{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:58:29Z","timestamp":1791874709989,"version":"4.3.4"},"reference-count":123,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine (KIOM)","doi-asserted-by":"publisher","award":["KSN2211010"],"award-info":[{"award-number":["KSN2211010"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Post-traumatic stress disorder (PTSD) occurs after exposure to traumatic events and is characterized by overwhelming fear and anxiety. Disturbances in the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis are involved in the pathogenesis of mood disorders, including anxiety, PTSD, and major depressive disorders. Studies have demonstrated the relationship between the HPA axis response and stress vulnerability, indicating that the HPA axis regulates the immune system, fear memory, and neurotransmission. The selective serotonin reuptake inhibitors (SSRIs), sertraline and paroxetine, are the only drugs that have been approved by the United States Food and Drug Administration for the treatment of PTSD. However, SSRIs require long treatment times and are associated with lower response and remission rates; therefore, additional pharmacological interventions are required. Complementary and alternative medicine therapies ameliorate HPA axis disturbances through regulation of gut dysbiosis, insomnia, chronic stress, and depression. We have described the cellular and molecular mechanisms through which the HPA axis is involved in PTSD pathogenesis and have evaluated the potential of herbal medicines for PTSD treatment. Herbal medicines could comprise a good therapeutic strategy for HPA axis regulation and can simultaneously improve PTSD-related symptoms. Finally, herbal medicines may lead to novel biologically driven approaches for the treatment and prevention of PTSD.<\/jats:p>","DOI":"10.3390\/ph15070898","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T03:34:40Z","timestamp":1658374480000},"page":"898","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Nutraceutical Interventions for Post-Traumatic Stress Disorder in Animal Models: A Focus on the Hypothalamic\u2013Pituitary\u2013Adrenal Axis"],"prefix":"10.3390","volume":"15","author":[{"given":"Mudan","family":"Cai","sequence":"first","affiliation":[{"name":"Department of KM Science Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Ra","family":"Park","sequence":"additional","affiliation":[{"name":"Department of KM Science Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of KM Science Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"ref_1","unstructured":"(2020, August 31). What is Posttraumatic Stress Disorder (PTSD)?. Available online: https:\/\/www.psychiatry.org\/patients-families\/ptsd\/what-is-ptsd."},{"key":"ref_2","first-page":"108","article-title":"Genetic Advances in Post-traumatic Stress Disorder","volume":"47","year":"2018","journal-title":"Rev. Colomb. Psiquiatr. (Engl. Ed.)"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00702-021-02330-2","article-title":"Genes and hormones of the hypothalamic-pituitary-adrenal axis in post-traumatic stress disorder. What is their role in symptom expression and treatment response?","volume":"128","author":"Fischer","year":"2021","journal-title":"J. Neural Transm."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Aliev, G., Beeraka, N.M., Nikolenko, V.N., Svistunov, A.A., Rozhnova, T., Kostyuk, S., Cherkesov, I., Gavryushova, L.V., Chekhonatsky, A.A., and Mikhaleva, L.M. (2020). Neurophysiology and Psychopathology Underlying PTSD and Recent Insights into the PTSD Therapies-A Comprehensive Review. J. Clin. Med., 9.","DOI":"10.3390\/jcm9092951"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1521\/psyc.2008.71.2.134","article-title":"Nonresponse and dropout rates in outcome studies on PTSD: Review and methodological considerations","volume":"71","author":"Schottenbauer","year":"2008","journal-title":"Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/ph3010019","article-title":"The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments","volume":"3","author":"Baumann","year":"2010","journal-title":"Pharmaceuticals"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pnpbp.2016.01.015","article-title":"Treatment-refractory posttraumatic stress disorder (TRPTSD): A review and framework for the future","volume":"70","author":"Koek","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"683293","DOI":"10.1155\/2014\/683293","article-title":"Treatment of posttraumatic stress disorder using the traditional Japanese herbal medicine saikokeishikankyoto: A randomized, observer-blinded, controlled trial in survivors of the great East Japan earthquake and tsunami","volume":"2014","author":"Numata","year":"2014","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"110810","DOI":"10.1016\/j.biopha.2020.110810","article-title":"From the perspective of Traditional Chinese Medicine: Treatment of mental disorders in COVID-19 survivors","volume":"132","author":"Ma","year":"2020","journal-title":"Biomed. Pharm."},{"key":"ref_10","first-page":"42","article-title":"Ellen Kamhi, phd, rn: Herbal Support for the HPA Axis","volume":"15","author":"Gustafson","year":"2016","journal-title":"Integr. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2174\/1570159X1304150831122734","article-title":"Herbal Medicine for Anxiety, Depression and Insomnia","volume":"13","author":"Liu","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"367619","DOI":"10.1093\/ecam\/nep218","article-title":"Total flavonoids extracted from xiaobuxin-tang on the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats","volume":"2011","author":"An","year":"2011","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pbb.2013.10.007","article-title":"Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: The HPA axis, BDNF expression and phosphorylation of ERK","volume":"112","author":"Wang","year":"2013","journal-title":"Pharm. Biochem. Behav."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1111\/j.1460-9568.2004.03267.x","article-title":"Differences between brain structures in nuclear translocation and DNA binding of the glucocorticoid receptor during stress and the circadian cycle","volume":"19","author":"Kitchener","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/da.20695","article-title":"Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder","volume":"27","author":"Coric","year":"2010","journal-title":"Depress. Anxiety"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1177\/1091581819827501","article-title":"Toxicity of Pexacerfont, a Corticotropin-Releasing Factor Type 1 Receptor Antagonist, in Rats and Dogs","volume":"38","author":"White","year":"2019","journal-title":"Int. J. Toxicol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0006-3223(89)90183-2","article-title":"Elevated CSF CRF in suicide victims","volume":"25","author":"Arato","year":"1989","journal-title":"Biol. Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1176\/ajp.152.9.1372","article-title":"Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer\u2019s disease and depression","volume":"152","author":"Raadsheer","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.biopsych.2015.01.005","article-title":"Diagnostic Biomarkers for Posttraumatic Stress Disorder: Promising Horizons from Translational Neuroscience Research","volume":"78","author":"Michopoulos","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"D\u2019Elia, A.T.D., Juruena, M.F., Coimbra, B.M., Mello, M.F., and Mello, A.F. (2021). Posttraumatic stress disorder (PTSD) and depression severity in sexually assaulted women: Hypothalamic-pituitary-adrenal (HPA) axis alterations. BMC Psychiatry, 21.","DOI":"10.1186\/s12888-021-03170-w"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1038\/sj.npp.1301605","article-title":"Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD","volume":"33","author":"Yamamoto","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3389\/fphar.2017.00615","article-title":"Using the Single Prolonged Stress Model to Examine the Pathophysiology of PTSD","volume":"8","author":"Souza","year":"2017","journal-title":"Front. Pharm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.biopsych.2017.11.019","article-title":"Current Status of Animal Models of Posttraumatic Stress Disorder: Behavioral and Biological Phenotypes, and Future Challenges in Improving Translation","volume":"83","author":"Deslauriers","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1089\/jmf.2017.4161","article-title":"Effects of Epigallocatechin Gallate on Behavioral and Cognitive Impairments, Hypothalamic-Pituitary-Adrenal Axis Dysfunction, and Alternations in Hippocampal BDNF Expression Under Single Prolonged Stress","volume":"21","author":"Lee","year":"2018","journal-title":"J. Med. Food"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4196\/kjpp.2018.22.5.525","article-title":"Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder","volume":"22","author":"Lee","year":"2018","journal-title":"Korean J. Physiol. Pharm."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1600001","article-title":"The role of corticotropin-releasing factor in depression and anxiety disorders","volume":"160","author":"Arborelius","year":"1999","journal-title":"J. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11655-020-2724-4","article-title":"Antidepressant-Like Effects of Hesperidin in Animal Model of Post-Traumatic Stress Disorder","volume":"27","author":"Lee","year":"2021","journal-title":"Chin. J. Integr. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3389\/fnins.2017.00604","article-title":"Regulatory Pathways of Monoamine Oxidase A during Social Stress","volume":"11","author":"Higuchi","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"821549","DOI":"10.6064\/2012\/821549","article-title":"Serotonergic modulation of conditioned fear","volume":"2012","author":"Homberg","year":"2012","journal-title":"Scientifica"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Raymundi, A.M., da Silva, T.R., Sohn, J.M.B., Bertoglio, L.J., and Stern, C.A. (2020). Effects of (9)-tetrahydrocannabinol on aversive memories and anxiety: A review from human studies. BMC Psychiatry, 20.","DOI":"10.1186\/s12888-020-02813-8"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00213-018-5116-0","article-title":"Glucocorticoid-induced enhancement of extinction-from animal models to clinical trials","volume":"236","author":"Wolf","year":"2019","journal-title":"Psychopharmacology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn.2016.155","article-title":"Stress, glucocorticoids and memory: Implications for treating fear-related disorders","volume":"18","author":"Schwabe","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.biopsych.2017.09.006","article-title":"Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results from Posttraumatic Stress Disorder Consortia","volume":"83","author":"Logue","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1017\/S0033291715000707","article-title":"Smaller hippocampal volume as a vulnerability factor for the persistence of post-traumatic stress disorder","volume":"45","author":"Kennis","year":"2015","journal-title":"Psychol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1001\/archgenpsychiatry.2012.50","article-title":"Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group","volume":"69","author":"Morey","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_36","first-page":"913","article-title":"Selectively reduced regional cortical volumes in post-traumatic stress disorder","volume":"14","author":"Rauch","year":"2003","journal-title":"Neuroreport"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.5607\/en.2016.25.6.277","article-title":"Molecular Neuroimaging in Posttraumatic Stress Disorder","volume":"25","author":"Im","year":"2016","journal-title":"Exp. Neurobiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1196\/annals.1410.012","article-title":"Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress","volume":"1148","author":"Jankord","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1001\/archgenpsychiatry.2009.205","article-title":"Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder","volume":"67","author":"Wang","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jpsychires.2017.09.007","article-title":"Automated measurement of hippocampal subfields in PTSD: Evidence for smaller dentate gyrus volume","volume":"95","author":"Hayes","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.physbeh.2009.09.008","article-title":"The effects of chronic glucocorticoid exposure on dendritic length, synapse numbers and glial volume in animal models: Implications for hippocampal volume reductions in depression","volume":"99","author":"Tata","year":"2010","journal-title":"Physiol. Behav."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/nn766","article-title":"Memory retrieval impairment induced by hippocampal CA3 lesions is blocked by adrenocortical suppression","volume":"4","author":"Roozendaal","year":"2001","journal-title":"Nat. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.1073\/pnas.81.19.6174","article-title":"Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response","volume":"81","author":"Sapolsky","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1523\/JNEUROSCI.09-09-03072.1989","article-title":"Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis","volume":"9","author":"Herman","year":"1989","journal-title":"J. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1523\/JNEUROSCI.10-09-02897.1990","article-title":"Hippocampal damage associated with prolonged glucocorticoid exposure in primates","volume":"10","author":"Sapolsky","year":"1990","journal-title":"J. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e22134","DOI":"10.1002\/syn.22134","article-title":"Synapse impairment associated with enhanced apoptosis in post-traumatic stress disorder","volume":"74","author":"Chen","year":"2020","journal-title":"Synapse"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13041-017-0295-x","article-title":"Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells","volume":"10","author":"Chen","year":"2017","journal-title":"Mol. Brain"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jad.2018.12.084","article-title":"Neonatal isolation modulates glucocorticoid-receptor function and synaptic plasticity of hippocampal and amygdala neurons in a rat model of single prolonged stress","volume":"246","author":"Cheng","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_49","first-page":"227","article-title":"Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats","volume":"24","author":"Wang","year":"2009","journal-title":"Int. J. Mol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1002\/hbm.25356","article-title":"Alterations in hippocampal subfield and amygdala subregion volumes in posttraumatic subjects with and without posttraumatic stress disorder","volume":"42","author":"Zhang","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrn2651","article-title":"Stress, memory and the amygdala","volume":"10","author":"Roozendaal","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1007\/s00429-019-01943-4","article-title":"Increases in dendritic spine density in BLA without metabolic changes in a rodent model of PTSD","volume":"224","author":"Neves","year":"2019","journal-title":"Brain Struct. Funct."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.3389\/fpsyg.2019.02394","article-title":"Traumatic Stress Produces Delayed Alterations of Synaptic Plasticity in Basolateral Amygdala","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Psychol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1006\/nlme.2002.4080","article-title":"Stress and memory: Opposing effects of glucocorticoids on memory consolidation and memory retrieval","volume":"78","author":"Roozendaal","year":"2002","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0306-4530(99)00058-X","article-title":"1999 Curt P. Richter award. Glucocorticoids and the regulation of memory consolidation","volume":"25","author":"Roozendaal","year":"2000","journal-title":"Psychoneuroendocrinology"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Han, F., Ding, J., and Shi, Y. (2014). Expression of amygdala mineralocorticoid receptor and glucocorticoid receptor in the single-prolonged stress rats. BMC Neurosci., 15.","DOI":"10.1186\/1471-2202-15-77"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0306-4530(94)00069-7","article-title":"Anxiolytic-like effects of selective mineralocorticoid and glucocorticoid antagonists on fear-enhanced behavior in the elevated plus-maze","volume":"20","author":"Korte","year":"1995","journal-title":"Psychoneuroendocrinology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1523\/JNEUROSCI.21-14-05222.2001","article-title":"Amygdala is critical for stress-induced modulation of hippocampal long-term potentiation and learning","volume":"21","author":"Kim","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1523\/JNEUROSCI.4623-04.2005","article-title":"Amygdalar inactivation blocks stress-induced impairments in hippocampal long-term potentiation and spatial memory","volume":"25","author":"Kim","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1523\/JNEUROSCI.21-07-02518.2001","article-title":"Basolateral amygdala-nucleus accumbens interactions in mediating glucocorticoid enhancement of memory consolidation","volume":"21","author":"Roozendaal","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tins.2011.06.007","article-title":"Fear conditioning, synaptic plasticity and the amygdala: Implications for posttraumatic stress disorder","volume":"35","author":"Mahan","year":"2012","journal-title":"Trends Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1037\/0735-7044.109.4.681","article-title":"Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats","volume":"109","author":"Morgan","year":"1995","journal-title":"Behav. Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/380069a0","article-title":"Dissociation in prefrontal cortex of affective and attentional shifts","volume":"380","author":"Dias","year":"1996","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"8800","DOI":"10.1523\/JNEUROSCI.23-25-08800.2003","article-title":"Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons","volume":"23","author":"Quirk","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0959-4388(00)00080-5","article-title":"Neurobiology of posttraumatic stress disorder","volume":"10","author":"Newport","year":"2000","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0306-4522(95)00417-3","article-title":"Projections of the medial and lateral prefrontal cortices to the amygdala: A Phaseolus vulgaris leucoagglutinin study in the rat","volume":"71","author":"McDonald","year":"1996","journal-title":"Neuroscience"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Licznerski, P., Duric, V., Banasr, M., Alavian, K.N., Ota, K.T., Kang, H.J., Jonas, E.A., Ursano, R., Krystal, J.H., and Duman, R.S. (2015). Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. PLoS Biol., 13.","DOI":"10.1371\/journal.pbio.1002282"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1523\/JNEUROSCI.13-09-03839.1993","article-title":"The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress","volume":"13","author":"Diorio","year":"1993","journal-title":"J. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s12031-014-0464-7","article-title":"Changes in the glucocorticoid receptor and Ca(2)(+)\/calreticulin-dependent signalling pathway in the medial prefrontal cortex of rats with post-traumatic stress disorder","volume":"56","author":"Wen","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/10253890.2018.1470238","article-title":"Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility","volume":"21","author":"Gjerstad","year":"2018","journal-title":"Stress"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","article-title":"The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation","volume":"332","author":"Chrousos","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"780616","DOI":"10.1155\/2014\/780616","article-title":"A possible change process of inflammatory cytokines in the prolonged chronic stress and its ultimate implications for health","volume":"2014","author":"Tian","year":"2014","journal-title":"Sci. World J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1999.tb07618.x","article-title":"Stress, corticotropin-releasing hormone, glucocorticoids, and the immune\/inflammatory response: Acute and chronic effects","volume":"876","author":"Elenkov","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"177","DOI":"10.6000\/1927-5129.2014.10.25","article-title":"Depression: An Insight and Need for Personalized Psychological Stress Monitoring and Management","volume":"10","author":"Vashist","year":"2014","journal-title":"J. Basic Appl. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1523\/JNEUROSCI.0802-06.2006","article-title":"Stress increases vulnerability to inflammation in the rat prefrontal cortex","volume":"26","author":"Villaran","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cyto.2011.03.025","article-title":"C-reactive protein, interleukin-6, and posttraumatic stress disorder symptomology in urban police officers","volume":"55","author":"McCanlies","year":"2011","journal-title":"Cytokine"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/npp.2016.146","article-title":"Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond","volume":"42","author":"Michopoulos","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.psychres.2015.05.036","article-title":"Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders","volume":"229","author":"Furtado","year":"2015","journal-title":"Psychiatry Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s10571-020-00791-9","article-title":"TLR4\/MyD88\/NF-kappaB-Mediated Inflammation Contributes to Cardiac Dysfunction in Rats of PTSD","volume":"40","author":"Liu","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neulet.2016.11.064","article-title":"Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies","volume":"649","author":"Averill","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s11064-015-1549-6","article-title":"Loss of Glial Cells of the Hippocampus in a Rat Model of Post-traumatic Stress Disorder","volume":"40","author":"Han","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neulet.2010.05.052","article-title":"Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex","volume":"480","author":"Knox","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1037\/0735-7044.118.3.505","article-title":"D-cycloserine and the facilitation of extinction of conditioned fear: Consequences for reinstatement","volume":"118","author":"Ledgerwood","year":"2004","journal-title":"Behav. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1523\/JNEUROSCI.22-06-02343.2002","article-title":"Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats","volume":"22","author":"Walker","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1017\/S1461145709000339","article-title":"Pilot controlled trial of D-serine for the treatment of post-traumatic stress disorder","volume":"12","author":"Vass","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1038\/s41380-022-01498-7","article-title":"Positive modulation of N-methyl-D-aspartate receptors in the mPFC reduces the spontaneous recovery of fear","volume":"27","author":"Lee","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.steroids.2015.05.010","article-title":"Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice","volume":"101","author":"Ali","year":"2015","journal-title":"Steroids"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11011-016-9927-6","article-title":"Neurobehavioural evaluation of resveratrol in murine models of anxiety and schizophrenia","volume":"32","author":"Magaji","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pbb.2017.09.004","article-title":"Resveratrol ameliorated the behavioral deficits in a mouse model of post-traumatic stress disorder","volume":"161","author":"Zhang","year":"2017","journal-title":"Pharm. Biochem. Behav."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jgr.2014.05.010","article-title":"Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats","volume":"38","author":"Zhao","year":"2014","journal-title":"J. Ginseng Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1248\/bpb.28.1621","article-title":"Anxiolytic-like effects of ginsenosides on the elevated plus-maze model in mice","volume":"28","author":"Cha","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4014\/jmb.1112.12046","article-title":"Effect of ginsenoside Re on depression- and anxiety-like behaviors and cognition memory deficit induced by repeated immobilization in rats","volume":"22","author":"Lee","year":"2012","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11418-015-0943-3","article-title":"Ginsenoside Rb1 rescues anxiety-like responses in a rat model of post-traumatic stress disorder","volume":"70","author":"Lee","year":"2016","journal-title":"J. Nat. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1080\/10286020.2015.1031117","article-title":"Ginsenoside Rg1 relieves tert-Butyl hydroperoxide-induced cell impairment in mouse microglial BV2 cells","volume":"17","author":"Lu","year":"2015","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neulet.2015.08.017","article-title":"Preventive effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD)-like behavior in male C57\/B6 mice","volume":"605","author":"Wang","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1007\/s12035-020-02213-9","article-title":"Ginsenoside Rg1 Prevents PTSD-Like Behaviors in Mice Through Promoting Synaptic Proteins, Reducing Kir4.1 and TNF-alpha in the Hippocampus","volume":"58","author":"Zhang","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s11418-016-1010-4","article-title":"Gastrodin reversed the traumatic stress-induced depressed-like symptoms in rats","volume":"70","author":"Lee","year":"2016","journal-title":"J. Nat. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainresbull.2014.03.004","article-title":"Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: Possible role of l-arginine-NO-cGMP pathway and BDNF levels","volume":"104","author":"Donato","year":"2014","journal-title":"Brain Res. Bull."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1089\/jmf.2019.4519","article-title":"Genistein Prevents Single Prolonged Stress-Induced Cognitive Impairment in a Post-Traumatic Stress Disorder Rat Model via Activation of the Serotonergic System","volume":"23","author":"Lee","year":"2020","journal-title":"J. Med. Food"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.phymed.2011.05.010","article-title":"Protective effect of olive leaf extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in Mongolian gerbils","volume":"18","author":"Dekanski","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12576-016-0437-4","article-title":"Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats","volume":"66","author":"Pourkhodadad","year":"2016","journal-title":"J. Physiol. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11418-017-1103-8","article-title":"Effect of oleuropein on cognitive deficits and changes in hippocampal brain-derived neurotrophic factor and cytokine expression in a rat model of post-traumatic stress disorder","volume":"72","author":"Lee","year":"2018","journal-title":"J. Nat. Med."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Han, Y., Zhang, W., Tang, Y., Bai, W., Yang, F., Xie, L., Li, X., Zhou, S., Pan, S., and Chen, Q. (2012). l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischaemia-reperfusion injury in rats. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038627"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4062\/biomolther.2014.032","article-title":"L-tetrahydropalmatine ameliorates development of anxiety and depression-related symptoms induced by single prolonged stress in rats","volume":"22","author":"Lee","year":"2014","journal-title":"Biomol. Ther."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.brainres.2015.09.029","article-title":"Silibinin suppresses astroglial activation in a mouse model of acute Parkinson\u2019s disease by modulating the ERK and JNK signaling pathways","volume":"1627","author":"Lee","year":"2015","journal-title":"Brain Res."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Lee, B., Choi, G.M., and Sur, B. (2020). Silibinin prevents depression-like behaviors in a single prolonged stress rat model: The possible role of serotonin. BMC Complement. Med., 20.","DOI":"10.1186\/s12906-020-2868-y"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/0269881116686883","article-title":"Curcumin for neuropsychiatric disorders: A review of in vitro, animal and human studies","volume":"31","author":"Lopresti","year":"2017","journal-title":"J. Psychopharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"9041309","DOI":"10.1155\/2018\/9041309","article-title":"Systemic Administration of Curcumin Affect Anxiety-Related Behaviors in a Rat Model of Posttraumatic Stress Disorder via Activation of Serotonergic Systems","volume":"2018","author":"Lee","year":"2018","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.2174\/092986709789578187","article-title":"The structure and pharmacological functions of coumarins and their derivatives","volume":"16","author":"Wu","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s11418-019-01373-w","article-title":"Umbelliferone modulates depression-like symptoms by altering monoamines in a rat post-traumatic stress disorder model","volume":"74","author":"Lee","year":"2020","journal-title":"J. Nat. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/j.apsb.2021.01.014","article-title":"Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder","volume":"11","author":"Pang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0091-3057(01)00730-4","article-title":"The effect of Morinda officinalis How, a Chinese traditional medicinal plant, on the DRL 72-s schedule in rats and the forced swimming test in mice","volume":"72","author":"Zhang","year":"2002","journal-title":"Pharm. Biochem. Behav."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s11011-016-9853-7","article-title":"The inulin-type oligosaccharides extract from morinda officinalis, a traditional Chinese herb, ameliorated behavioral deficits in an animal model of post-traumatic stress disorder","volume":"31","author":"Qiu","year":"2016","journal-title":"Metab. Brain Dis."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jgr.2015.04.009","article-title":"Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition","volume":"39","author":"Lee","year":"2015","journal-title":"J. Ginseng Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.jgr.2019.09.005","article-title":"Korean Red Ginseng prevents posttraumatic stress disorder-triggered depression-like behaviors in rats via activation of the serotonergic system","volume":"44","author":"Lee","year":"2020","journal-title":"J. Ginseng Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jams.2012.11.009","article-title":"Chinese herbs for memory disorders: A review and systematic analysis of classical herbal literature","volume":"6","author":"May","year":"2013","journal-title":"J. Acupunct. Meridian Stud."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1248\/bpb.30.1727","article-title":"Effect of Polygala tenuifolia root extract on scopolamine-induced impairment of rat spatial cognition in an eight-arm radial maze task","volume":"30","author":"Sun","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Shin, I.J., Son, S.U., Park, H., Kim, Y., Park, S.H., Swanberg, K., Shin, J.Y., Ha, S.K., Cho, Y., and Bang, S.Y. (2014). Preclinical evidence of rapid-onset antidepressant-like effect in Radix Polygalae extract. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088617"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1083\/jcb.146.5.929","article-title":"A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity","volume":"146","author":"Schneikert","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5607\/en.2018.27.3.200","article-title":"Radix Polygalae Extract Attenuates PTSD-like Symptoms in a Mouse Model of Single Prolonged Stress and Conditioned Fear Possibly by Reversing BAG1","volume":"27","author":"Shin","year":"2018","journal-title":"Exp. Neurobiol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Lee, B., Hong, R., Lim, P., Cho, D., Yeom, M., Lee, S., Kang, K.S., Lee, S.C., Shim, I., and Lee, H. (2019). The ethanolic extract of Aralia continentalis ameliorates cognitive deficits via modifications of BDNF expression and anti-inflammatory effects in a rat model of post-traumatic stress disorder. BMC Complement. Altern. Med., 19.","DOI":"10.1186\/s12906-018-2417-0"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neulet.2015.06.055","article-title":"Free and Easy Wanderer Plus (FEWP) improves behavioral deficits in an animal model of post-traumatic stress disorder by stimulating allopregnanolone biosynthesis","volume":"602","author":"Qiu","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"154139","DOI":"10.1016\/j.phymed.2022.154139","article-title":"Anshen Dingzhi prescription in the treatment of PTSD in mice: Investigation of the underlying mechanism from the perspective of hippocampal synaptic function","volume":"101","author":"Yang","year":"2022","journal-title":"Phytomedicine"}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/15\/7\/898\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:54:33Z","timestamp":1760140473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/15\/7\/898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":123,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["ph15070898"],"URL":"https:\/\/doi.org\/10.3390\/ph15070898","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,20]]}}}