{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:47:01Z","timestamp":1784616421261,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>We evaluated the effects of cannabidiol (CBD) on seizures and peroxisome proliferator-activated receptor gamma (PPAR\u03b3) levels in an animal model of temporal lobe epilepsy (TLE). Adult male Sprague-Dawley rats were continuously monitored by video-electrocorticography up to 10 weeks after an intraperitoneal kainic acid (15 mg\/kg) injection. Sixty-seven days after the induction of status epilepticus and the appearance of spontaneous recurrent seizures in all rats, CBD was dissolved in medium-chain triglyceride (MCT) oil and administered subcutaneously at 120 mg\/kg (n = 10) or 12 mg\/kg (n = 10), twice a day for three days. Similarly, the vehicle was administered to ten epileptic rats. Brain levels of PPAR\u03b3 immunoreactivity were compared to those of six healthy controls. CBD at 120 mg\/kg abolished the seizures in 50% of rats (p = 0.033 vs. pre-treatment, Fisher\u2019s exact test) and reduced total seizure duration (p &lt; 0.05, Tukey Test) and occurrence (p &lt; 0.05). PPAR\u03b3 levels increased with CBD in the hippocampal CA1 subfield and subiculum (p &lt; 0.05 vs. controls, Holm\u2013\u0160id\u00e1k test), but only the highest dose increased the immunoreactivity in the hippocampal CA3 subfield (p &lt; 0.001), perirhinal cortex, and amygdala (p &lt; 0.05). Overall, these results suggest that the antiseizure effects of CBD are associated with upregulation of PPAR\u03b3 in the hippocampal CA3 region.<\/jats:p>","DOI":"10.3390\/ph15050495","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:22:43Z","timestamp":1650414163000},"page":"495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Antiseizure Effects of Cannabidiol Leading to Increased Peroxisome Proliferator-Activated Receptor Gamma Levels in the Hippocampal CA3 Subfield of Epileptic Rats"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3152-9890","authenticated-orcid":false,"given":"Anna-Maria","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 287 Campi Street, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Russo","sequence":"additional","affiliation":[{"name":"Ph.D. School of Clinical and Experimental Medicine (CEM), University of Modena and Reggio Emilia, 287 Campi Street, 41125 Modena, Italy"},{"name":"Department of Life Sciences, University of Modena and Reggio Emilia, 103 Campi Street, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Senn","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 287 Campi Street, 41125 Modena, Italy"},{"name":"Ph.D. School of Clinical and Experimental Medicine (CEM), University of Modena and Reggio Emilia, 287 Campi Street, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Ibatici","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 287 Campi Street, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cannazza","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Modena and Reggio Emilia, 103 Campi Street, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-2511","authenticated-orcid":false,"given":"Giuseppe","family":"Biagini","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 287 Campi Street, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Costa, A.-M., Marchi\u00f2, M., Bruni, G., Bernabei, S.M., Cavalieri, S., Bondi, M., and Biagini, G. 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