{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:52:39Z","timestamp":1789966359376,"version":"4.0.1"},"reference-count":50,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Leishmaniasis and Chagas disease are neglected tropical diseases that cause problems in developing countries. The causative agents, Leishmania spp. and Trypanosoma cruzi, produce a clinical picture that can be fatal for the patient, such as Chagas heart disease, visceral leishmaniasis and megacolon, among others. Current treatments for these diseases are not very effective and highly toxic, since they require very prolonged treatments. The development of innovative, effective and safe drugs to fight infections caused by these parasites remains a challenge. For this reason, in recent years, there has been an increase in the search for new therapies. In this study, the antikinetoplastid activity of 13 sesquiterpene lactones obtained from Palythoa aff. clavata was screened against L. amazonensis, L. donovani and T. cruzi. The results revealed that the sesquiterpene lactones anhydroartemorin (2), cis,trans-costunolide-14-acetate (3) and 4-hydroxyarbusculin A (11) were the most selective against the kinetoplastid species studied. These molecules seem to induce the mechanisms involved in an apoptotic-like death or programmed cell death (PCD) in the kinetoplastids, and since they do not cause necrosis, the inflammatory events associated with this type of cell death will not be triggered.<\/jats:p>","DOI":"10.3390\/ph14111095","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T23:51:36Z","timestamp":1635465096000},"page":"1095","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Antikinetoplastid Activity of Sesquiterpenes Isolated from the Zoanthid Palythoa aff. clavata"],"prefix":"10.3390","volume":"14","author":[{"given":"Carlos J.","family":"Bethencourt-Estrella","sequence":"first","affiliation":[{"name":"Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias (IUETSPC), Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Spain"},{"name":"Departamento de Obstetricia y Ginecolog\u00eda, Pediatr\u00eda, Medicina Preventiva y Salud P\u00fablica, Toxicolog\u00eda, Medicina Legal y Forense y Parasitolog\u00eda, Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Spain"},{"name":"Red de Investigaci\u00f3n Cooperativa en Enfermedades Tropicales (RICET), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia","family":"Nocchi","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez (IUBO AG), Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna, Spain"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atteneri","family":"L\u00f3pez-Arencibia","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias (IUETSPC), Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Spain"},{"name":"Departamento de Obstetricia y Ginecolog\u00eda, Pediatr\u00eda, Medicina Preventiva y Salud P\u00fablica, Toxicolog\u00eda, Medicina Legal y Forense y Parasitolog\u00eda, Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Spain"},{"name":"Red de Investigaci\u00f3n Cooperativa en Enfermedades Tropicales (RICET), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desir\u00e9e","family":"San Nicol\u00e1s-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Enfermedades Tropicales y Salud 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Org\u00e1nica, Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Su\u00e1rez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez (IUBO AG), Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8886-7519","authenticated-orcid":false,"given":"Ana R.","family":"D\u00edaz-Marrero","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez (IUBO AG), Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-8317","authenticated-orcid":false,"given":"Jos\u00e9 J.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez (IUBO AG), Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna, Spain"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Lorenzo-Morales","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias (IUETSPC), Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Spain"},{"name":"Departamento de Obstetricia y Ginecolog\u00eda, Pediatr\u00eda, Medicina Preventiva y Salud P\u00fablica, Toxicolog\u00eda, Medicina Legal y Forense y Parasitolog\u00eda, Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Spain"},{"name":"Red de Investigaci\u00f3n Cooperativa en Enfermedades Tropicales (RICET), 28029 Madrid, Spain"},{"name":"Consorcio Centro de Investigacion Biomedica en Red M.P. (CIBER) de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-8224","authenticated-orcid":false,"given":"Jos\u00e9 E.","family":"Pi\u00f1ero","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias (IUETSPC), Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Spain"},{"name":"Departamento de Obstetricia y Ginecolog\u00eda, Pediatr\u00eda, Medicina Preventiva y Salud P\u00fablica, Toxicolog\u00eda, Medicina Legal y Forense y Parasitolog\u00eda, Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Spain"},{"name":"Red de Investigaci\u00f3n Cooperativa en Enfermedades Tropicales (RICET), 28029 Madrid, Spain"},{"name":"Consorcio Centro de Investigacion Biomedica en Red M.P. 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Investing to Overcome the Global Impact of Neglected Tropical Diseases: Third WHO Report on Neglected Tropical Diseases 2015, World Health Organization."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kourbeli, V., Chontzopoulou, E., Moschovou, K., Pavlos, D., Mavromoustakos, T., and Papanastasiou, I. (2021). An Overview on Target-Based Drug Design against Kinetoplastid Protozoan Infections: Human African Trypanosomiasis, Chagas Disease and Leishmaniases. Molecules, 26.","DOI":"10.3390\/molecules26154629"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"750","DOI":"10.12688\/f1000research.11120.1","article-title":"Leishmaniasis: A review","volume":"6","author":"Arenas","year":"2017","journal-title":"F1000Research"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s40475-021-00232-7","article-title":"A Review of Leishmaniasis: Current Knowledge and Future Directions","volume":"8","author":"Mann","year":"2021","journal-title":"Curr. Trop. Med. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Claborn, D. (2017). Clinical Manifestations of Visceral Leishmaniasis (American Visceral Leishmaniasis). The Epidemiology and Ecology of Leishmaniasis, IntechOpen.","DOI":"10.5772\/62617"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jaad.2014.08.051","article-title":"Cutaneous and mucocutaneous leishmaniasis: Clinical perspectives","volume":"73","author":"Handler","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"489","DOI":"10.4269\/ajtmh.15-0408","article-title":"Social and Economic Burden of Human Leishmaniasis","volume":"94","author":"Okwor","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1590\/S0074-02762003000500001","article-title":"Chagas disease: Current epidemiological trends after the interruption of vectorial and transfusional transmission in the Southern Cone countries","volume":"98","author":"Moncayo","year":"2003","journal-title":"Mem\u00f3rias Inst. Oswaldo Cruz"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.pt.2016.08.009","article-title":"Putting Infection Dynamics at the Heart of Chagas Disease","volume":"32","author":"Lewis","year":"2016","journal-title":"Trends Parasitol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1051\/parasite\/2014012","article-title":"Chagas disease in the 21st Century: A public health success or an emerging threat?","volume":"21","author":"Bonney","year":"2014","journal-title":"Parasite"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1021\/acsinfecdis.8b00298","article-title":"Drug Discovery for Kinetoplastid Diseases: Future Directions","volume":"5","author":"Rao","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ijpddr.2021.01.003","article-title":"The ultimate fate determinants of drug induced cell-death mechanisms in Trypanosomatids","volume":"15","author":"Das","year":"2021","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"ref_15","first-page":"1","article-title":"Cell death pathways in pathogenic trypanosomatids: Lessons of (over)kill","volume":"10","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fcimb.2012.00095","article-title":"Programmed cell death in Leishmania: Biochemical evidence and role in parasite infectivity","volume":"2","author":"Gannavaram","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Moujir, L., Callies, O., Sousa, P.M.C., Sharopov, F., and Seca, A.M.L. (2020). Applications of Sesquiterpene Lactones: A Review of Some Potential Success Cases. Appl. Sci., 10.","DOI":"10.3390\/app10093001"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fitote.2017.05.017","article-title":"Sesquiterpene lactones with unusual structure. Their biogenesis and biological activity","volume":"121","author":"Adekenov","year":"2017","journal-title":"Fitoterapia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.phytochem.2019.02.001","article-title":"Sesquiterpene lactones and their precursors as chemosystematic markers in the tribe Cichorieae of the Asteraceae revisited: An update (2008\u20132017)","volume":"163","author":"Shulha","year":"2019","journal-title":"Phytochemistry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1080\/14786419.2019.1680669","article-title":"Isolation, structural elucidation, and antimicrobial evaluation of the metabolites from a marine-derived fungus Penicillium sp. ZZ1283","volume":"35","author":"Kaleem","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.3390\/md13063567","article-title":"Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium minioluteum)","volume":"13","author":"Ngokpol","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"151504","DOI":"10.1016\/j.tetlet.2019.151504","article-title":"Bioactive drimane sesquiterpenoids and isocoumarins from the marine-derived fungus Penicillium minioluteum ZZ1657","volume":"61","author":"Ma","year":"2020","journal-title":"Tetrahedron Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1002\/hlca.19960790813","article-title":"Rarisetenolide, Epoxyrarisetenolide, and Epirarisetenolide, New-Skeleton Sesquiterpene Lactones as Taxonomic Markers and Defensive Agents of the Marine Ciliated Morphospecies Euplotes rariseta","volume":"79","author":"Guella","year":"1996","journal-title":"Helvetica Chim. Acta"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1246\/cl.1990.2187","article-title":"The Structure of a Germacrane-Type Sesquiterpene Alcohol, a Possible Precursor of Guaiane-Type Sesquiterpenes from the Brown Alga Dictyopteris divaricata","volume":"19","author":"Suzuki","year":"1990","journal-title":"Chem. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1080\/14786419.2019.1679132","article-title":"Cytotoxic sesquiterpenoid quinones from South China Sea sponge Dysidea sp.","volume":"35","author":"Luo","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_26","first-page":"1341","article-title":"Sesquiterpenes from the Vietnamese Marine Sponge Dysidea Fragilis","volume":"10","author":"Cuc","year":"2015","journal-title":"Nat. Prod. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1016\/j.tetlet.2015.10.102","article-title":"Structures and absolute stereochemistry of guaiane sesquiterpenoids from the gorgonian Menella woodin","volume":"56","author":"Diep","year":"2015","journal-title":"Tetrahedron Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0040-4020(01)81958-X","article-title":"New germacrane derivatives from gorgonian octocorals of the genus Pseudopterogorgia","volume":"46","author":"Ghan","year":"1990","journal-title":"Tetrahedon"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bse.2011.10.012","article-title":"Seco-germacrane anhydride: Occurrence of a sesquiterpene lactone in the gorgonian coral Menella sp. (Plexauridae)","volume":"40","author":"Sung","year":"2012","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/1568011053765976","article-title":"Anti-Cancer Potential of Sesquiterpene Lactones: Bioactivity and Molecular Mechanisms","volume":"5","author":"Zhang","year":"2005","journal-title":"Curr. Med. Chem. Agents"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Matos, M.S., Anast\u00e1cio, J.D., and Dos Santos, C.N. (2021). Sesquiterpene lactones: Promising natural compounds to fight inflammation. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13070991"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/13102818.2010.10817819","article-title":"Pharmacological Activity of Sesquiterpene Lactones","volume":"24","year":"2010","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"104682","DOI":"10.1016\/j.bioorg.2021.104682","article-title":"Antiamoebic effects of sesquiterpene lactones isolated from the zoanthid Palythoa aff. clavata","volume":"108","author":"Nocchi","year":"2021","journal-title":"Bioorganic Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1055\/a-0824-1294","article-title":"Antiprotozoal Germacranolide Sesquiterpene Lactones from Tanacetum sonbolii","volume":"85","author":"Tabatabaei","year":"2019","journal-title":"Planta Medica"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00338-019-01773-0","article-title":"Diversity of zoantharian species and their symbionts from the Macaronesian and Cape Verde ecoregions demonstrates their widespread distribution in the Atlantic Ocean","volume":"38","author":"Reimer","year":"2019","journal-title":"Coral Reefs"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.fitote.2011.05.010","article-title":"Antitrypanosomal sesquiterpene lactones from Saussurea costus","volume":"82","author":"Julianti","year":"2011","journal-title":"Fitoterapia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.exppara.2007.08.015","article-title":"Trypanosoma cruzi: Antiprotozoal activity of parthenolide obtained from Tanacetum parthenium (L.) Schultz Bip. (Asteraceae, Compositae) against epimastigote and amastigote forms","volume":"118","author":"Izumi","year":"2008","journal-title":"Exp. Parasitol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.3390\/molecules14062062","article-title":"Quantitative Structure\u2014Antiprotozoal Activity Relationships of Sesquiterpene Lactones","volume":"14","author":"Schmidt","year":"2009","journal-title":"Molecules"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S1572-5995(06)80030-X","article-title":"Structure-Activity Relationships of Sesquiterpene Lactones","volume":"Volume 33","author":"Rahman","year":"2006","journal-title":"Studies in Natural Products Chemistry"},{"key":"ref_40","first-page":"1","article-title":"Laurinterol from Laurencia johnstonii eliminates Naegleria fowleri triggering PCD by inhibition of ATPases","volume":"10","author":"Sifaoui","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"110518","DOI":"10.1016\/j.biopha.2020.110518","article-title":"Sesquiterpenoids and flavonoids from Inula viscosa induce programmed cell death in kinetoplastids","volume":"130","author":"Zeouk","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.phymed.2014.06.005","article-title":"Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: A new therapeutic target?","volume":"21","author":"Jimenez","year":"2014","journal-title":"Phytomedicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41598-017-00186-9","article-title":"Methionine aminopeptidase 2 is a key regulator of apoptotic like cell death in Leishmania donovani","volume":"7","author":"Kumar","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Cartuche, L., Sifaoui, I., L\u00f3pez-Arencibia, A., Bethencourt-Estrella, C.J., Nicol\u00e1s-Hern\u00e1ndez, D.S., Lorenzo-Morales, J., Pi\u00f1ero, J.E., D\u00edaz-Marrero, A.R., and Fern\u00e1ndez, J.J. (2020). Antikinetoplastid Activity of Indolocarbazoles from Streptomyces sanyensis. Biomolecules, 10.","DOI":"10.3390\/biom10040657"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Rizo-Liendo, A., Sifaoui, I., Reyes-Batlle, M., Chiboub, O., Rodr\u00edguez-Exp\u00f3sito, R.L., Bethencourt-Estrella, C.J., Nicol\u00e1s-Hern\u00e1ndez, D.S., Hendiger, E.B., L\u00f3pez-Arencibia, A., and Rocha-Cabrera, P. (2019). In Vitro Activity of Statins against Naegleria fowleri. Pathogens, 8.","DOI":"10.3390\/pathogens8030122"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Arencibia, A., Nicol\u00e1s-Hern\u00e1ndez, D.S., Bethencourt-Estrella, C.J., Sifaoui, I., Reyes-Batlle, M., Rodr\u00edguez-Exp\u00f3sito, R.L., Rizo-Liendo, A., Lorenzo-Morales, J., Bazzocchi, I.L., and Pi\u00f1ero, J.E. (2019). Withanolides from Withania aristata as Antikinetoplastid Agents through Induction of Programmed Cell Death. Pathogens, 8.","DOI":"10.3390\/pathogens8040172"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"103276","DOI":"10.1016\/j.bioorg.2019.103276","article-title":"Antiprotozoal activities of marine polyether triterpenoids","volume":"92","author":"Sifaoui","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"110814","DOI":"10.1016\/j.biopha.2020.110814","article-title":"New phenalenone analogues with improved activity against Leishmania species","volume":"132","author":"Freijo","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_49","first-page":"1","article-title":"In vitro activity of 1H-phenalen-1-one derivatives against Leishmania spp. and evidence of programmed cell death","volume":"12","author":"Freijo","year":"2019","journal-title":"Parasites Vectors"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Bethencourt-Estrella, C., Delgado-Hern\u00e1ndez, S., L\u00f3pez-Arencibia, A., Nicol\u00e1s-Hern\u00e1ndez, D.S., Sifaoui, I., Tejedor, D., Garc\u00eda-Tellado, F., Lorenzo-Morales, J., and Pi\u00f1ero, J. (2021). Acrylonitrile Derivatives against Trypanosoma cruzi: In Vitro Activity and Programmed Cell Death Study. 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