{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:47:19Z","timestamp":1789681639349,"version":"4.0.1"},"reference-count":61,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BRAND\u2019S Health Research Awards from Cerebos Health Research Foundation for Thai Society, Thailand"},{"name":"Mahidol University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive neurological illness with few effective treatments. Thus, ameliorating the effects of AD using natural products has attracted global attention with promising efficacy and safety. In this study, ten tropical fruits including Ananas comosus \u2018Phulae\u2019, Ananas comosus \u2018Pattavia\u2019, Carica papaya \u2018Khaekdum\u2019, Carica papaya \u2018Khaeknuan\u2019, Durio zibethinus \u2018Monthong\u2019, Durio zibethinus \u2018Chanee\u2019, Psidium guajava \u2018Kimju\u2019, Psidium guajava \u2018Keenok\u2019, Mangifera indica \u2018Kaew\u2019 and Mangifera indica \u2018Namdokmai\u2019 were screened for their inhibitory activities against the key enzymes, cholinesterases and \u03b2-secretase (BACE-1), involved in AD pathogenesis. The top three fruit extracts with promising in vitro anti-AD activities were further investigated using rat pheochromocytoma PC-12 neuronal cell line and Drosophila AD model. Data showed that M. indica \u2018Kaew\u2019, M. indica \u2018Namdokmai\u2019 and P. guajava \u2018Kimju\u2019 reduced A\u03b21\u201342-mediated neurotoxicity by promoting glutathione-dependent enzymes, while M. indica \u2018Namdokmai\u2019 limited A\u03b21\u201342 peptide formation via BACE-1 inhibition and amended locomotory behavior of the Drosophila AD model. Results indicated the potential anti-AD properties of tropical fruits, particularly M. indica \u2018Namdokmai\u2019 in the prevention of A\u03b21\u201342-mediated neurotoxicity and as a BACE-1 blocker.<\/jats:p>","DOI":"10.3390\/ph15050591","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T05:10:32Z","timestamp":1652332232000},"page":"591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mangifera indica \u2018Namdokmai\u2019 Prevents Neuronal Cells from Amyloid Peptide Toxicity and Inhibits BACE-1 Activities in a Drosophila Model of Alzheimer\u2019s Amyloidosis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7590-7024","authenticated-orcid":false,"given":"Piya","family":"Temviriyanukul","sequence":"first","affiliation":[{"name":"Food and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4107-595X","authenticated-orcid":false,"given":"Suwapat","family":"Kittibunchakul","sequence":"additional","affiliation":[{"name":"Food and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9243-2131","authenticated-orcid":false,"given":"Piyapat","family":"Trisonthi","sequence":"additional","affiliation":[{"name":"Institute of Food Research and Product Development, Kasetsart University, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanit","family":"Kunkeaw","sequence":"additional","affiliation":[{"name":"Food and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4282-4908","authenticated-orcid":false,"given":"Woorawee","family":"Inthachat","sequence":"additional","affiliation":[{"name":"Food and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-8832","authenticated-orcid":false,"given":"Dalad","family":"Siriwan","sequence":"additional","affiliation":[{"name":"Institute of Food Research and Product Development, Kasetsart University, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-6329","authenticated-orcid":false,"given":"Uthaiwan","family":"Suttisansanee","sequence":"additional","affiliation":[{"name":"Food and Nutrition Academic and Research Cluster, Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1212\/WNL.0000000000000240","article-title":"Contribution of Alzheimer disease to mortality in the United States","volume":"82","author":"James","year":"2014","journal-title":"Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.31887\/DCNS.2009.11.2\/cqiu","article-title":"Epidemiology of Alzheimer\u2019s disease: Occurrence, determinants, and strategies toward intervention","volume":"11","author":"Qiu","year":"2009","journal-title":"Dialogues Clin. 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