{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:59:03Z","timestamp":1772071143380,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Inferior alveolar nerve block (IANB) has a high failure rate in subjects with symptomatic irreversible pulpitis (SIP). It has been suggested that drugs with anti-inflammatory activity could improve the efficacy of the anesthetic used for IANB. The aim of this study was to assess the effect of dexamethasone on the success of dental anesthesia in patients with SIP. An information search was performed using PubMed and Google Scholar. The risk of bias of the included studies was evaluated with the Cochrane Collaboration\u2019s risk-of-bias tool. The anesthetic success rate, pain intensity (VAS), and adverse effects were extracted. Data were analyzed using the Mantel\u2013Haenszel test and odds ratio or the inverse variance and standardized mean difference. Dexamethasone increased the anesthetic success in comparison with placebo (n = 502; p &lt; 0.001; OR = 2.59; 95% CIs: 1.46 to 4.59). Moreover, patients who were given dexamethasone had lower pain scores at 6 h (n = 302; p &lt; 0.001; MD= \u22121.43; 95% CIs: \u22122.28 to \u22120.58), 12 h (n = 302; p &lt; 0.0001; MD = \u22121.65; 95% CIs: \u22122.39 to \u22120.92), and 24 h (n = 302; p &lt; 0.0008; MD = \u22121.27; 95% CIs: \u22122.01 to \u22120.53) when compared with placebo. In conclusion, the systemic administration of dexamethasone increases the anesthetic success rate and improves pain management in patients with SIP.<\/jats:p>","DOI":"10.3390\/ph15070878","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T01:53:22Z","timestamp":1658109202000},"page":"878","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"given":"Lorenzo","family":"Franco-de la Torre","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias M\u00e9dicas, Departamento de Cl\u00ednicas, Divisi\u00f3n de Ciencias Biom\u00e9dicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitl\u00e1n de Morelos 47620, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"G\u00f3mez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Fisiol\u00f3gicas, Divisi\u00f3n de Disciplinas B\u00e1sicas para la Salud, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0402-3985","authenticated-orcid":false,"given":"Nicol\u00e1s Addiel","family":"Seraf\u00edn-Higuera","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Baja California, Mexicali 21040, Baja California, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-8156","authenticated-orcid":false,"given":"\u00c1ngel Josabad","family":"Alonso-Castro","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Divisi\u00f3n de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato 36040, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"L\u00f3pez-Verd\u00edn","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Odontolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0435-053X","authenticated-orcid":false,"given":"Nelly","family":"Molina-Frechero","sequence":"additional","affiliation":[{"name":"Departamento de Salud, Laboratorio de Cariolog\u00eda y Medicina Oral, Universidad Aut\u00f3noma Metropolitana-Xochimilco, Coyoac\u00e1n 04960, Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1038-8400","authenticated-orcid":false,"given":"Vinicio","family":"Granados-Soto","sequence":"additional","affiliation":[{"name":"Neurobiology of Pain Laboratory, Departamento de Farmacobiolog\u00eda, Cinvestav, South Campus, Mexico City 14330, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8389-6866","authenticated-orcid":false,"given":"Mario Alberto","family":"Isiordia-Espinoza","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias M\u00e9dicas, Departamento de Cl\u00ednicas, Divisi\u00f3n de Ciencias Biom\u00e9dicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitl\u00e1n de Morelos 47620, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.joen.2019.09.002","article-title":"Efficacy and safety of pulpal anesthesia strategies during endodontic treatment of permanent mandibular molars with symptomatic irreversible pulpitis: A systematic review and network meta-analysis","volume":"45","author":"Zanjir","year":"2019","journal-title":"J. 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