{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:23:32Z","timestamp":1791321812009,"version":"4.3.1"},"reference-count":69,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Center","doi-asserted-by":"publisher","award":["2015\/19\/B\/NZ7\/02270"],"award-info":[{"award-number":["2015\/19\/B\/NZ7\/02270"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005297","name":"Medical University of Bia\u0142ystok","doi-asserted-by":"publisher","award":["SUB\/2\/DN\/21\/001\/2213"],"award-info":[{"award-number":["SUB\/2\/DN\/21\/001\/2213"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Our study aimed to examine the endothelium (vascular)-protecting effects of chronic cannabidiol (CBD) administration (10 mg\/kg once daily for 2 weeks) in aortas and small mesenteric (G3) arteries isolated from deoxycorticosterone-induced hypertensive (DOCA-salt) rats and spontaneously hypertensive rats (SHR). CBD reduced hypertrophy and improved the endothelium-dependent vasodilation in response to acetylcholine in the aortas and G3 of DOCA-salt rats and SHR. The enhancement of vasorelaxation was prevented by the inhibition of nitric oxide (NO) with L-NAME and\/or the inhibition of cyclooxygenase (COX) with indomethacin in the aortas and G3 of DOCA-salt and SHR, respectively. The mechanism of the CBD-mediated improvement of endothelial function in hypertensive vessels depends on the vessel diameter and may be associated with its NO-, the intermediate-conductance calcium-activated potassium channel- or NO-, COX-, the intermediate and the small-conductance calcium-activated potassium channels-dependent effect in aortas and G3, respectively. CBD increased the vascular expression of the cannabinoid CB1 and CB2 receptors and aortic levels of endocannabinoids with vasorelaxant properties e.g., anandamide, 2-arachidonoylglycerol and palmitoyl ethanolamide in aortas of DOCA-salt and\/or SHR. In conclusion, CBD treatment has vasoprotective effects in hypertensive rats, in a vessel-size- and hypertension-model-independent manner, at least partly via inducing local vascular changes in the endocannabinoid system.<\/jats:p>","DOI":"10.3390\/ph14111120","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:24:22Z","timestamp":1635805462000},"page":"1120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Vasoprotective Endothelial Effects of Chronic Cannabidiol Treatment and Its Influence on the Endocannabinoid System in Rats with Primary and Secondary Hypertension"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-2656","authenticated-orcid":false,"given":"Marta","family":"Baranowska-Kuczko","sequence":"first","affiliation":[{"name":"Department of Experimental Physiology and Pathophysiology, Medical University of Bia\u0142ystok, ul. Mickiewicza 2A, 15-222 Bia\u0142ystok, Poland"},{"name":"Department of Clinical Pharmacy, Medical University of Bia\u0142ystok, ul. Mickiewicza 2A, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2105-3350","authenticated-orcid":false,"given":"Hanna","family":"Koz\u0142owska","sequence":"additional","affiliation":[{"name":"Department of Experimental Physiology and Pathophysiology, Medical University of Bia\u0142ystok, ul. Mickiewicza 2A, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Kloza","sequence":"additional","affiliation":[{"name":"Department of Experimental Physiology and Pathophysiology, Medical University of Bia\u0142ystok, ul. Mickiewicza 2A, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kusaczuk","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biochemistry, Medical University of Bia\u0142ystok, ul. Mickiewicza 2A, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3507-4686","authenticated-orcid":false,"given":"Ewa","family":"Harasim-Symbor","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Bia\u0142ystok, ul. Mickiewicza 2C, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9101-5125","authenticated-orcid":false,"given":"Micha\u0142","family":"Biernacki","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Bia\u0142ystok, ul. Mickiewicza 2D, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2954-942X","authenticated-orcid":false,"given":"Irena","family":"Kasacka","sequence":"additional","affiliation":[{"name":"Department of Histology and Cytophysiology, Medical University of Bia\u0142ystok, ul. Mickiewicza 2C, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Malinowska","sequence":"additional","affiliation":[{"name":"Department of Experimental Physiology and Pathophysiology, Medical University of Bia\u0142ystok, ul. Mickiewicza 2A, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1124\/pharmrev.120.000096","article-title":"Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies","volume":"73","author":"Xu","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s40265-016-0642-8","article-title":"Drug Treatment of Hypertension: Focus on Vascular Health","volume":"76","author":"Cameron","year":"2016","journal-title":"Drugs"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/HYPERTENSIONAHA.114.03575","article-title":"Endothelial dysfunction and hypertension","volume":"64","author":"Brandes","year":"2014","journal-title":"Hypertension"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Baranowska-Kuczko, M., Koz\u0142owska, H., Kloza, M., Harasim-Symbor, E., Biernacki, M., Kasacka, I., and Malinowska, B. (2021). Beneficial Changes in Rat Vascular Endocannabinoid System in Primary Hypertension and under Treatment with Chronic Inhibition of Fatty Acid Amide Hydrolase by URB597. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094833"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kicman, A., and Toczek, M. (2020). The Effects of Cannabidiol, a Non-Intoxicating Compound of Cannabis, on the Cardiovascular System in Health and Disease. Int J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186740"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1146\/annurev-pharmtox-010818-021441","article-title":"Beyond THC and Endocannabinoids","volume":"60","author":"Pacher","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1161\/CIR.0000000000000883","article-title":"Medical Marijuana, Recreational Cannabis, and Cardiovascular Health: A Scientific Statement From the American Heart Association","volume":"142","author":"Page","year":"2020","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pharmthera.2017.02.041","article-title":"Cannabidiol: State of the art and new challenges for therapeutic applications","volume":"175","author":"Pisanti","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.lfs.2016.03.014","article-title":"Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats","volume":"151","author":"Kloza","year":"2016","journal-title":"Life Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/HJH.0000000000002333","article-title":"Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: Modification by hypertension and the potential pharmacological opportunities","volume":"38","author":"Kloza","year":"2020","journal-title":"J. Hypertens."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1111\/bph.14168","article-title":"Cannabinoids in arterial, pulmonary and portal hypertension - mechanisms of action and potential therapeutic significance","volume":"176","author":"Malinowska","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sadowska, O., Baranowska-Kuczko, M., Gromotowicz-Pop\u0142awska, A., Biernacki, M., Kicman, A., Malinowska, B., Kasacka, I., Krzy\u017cewska, A., and Koz\u0142owska, H. (2020). Cannabidiol ameliorates monocrotaline-induced pulmonary hypertension in rats. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197077"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Remiszewski, P., Jarocka-Karpowicz, I., Biernacki, M., Jastrz\u0105b, A., Schlicker, E., Toczek, M., Harasim-Symbor, E., P\u0119dzi\u0144ska-Betiuk, A., and Malinowska, B. (2020). Chronic Cannabidiol Administration Fails to Diminish Blood Pressure in Rats with Primary and Secondary Hypertension Despite Its Effects on Cardiac and Plasma Endocannabinoid System, Oxidative Stress and Lipid Metabolism. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041295"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e93760","DOI":"10.1172\/jci.insight.93760","article-title":"A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study","volume":"2","author":"Jadoon","year":"2017","journal-title":"JCI Insight"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/bcp.14225","article-title":"The effects of acute and sustained cannabidiol dosing for seven days on the haemodynamics in healthy men: A randomised controlled trial","volume":"86","author":"Sultan","year":"2020","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1124\/mol.63.3.699","article-title":"Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor","volume":"63","author":"Mo","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejphar.2009.03.010","article-title":"Time-dependent vascular actions of cannabidiol in the rat aorta","volume":"612","author":"Sun","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ejphar.2013.10.002","article-title":"Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes","volume":"720","author":"Stanley","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/cvr\/cvv179","article-title":"Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation","volume":"107","author":"Stanley","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1124\/jpet.114.217125","article-title":"Cannabidiol improves vasorelaxation in Zucker diabetic fatty rats through cyclooxygenase activation","volume":"351","author":"Wheal","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fphar.2017.00248","article-title":"In vivo cannabidiol treatment improves endothelium-dependent vasorelaxation in mesenteric arteries of Zucker Diabetic Fatty rats","volume":"8","author":"Wheal","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"173767","DOI":"10.1016\/j.ejphar.2020.173767","article-title":"Cannabidiol selectively inhibits the contraction of rat small resistance arteries: Possible role for CGRP and voltage-gated calcium channels","volume":"891","author":"Mazeh","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"34595","DOI":"10.18632\/oncotarget.26191","article-title":"Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells","volume":"9","author":"Schwartz","year":"2018","journal-title":"Oncotarget"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/j.1471-4159.2007.04565.x","article-title":"Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism","volume":"102","author":"Hayakawa","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/01.STR.0000163083.59201.34","article-title":"Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine 1A receptor-dependent mechanism","volume":"36","author":"Mishima","year":"2005","journal-title":"Stroke"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1742-2094-8-5","article-title":"Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: An intravital microscopy study","volume":"8","author":"Benito","year":"2011","journal-title":"J. Neuroinflamm."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2353\/ajpath.2006.050500","article-title":"Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes","volume":"168","author":"Khalifa","year":"2006","journal-title":"Am. J. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"H610","DOI":"10.1152\/ajpheart.00236.2007","article-title":"Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption","volume":"293","author":"Rajesh","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"115368","DOI":"10.1016\/j.taap.2020.115368","article-title":"Chronic cannabidiol treatment reduces the carbachol-induced coronary constriction and left ventricular cardiomyocyte width of the isolated hypertensive rat heart","volume":"411","author":"Weresa","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0008-6363(97)00039-4","article-title":"von Willebrand factor: A marker of endothelial dysfunction in vascular disorders?","volume":"34","author":"Lip","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/jth.15191","article-title":"The ADAMTS13-von Willebrand factor axis in COVID-19 patients","volume":"19","author":"Mancini","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1161\/HYP.0000000000000090","article-title":"Animal models of hypertension: A scientific statement from the American Heart Association","volume":"73","author":"Lerman","year":"2019","journal-title":"Hypertension"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1476-5381.2008.00046.x","article-title":"5-HT1A receptors are involved in the cannabidiol induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats","volume":"156","author":"Resstel","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2119\/molmed.2014.00261","article-title":"Cannabidiol protects against doxorubicin-induced cardiomyopathy by modulating mitochondrial function and biogenesis","volume":"21","author":"Hao","year":"2015","journal-title":"Mol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.jacc.2010.07.033","article-title":"Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy","volume":"56","author":"Rajesh","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"H77","DOI":"10.1152\/ajpheart.01021.2020","article-title":"Guidelines for the measurement of vascular function and structure in isolated arteries and veins","volume":"321","author":"Wenceslau","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/CIRCRESAHA.116.303596","article-title":"The structural factor of hypertension: Large and small artery alterations","volume":"116","author":"Laurent","year":"2015","journal-title":"Circ. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/10641963.2016.1148155","article-title":"Differential contribution of endothelium-derived relaxing factors to vascular reactivity in conduit and resistance arteries from normotensive and hypertensive rats","volume":"38","author":"Jiang","year":"2016","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"598271","DOI":"10.1155\/2014\/598271","article-title":"Endothelial dysfunction in experimental models of arterial hypertension: Cause or consequence?","volume":"2014","author":"Bernatova","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Kloza, M., Baranowska-Kuczko, M., Toczek, M., Kusaczuk, M., Sadowska, O., Kasacka, I., and Koz\u0142owska, H. (2019). Modulation of Cardiovascular Function in Primary Hypertension in Rat by SKA-31, an Activator of KCa2.x and KCa3.1 Channels. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20174118"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/apha.12628","article-title":"Endothelium-dependent hyperpolarization: Age, gender and blood pressure, do they matter?","volume":"219","author":"Leung","year":"2017","journal-title":"Acta Physiol. (Oxf.)"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1097\/HJH.0b013e328329bbd7","article-title":"Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension","volume":"27","author":"Li","year":"2009","journal-title":"J. Hypertens."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ejphar.2016.11.040","article-title":"The endogenous lipid N-arachidonoyl glycine is hypotensive and nitric oxide-cGMP-dependent vasorelaxant","volume":"794","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-3-030-21737-2_5","article-title":"Cannabinoids and Cardiovascular System","volume":"1162","author":"Bondarenko","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1089\/can.2019.0030","article-title":"2-Linoleoylglycerol Is a Partial Agonist of the Human Cannabinoid Type 1 Receptor that Can Suppress 2-Arachidonolyglycerol and Anandamide Activity","volume":"4","author":"Lu","year":"2019","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/sj.bjp.0707141","article-title":"Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol","volume":"150","author":"Ho","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/bjp.2008.324","article-title":"Entourage\u2019 effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors","volume":"155","author":"Ho","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2013.01.006","article-title":"Mechanisms of vasorelaxation induced by oleoylethanolamide in the rat small mesenteric artery","volume":"702","author":"AlSuleimani","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/1753944718773690","article-title":"Anandamide and endocannabinoid system: An attractive therapeutic approach for cardiovascular disease","volume":"12","author":"Noriega","year":"2018","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6096","DOI":"10.1167\/iovs.10-7057","article-title":"Ocular hypotensive effect of oral palmitoyl-ethanolamide: A clinical trial","volume":"52","author":"Gagliano","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000506158","article-title":"Potential Mechanisms Involved in Palmitoylethanolamide-Induced Vasodepressor Effects in Rats","volume":"57","author":"MaassenVanDenBrink","year":"2020","journal-title":"J. Vasc. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.phrs.2017.06.014","article-title":"Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury","volume":"123","author":"Gugliandolo","year":"2017","journal-title":"Pharm. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejps.2017.04.022","article-title":"Treatment with sodium nitroprusside improves the endothelial function in aortic rings with endothelial dysfunction","volume":"105","author":"Buzinari","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"H2434","DOI":"10.1152\/ajpheart.00568.2005","article-title":"Acetylcholine and sodium nitroprusside cause long-term inhibition of EDCF-mediated contractions","volume":"289","author":"Tang","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.mvr.2015.01.005","article-title":"Effects of rosuvastatin correlated with the down-regulation of CYP4A1 in spontaneously hypertensive rats","volume":"98","author":"Li","year":"2015","journal-title":"Microvasc. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/HJH.0b013e32831ef369","article-title":"Rosuvastatin protects against angiotensin II-induced renal injury in a dose-dependent fashion","volume":"27","author":"Park","year":"2009","journal-title":"J. Hypertens."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/FJC.0000000000000828","article-title":"Rosuvastatin Reverses Hypertension-Induced Changes in the Aorta Structure and Endothelium-Dependent Relaxation in Rats Through Suppression of Apoptosis and Inflammation","volume":"75","author":"Lv","year":"2020","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1161\/HYPERTENSIONAHA.113.01803","article-title":"Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone\/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure","volume":"63","author":"Rickard","year":"2014","journal-title":"Hypertension"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1124\/jpet.119.263319","article-title":"Antinociceptive and Immune Effects of Delta-9-Tetrahydrocannabinol or Cannabidiol in Male Versus Female Rats with Persistent Inflammatory Pain","volume":"373","author":"Britch","year":"2020","journal-title":"J. Pharm. Exp. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13148-020-00993-4","article-title":"Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice","volume":"13","author":"Wanner","year":"2021","journal-title":"Clin. Epigenet."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2013.01.002","article-title":"Modulation by 17\u03b2-estradiol of anandamide vasorelaxation in normotensive and hypertensive rats: A role for TRPV1 but not fatty acid amide hydrolase","volume":"701","author":"Ho","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"ESC Scientific Document Group. 2018 ESC\/ESH Guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_63","first-page":"e13","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"7","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"974","DOI":"10.2174\/1570159X17666190603171901","article-title":"Cannabidiol Adverse Effects and Toxicity","volume":"17","author":"Huestis","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/phar.2512","article-title":"Food effects on the formulation, dosing, and administration of cannabidiol (CBD) in humans: A systematic review of clinical studies","volume":"41","author":"Silmore","year":"2021","journal-title":"Pharmacotherapy"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Percie du Sert, N., Ahluwalia, A., Alam, S., Avey, M.T., Baker, M., Browne, W.J., Clark, A., Cuthill, I.C., Dirnagl, U., and Emerson, M. (2020). Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PLoS Biol., 18.","DOI":"10.1371\/journal.pbio.3000411"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Frost, M., Keable, A., Baseley, D., Sealy, A., Andreea Zbarcea, D., Gatherer, M., Yuen, H.M., Sharp, M.M., Weller, R.O., and Attems, J. (2020). Vascular \u03b11A Adrenergic Receptors as a Potential Therapeutic Target for IPAD in Alzheimer\u2019s Disease. Pharmaceuticals, 13.","DOI":"10.3390\/ph13090261"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.talanta.2018.04.033","article-title":"Study of sample preparation for determination of endocannabinoids and analogous compounds in human serum by LC-MS\/MS in MRM mode","volume":"185","year":"2018","journal-title":"Talanta"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/14\/11\/1120\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:24:06Z","timestamp":1760167446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/14\/11\/1120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,31]]},"references-count":69,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ph14111120"],"URL":"https:\/\/doi.org\/10.3390\/ph14111120","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,31]]}}}