{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:50:11Z","timestamp":1790675411704,"version":"4.1.0"},"reference-count":117,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2017\/26815-1"],"award-info":[{"award-number":["2017\/26815-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2018\/12119-6"],"award-info":[{"award-number":["2018\/12119-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["141585\/2016-1"],"award-info":[{"award-number":["141585\/2016-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["8020-00310B"],"award-info":[{"award-number":["8020-00310B"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union's Horizon 2020","award":["754513"],"award-info":[{"award-number":["754513"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Cannabidiol (CBD) is a non-intoxicating compound extracted from Cannabis sativa, showing antidepressant-like effects in different rodent models. However, inconsistent results have been described depending on the species and the strain used to assess depressive-like behavior. Moreover, only a few studies investigated the effect of CBD in female rodents. Therefore, we aimed to (i) investigate the effects of CBD in two different strains of mice (Swiss and C57BL\/6) and a rat model of depression based on selective breeding (Flinders Sensitive and Resistant Lines, FSL and FRL) subjected to tests predictive of antidepressant-like effects and (ii) investigate the influence of sex in the effects of CBD in both mice and rats. CBD induced an antidepressant-like effect in male Swiss but not in female Swiss or C57BL\/6 mice in the tail suspension test (TST). In male FSL rats, CBD produced an antidepressant-like effect 1 h post injection. However, in female FSL, CBD induced a bimodal effect, increasing the immobility time at 1 h and decreasing it at 2 h. In conclusion, strain, sex, and administration time affect CBD\u2019s behavioral response to rodents exposed to tests predictive of antidepressant effects.<\/jats:p>","DOI":"10.3390\/ph14121269","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T22:18:42Z","timestamp":1638829122000},"page":"1269","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8959-1008","authenticated-orcid":false,"given":"Gabriela P.","family":"Silote","sequence":"first","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto (FCFRP), University of S\u00e3o Paulo (USP), Ribeir\u00e3o Preto 14040-903, SP, Brazil"},{"name":"Translational Neuropsychiatry Unit (TNU), Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle C.","family":"Gatto","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto (FCFRP), University of S\u00e3o Paulo (USP), Ribeir\u00e3o Preto 14040-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Eskelund","sequence":"additional","affiliation":[{"name":"Translational Neuropsychiatry Unit (TNU), Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco S.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14049-900, SP, Brazil"},{"name":"Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0081-0068","authenticated-orcid":false,"given":"Gregers","family":"Wegener","sequence":"additional","affiliation":[{"name":"Translational Neuropsychiatry Unit (TNU), Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e2mia R. L.","family":"Joca","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto (FCFRP), University of S\u00e3o Paulo (USP), Ribeir\u00e3o Preto 14040-903, SP, Brazil"},{"name":"Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"APA (2013). Diagnostic and Statictical Manual of Mental Disorders, American Psychiatric Association.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_2","unstructured":"WHO (2017). Depression and Other Common Mental Disorders: Global Health Estimates, WHO."},{"key":"ref_3","unstructured":"WHO (2017). 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