticles","volume":"33","author":"Mortazavian","year":"2016","journal-title":"J. Microencapsul."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ijpharm.2015.06.022","article-title":"Lyophilized sponges loaded with curcumin solid lipid nanoparticles for buccal delivery: Development and characterization","volume":"492","author":"Hazzah","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/02652048.2017.1345996","article-title":"Mucoadhesive buccal tablets containing silymarin Eudragit-loaded nanoparticles: Formulation, characterisation and ex vivo permeation","volume":"34","author":"Allam","year":"2017","journal-title":"J. Microencapsul."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.carbpol.2016.07.075","article-title":"Polymeric mucoadhesive tablets for topical or systemic buccal delivery of clonazepam: Effect of cyclodextrin complexation","volume":"152","author":"Mura","year":"2016","journal-title":"Carbohydr. Polym."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/14\/8\/752\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:37:31Z","timestamp":1760164651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/14\/8\/752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,30]]},"references-count":298,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ph14080752"],"URL":"https:\/\/doi.org\/10.3390\/ph14080752","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,30]]}}}