{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:25:41Z","timestamp":1792211141691,"version":"4.4.0"},"reference-count":57,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/103.198\/2011"],"award-info":[{"award-number":["E-26\/103.198\/2011"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/010.001882\/2014"],"award-info":[{"award-number":["E-26\/010.001882\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Financial Code 001"],"award-info":[{"award-number":["Financial Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["PQ- CNPQ 308097\/2016-5"],"award-info":[{"award-number":["PQ- CNPQ 308097\/2016-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Recently, the well-known geographically wide distribution of sporotrichosis in Brazil, combined with the difficulties of effective domestic feline treatment, has emphasized the pressing need for new therapeutic alternatives. This work considers a range of synthetic derivatives as potential antifungals against Sporothrix brasiliensis isolated from cats from the hyperendemic Brazilian region. Six S. brasiliensis isolates from the sporotrichotic lesions of itraconazole responsive or non-responsive domestic cats were studied. The minimum inhibitory concentrations (MICs) of three novel hydrazone derivatives and eleven novel quinone derivatives were determined using the broth microdilution method (M38-A2). In silico tests were also used to predict the pharmacological profile and toxicity parameters of these synthetic derivatives. MICs and MFCs ranged from 1 to &gt;128 \u00b5g\/mL. The ADMET computational analysis failed to detect toxicity while a good pharmacological predictive profile, with parameters similar to itraconazole, was obtained. Three hydrazone derivatives were particularly promising candidates as antifungal agents against itraconazole-resistant S. brasiliensis from the Brazilian hyperendemic region. Since sporotrichosis is a neglected zoonosis currently spreading in Latin America, particularly in Brazil, the present data can contribute to its future control by alternative antifungal drug design against S. brasiliensis, the most virulent and prevalent species of the hyperendemic context.<\/jats:p>","DOI":"10.3390\/ph15010055","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T20:21:56Z","timestamp":1641759716000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Synthetic Derivatives against Wild-Type and Non-Wild-Type Sporothrix brasiliensis: In Vitro and In Silico Analyses"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-2687","authenticated-orcid":false,"given":"Lais Cavalcanti dos Santos Velasco","family":"de Souza","sequence":"first","affiliation":[{"name":"Center for Microorganisms\u2019 Investigation, Fluminense Federal University, Niter\u00f3i 24020-150, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Martins","family":"Alc\u00e2ntara","sequence":"additional","affiliation":[{"name":"Center for Microorganisms\u2019 Investigation, Fluminense Federal University, Niter\u00f3i 24020-150, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e3mella Antunes","family":"de Mac\u00eado-Sales","sequence":"additional","affiliation":[{"name":"Center for Microorganisms\u2019 Investigation, Fluminense Federal University, Niter\u00f3i 24020-150, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia Faria","family":"Reis","sequence":"additional","affiliation":[{"name":"Center for Microorganisms\u2019 Investigation, Fluminense Federal University, Niter\u00f3i 24020-150, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Sena","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Center for Microorganisms\u2019 Investigation, Fluminense Federal University, Niter\u00f3i 24020-150, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8955-3204","authenticated-orcid":false,"given":"Ricardo Luiz Dantas","family":"Machado","sequence":"additional","affiliation":[{"name":"Center for Microorganisms\u2019 Investigation, Fluminense Federal University, Niter\u00f3i 24020-150, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6729-075X","authenticated-orcid":false,"given":"Reinaldo Barros","family":"Geraldo","sequence":"additional","affiliation":[{"name":"Laboratory of Antibiotics, Biochemistry and Molecular Modeling, Institute of Biology, Fluminense Federal University, Niter\u00f3i 24210-201, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-8592","authenticated-orcid":false,"given":"Andr\u00e9 Luis Souza","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Advanced Studies of Emerging and Resistant Microorganisms, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2166-766X","authenticated-orcid":false,"given":"V\u00edtor Francisco","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Graduate Program in Applied Health Sciences, Niter\u00f3i 24241-000, Brazil"},{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Fluminense Federal University, Niter\u00f3i 24241-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Tadeu Gomes","family":"Gonzaga","sequence":"additional","affiliation":[{"name":"Pharmacy Unit, State University of the West Zone, Rio de Janeiro 23070-200, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2042-3778","authenticated-orcid":false,"given":"Fernando de Carvalho","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Institute of Chemistry, Fluminense Federal University, Niter\u00f3i 24020-150, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Carla","family":"Castro","sequence":"additional","affiliation":[{"name":"Laboratory of Antibiotics, Biochemistry and Molecular Modeling, Institute of Biology, Fluminense Federal University, Niter\u00f3i 24210-201, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0461-7521","authenticated-orcid":false,"given":"Andr\u00e9a Regina de Souza","family":"Baptista","sequence":"additional","affiliation":[{"name":"Center for Microorganisms\u2019 Investigation, Fluminense Federal University, Niter\u00f3i 24020-150, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gremi\u00e3o, I.D.F., Miranda, L.H.M., Reis, E.G., Rodrigues, A.M., and Pereira, S.A. 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