{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:34:57Z","timestamp":1770986097810,"version":"3.50.1"},"reference-count":117,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T00:00:00Z","timestamp":1652572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"School of Medicine, the Union of the Colleges of the Great Lakes","award":["UNILAGO"],"award-info":[{"award-number":["UNILAGO"]}]},{"name":"School of Medicine, the Union of the Colleges of the Great Lakes","award":["PADC-UNILAGO"],"award-info":[{"award-number":["PADC-UNILAGO"]}]},{"name":"SJRP, SP, and the Program for the Scientific Development, Brazil","award":["UNILAGO"],"award-info":[{"award-number":["UNILAGO"]}]},{"name":"SJRP, SP, and the Program for the Scientific Development, Brazil","award":["PADC-UNILAGO"],"award-info":[{"award-number":["PADC-UNILAGO"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Chagas disease (CD) is a neglected protozoan infection caused by Trypanosoma cruzi, which affects about 7 million people worldwide. There are two available drugs in therapeutics, however, they lack effectiveness for the chronic stage\u2014characterized mainly by cardiac (i.e., cardiomyopathy) and digestive manifestations (i.e., megaesophagus, megacolon). Due to the involvement of the immuno-inflammatory pathways in the disease\u2019s progress, compounds exhibiting antioxidant and anti-inflammatory activity seem to be effective for controlling some clinical manifestations, mainly in the chronic phase. Resveratrol (RVT) and curcumin (CUR) are natural compounds with potent antioxidant and anti-inflammatory properties and their cardioprotective effect have been proposed to have benefits to treat CD. Such effects could decrease or block the progression of the disease\u2019s severity. The purpose of this systematic review is to analyze the effectiveness of RVT and CUR in animal and clinical research for the treatment of CD. The study was performed according to PRISMA guidelines and it was registered on PROSPERO (CDR42021293495). The results did not find any clinical study, and the animal research was analyzed according to the SYRCLES risk of bias tools and ARRIVE 2.0 guidelines. We found 9 eligible reports in this study. We also discuss the potential RVT and CUR derivatives for the treatment of CD as well.<\/jats:p>","DOI":"10.3390\/ph15050609","type":"journal-article","created":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T22:24:24Z","timestamp":1652653464000},"page":"609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Resveratrol and Curcumin for Chagas Disease Treatment\u2014A Systematic Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Carlos Henrique Lima","family":"Imperador","sequence":"first","affiliation":[{"name":"Advanced Research Center in Medicine (CEPAM), School of Medicine, Union of the Colleges of the Great Lakes (UNILAGO), Sao Jose do Rio Preto 15030-070, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2540-6395","authenticated-orcid":false,"given":"Cau\u00ea Benito","family":"Scarim","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Design (LAPDESF), School of Pharmaceutical Sciences, University of S\u00e3o Paulo State (UNESP), Araraquara 14800-903, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila Longhin","family":"Bosquesi","sequence":"additional","affiliation":[{"name":"Advanced Research Center in Medicine (CEPAM), School of Medicine, Union of the Colleges of the Great Lakes (UNILAGO), Sao Jose do Rio Preto 15030-070, SP, Brazil"},{"name":"Laboratory of Drug Design (LAPDESF), School of Pharmaceutical Sciences, University of S\u00e3o Paulo State (UNESP), Araraquara 14800-903, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Romano","family":"Lopes","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Design (LAPDESF), School of Pharmaceutical Sciences, University of S\u00e3o Paulo State (UNESP), Araraquara 14800-903, SP, Brazil"},{"name":"Chemical Institute, University of S\u00e3o Paulo State (UNESP), Araraquara 14800-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Cardinalli Neto","sequence":"additional","affiliation":[{"name":"Advanced Research Center in Medicine (CEPAM), School of Medicine, Union of the Colleges of the Great Lakes (UNILAGO), Sao Jose do Rio Preto 15030-070, SP, Brazil"},{"name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto ( FAMERP), Sao Jose do Rio Preto 15090-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5836-1798","authenticated-orcid":false,"given":"Jeanine","family":"Giarolla","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis and Drug Design for Neglected Disease (LAPEN), School of Pharmaceutical Sciences, University of S\u00e3o Paulo (USP), S\u00e3o Paulo 05508-220, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Igne","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis and Drug Design for Neglected Disease (LAPEN), School of Pharmaceutical Sciences, University of S\u00e3o Paulo (USP), S\u00e3o Paulo 05508-220, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2460-2829","authenticated-orcid":false,"given":"Jean Leandro","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Design (LAPDESF), School of Pharmaceutical Sciences, University of S\u00e3o Paulo State (UNESP), Araraquara 14800-903, SP, Brazil"},{"name":"Chemical Institute, University of S\u00e3o Paulo State (UNESP), Araraquara 14800-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4141-0455","authenticated-orcid":false,"given":"Chung Man","family":"Chin","sequence":"additional","affiliation":[{"name":"Advanced Research Center in Medicine (CEPAM), School of Medicine, Union of the Colleges of the Great Lakes (UNILAGO), Sao Jose do Rio Preto 15030-070, SP, Brazil"},{"name":"Laboratory of Drug Design (LAPDESF), School of Pharmaceutical Sciences, University of S\u00e3o Paulo State (UNESP), Araraquara 14800-903, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.amjmed.2020.05.022","article-title":"Chagas Disease: Epidemiology and Barriers to Treatment","volume":"11","author":"Mills","year":"2020","journal-title":"Am. 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