{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:26:37Z","timestamp":1791919597808,"version":"4.3.4"},"reference-count":274,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The Wnt\/\u03b2-catenin signaling pathway plays a major role in cell survival and proliferation, as well as in angiogenesis, migration, invasion, metastasis, and stem cell renewal in various cancer types. However, the modulation (either up- or downregulation) of this pathway can inhibit cell proliferation and apoptosis both through \u03b2-catenin-dependent and independent mechanisms, and by crosstalk with other signaling pathways in a wide range of malignant tumors. Existing studies have reported conflicting results, indicating that the Wnt signaling can have both oncogenic and tumor-suppressing roles, depending on the cellular context. This review summarizes the available information on the role of the Wnt\/\u03b2-catenin pathway and its crosstalk with other signaling pathways in apoptosis induction in cancer cells and presents a modified dual-signal model for the function of \u03b2-catenin. Understanding the proapoptotic mechanisms induced by the Wnt\/\u03b2-catenin pathway could open new therapeutic opportunities.<\/jats:p>","DOI":"10.3390\/ph14090871","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T04:07:28Z","timestamp":1630382848000},"page":"871","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Crosstalk of the Wnt\/\u03b2-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells"],"prefix":"10.3390","volume":"14","author":[{"given":"Cristina","family":"Trejo-Solis","sequence":"first","affiliation":[{"name":"Laboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Ciudad de Mexico 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7240-3437","authenticated-orcid":false,"given":"Angel","family":"Escamilla-Ramirez","sequence":"additional","affiliation":[{"name":"Laboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Ciudad de Mexico 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0152-5429","authenticated-orcid":false,"given":"Dolores","family":"Jimenez-Farfan","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda, Divisi\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Facultad de Odontolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de Mexico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-6689","authenticated-orcid":false,"given":"Rosa Angelica","family":"Castillo-Rodriguez","sequence":"additional","affiliation":[{"name":"CONACYT-Instituto Nacional de Pediatr\u00eda, Ciudad de Mexico 04530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athenea","family":"Flores-Najera","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Nacional 20 de Noviembre, Departamento de Cirug\u00eda General, Ciudad de Mexico 03229, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Cruz-Salgado","sequence":"additional","affiliation":[{"name":"Laboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, Ciudad de Mexico 14269, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,28]]},"reference":[{"key":"ref_1","first-page":"185","article-title":"Wnt signaling pathway in development and cancer","volume":"69","author":"Taciak","year":"2018","journal-title":"J. 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