{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:30:22Z","timestamp":1782981022543,"version":"3.54.5"},"reference-count":44,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["MSCA-RISE-2016-734759, acronym Vahvistus"],"award-info":[{"award-number":["MSCA-RISE-2016-734759, acronym Vahvistus"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>We report the design and synthesis of a new diazepine derivative, 4-(4-methoxyphenyl)-2,3,4,5-tetrahydro-2,3-benzodiazepin-1-one (VBZ102), and the evaluation of its anxiolytic-like profile, memory impairment effect, and toxicity in Swiss mice. VBZ102 was evaluated for central nervous system effects in an open field, light\u2013dark box, and novel object recognition tests under oral administration for acute and sub-acute treatment. We tested the VBZ102 toxicity in mice through a determination of LD50 values and examination of the biochemical and histopathological parameters. The VBZ102 induced an anxiolytic effect at different doses both in the light\u2013dark box and open field tests. Unlike other benzodiazepines (e.g., bromazepam), a sedative effect was noted only after administration of the VBZ102 at 10.0 mg\/kg.<\/jats:p>","DOI":"10.3390\/ph14080814","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T09:58:06Z","timestamp":1629367086000},"page":"814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New 2,3-Benzodiazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-3312","authenticated-orcid":false,"given":"Amal","family":"Amaghnouje","sequence":"first","affiliation":[{"name":"Laboratory of Biotechnology, Environment, Agrofood and Health, Dhar al Mehraz Faculty of Sciences, Sidi Mohammed Ben Abdellah University, Fez 30003, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhii","family":"Bohza","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, National Academy of Sciences, 02660 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bohdan","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, National Academy of Sciences, 02660 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-3045","authenticated-orcid":false,"given":"Imane","family":"Es-Safi","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology, Environment, Agrofood and Health, Dhar al Mehraz Faculty of Sciences, Sidi Mohammed Ben Abdellah University, Fez 30003, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-5194","authenticated-orcid":false,"given":"Andrii","family":"Kyrylchuk","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, National Academy of Sciences, 02660 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanae","family":"Achour","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Laboratory of Medical Analysis, Hassan II University Hospital, Fez 30050, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinde","family":"El Fatemi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hassan II University Hospital, Fez 30050, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalila","family":"Bousta","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology, Environment, Agrofood and Health, Dhar al Mehraz Faculty of Sciences, Sidi Mohammed Ben Abdellah University, Fez 30003, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7387-3676","authenticated-orcid":false,"given":"Andriy","family":"Grafov","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Materials Science Division, University of Helsinki, 00560 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"ref_1","unstructured":"De Souza Schmitt, R.L. 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