{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:30:43Z","timestamp":1784629843553,"version":"3.55.0"},"reference-count":26,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Chronic fatigue syndrome and fibromyalgia (CFS\/FMS) affect 2.1% of the world\u2019s population and ~10\u201325% of people who have had COVID-19. Previous clinical data suggested that a unique Panax ginseng (C.A. Meyer, family Araliaceae) root extract (HRG80\u2122 Red Ginseng) often resulted in marked improvement. We aimed to study this hydroponic form of red ginseng root, containing high levels of rare ginsenosides, for improving energy, cognition, and stamina. This open-label prospective study included participants with severe CFS\/FMS who took a daily supplement of HRG80 capsules (200\u2013400 mg) or tablets (100\u2013200 mg) for one month. A total of 188 subject patients completed the one-month treatment trial. Of these, 60.1% rated themselves as improved, with 13.3% rating themselves as being much better. In this group, the mean composite score improved from 11.9 to 18.8 (p &lt; 0.001), with a 67% average increase in energy, 44% average increase in overall well-being, 48% average improvement in mental clarity, 58% average composite improvement in the previous three measurements (primary outcome measure), 46% average improvement in sleep, 33% average decrease in pain, and 72% average increase in stamina. Our study showed that HRG80 red ginseng root powder resulted in a marked improvement in people with CFS and fibromyalgia. This included the subgroup with post-viral CFS\/FMS.<\/jats:p>","DOI":"10.3390\/ph15010043","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T08:12:15Z","timestamp":1640765535000},"page":"43","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["An Open-Label, Pilot Trial of HRG80\u2122 Red Ginseng in Chronic Fatigue Syndrome, Fibromyalgia, and Post-Viral Fatigue"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9946-0506","authenticated-orcid":false,"given":"Jacob","family":"Teitelbaum","sequence":"first","affiliation":[{"name":"Kona Research Center, 76-6322 Kaheiau St., Kailua Kona, HI 96740, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Goudie","sequence":"additional","affiliation":[{"name":"Kona Research Center, 76-6322 Kaheiau St., Kailua Kona, HI 96740, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"ref_1","first-page":"47","article-title":"Magnesium metabolism and its disorders","volume":"24","author":"Swaminathan","year":"2003","journal-title":"Clin. 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