{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:49:40Z","timestamp":1790797780150,"version":"4.1.0"},"reference-count":56,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["#HL117037"],"award-info":[{"award-number":["#HL117037"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007080","name":"Paralyzed Veterans of America","doi-asserted-by":"publisher","award":["JA Taylor"],"award-info":[{"award-number":["JA Taylor"]}],"id":[{"id":"10.13039\/100007080","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012019","name":"Fondation du Souffle","doi-asserted-by":"publisher","award":["Doctoral support (IV)"],"award-info":[{"award-number":["Doctoral support (IV)"]}],"id":[{"id":"10.13039\/100012019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Spinal cord injury is associated with damage in descending and ascending pathways between brainstem\/cortex and spinal neurons, leading to loss in sensory-motor functions. This leads not only to locomotor reduction but also to important respiratory impairments, both reducing cardiorespiratory engagement, and increasing cardiovascular risk and mortality. Moreover, individuals with high-level injuries suffer from sleep-disordered breathing in a greater proportion than the general population. Although no current treatments exist to restore motor function in spinal cord injury (SCI), serotoninergic (5-HT) 1A receptor agonists appear as pharmacologic neuromodulators that could be important players in inducing functional improvements by increasing the activation of spared motoneurons. Indeed, single therapies of serotoninergic 1A (5-HT1A) agonists allow for acute and temporary recovery of locomotor function. Moreover, the 5-HT1A agonist could be even more promising when combined with other pharmacotherapies, exercise training, and\/or spinal stimulation, rather than administered alone. In this review, we discuss previous and emerging evidence showing the value of the 5HT1A receptor agonist therapies for motor and respiratory limitations in SCI. Moreover, we provide mechanistic hypotheses and clinical impact for the potential benefit of 5-HT1A agonist pharmacology in inducing neuroplasticity and improving locomotor and respiratory functions in SCI.<\/jats:p>","DOI":"10.3390\/ph15040460","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T02:48:59Z","timestamp":1649731739000},"page":"460","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serotonin 1A Receptor Pharmacotherapy and Neuroplasticity in Spinal Cord Injury"],"prefix":"10.3390","volume":"15","author":[{"given":"Afaf","family":"Bajjig","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, UMR_S1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Cayetanot","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, UMR_S1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Andrew","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Harvard Medical School, Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0085-9021","authenticated-orcid":false,"given":"Laurence","family":"Bodineau","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, UMR_S1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-8603","authenticated-orcid":false,"given":"Isabelle","family":"Vivodtzev","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, UMR_S1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/10790268.1999.11719583","article-title":"Breathlessness and exercise in spinal cord injury","volume":"22","author":"Wien","year":"1999","journal-title":"J. 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