{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:38:35Z","timestamp":1790696315713,"version":"4.1.0"},"reference-count":205,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Carlos III Health In-677 stitute (ISCIII), Ministry of Economy and Competitiveness (MINECO) and the European Regional 678 Development Fund\/European Social Fund (FEDER\/ESF)","award":["RD16\/0017\/0001"],"award-info":[{"award-number":["RD16\/0017\/0001"]}]},{"name":"ISCIII and FEDER\/FSE","award":["DTS19\/00125 679 and PI19\/01577"],"award-info":[{"award-number":["DTS19\/00125 679 and PI19\/01577"]}]},{"name":"Ministerio de Educaci\u00f3n Cultura y Deporte. Gobierno de Espa-681 \u00f1a. Proyecto de Investigaci\u00f3n en Salud, Consejer\u00eda de Salud y Familias","award":["(CAS15\/00257),"],"award-info":[{"award-number":["(CAS15\/00257),"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Obesity is a complex disorder, and the number of people affected is growing every day. In recent years, research has confirmed the hypothesis that food addiction is a determining factor in obesity. Food addiction is a behavioral disorder characterized by disruptions in the reward system in response to hedonic eating. The endocannabinoid system (ECS) plays an important role in the central and peripheral control of food intake and reward-related behaviors. Moreover, both obesity and food addiction have been linked to impairments in the ECS function in various brain regions integrating peripheral metabolic signals and modulating appetite. For these reasons, targeting the ECS could be a valid pharmacological therapy for these pathologies. However, targeting the cannabinoid receptors with inverse agonists failed when used in clinical contexts as a consequence of the induction of affective disorders. In this context, new classes of drugs acting either on CB1 and\/or CB2 receptors or on synthetic and degradation enzymes of endogenous cannabinoids are being studied. However, further investigation is necessary to find safe and effective treatments that can exert anti-obesity effects, normalizing reward-related behaviors without causing important adverse mood effects.<\/jats:p>","DOI":"10.3390\/ph14101002","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:03:42Z","timestamp":1632960222000},"page":"1002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4256-7702","authenticated-orcid":false,"given":"Marialuisa","family":"de Ceglia","sequence":"first","affiliation":[{"name":"UGC Salud Mental, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Universidad de M\u00e1laga-Hospital Universitario Regional de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-015X","authenticated-orcid":false,"given":"Juan","family":"Decara","sequence":"additional","affiliation":[{"name":"UGC Salud Mental, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Universidad de M\u00e1laga-Hospital Universitario Regional de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Gaetani","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cV. Erspamer\u201d, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4516-5795","authenticated-orcid":false,"given":"Fernando","family":"Rodr\u00edguez de Fonseca","sequence":"additional","affiliation":[{"name":"UGC Salud Mental, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Universidad de M\u00e1laga-Hospital Universitario Regional de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"ref_1","unstructured":"(2020, April 29). Most Obese Countries. Available online: https:\/\/worldpopulationreview.com\/countries\/most-obese-countries\/."},{"key":"ref_2","unstructured":"WHO (2013). Controlling the Global Obesity Epidemic, WHO."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/S0002-8223(98)00704-4","article-title":"Obesity as a chronic disease: Modern medical and lifestyle management","volume":"98","author":"Rippe","year":"1998","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.fertnstert.2017.02.104","article-title":"Obesity pandemic: Causes, consequences, and solutions\u2014But do we have the will?","volume":"107","author":"Meldrum","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/ajcn\/76.4.743","article-title":"Waist circumference and obesity-associated risk factors among whites in the third National Health and Nutrition Examination Survey: Clinical action thresholds","volume":"76","author":"Zhu","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.pcl.2011.09.006","article-title":"Etiologies of obesity in children: Nature and nurture","volume":"58","author":"Skelton","year":"2011","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1080\/10408390903372599","article-title":"Ten putative contributors to the obesity epidemic","volume":"49","author":"McAllister","year":"2009","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1079\/PNS2003256","article-title":"Energy balance in obesity","volume":"62","author":"Webber","year":"2003","journal-title":"Proc. Nutr. Soc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/35007519","article-title":"Genetics of body-weight regulation","volume":"404","author":"Barsh","year":"2000","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.biopsycho.2016.12.013","article-title":"The role of reward circuitry and food addiction in the obesity epidemic: An update","volume":"131","author":"Leigh","year":"2018","journal-title":"Biol. Psychol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1017\/S0029665112000602","article-title":"The neurobiology of food intake in an obesogenic environment","volume":"71","author":"Berthoud","year":"2012","journal-title":"Proc. Nutr. Soc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neubiorev.2014.12.002","article-title":"Why is obesity such a problem in the 21st century? The intersection of palatable food, cues and reward pathways, stress, and cognition","volume":"58","author":"Morris","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11696","DOI":"10.1073\/pnas.1934666100","article-title":"Chronic stress and obesity: A new view of comfort food","volume":"100","author":"Dallman","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"88S","DOI":"10.1038\/oby.2004.273","article-title":"The Obesity Pandemic: Where Have We Been and Where Are We Going?","volume":"12","author":"Roth","year":"2004","journal-title":"Obes. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1001\/jama.1978.03290150053024","article-title":"Weight and blood pressure. Findings in hypertension screening of 1 million Americans","volume":"240","author":"Stamler","year":"1978","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0002-8703(03)00181-9","article-title":"Risk factors for myocardial infarction in Brazil","volume":"146","author":"Piegas","year":"2003","journal-title":"Am. Heart J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/oxfordjournals.aje.a008892","article-title":"Body size and fat distribution as predictors of stroke among US men","volume":"144","author":"Walker","year":"1996","journal-title":"Am. J. Epidemiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2337\/diacare.21.4.518","article-title":"Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults: The Third National Health and Nutrition Examination Survey, 1988\u20131994","volume":"21","author":"Harris","year":"1998","journal-title":"Diabetes Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1262-3636(07)70103-9","article-title":"Comparison of men with impaired fasting glycaemia to controls and to diabetic subjects with fasting glycaemia from 7.0 to 7.7 mmol\/L: Clinical, nutritional and biological status","volume":"30","author":"Combe","year":"2004","journal-title":"Diabetes Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1001\/archinte.164.12.1327","article-title":"Change in cognitive function by glucose tolerance status in older adults: A 4-year prospective study of the Rancho Bernardo Study cohort","volume":"164","author":"Kanaya","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1001\/archinte.163.13.1524","article-title":"An 18-year follow-up of overweight and risk of Alzheimer disease","volume":"163","author":"Gustafson","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0021-9681(79)90119-X","article-title":"Variations in mortality by weight among 750,000 men and women","volume":"32","author":"Lew","year":"1979","journal-title":"J. Chronic Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.rmed.2003.08.004","article-title":"Body mass index and the risk of asthma in adults","volume":"98","author":"Luder","year":"2004","journal-title":"Respir. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7326\/0003-4819-109-1-18","article-title":"Obesity and knee osteoarthritis. The Framingham Study","volume":"109","author":"Felson","year":"1988","journal-title":"Ann. Intern. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/humupd\/dmg024","article-title":"Obesity and reproductive disorders in women","volume":"9","author":"Pasquali","year":"2003","journal-title":"Hum. Reprod. Update"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/sj.ijo.0802626","article-title":"Relationship of obesity to depression: A family-based study","volume":"28","author":"Dong","year":"2004","journal-title":"Int. J. Obes."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2337\/db09-1471","article-title":"A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes","volume":"59","author":"Butler","year":"2010","journal-title":"Diabetes"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.tem.2009.12.010","article-title":"Cytokine production by islets in health and diabetes: Cellular origin, regulation and function","volume":"21","author":"Donath","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/hep.20826","article-title":"Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease","volume":"42","author":"Li","year":"2005","journal-title":"Hepatology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI118504","article-title":"The expression of TNF alpha by human muscle. Relationship to insulin resistance","volume":"97","author":"Saghizadeh","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tins.2017.02.005","article-title":"Obesity-Induced Neuroinflammation: Beyond the Hypothalamus","volume":"40","author":"Muccioli","year":"2017","journal-title":"Trends Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/1753-0407.12529","article-title":"Making sense of metabolic obesity and hedonic obesity","volume":"9","author":"Yu","year":"2017","journal-title":"J. Diabetes"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1172\/JCI129186","article-title":"Metabolically healthy obesity: Facts and fantasies","volume":"129","author":"Smith","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/obr.12246","article-title":"Metabolic vs. hedonic obesity: A conceptual distinction and its clinical implications","volume":"16","author":"Yu","year":"2015","journal-title":"Obes. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1098\/rstb.2008.0107","article-title":"Overlapping neuronal circuits in addiction and obesity: Evidence of systems pathology","volume":"363","author":"Volkow","year":"2008","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"198","DOI":"10.15288\/qjsa.1956.17.198","article-title":"The descriptive features of food addiction; addictive eating and drinking","volume":"17","author":"Randolph","year":"1956","journal-title":"Q. J. Stud. Alcohol"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.appet.2008.12.003","article-title":"Preliminary validation of the Yale Food Addiction Scale","volume":"52","author":"Gearhardt","year":"2009","journal-title":"Appetite"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.3390\/nu6104552","article-title":"The Prevalence of Food Addiction as Assessed by the Yale Food Addiction Scale: A Systematic Review","volume":"6","author":"Pursey","year":"2014","journal-title":"Nutrients"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Epel, E.S., Tomiyama, A.J., Mason, A.E., Laraia, B.A., Hartman, W., Ready, K., Acree, M., Adam, T.C., Jeor, S.S., and Kessler, D. (2014). The Reward-Based Eating Drive Scale: A Self-Report Index of Reward-Based Eating. PLoS ONE, 9.","DOI":"10.1037\/t53609-000"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.appet.2015.04.062","article-title":"Acute responses to opioidergic blockade as a biomarker of hedonic eating among obese women enrolled in a mindfulness-based weight loss intervention trial","volume":"91","author":"Mason","year":"2015","journal-title":"Appetite"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/nn1584","article-title":"Decision making, impulse control and loss of willpower to resist drugs: A neurocognitive perspective","volume":"8","author":"Bechara","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/10550490903205579","article-title":"Obesity and its relationship to addictions: Is overeating a form of Addictive Behavior?","volume":"18","author":"Barry","year":"2009","journal-title":"Am. J. Addict."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev-nutr-071715-050909","article-title":"The Neurobiology of \u2018Food Addiction\u2019 and Its Implications for Obesity Treatment and Policy","volume":"36","author":"Carter","year":"2016","journal-title":"Annu. Rev. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1037\/a0024286","article-title":"Personality and obesity across the adult life span","volume":"101","author":"Sutin","year":"2011","journal-title":"J. Pers. Soc. Psychol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1038\/ijo.2016.11","article-title":"What nutritional physiology tells us about diet, sugar and obesity","volume":"40","author":"Tappy","year":"2016","journal-title":"Int. J. Obes."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.3390\/nu6093653","article-title":"Food Addiction in the Light of DSM-5","volume":"6","author":"Meule","year":"2014","journal-title":"Nutrients"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/j.1360-0443.2010.03301.x","article-title":"Can food be addictive? Public health and policy implications","volume":"106","author":"Gearhardt","year":"2011","journal-title":"Addiction"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Schulte, E.M., Avena, N.M., and Gearhardt, A.N. (2015). Which Foods May Be Addictive? The Roles of Processing, Fat Content, and Glycemic Load. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117959"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"M\u00fcnzberg, H., Qualls-Creekmore, E., Yu, S., Morrison, C.D., and Berthoud, H.R. (2016). Hedonics Act in Unison with the Homeostatic System to Unconsciously Control Body Weight. Front. Nutr., 3.","DOI":"10.3389\/fnut.2016.00006"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s11920-015-0634-5","article-title":"Genetic Similarities between Compulsive Overeating and Addiction Phenotypes: A Case for \u2018Food Addiction\u2019?","volume":"17","author":"Carlier","year":"2015","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1467-789X.2012.01031.x","article-title":"Obesity and addiction: Neurobiological overlaps","volume":"14","author":"Volkow","year":"2013","journal-title":"Obes. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.appet.2011.08.017","article-title":"Evidence that food addiction is a valid phenotype of obesity","volume":"57","author":"Davis","year":"2011","journal-title":"Appetite"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2741\/4618","article-title":"Food addiction: A common neurobiological mechanism with drug abuse","volume":"23","author":"Lindgren","year":"2018","journal-title":"Front. Biosci. Landmark"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.biopsych.2012.08.026","article-title":"The neurobiological underpinnings of obesity and binge eating: A rationale for adopting the food addiction model","volume":"73","author":"Smith","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00213-006-0521-1","article-title":"Opioids for hedonic experience and dopamine to get ready for it","volume":"191","author":"Barbano","year":"2007","journal-title":"Psychopharmacology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn1247","article-title":"The molecular logic of endocannabinoid signalling","volume":"4","author":"Piomelli","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1063545","article-title":"Endocannabinoid signaling in the brain","volume":"296","author":"Wilson","year":"2002","journal-title":"Science"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nn.3053","article-title":"Mitochondrial CB\u2081 receptors regulate neuronal energy metabolism","volume":"15","author":"Massa","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nature20127","article-title":"A cannabinoid link between mitochondria and memory","volume":"539","author":"Desprez","year":"2016","journal-title":"Nature"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0165-6147(00)01482-6","article-title":"The endocannabinoid system as a target for therapeutic drugs","volume":"21","author":"Piomelli","year":"2000","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-psych-113011-143739","article-title":"The endocannabinoid system and the brain","volume":"64","author":"Mechoulam","year":"2013","journal-title":"Annu. Rev. Psychol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/bs.apha.2017.03.007","article-title":"CB1 and CB2 Receptor Pharmacology","volume":"80","author":"Howlett","year":"2017","journal-title":"Adv. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.plipres.2016.02.002","article-title":"Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders","volume":"62","author":"Iannotti","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","article-title":"An introduction to the endogenous cannabinoid system","volume":"79","author":"Lu","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2018.05.002","article-title":"2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain","volume":"71","author":"Baggelaar","year":"2018","journal-title":"Prog. Lipid Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41401-018-0075-x","article-title":"Brain activity of anandamide: A rewarding bliss?","volume":"40","author":"Scherma","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1472-8206.2006.00454.x","article-title":"Anandamide: An update","volume":"21","author":"Smita","year":"2007","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/35102582","article-title":"An anorexic lipid mediator regulated by feeding","volume":"414","author":"Navarro","year":"2001","journal-title":"Nature"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0074-7742(09)85005-8","article-title":"Chapter 5 The Endocannabinoid System as A Target for Novel Anxiolytic and Antidepressant Drugs","volume":"85","author":"Gaetani","year":"2009","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fphar.2015.00137","article-title":"Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: Different lipid signals?","volume":"6","author":"Romano","year":"2015","journal-title":"Front. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3389\/fnmol.2018.00490","article-title":"Oleoylethanolamide, neuroinflammation, and alcohol abuse","volume":"11","author":"Orio","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1126\/science.1239275","article-title":"A gut lipid messenger links excess dietary fat to dopamine deficiency","volume":"341","author":"Tellez","year":"2013","journal-title":"Science"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Zou, S., and Kumar, U. (2018). Cannabinoid receptors and the endocannabinoid system: Signaling and function in the central nervous system. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030833"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"9612","DOI":"10.1523\/JNEUROSCI.22-21-09612.2002","article-title":"A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding","volume":"22","author":"Navarro","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00018-018-2994-6","article-title":"Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues","volume":"76","author":"Lutz","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/09540260902782810","article-title":"Cannabinoids and appetite: Food craving and food pleasure","volume":"21","author":"Kirkham","year":"2009","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nn.2494","article-title":"Bimodal control of stimulated food intake by the endocannabinoid system","volume":"13","author":"Bellocchio","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1038\/sj.npp.1301376","article-title":"Endocannabinoid hedonic hotspot for sensory pleasure: Anandamide in nucleus accumbens shell enhances liking of a sweet reward","volume":"32","author":"Mahler","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuropharm.2017.05.033","article-title":"Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits","volume":"124","author":"Lau","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.euroneuro.2018.08.002","article-title":"CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats","volume":"28","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature14260","article-title":"Hypothalamic POMC neurons promote cannabinoid-induced feeding","volume":"519","author":"Koch","year":"2015","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3389\/fnins.2018.00271","article-title":"Hedonic eating and the delicious circle: From lipid-derived mediators to brain dopamine and back","volume":"12","author":"Coccurello","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.tem.2015.07.007","article-title":"The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease","volume":"26","author":"Mazier","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.cmet.2013.03.001","article-title":"The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders","volume":"17","author":"Silvestri","year":"2013","journal-title":"Cell Metab."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.tins.2012.04.006","article-title":"The thrifty lipids: Endocannabinoids and the neural control of energy conservation","volume":"35","author":"DiPatrizio","year":"2012","journal-title":"Trends Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Sipe, J.C., Scott, T.M., Murray, S., Harismendy, O., Simon, G.M., Cravatt, B.F., and Waalen, J. (2010). Biomarkers of endocannabinoid system activation in severe obesity. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0008792"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-2826.2008.01683.x","article-title":"Dysregulation of the Endocannabinoid System in Obesity","volume":"20","author":"Engeli","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Forte, N., Fern\u00e1ndez-Rilo, A., Palomba, L., di Marzo, V., and Cristino, L. (2020). Obesity Affects the Microbiota-Gut-Brain Axis and the Regulation Thereof by Endocannabinoids and Related Mediators. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051554"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Rossi, F., Punzo, F., Umano, G.R., Argenziano, M., and del Giudice, E.M. (2018). Role of cannabinoids in obesity. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092690"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Vaitheesvaran, B., Yang, L., Hartil, K., Glaser, S., Yazulla, S., Bruce, J.E., and Kurland, I.J. (2012). Peripheral effects of FAAH deficiency on fuel and energy homeostasis: Role of dysregulated lysine acetylation. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033717"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbalip.2008.01.006","article-title":"Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine","volume":"1781","author":"Artmann","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/mnfr.200900516","article-title":"Effect of dietary fat on endocannabinoids and related mediators: Consequences on energy homeostasis, inflammation and mood","volume":"54","author":"Banni","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.3389\/fphys.2017.01006","article-title":"Polymorphism rs1761667 in the CD36 Gene Is Associated to Changes in Fatty Acid Metabolism and Circulating Endocannabinoid Levels Distinctively in Normal Weight and Obese Subjects","volume":"8","author":"Melis","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.nut.2012.09.018","article-title":"Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals","volume":"29","author":"Barbarossa","year":"2013","journal-title":"Nutrition"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/s41598-017-01562-1","article-title":"Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids","volume":"7","author":"Carta","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.amjmed.2007.06.007","article-title":"Understanding metabolic homeostasis and imbalance: What is the role of the endocannabinoid system?","volume":"120","author":"Kunos","year":"2007","journal-title":"Am. J. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/1028415X.2017.1347373","article-title":"Polyunsaturated fatty acids and endocannabinoids in health and disease","volume":"21","author":"Freitas","year":"2018","journal-title":"Nutr. Neurosci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1194\/jlr.M092742","article-title":"Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice","volume":"60","author":"Miralpeix","year":"2019","journal-title":"J. Lipid Res."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Pucci, M., Zaplatic, E., di Bonaventura, M.V.M., di Bonaventura, E.M., de Cristofaro, P., Maccarrone, M., Cifani, C., and D\u2019Addario, C. (2021). On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010398"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/jnc.13890","article-title":"Fabp1 gene ablation inhibits high-fat diet-induced increase in brain endocannabinoids","volume":"140","author":"Martin","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.npep.2018.04.001","article-title":"Orexin-A and endocannabinoid signaling regulate glucose-responsive arcuate nucleus neurons and feeding behavior in obese rats","volume":"69","author":"Yang","year":"2018","journal-title":"Neuropeptides"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"DiPatrizio, N.V. (2021). Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity. Nutrients, 13.","DOI":"10.3390\/nu13041214"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0006-8993(02)03245-6","article-title":"Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: A role for endogenous cannabinoids in driving appetite for palatable food?","volume":"952","author":"Harrold","year":"2002","journal-title":"Brain Res."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Bourdy, R., Hertz, A., Filliol, D., Andry, V., Goumon, Y., Mendoza, J., Olmstead, M.C., and Befort, K. (2021). The endocannabinoid system is modulated in reward and homeostatic brain regions following diet-induced obesity in rats: A cluster analysis approach. Eur. J. Nutr., 1\u201313.","DOI":"10.1007\/s00394-021-02613-0"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nn.3321","article-title":"Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids","volume":"16","author":"Liu","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/WNR.0000000000001400","article-title":"Anandamide and sucralose change \u0394FosB expression in the reward system","volume":"31","year":"2020","journal-title":"Neuroreport"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1073\/pnas.0912048107","article-title":"Endocannabinoids selectively enhance sweet taste","volume":"107","author":"Yoshida","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejphar.2004.07.009","article-title":"Endocannabinoids and food consumption: Comparisons with benzodiazepine and opioid palatability-dependent appetite","volume":"500","author":"Cooper","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainres.2010.04.003","article-title":"The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders","volume":"1350","author":"Berridge","year":"2010","journal-title":"Brain Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.neuron.2006.09.009","article-title":"Leptin in energy balance and reward: Two faces of the same coin?","volume":"51","author":"Cota","year":"2006","journal-title":"Neuron"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0163-7258(02)00257-7","article-title":"Tetrahydrocannabinol and endocannabinoids in feeding and appetite","volume":"95","author":"Berry","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00702-021-02326-y","article-title":"Endocannabinoid and dopaminergic system: The pas de deux underlying human motivation and behaviors","volume":"128","author":"Laksmidewi","year":"2021","journal-title":"J. Neural Transm."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.neuron.2011.11.018","article-title":"Endocannabinoids shape accumbal encoding of cue-motivated behavior via CB1 receptor activation in the ventral tegmentum","volume":"73","author":"Oleson","year":"2012","journal-title":"Neuron"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neubiorev.2014.08.008","article-title":"Endocannabinoid signaling and food addiction","volume":"47","author":"Pucci","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms12199","article-title":"Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons","volume":"7","author":"Tung","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrn4004","article-title":"Endocannabinoid signalling in reward and addiction","volume":"16","author":"Parsons","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"20016","DOI":"10.1073\/pnas.0908789106","article-title":"CRF system recruitment mediates dark side of compulsive eating","volume":"106","author":"Cottone","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","first-page":"1","article-title":"A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction","volume":"11","author":"Dominguez","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.physbeh.2014.03.002","article-title":"Is fat taste ready for primetime?","volume":"136","author":"DiPatrizio","year":"2014","journal-title":"Physiol. Behav."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s002130050518","article-title":"Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats","volume":"135","author":"Chaperon","year":"1998","journal-title":"Psychopharmacology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/erv.2641","article-title":"Unravelling the role and mechanism of adipokine and gastrointestinal signals in animal models in the nonhomeostatic control of energy homeostasis: Implications for binge eating disorder","volume":"26","author":"Novelle","year":"2018","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.expneurol.2010.03.020","article-title":"The endocannabinoid system and nondrug rewarding behaviours","volume":"224","author":"Fattore","year":"2010","journal-title":"Exp. Neurol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.neuroscience.2009.07.022","article-title":"Central cannabinoid signaling mediating food intake: A pharmacological-challenge magnetic resonance imaging and functional histology study in rat","volume":"163","author":"Dodd","year":"2009","journal-title":"Neuroscience"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuropharm.2011.10.018","article-title":"Cannabinoid facilitation of behavioral and biochemical hedonic taste responses","volume":"63","author":"Solinas","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00213-004-1877-8","article-title":"Reduced sensitivity to reward in CB1 knockout mice","volume":"176","author":"Cline","year":"2004","journal-title":"Psychopharmacology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1038\/npp.2015.129","article-title":"Epigenetic and Proteomic Expression Changes Promoted by Eating Addictive-Like Behavior","volume":"40","author":"Mancino","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nn.3647","article-title":"The endocannabinoid system controls food intake via olfactory processes","volume":"17","author":"Bellocchio","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.celrep.2018.11.026","article-title":"Ghrelin Enhances Food Odor Conditioning in Healthy Humans: An fMRI Study","volume":"25","author":"Han","year":"2018","journal-title":"Cell Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.physbeh.2016.12.044","article-title":"Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity","volume":"171","author":"Argueta","year":"2017","journal-title":"Physiol. Behav."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41386-019-0580-8","article-title":"D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: Implication for addiction","volume":"45","author":"Mansouri","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev.nutr.012809.104701","article-title":"The endocannabinoid system and its relevance for nutrition","volume":"30","author":"Maccarrone","year":"2010","journal-title":"Annu. Rev. Nutr."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"R1409","DOI":"10.1152\/ajpregu.90484.2008","article-title":"Inhibiting parabrachial fatty acid amide hydrolase activity selectively increases the intake of palatable food via cannabinoid CB1 receptors","volume":"295","author":"Dipatrizio","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/sj.npp.1300695","article-title":"Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa","volume":"30","author":"Monteleone","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"E917","DOI":"10.1210\/jc.2011-3018","article-title":"Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: A pilot study","volume":"97","author":"Monteleone","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1007\/s00394-016-1153-9","article-title":"Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity","volume":"55","author":"Monteleone","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Higuchi, S., Irie, K., Yamaguchi, R., Katsuki, M., Araki, M., Ohji, M., Hayakawa, K., Mishima, S., Akitake, Y., and Matsuyama, K. (2012). Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038609"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1590\/S1516-44462009000200012","article-title":"The psychiatric side-effects of rimonabant","volume":"31","author":"Moreira","year":"2009","journal-title":"Rev. Bras. Psiquiatr."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00001756-199701200-00023","article-title":"Acute administration of the CB1 cannabinoid receptor antagonist SR 141716A induces anxiety-like responses in the rat","volume":"8","author":"Navarro","year":"1997","journal-title":"Neuroreport"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1038\/npp.2013.153","article-title":"Rimonabant precipitates anxiety in rats withdrawn from palatable food: Role of the central amygdala","volume":"38","author":"Blasio","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1517\/13543784.2014.918952","article-title":"Investigational drugs in Phase II clinical trials for the treatment of obesity: Implications for future development of novel therapies","volume":"23","author":"Jackson","year":"2014","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1517\/17460441.2015.1044966","article-title":"Latest approaches for the treatment of obesity","volume":"10","author":"Jackson","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Elliott, A., Lang, S., Truby, H., Brennan, L., and Gibson, S. (2021). Tackling the challenge of treating obesity using design research methods: A scoping review. Obes. Rev.","DOI":"10.1111\/obr.13360"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"14302","DOI":"10.1074\/jbc.M115.655662","article-title":"Modulation of Glucagon-like Peptide-1 (GLP-1) Potency by Endocannabinoid-like Lipids Represents a Novel Mode of Regulating GLP-1 Receptor Signaling","volume":"290","author":"Cheng","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"6","DOI":"10.12659\/MSMBR.883726","article-title":"Effects of glucagon-like peptide-1 receptor stimulation and blockade on food consumption and body weight in rats treated with a cannabinoid CB1 receptor agonist WIN 55,212-2 BCDEF El\u017cbieta Radziszewska ACDEFG Ewa Bojanowska","volume":"19","author":"Radziszewska","year":"2013","journal-title":"Med. Sci. Monit. Basic Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2015.12.015","article-title":"Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice","volume":"423","author":"Kim","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Murphy, T., and Le Foll, B. (2020). Targeting the Endocannabinoid CB1 Receptor to Treat Body Weight Disorders: A Preclinical and Clinical Review of the Therapeutic Potential of Past and Present CB1 Drugs. Biomolecules, 10.","DOI":"10.3390\/biom10060855"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cmet.2007.11.012","article-title":"The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake","volume":"7","author":"Addy","year":"2008","journal-title":"Cell Metab."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.physbeh.2007.04.013","article-title":"Cannabinoid CB1 receptor inverse agonists and neutral antagonists: Effects on food intake, food-reinforced behavior and food aversions","volume":"91","author":"Salamone","year":"2007","journal-title":"Physiol. Behav."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.metabol.2013.06.011","article-title":"Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats","volume":"62","author":"Merroun","year":"2013","journal-title":"Metabolism"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Cifuentes, L., and Acosta, A. (2021). Homeostatic regulation of food intake. Clin. Res. Hepatol. Gastroenterol., 101794.","DOI":"10.1016\/j.clinre.2021.101794"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"104418","DOI":"10.1016\/j.psyneuen.2019.104418","article-title":"Adipocyte cannabinoid CB1 receptor deficiency alleviates high fat diet-induced memory deficit, depressive-like behavior, neuroinflammation and impairment in adult neurogenesis","volume":"110","author":"Rivera","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuropharm.2006.03.029","article-title":"Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole\u2014LH 21","volume":"51","author":"Pavon","year":"2006","journal-title":"Neuropharmacology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1111\/j.1476-5381.2011.01698.x","article-title":"Anti-obesity efficacy of LH-21, a cannabinoid CB (1) receptor antagonist with poor brain penetration, in diet-induced obese rats","volume":"165","author":"Alonso","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fendo.2018.00167","article-title":"LH-21, A Peripheral Cannabinoid Receptor 1 Antagonist, Exerts Favorable Metabolic Modulation Including Antihypertensive Effect in KKAy Mice by Regulating Inflammatory Cytokines and Adipokines on Adipose Tissue","volume":"9","author":"Dong","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_157","unstructured":"Noerregaard, P.K., Fridberg, M., and Elling, C.E. TM38837\u2013A novel second generation peripheral selective CB1 receptor antagonist with efficacy and potency in rodent obesity models equal to brain-penetrant CB1 antagonist rimonabant. Proceedings of the 20th Annual Symposium of the International Cannabinoid Research Society, Lund, Sweden."},{"key":"ref_158","first-page":"4314","article-title":"A novel peripheral cannabinoid 1 receptor antagonist, AJ5012, improves metabolic outcomes and suppresses adipose tissue inflammation in obese mice","volume":"33","author":"Han","year":"2019","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1111\/dom.13350","article-title":"Peripheral cannabinoid 1 receptor blockade mitigates adipose tissue inflammation via NLRP3 inflammasome in mouse models of obesity","volume":"20","author":"Han","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2012.07.002","article-title":"Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance","volume":"16","author":"Tam","year":"2012","journal-title":"Cell Metab."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/dom.12447","article-title":"A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis","volume":"17","author":"Hsiao","year":"2015","journal-title":"Diabetes Obes. Metab."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/ijo.2011.171","article-title":"Induction of fatty acid oxidation resists weight gain, ameliorates hepatic steatosis and reduces cardiometabolic risk factors","volume":"36","author":"Vijayakumar","year":"2012","journal-title":"Int. J. Obes."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3389\/fphar.2017.00707","article-title":"Novel Peripherally Restricted Cannabinoid 1 Receptor Selective Antagonist TXX-522 with Prominent Weight-Loss Efficacy in Diet Induced Obese Mice","volume":"8","author":"Chen","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.pbb.2015.06.007","article-title":"ENP11, a potential CB1R antagonist, induces anorexia in rats","volume":"135","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"107477","DOI":"10.1016\/j.pharmthera.2020.107477","article-title":"The therapeutic potential of second and third generation CB 1 R antagonists","volume":"208","author":"Cinar","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/jlcr.3433","article-title":"The syntheses of isotopically labelled CB-1 antagonists for the treatment of obesity","volume":"59","author":"Tran","year":"2016","journal-title":"J. Label. Comp. Radiopharm."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/bcp.12141","article-title":"Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects","volume":"76","author":"Klumpers","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.molmet.2016.10.004","article-title":"Targeting the endocannabinoid\/CB1 receptor system for treating obesity in Prader-Willi syndrome","volume":"5","author":"Knani","year":"2016","journal-title":"Mol. Metab."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"104483","DOI":"10.1016\/j.yrtph.2019.104483","article-title":"Preclinical toxicity evaluation of JD5037, a peripherally restricted CB 1 receptor inverse agonist, in rats and dogs for treatment of nonalcoholic steatohepatitis","volume":"109","author":"Kale","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1016\/j.bmcl.2016.09.025","article-title":"Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists","volume":"26","author":"Matthews","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.mehy.2013.01.019","article-title":"Cannabis and \u03949-tetrahydrocannabinol (THC) for weight loss?","volume":"80","author":"Trigo","year":"2013","journal-title":"Med. Hypotheses"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.pharep.2018.06.004","article-title":"The role of (E)-6-chloro-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-2-styrylquinazolin-4(3H)-one in the modulation of cannabinoidergic system. A pilot study","volume":"70","author":"Plescia","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1124\/dmd.109.026930","article-title":"Cannabidiol-2, 6-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor","volume":"37","author":"Takeda","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Behl, T., Chadha, S., Sachdeva, M., Sehgal, A., Kumar, A., Venkatachalam, T., Hafeez, A., Aleya, L., Arora, S., and Batiha, G. (2021). Understanding the possible role of endocannabinoid system in obesity. Prostaglandins Other Lipid Mediat., 152.","DOI":"10.1016\/j.prostaglandins.2020.106520"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Cluny, N., Keenan, C., Reimer, R., Le Foll, B., and Sharkey, K. (2015). Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with \u03949-Tetrahydrocannabinol. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144270"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1476-5381.2010.00908.x","article-title":"A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents","volume":"161","author":"Cluny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1172\/JCI42551","article-title":"Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity","volume":"120","author":"Tam","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Wargent, E., Zaibi, M., Silvestri, C., Hislop, D., Stocker, C., Stott, C., Guy, G., Duncan, M., di Marzo, V., and Ma, C. (2011). The cannabinoid \u0394(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity. Nutr. Diabetes, 3.","DOI":"10.1038\/nutd.2013.9"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fendo.2020.00114","article-title":"Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol","volume":"11","author":"Bielawiec","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_180","first-page":"1","article-title":"The CB1 Neutral Antagonist Tetrahydrocannabivarin Reduces Default Mode Network and Increases Executive Control Network Resting State Functional Connectivity in Healthy Volunteers","volume":"19","author":"Rzepa","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.phrs.2013.06.001","article-title":"NESS06SM reduces body weight with an improved profile relative to SR141716A","volume":"74","author":"Mastinu","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.phrs.2016.08.012","article-title":"The novel cannabinoid antagonist SM-11 reduces hedonic aspect of food intake through a dopamine-dependent mechanism","volume":"113","author":"Fois","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/bs.mie.2017.06.025","article-title":"Metabolic Profiling of CB1 Neutral Antagonists","volume":"593","author":"Seltzman","year":"2017","journal-title":"Methods Enzymol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41387-020-0110-0","article-title":"Novel CB1 receptor antagonist BAR-1 modifies pancreatic islet function and clinical parameters in prediabetic and diabetic mice","volume":"10","author":"Vega","year":"2020","journal-title":"Nutr. Diabetes"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.euroneuro.2017.03.010","article-title":"Metabolic side effects induced by olanzapine treatment are neutralized by CB1 receptor antagonist compounds co-administration in female rats","volume":"27","author":"Lazzari","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.bmcl.2009.11.125","article-title":"Novel thioamide derivatives as neutral CB1 receptor antagonists","volume":"20","author":"Olsson","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"10276","DOI":"10.1021\/acs.jmedchem.8b01467","article-title":"6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity","volume":"61","author":"Zhang","year":"2018","journal-title":"J. Med. Chem."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Hirsch, S., and Tam, J. (2019). Cannabis: From a Plant That Modulates Feeding Behaviors toward Developing Selective Inhibitors of the Peripheral Endocannabinoid System for the Treatment of Obesity and Metabolic Syndrome. Toxins, 11.","DOI":"10.3390\/toxins11050275"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00213-010-2124-0","article-title":"AVE1625, a cannabinoid CB1 receptor antagonist, as a co-treatment with antipsychotics for schizophrenia: Improvement in cognitive function and reduction of antipsychotic-side effects in rodents","volume":"215","author":"Black","year":"2010","journal-title":"Psychopharmacol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/13543776.2019.1597851","article-title":"A patent update on cannabinoid receptor 1 antagonists (2015\u20132018)","volume":"29","author":"Amato","year":"2019","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/bph.14849","article-title":"Dual inhibition of cannabinoid CB 1 receptor and inducible NOS attenuates obesity-induced chronic kidney disease","volume":"177","author":"Udi","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Santos-Molina, L., Herrerias, A., Zawatsky, C.N., Gunduz-Cinar, O., Cinar, R., Iyer, M.R., Wood, C.M., Lin, Y., Gao, B., and Kunos, G. (2021). Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia. Molecules, 26.","DOI":"10.3390\/molecules26165089"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1021\/jf203814r","article-title":"Unsaturated Fatty Alcohol Derivatives of Olive Oil Phenolic Compounds with Potential Low-Density Lipoprotein (LDL) Antioxidant and Antiobesity Properties","volume":"60","author":"Cotrim","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1242\/dmm.019919","article-title":"Treatment with a novel oleic-acid-dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats","volume":"8","author":"Decara","year":"2015","journal-title":"Dis. Models Mech."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bmcl.2008.12.059","article-title":"Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice","volume":"19","author":"Loverme","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.jhep.2015.01.001","article-title":"Two non-psychoactive cannabinoids reduce intracellular lipid levels and inhibit hepatosteatosis","volume":"62","author":"Silvestri","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.npep.2018.10.002","article-title":"Effects of RVD-hemopressin (\u03b1) on feeding and body weight after standard or cafeteria diet in rats","volume":"72","author":"Leone","year":"2018","journal-title":"Neuropeptides"},{"key":"ref_198","first-page":"1043","article-title":"(+)-trans-Cannabidiol-2-hydroxy pentyl is a dual CB 1 R antagonist\/CB 2 R agonist that prevents diabetic nephropathy in mice","volume":"169","author":"Winkler","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1210\/jc.2015-4381","article-title":"Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation","volume":"101","author":"Rossi","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Palomares, B., Ruiz-Pino, F., Navarrete, C., Velasco, I., S\u00e1nchez-Garrido, M., Jimenez-Jimenez, C., Pavicic, C., Vazquez, M., Appendino, G., and Bellido, M. (2018). VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-34259-0"},{"key":"ref_201","first-page":"784","article-title":"A novel fluorophosphonate inhibitor of the biosynthesis pf the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects","volume":"169","author":"Bisogno","year":"2013","journal-title":"J. Pharmacol."},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Tovar, R., Gavito, A.L., Vargas, A., Soverchia, L., Hernandez-Folgado, L., Jagerovic, N., Baixeras, E., Ciccocioppo, R., de Fonseca, F., and Decara, J. (2021). Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity. Nutrients, 13.","DOI":"10.3390\/nu13082589"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/sj.bjp.0707424","article-title":"Role and regulation of acylethanolamides in energy balance: Focus on adipocytes and \u03b2-cells","volume":"152","author":"Matias","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"24770","DOI":"10.1073\/pnas.1916288116","article-title":"N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis","volume":"116","author":"Grevengoed","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/0024-3205(95)00174-5","article-title":"Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist","volume":"56","author":"Barth","year":"1995","journal-title":"Life Sci."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/14\/10\/1002\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:07:30Z","timestamp":1760166450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/14\/10\/1002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,29]]},"references-count":205,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["ph14101002"],"URL":"https:\/\/doi.org\/10.3390\/ph14101002","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,29]]}}}