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C. Wong Medical Fellowship Fund","award":["82170694"],"award-info":[{"award-number":["82170694"]}]},{"name":"Shanghai \u201cRising stars of medical talent\u201d Youth development program, Shanghai Jiao Tong University K. C. Wong Medical Fellowship Fund","award":["81700590"],"award-info":[{"award-number":["81700590"]}]},{"name":"Shanghai \u201cRising stars of medical talent\u201d Youth development program, Shanghai Jiao Tong University K. C. Wong Medical Fellowship Fund","award":["YG2022ZD020"],"award-info":[{"award-number":["YG2022ZD020"]}]},{"name":"Shanghai \u201cRising stars of medical talent\u201d Youth development program, Shanghai Jiao Tong University K. C. Wong Medical Fellowship Fund","award":["YG2017QN15"],"award-info":[{"award-number":["YG2017QN15"]}]},{"name":"Shanghai \u201cRising stars of medical talent\u201d Youth development program, Shanghai Jiao Tong University K. C. Wong Medical Fellowship Fund","award":["20184Y0053"],"award-info":[{"award-number":["20184Y0053"]}]},{"name":"Shanghai \u201cRising stars of medical talent\u201d Youth development program, Shanghai Jiao Tong University K. C. Wong Medical Fellowship Fund","award":["QNTD202104"],"award-info":[{"award-number":["QNTD202104"]}]},{"name":"Shanghai \u201cRising stars of medical talent\u201d Youth development program, Shanghai Jiao Tong University K. C. Wong Medical Fellowship Fund","award":["BE2017664"],"award-info":[{"award-number":["BE2017664"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>In recent years, Prussian blue nanoparticles (PBNPs), also named Prussian blue nano-enzymes, have been shown to demonstrate excellent multi-enzyme simulation activity and anti-inflammatory properties, and can be used as reactive oxygen scavengers. Their good biocompatibility and biodegradability mean that they are ideal candidates for in vivo use. PBNPs are highly efficient electron transporters with oxidation and reduction activities. PBNPs also show considerable promise as nano-drug carriers and biological detection sensors owing to their huge specific surface area, good chemical characteristics, and changeable qualities, which might considerably increase the therapeutic impact. More crucially, PBNPs, as therapeutic and diagnostic agents, have made significant advances in biological nanomedicine. This review begins with a brief description of the synthesis methods of PBNPs, then focuses on the applications of PBNPs in tissue regeneration and inflammation according to the different properties of PBNPs. This article will provide a timely reference for further study of PBNPs as therapeutic agents.<\/jats:p>","DOI":"10.3390\/ph15070769","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:12:01Z","timestamp":1655871121000},"page":"769","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Synthesis of Prussian Blue Nanoparticles and Their Antibacterial, Antiinflammation and Antitumor Applications"],"prefix":"10.3390","volume":"15","author":[{"given":"Danyang","family":"Li","sequence":"first","affiliation":[{"name":"The Department of Urology, Affiliated Sixth People\u2019s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China"},{"name":"School of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"The Department of Urology, Affiliated Sixth People\u2019s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3634-2021","authenticated-orcid":false,"given":"Wenyao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[{"name":"The Department of Urology, Affiliated Sixth People\u2019s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enping","family":"Lai","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Green Processing of Sugar Resources, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545026, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Wake Forest Institute of Regenerative Medicine, Winston Salem, NC 27101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaile","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Department of Urology, Affiliated Sixth People\u2019s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1021\/ed085p612","article-title":"Prussian Blue: Artists\u2019 Pigment and Chemists\u2019 Sponge","volume":"85","author":"Ware","year":"2008","journal-title":"J. Chem. Educ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/137577a0","article-title":"Structures and Formula! of the Prussian Blues and Related Compounds","volume":"137","author":"Keggin","year":"1936","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1021\/ic50177a008","article-title":"The Crystal Structure of Prussian Blue: Fe4[Fe(CN)6]3.xH20","volume":"16","author":"Buser","year":"1977","journal-title":"Inorg. Chem. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41586-020-1980-y","article-title":"Hidden diversity of vacancy networks in Prussian blue analogues","volume":"578","author":"Simonov","year":"2020","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1021\/ja051168t","article-title":"Hydrogen storage in the dehydrated prussian blue analogues M3[Co(CN)6]2 (M = Mn, Fe, Co, Ni, Cu, Zn)","volume":"127","author":"Kaye","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1021\/ja100385f","article-title":"High proton conductivity in prussian blue analogues and the interference effect by magnetic ordering","volume":"132","author":"Ohkoshi","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ccr.2015.09.002","article-title":"Metal\u2013organic frameworks for energy storage: Batteries and supercapacitors","volume":"307","author":"Wang","year":"2016","journal-title":"Coord. Chem. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Mass\u00e91, R.C., Uchaker, E., and Cao, G. (2015). Beyond Li-ion: Electrode materials for sodium- and magnesium-ion batteries. Sci. China Mater., 58, 715\u2013766.","DOI":"10.1007\/s40843-015-0084-8"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1016\/j.snb.2017.09.036","article-title":"Photochemical one-pot synthesis of reduced graphene oxide\/Prussian blue nanocomposite for simultaneous electrochemical detection of ascorbic acid, dopamine, and uric acid","volume":"255","author":"Kalil","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1604307","DOI":"10.1002\/adfm.201604307","article-title":"Potassium Prussian Blue Nanoparticles: A Low-Cost Cathode Material for Potassium-Ion Batteries","volume":"27","author":"Zhang","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1063\/1.1737044","article-title":"Finite-size effect on magnetic properties in Prussian blue nanowire arrays","volume":"96","author":"Zhou","year":"2004","journal-title":"J. Appl. Phys."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1021\/jacs.5b12070","article-title":"Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers","volume":"138","author":"Zhang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1021\/ic50002a028","article-title":"The Color and Electronic Configurations of Prussian Blue","volume":"1","author":"Robin","year":"1962","journal-title":"Inorg. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1800347","DOI":"10.1002\/adhm.201800347","article-title":"Progress in Applications of Prussian Blue Nanoparticles in Biomedicine","volume":"7","author":"Qin","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.2217\/nnm-2020-0191","article-title":"Biosafety and biocompatibility assessment of Prussian blue nanoparticles in vitro and in vivo","volume":"15","author":"Wang","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22380","DOI":"10.1039\/C7TA08025E","article-title":"A thermo-sensitive polymer network crosslinked by Prussian blue nanocrystals for cesium adsorption from aqueous solution with large capacity","volume":"5","author":"Qian","year":"2017","journal-title":"J. Mater. Chem. A"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2174\/156720111795767988","article-title":"Nanocrystal technology in the delivery of poorly soluble drugs: An overview","volume":"8","author":"Nagarwal","year":"2011","journal-title":"Curr. Drug Deliv."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"36014","DOI":"10.1021\/acsami.0c08084","article-title":"Elucidating Structure-Composition-Property Relationships of Ni-Based Prussian Blue Analogues for Electrochemical Seawater Desalination","volume":"12","author":"Lumley","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Dacarro, G., Taglietti, A., and Pallavicini, P. (2018). Prussian Blue Nanoparticles as a Versatile Photothermal Tool. Molecules, 23.","DOI":"10.3390\/molecules23061414"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1149\/1.1838625","article-title":"Electrochemical Deposition of Prussian Blue from a Single Ferricyanide Solution","volume":"145","author":"Yang","year":"1998","journal-title":"J. Electrochem. Soc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/(SICI)1521-3773(20000515)39:10<1793::AID-ANIE1793>3.0.CO;2-Y","article-title":"Synthesis of Prussian Blue Nanoparticles and Nanocrystal Superlattices in Reverse Microemulsions We thank the Swiss National Science Foundation for a postdoctoral fellowship to S.V. and the University of Bristol for a postgraduate studentship to M.L","volume":"39","author":"Vaucher","year":"2000","journal-title":"Angew. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2147\/IJN.S183858","article-title":"Large-scale synthesis of monodisperse Prussian blue nanoparticles for cancer theranostics via an \u201cin situ modification\u201d strategy","volume":"14","author":"Xu","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7814","DOI":"10.1021\/ja0356582","article-title":"Prussian blue nanoparticles protected by poly(vinylpyrrolidone)","volume":"125","author":"Uemura","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.colsurfa.2007.02.053","article-title":"Preparation of prussian blue nanoparticles with single precursor","volume":"302","author":"Jia","year":"2007","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jcis.2007.02.022","article-title":"Synthesis and stabilization of Prussian blue nanoparticles and application for sensors","volume":"309","author":"Hornok","year":"2007","journal-title":"J. Colloid Interface Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2006581","DOI":"10.1002\/adfm.202006581","article-title":"Enhancement of Nanozyme Permeation by Endovascular Interventional Treatment to Prevent Vascular Restenosis via Macrophage Polarization Modulation","volume":"30","author":"Feng","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_27","first-page":"2439","article-title":"Excavating bioactivities of nanozyme to remodel microenvironment for protecting chondrocytes and delaying osteoarthritis","volume":"6","author":"Hou","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.5012\/bkcs.2012.33.3.1078","article-title":"Preferential Evolution of Prussian Blue\u2019s Morphology from Cube to Hexapod","volume":"33","author":"Lee","year":"2012","journal-title":"Bull. Korean Chem. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.2147\/IJN.S252505","article-title":"Hollow Prussian Blue Nanospheres for Photothermal\/Chemo-Synergistic Therapy","volume":"15","author":"Lu","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1021\/acs.nanolett.8b04729","article-title":"Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis","volume":"19","author":"Zhang","year":"2019","journal-title":"Nano Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7822","DOI":"10.1021\/acs.analchem.0c01028","article-title":"Enhancing Enzyme-like Activities of Prussian Blue Analog Nanocages by Molybdenum Doping: Toward Cytoprotecting and Online Optical Hydrogen Sulfide Monitoring","volume":"92","author":"Wang","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1039\/C8CS00718G","article-title":"Nanozyme: New horizons for responsive biomedical applications","volume":"48","author":"Jiang","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1021\/acs.chemrev.8b00672","article-title":"Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications","volume":"119","author":"Huang","year":"2019","journal-title":"Chem. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"21046","DOI":"10.1039\/C9NR06596B","article-title":"Therapeutic applications of multifunctional nanozymes","volume":"11","author":"Liu","year":"2019","journal-title":"Nanoscale"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12951-021-01235-2","article-title":"Mn doped Prussian blue nanoparticles for T1\/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor","volume":"20","author":"Tao","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e1900948","DOI":"10.1002\/adhm.201900948","article-title":"Zn2+ Doped Ultrasmall Prussian Blue Nanotheranostic Agent for Breast Cancer Photothermal Therapy under MR Imaging Guidance","volume":"9","author":"Shou","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"110982","DOI":"10.1016\/j.msec.2020.110982","article-title":"Robust dual modality antibacterial action using silver-Prussian blue nanoscale coordination polymer","volume":"113","author":"Sharma","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"12327","DOI":"10.1039\/D0DT02152K","article-title":"Controllable synthesis of rare earth (Gd3+,Tm3+) doped Prussian blue for multimode imaging guided synergistic treatment","volume":"49","author":"Xu","year":"2020","journal-title":"Dalton Trans."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"110655","DOI":"10.1016\/j.colsurfb.2019.110655","article-title":"Folic acid conjugated Prussian blue nanoparticles: Synthesis, physicochemical characterization and targeted cancer cell sensing","volume":"187","author":"Akbal","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1021\/acsnano.0c10388","article-title":"Platinum-Doped Prussian Blue Nanozymes for Multiwavelength Bioimaging Guided Photothermal Therapy of Tumor and Anti-Inflammation","volume":"15","author":"Li","year":"2021","journal-title":"ACS Nano"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"26108","DOI":"10.1021\/acsami.8b10345","article-title":"Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice","volume":"10","author":"Zhao","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"112789","DOI":"10.1016\/j.bios.2020.112789","article-title":"Multifunctional nanoplatform for dual-mode sensitive detection of pathogenic bacteria and the real-time bacteria inactivation","volume":"173","author":"Hao","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Estelrich, J., and Busquets, M.A. (2021). Prussian Blue: A Nanozyme with Versatile Catalytic Properties. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115993"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S1474-4422(18)30195-9","article-title":"Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): Secondary analysis of a randomised trial","volume":"17","author":"Bonati","year":"2018","journal-title":"Lancet. Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrcardio.2011.148","article-title":"Restenosis after PCI. Part 2: Prevention and therapy","volume":"9","author":"Jukema","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.jcin.2018.03.038","article-title":"Combined Transradial and Transpedal Approach for Femoral Artery Interventions","volume":"11","author":"Ruzsa","year":"2018","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1021\/acsnano.0c07973","article-title":"Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery","volume":"15","author":"Feng","year":"2021","journal-title":"ACS Nano"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e2106723","DOI":"10.1002\/adma.202106723","article-title":"Prussian Blue Nanozyme as a Pyroptosis Inhibitor Alleviates Neurodegeneration","volume":"34","author":"Ma","year":"2022","journal-title":"Adv. Mater."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"37746","DOI":"10.1021\/acsami.1c12675","article-title":"Near-Infrared Radiation-Assisted Drug Delivery Nanoplatform to Realize Blood-Brain Barrier Crossing and Protection for Parkinsonian Therapy","volume":"13","author":"Liu","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.7150\/thno.33727","article-title":"Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease","volume":"9","author":"Zhao","year":"2019","journal-title":"Theranostics"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/iwj.12557","article-title":"Reactive oxygen species (ROS) and wound healing: The functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process","volume":"14","author":"Dunnill","year":"2017","journal-title":"Int. Wound J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.phrs.2008.06.004","article-title":"Oxidative stress in normal and impaired wound repair","volume":"58","author":"Werner","year":"2008","journal-title":"Pharmacol. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1001\/archderm.138.11.1462","article-title":"Mechanisms of photoaging and chronological skin aging","volume":"138","author":"Fisher","year":"2002","journal-title":"Arch. Dermatol."},{"key":"ref_54","first-page":"3987","article-title":"A treatment combined prussian blue nanoparticles with low-intensity pulsed ultrasound alleviates cartilage damage in knee osteoarthritis by initiating PI3K\/Akt\/mTOR pathway","volume":"13","author":"Zuo","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pan.2016.05.001","article-title":"NF-\u03baB in acute pancreatitis: Mechanisms and therapeutic potential","volume":"16","author":"Jakkampudi","year":"2016","journal-title":"Pancreatol. Off. J. Int. Assoc. Pancreatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.7150\/thno.46934","article-title":"ATF6 aggravates acinar cell apoptosis and injury by regulating p53\/AIFM2 transcription in Severe Acute Pancreatitis","volume":"10","author":"Tan","year":"2020","journal-title":"Theranostics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/MOG.0b013e3283567f52","article-title":"Pathogenic mechanisms of acute pancreatitis","volume":"28","author":"Sah","year":"2012","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","article-title":"New insights into acute pancreatitis","volume":"16","author":"Lee","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000085265","article-title":"Pathophysiology of acute pancreatitis","volume":"5","author":"Bhatia","year":"2005","journal-title":"Pancreatol. Off. J. Int. Assoc. Pancreatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.7150\/thno.52010","article-title":"Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs\/NF-\u03baB signaling pathway","volume":"11","author":"Xie","year":"2021","journal-title":"Theranostics"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1039\/C8SC04464C","article-title":"Rationally designed pure-inorganic upconversion nanoprobes for ultra-highly selective hydrogen sulfide imaging and elimination in vivo","volume":"10","author":"Liu","year":"2019","journal-title":"Chem. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1039\/D1BM01796A","article-title":"Hyaluronan-coated Prussian blue nanoparticles relieve LPS-induced peritonitis by suppressing oxidative species generation in tissue-resident macrophages","volume":"10","author":"Mathew","year":"2022","journal-title":"Biomater. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"111596","DOI":"10.1016\/j.msec.2020.111596","article-title":"Antioxidant and anti-inflammatory activities of Prussian blue nanozyme promotes full-thickness skin wound healing","volume":"119","author":"Sahu","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"27895","DOI":"10.1021\/acsami.1c05705","article-title":"Near-Infrared Photothermal\/Photodynamic-in-One Agents Integrated with a Guanidinium-Based Covalent Organic Framework for Intelligent Targeted Imaging-Guided Precision Chemo\/PTT\/PDT Sterilization","volume":"13","author":"Liu","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1604053","DOI":"10.1002\/adfm.201604053","article-title":"Activatable Photosensitizers: Agents for Selective Photodynamic Therapy","volume":"27","author":"Li","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.carbpol.2019.05.007","article-title":"Versatile Chlorin e6-based magnetic polydopamine nanoparticles for effectively capturing and killing MRSA","volume":"218","author":"Lu","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1039\/D0BM00821D","article-title":"Broad spectrum antibacterial photodynamic and photothermal therapy achieved with indocyanine green loaded SPIONs under near infrared irradiation","volume":"8","author":"Bilici","year":"2020","journal-title":"Biomater. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1021\/acsnano.8b01010","article-title":"Synthesis of Self-Assembled Porphyrin Nanoparticle Photosensitizers","volume":"12","author":"Wang","year":"2018","journal-title":"ACS Nano"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"30470","DOI":"10.1021\/acsami.7b09638","article-title":"Single Continuous Near-Infrared Laser-Triggered Photodynamic and Photothermal Ablation of Antibiotic-Resistant Bacteria Using Effective Targeted Copper Sulfide Nanoclusters","volume":"9","author":"Dai","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1021\/acsnano.9b09871","article-title":"Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination","volume":"14","author":"Yuan","year":"2020","journal-title":"ACS Nano"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1039\/D1CS00074H","article-title":"Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections","volume":"50","author":"Huo","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1038\/s41467-019-12429-6","article-title":"Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1021\/acs.analchem.0c03981","article-title":"Integrated SERS Platform for Reliable Detection and Photothermal Elimination of Bacteria in Whole Blood Samples","volume":"93","author":"Gao","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1021\/acscentsci.9b00639","article-title":"Dual Metal-Organic Framework Heterointerface","volume":"5","author":"Luo","year":"2019","journal-title":"ACS Cent. Sci."},{"key":"ref_75","first-page":"108","article-title":"Role of nitric oxide, nitroxidative and oxidative stress in wound healing","volume":"57","author":"Soneja","year":"2005","journal-title":"Pharmacol. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1745-7254.2005.00058.x","article-title":"Nitric oxide: A newly discovered function on wound healing","volume":"26","author":"Luo","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0002-9610(02)00815-2","article-title":"Role of nitric oxide in wound repair","volume":"183","author":"Witte","year":"2002","journal-title":"Am. J. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1021\/acsnano.8b09417","article-title":"Enhancing Microcirculation on Multitriggering Manner Facilitates Angiogenesis and Collagen Deposition on Wound Healing by Photoreleased NO from Hemin-Derivatized Colloids","volume":"13","author":"Su","year":"2019","journal-title":"ACS Nano"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jcis.2021.11.108","article-title":"Rational synthesis of Three-Layered plasmonic nanocomposites of copper Sulfide\/Gold\/Zinc-Doped Prussian blue analogues for improved photothermal disinfection and wound healing","volume":"610","author":"Cao","year":"2022","journal-title":"J. Colloid. Interface Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1039\/C8CS00618K","article-title":"Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer","volume":"48","author":"Liu","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.2217\/nnm-2019-0043","article-title":"H2O2\/near-infrared light-responsive nanotheronostics for MRI-guided synergistic chemo\/photothermal cancer therapy","volume":"14","author":"Yu","year":"2019","journal-title":"Nanomedicine"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"11575","DOI":"10.1021\/acsami.5b02510","article-title":"Mn2+-doped prussian blue nanocubes for bimodal imaging and photothermal therapy with enhanced performance","volume":"7","author":"Zhu","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"12679","DOI":"10.1021\/acsnano.0c01453","article-title":"A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence","volume":"14","author":"Zhou","year":"2020","journal-title":"ACS Nano"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"119566","DOI":"10.1016\/j.saa.2021.119566","article-title":"Fine synthesis of Prussian-blue analogue coated gold nanoparticles (Au@PBA NPs) for sorting specific cancer cell subtypes","volume":"252","author":"Shen","year":"2021","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"114139","DOI":"10.1016\/j.bios.2022.114139","article-title":"Biocatalysis-mediated MOF-to-prussian blue transformation enabling sensitive detection of NSCLC-associated miRNAs with dual-readout signals","volume":"206","author":"Tang","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6061","DOI":"10.7150\/thno.42114","article-title":"Gadolinium-doped Au@prussian blue nanoparticles as MR\/SERS bimodal agents for dendritic cell activating and tracking","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"9870","DOI":"10.1039\/D1CC03957A","article-title":"A Prussian blue-doped RGO\/MXene composite aerogel with peroxidase-like activity for real-time monitoring of H2O2 secretion from living cells","volume":"57","author":"Zhao","year":"2021","journal-title":"Chem. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/s11671-018-2730-z","article-title":"Prussian Blue Nanoparticle-Labeled Mesenchymal Stem Cells: Evaluation of Cell Viability, Proliferation, Migration, Differentiation, Cytoskeleton, and Protein Expression In Vitro","volume":"13","author":"Wen","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jconrel.2010.10.024","article-title":"Optimizing tumor targeting of the lipophilic EGFR-binding radiotracer SKI 243 using a liposomal nanoparticle delivery system","volume":"149","author":"Medina","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.bcp.2012.01.008","article-title":"Nanoparticle-based combination therapy toward overcoming drug resistance in cancer","volume":"83","author":"Hu","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jconrel.2010.05.013","article-title":"Nanoparticle-based theragnostics: Integrating diagnostic and therapeutic potentials in nanomedicine","volume":"146","author":"Fang","year":"2010","journal-title":"J. Control. Release"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"7339","DOI":"10.1021\/ic0488435","article-title":"Size and surface effects of prussian blue nanoparticles protected by organic polymers","volume":"43","author":"Uemura","year":"2004","journal-title":"Inorg. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"025001","DOI":"10.1088\/1468-6996\/10\/2\/025001","article-title":"Assembly and electroanalytical performance of Prussian blue\/polypyrrole composite nanoparticles synthesized by the reverse micelle method","volume":"10","author":"Miao","year":"2009","journal-title":"Sci. Technol. Adv. Mater."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.inoche.2009.10.015","article-title":"Biocompatible Prussian blue nanoparticles: Preparation, stability, cytotoxicity, and potential use as an MRI contrast agent","volume":"13","author":"Shokouhimehr","year":"2010","journal-title":"Inorg. Chem. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1039\/c2ce25040c","article-title":"Size- and shape-controlled synthesis of Prussian Blue nanoparticles by a polyvinylpyrrolidone-assisted crystallization process","volume":"14","author":"Ming","year":"2012","journal-title":"CrystEngComm"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.2147\/IJN.S327598","article-title":"Synergistic Therapy Using Doxorubicin-Loading and Nitric Oxide-Generating Hollow Prussian Blue Nanoparticles with Photoacoustic Imaging Potential Against Breast Cancer","volume":"16","author":"Fu","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"44410","DOI":"10.1021\/acsami.7b17022","article-title":"Erythrocyte-Membrane-Coated Prussian Blue\/Manganese Dioxide Nanoparticles as H2O2-Responsive Oxygen Generators To Enhance Cancer Chemotherapy\/Photothermal Therapy","volume":"9","author":"Peng","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"044405","DOI":"10.1088\/1468-6996\/14\/4\/044405","article-title":"Prussian blue nanoparticles as nanocargoes for delivering DNA drugs to cancer cells","volume":"14","author":"Wang","year":"2013","journal-title":"Sci. Technol. Adv. Mater."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.1039\/C7TB01712J","article-title":"Multifunctional phase-change hollow mesoporous Prussian blue nanoparticles as a NIR light responsive drug co-delivery system to overcome cancer therapeutic resistance","volume":"5","author":"Chen","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jaad.2004.08.052","article-title":"Molecular diagnosis of infectious diseases in dermatology","volume":"53","author":"Sra","year":"2005","journal-title":"J. Am. Acad. Dermatol."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/15\/7\/769\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:36:31Z","timestamp":1760139391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/15\/7\/769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":100,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["ph15070769"],"URL":"https:\/\/doi.org\/10.3390\/ph15070769","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]}}}