{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:25:34Z","timestamp":1787239534402,"version":"build-2736575974"},"reference-count":46,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education and Science of Russia","award":["FSRG-2020-0019"],"award-info":[{"award-number":["FSRG-2020-0019"]}]},{"name":"Ministry of Education and Science of Russia","award":["121030100227-7"],"award-info":[{"award-number":["121030100227-7"]}]},{"name":"World-class Interregional Scientific and Educational Center \u2018Baikal\u2019","award":["2021"],"award-info":[{"award-number":["2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>In modern life, the use of plant stress-protectors has taken on particular significance due to the wide distribution of neurosis-like and neurotic diseases caused by neuroendocrine-immune system imbalance. Special attention has been paid to the plants containing ecdysteroids, i.e., hormone-like bioactive substances with high adaptogenic activity. The article deals with the study of bioactivity of two plant extracts as Rhaponticum uniflorum (L.) DC. and Serratula centauroides L. with a high content of ecdysteroids and phenolic compounds. The models of acute and chronic emotional stress in white rats were used to estimate the stress-protective activity of R. uniflorum and S. centauroides extracts. Both extracts showed the stress-protective effect via inhibiting the development of signs induced by single and long-term effects of stress factors. In acute stress, the development of Selye's triad signs was less pronounced against the background of the plant remedies introduction. In chronic stress, the extracts prevented the development of anxiety-depressive syndrome. Besides, R. uniflorum and S. centauroides extracts banned the development of stress-induced injuries in the brain cortex and had a neuroprotective effect on ischemia against chronic stress. The stress-protective effects of both plant extracts were based on a decrease of hyperactivation of the central stress-promoting systems (sympathoadrenal, hypothalamic-pituitary-adrenal) due to their GABA-mimetic effects. Peripheral mechanisms were connected with the inhibition of free radical oxidation processes and with an increase in the endogenous antioxidant system activity. Thus, R. uniflorum and S. centauroides extracts have a high potential to increase non-specific body resistance against acute and chronic emotional stress effects.<\/jats:p>","DOI":"10.3390\/ph14111186","type":"journal-article","created":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T21:00:50Z","timestamp":1637528450000},"page":"1186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Rhaponticum uniflorum and Serratula centauroides Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress"],"prefix":"10.3390","volume":"14","author":[{"given":"Larisa N.","family":"Shantanova","sequence":"first","affiliation":[{"name":"Institute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, Russia"},{"name":"Institute of Medicine, Buryat State University, Oktyabrskaya Str.36a, 670002 Ulan-Ude, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8194-1061","authenticated-orcid":false,"given":"Daniil N.","family":"Olennikov","sequence":"additional","affiliation":[{"name":"Institute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irinchey E.","family":"Matkhanov","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Buryat State University, Oktyabrskaya Str.36a, 670002 Ulan-Ude, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8412-5799","authenticated-orcid":false,"given":"Sergey M.","family":"Gulyaev","sequence":"additional","affiliation":[{"name":"Institute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anyuta A.","family":"Toropova","sequence":"additional","affiliation":[{"name":"Institute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, Russia"},{"name":"Institute of Medicine, Buryat State University, Oktyabrskaya Str.36a, 670002 Ulan-Ude, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina G.","family":"Nikolaeva","sequence":"additional","affiliation":[{"name":"Institute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, Russia"},{"name":"Institute of Medicine, Buryat State University, Oktyabrskaya Str.36a, 670002 Ulan-Ude, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey M.","family":"Nikolaev","sequence":"additional","affiliation":[{"name":"Institute of General and Experimental Biology, Siberian Branch of Russian Academy of Science, Sakhyanovoy Str. 6, 670047 Ulan-Ude, Russia"},{"name":"Institute of Medicine, Buryat State University, Oktyabrskaya Str.36a, 670002 Ulan-Ude, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.phymed.2018.09.204","article-title":"Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology","volume":"50","author":"Panossian","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1161\/STROKEAHA.111.639732","article-title":"Socioeconomic status and stroke: An updated review","volume":"43","author":"Addo","year":"2012","journal-title":"Stroke"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.euroneuro.2020.08.007","article-title":"Systemic neuro-dysregulation in depression: Evidence from genome-wide association","volume":"39","author":"Tubbs","year":"2020","journal-title":"Eur. 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