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CBD suppresses the development of cancer in both in vitro (cancer cell culture) and in vivo (xenografts in immunodeficient mice) models. For critical evaluation of the advances of CBD on its path from laboratory research to practical application, in this review, we wish to call the attention of scientists and clinicians to the following issues: (a) the biological effects of CBD in cancer and healthy cells; (b) the anticancer effects of CBD in animal models and clinical case reports; (c) CBD\u2019s interaction with conventional anticancer drugs; (d) CBD\u2019s potential in palliative care for cancer patients; (e) CBD\u2019s tolerability and reported side effects; (f) CBD delivery for anticancer treatment.<\/jats:p>","DOI":"10.3390\/ph15030366","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:34:27Z","timestamp":1647812067000},"page":"366","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Cannabidiol on the Path from the Lab to the Cancer Patient: Opportunities and Challenges"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-128X","authenticated-orcid":false,"given":"Miguel","family":"Olivas-Aguirre","sequence":"first","affiliation":[{"name":"Laboratory of Immunobiology and Ionic Transport Regulation, Centro Universitario de Investigaciones Biom\u00e9dicas, Universidad de Colima, Colima 28045, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1424-1596","authenticated-orcid":false,"given":"Liliana","family":"Torres-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Ionic Transport Regulation, Centro Universitario de Investigaciones Biom\u00e9dicas, Universidad de Colima, Colima 28045, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8544-297X","authenticated-orcid":false,"given":"Kathya","family":"Villatoro-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Ionic Transport Regulation, Centro Universitario de Investigaciones Biom\u00e9dicas, Universidad de Colima, Colima 28045, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Mayra","family":"Perez-Tapia","sequence":"additional","affiliation":[{"name":"Unidad de Desarrollo e Investigaci\u00f3n en Bioterape\u00faticos (UDIBI), Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional (ENCB-IPN), Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9657-9226","authenticated-orcid":false,"given":"Igor","family":"Pottosin","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Ionic Transport Regulation, Centro Universitario de Investigaciones Biom\u00e9dicas, Universidad de Colima, Colima 28045, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1526-6517","authenticated-orcid":false,"given":"Oxana","family":"Dobrovinskaya","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology and Ionic Transport Regulation, Centro Universitario de Investigaciones Biom\u00e9dicas, Universidad de Colima, Colima 28045, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.2174\/138161212802884681","article-title":"A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation","volume":"18","author":"Zuardi","year":"2012","journal-title":"Curr. 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