{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:28:15Z","timestamp":1769578095012,"version":"3.49.0"},"reference-count":66,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The novel zinc(II) \u00b5-oxo-bridged-dimeric complex [Zn2(\u00b5-O)2(BMIP)2] (BMIP = 1,3-bis(5-methoxy-1-methyl-1H-indol-3-yl)propane-1,3-dione), 1, was synthetized and fully characterized. The spectral data indicate a zincoxane molecular structure, with the BMIP ligand coordinating in its neutral form via its oxygen atoms. Structural changes in 1 in dimethylsulfoxide (DMSO) were evidenced by means of spectroscopic techniques including infrared absorption and nuclear magnetic resonance, showing DMSO entrance in the coordination sphere of the metal ion. The resulting complex [Zn2(\u00b5-O)2(BMIP)2(DMSO)], 2, readily reacts in the presence of N-methyl-imidazole (NMI), a liquid-phase nucleoside mimic, to form [Zn2(\u00b5-O)2(BMIP)2(NMI)], 3, through DMSO displacement. The three complexes show high thermal stability, demonstrating that 1 has high affinity for hard nucleophiles. Finally, with the aim of probing the suitability of this system as model scaffold for new potential anticancer metallodrugs, the interactions of 1 with calf thymus DNA were investigated in vitro in pseudo-physiological environment through UV-Vis absorption and fluorescence emission spectroscopy, as well as time-resolved fluorescence studies. The latter analyses revealed that [Zn2(\u00b5-O)2(BMIP)2(DMSO)] binds to DNA with high affinity upon DMSO displacement, opening new perspectives for the development of optimized drug substances.<\/jats:p>","DOI":"10.3390\/ph14080760","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T02:16:07Z","timestamp":1628043367000},"page":"760","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synthesis, Characterization and DNA-Binding Affinity of a New Zinc(II) Bis(5-methoxy-indol-3-yl)propane-1,3-dione Complex"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3330-513X","authenticated-orcid":false,"given":"Luca","family":"Scapinello","sequence":"first","affiliation":[{"name":"Department of Science and High Technology, Universit\u00e0 degli Studi dell\u2019Insubria, Via Valleggio 9, 22100 Como, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Vesco","sequence":"additional","affiliation":[{"name":"Department of Science and High Technology, Universit\u00e0 degli Studi dell\u2019Insubria, Via Valleggio 9, 22100 Como, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8013-2905","authenticated-orcid":false,"given":"Luca","family":"Nardo","sequence":"additional","affiliation":[{"name":"Department of Science and High Technology, Universit\u00e0 degli Studi dell\u2019Insubria, Via Valleggio 9, 22100 Como, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7369-2867","authenticated-orcid":false,"given":"Angelo","family":"Maspero","sequence":"additional","affiliation":[{"name":"Department of Science and High Technology, Universit\u00e0 degli Studi dell\u2019Insubria, Via Valleggio 9, 22100 Como, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0884-7102","authenticated-orcid":false,"given":"Federico","family":"Vavassori","sequence":"additional","affiliation":[{"name":"Department of Science and High Technology, Universit\u00e0 degli Studi dell\u2019Insubria, Via Valleggio 9, 22100 Como, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Science and High Technology, Universit\u00e0 degli Studi dell\u2019Insubria, Via Valleggio 9, 22100 Como, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9508-294X","authenticated-orcid":false,"given":"Andrea","family":"Penoni","sequence":"additional","affiliation":[{"name":"Department of Science and High Technology, Universit\u00e0 degli Studi dell\u2019Insubria, Via Valleggio 9, 22100 Como, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/205698a0","article-title":"Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode","volume":"208","author":"Rosenberg","year":"1965","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1039\/D0SC04082G","article-title":"Metallodrugs are unique: Opportunities and challenges of discovery and development","volume":"11","author":"Anthony","year":"2020","journal-title":"Chem. 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