{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:17:49Z","timestamp":1787887069402,"version":"build-2784847793"},"reference-count":84,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["FK 124483"],"award-info":[{"award-number":["FK 124483"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical School, University of Pecs","award":["KA-2019-27"],"award-info":[{"award-number":["KA-2019-27"]}]},{"name":"Hungarian Ministry for Innovation and Technology","award":["UNKP-20-3-II-PTE-877"],"award-info":[{"award-number":["UNKP-20-3-II-PTE-877"]}]},{"name":"Ministry of Human Capacities in Hungary","award":["20765-3\/2018\/FEKUTSTRAT"],"award-info":[{"award-number":["20765-3\/2018\/FEKUTSTRAT"]}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["EFOP-3.6.1-16-2016-00004"],"award-info":[{"award-number":["EFOP-3.6.1-16-2016-00004"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["EFOP-3.6.3-VEKOP- 16-2017-00009"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP- 16-2017-00009"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["EFOP-3.6.2-16-2017-00008"],"award-info":[{"award-number":["EFOP-3.6.2-16-2017-00008"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["Janos Bolyai Scholarship"],"award-info":[{"award-number":["Janos Bolyai Scholarship"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["TKI14016"],"award-info":[{"award-number":["TKI14016"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research, Development and Innovation Fund of Hungary","award":["TKP2020-IKA-08"],"award-info":[{"award-number":["TKP2020-IKA-08"]}]},{"name":"NAP","award":["2017-1.2.1-NKP-2017-00002"],"award-info":[{"award-number":["2017-1.2.1-NKP-2017-00002"]}]},{"name":"GINOP","award":["2.3.2-15-2016-00050"],"award-info":[{"award-number":["2.3.2-15-2016-00050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Hydrogen sulfide (H2S) has been shown in previous studies to cause hypothermia and hypometabolism in mice, and its thermoregulatory effects were subsequently investigated. However, the molecular target through which H2S triggers its effects on deep body temperature has remained unknown. We investigated the thermoregulatory response to fast-(Na2S) and slow-releasing (GYY4137) H2S donors in C57BL\/6 mice, and then tested whether their effects depend on the transient receptor potential ankyrin-1 (TRPA1) channel in Trpa1 knockout (Trpa1\u2212\/\u2212) and wild-type (Trpa1+\/+) mice. Intracerebroventricular administration of Na2S (0.5\u20131 mg\/kg) caused hypothermia in C57BL\/6 mice, which was mediated by cutaneous vasodilation and decreased thermogenesis. In contrast, intraperitoneal administration of Na2S (5 mg\/kg) did not cause any thermoregulatory effect. Central administration of GYY4137 (3 mg\/kg) also caused hypothermia and hypometabolism. The hypothermic response to both H2S donors was significantly (p &lt; 0.001) attenuated in Trpa1\u2212\/\u2212 mice compared to their Trpa1+\/+ littermates. Trpa1 mRNA transcripts could be detected with RNAscope in hypothalamic and other brain neurons within the autonomic thermoeffector pathways. In conclusion, slow- and fast-releasing H2S donors induce hypothermia through hypometabolism and cutaneous vasodilation in mice that is mediated by TRPA1 channels located in the brain, presumably in hypothalamic neurons within the autonomic thermoeffector pathways.<\/jats:p>","DOI":"10.3390\/ph14100992","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:03:42Z","timestamp":1632960222000},"page":"992","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Hypothermic Effect of Hydrogen Sulfide Is Mediated by the Transient Receptor Potential Ankyrin-1 Channel in Mice"],"prefix":"10.3390","volume":"14","author":[{"given":"Emoke","family":"Olah","sequence":"first","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Rumbus","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3360-2425","authenticated-orcid":false,"given":"Viktoria","family":"Kormos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2918-4475","authenticated-orcid":false,"given":"Valeria","family":"Tekus","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School, University of Pecs, H-7622 Pecs, Hungary"},{"name":"Janos Szentagothai Research Centre, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Pakai","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah V.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Centre for Human & Applied Physiological Sciences, King\u2019s College London, London WC2R 2LS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kata","family":"Fekete","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Solymar","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Kelava","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Keringer","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2830-2732","authenticated-orcid":false,"given":"Balazs","family":"Gaszner","sequence":"additional","affiliation":[{"name":"Janos Szentagothai Research Centre, University of Pecs, H-7622 Pecs, Hungary"},{"name":"Research Group for Mood Disorders, Department of Anatomy, Medical School and Center for Neuroscience, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Whiteman","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Keeble","sequence":"additional","affiliation":[{"name":"Centre for Human & Applied Physiological Sciences, King\u2019s College London, London WC2R 2LS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9898-632X","authenticated-orcid":false,"given":"Erika","family":"Pinter","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School, University of Pecs, H-7622 Pecs, Hungary"},{"name":"Janos Szentagothai Research Centre, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-0571","authenticated-orcid":false,"given":"Andras","family":"Garami","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, H-7622 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bcp.2017.09.010","article-title":"A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator","volume":"149","author":"Szabo","year":"2018","journal-title":"Biochem. 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