{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:51:59Z","timestamp":1775022719508,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jeju TechnoPark","award":["2021-0981"],"award-info":[{"award-number":["2021-0981"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1F1A1063352"],"award-info":[{"award-number":["2021R1F1A1063352"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A6A1A10072987"],"award-info":[{"award-number":["2019R1A6A1A10072987"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Periodontitis is a common disease involving inflammation and tissue destruction in the periodontal region. Although uncontrolled long-term inflammation in the gingiva may lead to loss of the periodontal ligament, treatments or preventive solutions for periodontitis are scarce. The aim of this study is to find anti-inflammatory material from a natural source that can be used to treat or protect against periodontitis. Daphne species (Thymelaeaceae) are important and popular components of traditional Chinese medicine and are used as anti-inflammatory agents. Daphne jejudoensis is an endemic plant that grows on Jeju Island and was identified as a new species in 2013. In this study, for the first time, we investigated the anti-inflammatory effect of D. jejudoensis leaf extract (DJLE) on human periodontal ligament cells. The gene expression levels of pro-inflammatory cytokines (interleukin-1\u03b2 and 6 and tumor necrosis factor-\u03b1) and inflammation-inducible enzymes (inducible nitric oxide synthase and cyclooxygenase-2) were reduced after DJLE treatment with\/without lipopolysaccharide stimulation. The findings of this study indicate that D. jejudoensis possesses anti-inflammatory activities, suggesting that DJLE may be a potential preventive and therapeutic agent for periodontitis.<\/jats:p>","DOI":"10.3390\/ph15040387","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T23:30:23Z","timestamp":1647991823000},"page":"387","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Daphne jejudoensis Attenuates LPS-Induced Inflammation by Inhibiting TNF-\u03b1, IL-1\u03b2, IL-6, iNOS, and COX-2 Expression in Periodontal Ligament Cells"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0543-9138","authenticated-orcid":false,"given":"Ji-Yeong","family":"Bae","sequence":"first","affiliation":[{"name":"College of Pharmacy and Jeju Research Institute of Pharmaceutical Sciences, Jeju National University, Jeju 38655, Korea"},{"name":"Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Seol","family":"Lee","sequence":"additional","affiliation":[{"name":"R&D Center, Regenerative Dental Medicine Institute, HysensBio Co., Ltd., Gwacheon 13814, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You Kyoung","family":"Cho","sequence":"additional","affiliation":[{"name":"R&D Center, Regenerative Dental Medicine Institute, HysensBio Co., Ltd., Gwacheon 13814, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo-Hwang","family":"Park","sequence":"additional","affiliation":[{"name":"R&D Center, Regenerative Dental Medicine Institute, HysensBio Co., Ltd., Gwacheon 13814, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Jeju Research Institute of Pharmaceutical Sciences, Jeju National University, Jeju 38655, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat. 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