{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:21:58Z","timestamp":1777785718133,"version":"3.51.4"},"reference-count":39,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad CEU Cardenal Herrera and the ESI International Chair @ UCH-CEU","award":["INDI21\/15"],"award-info":[{"award-number":["INDI21\/15"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Quinolones are one of the most extensively used therapeutic families of antibiotics. However, the increase in antibiotic-resistant bacteria has rendered many of the available compounds useless. After applying our prediction model of activity against E. coli to a library of 1000 quinolones, two quinolones were selected to be synthesized. Additionally, a series of zwitterionic quinolonates were also synthesized. Quinolones and zwitterionic quinolonates were obtained by coupling the corresponding amine with reagent 1 in acetonitrile. Antibacterial activity was assessed using a microdilution method. All the compounds presented antibacterial activity, especially quinolones 2 and 3, selected by the prediction model, which had broad-spectrum activity. Furthermore, a new type of zwitterionic quinolonate with antibacterial activity was found. These compounds can lead to a new line of antimicrobials, as the structures, and, therefore, their properties, are easily adjustable in the amine in position 4 of the pyridine ring.<\/jats:p>","DOI":"10.3390\/ph15070818","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T20:59:18Z","timestamp":1656968358000},"page":"818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis of Quinolones and Zwitterionic Quinolonate Derivatives with Broad-Spectrum Antibiotic Activity"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9335-1920","authenticated-orcid":false,"given":"Beatriz","family":"Suay-Garc\u00eda","sequence":"first","affiliation":[{"name":"ESI International Chair@CEU-UCH, Departamento de Matem\u00e1ticas, F\u00edsica y Ciencias Tecnol\u00f3gicas, Universidad Cardenal Herrera-CEU, CEU Universities San Bartolom\u00e9 55, 46115 Alfara del Patriarca, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2231-090X","authenticated-orcid":false,"given":"Jose-Ignacio","family":"Bueso-Bordils","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Universidad Cardenal Herrera-CEU, CEU Universities C\/Ram\u00f3n y Cajal s\/n, 46115 Alfara del Patriarca, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-5396","authenticated-orcid":false,"given":"Gerardo","family":"Ant\u00f3n-Fos","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Universidad Cardenal Herrera-CEU, CEU Universities C\/Ram\u00f3n y Cajal s\/n, 46115 Alfara del Patriarca, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5083-9267","authenticated-orcid":false,"given":"Mar\u00eda-Teresa","family":"P\u00e9rez-Gracia","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Universidad Cardenal Herrera-CEU, CEU Universities C\/Ram\u00f3n y Cajal s\/n, 46115 Alfara del Patriarca, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6225-0935","authenticated-orcid":false,"given":"Antonio","family":"Falc\u00f3","sequence":"additional","affiliation":[{"name":"ESI International Chair@CEU-UCH, Departamento de Matem\u00e1ticas, F\u00edsica y Ciencias Tecnol\u00f3gicas, Universidad Cardenal Herrera-CEU, CEU Universities San Bartolom\u00e9 55, 46115 Alfara del Patriarca, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1558-0250","authenticated-orcid":false,"given":"Pedro","family":"Alem\u00e1n-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Universidad Cardenal Herrera-CEU, CEU Universities C\/Ram\u00f3n y Cajal s\/n, 46115 Alfara del Patriarca, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1586\/eri.09.106","article-title":"49th ICAAC annual meeting: Optimization of anti-infective use in the clinical setting","volume":"7","author":"Yeh","year":"2009","journal-title":"Expert. 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