{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:58:28Z","timestamp":1784347108508,"version":"3.55.0"},"reference-count":70,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Microbial resistance has become a worrying problem in recent decades after the abusive use of antibiotics causing the selection of resistant microorganisms. In order to circumvent such resistance, researchers have invested efforts in the search for promising natural substances, such as essential oils. Thus, the objective of this work was to determine the chemical composition of the essential oil of Acritopappus confertus leaves, to evaluate its intrinsic effect and its effects in combination with drugs against pathogenic fungi and bacteria, in addition to verifying the inhibition of virulence in Candida strains. To this end, the oil was verified by gas chromatography coupled with mass spectrometry (GC\/MS). Candida strains were used for antifungal assays by means of the serial microdilution technique, in order to determine the average inhibitory concentration (IC50), and for the modification assays, sub-inhibitory concentrations (MIC\/8) were used. Finally, the natural product\u2019s ability to inhibit the formation of filamentous structures was evaluated. In antibacterial tests, the MIC of the oil against strains of Staphylococcus aureus and Escherichia coli and its modifying effects in association with gentamicin, erythromycin, and norfloxacin were determined. The major constituent of the essential oil was the monoterpene myrcene (54.71%). The results show that the essential oil has an antifungal effect, with C. albicans strains being the most susceptible. Furthermore, the oil can potentiate the effect of fluconazole against strains of C. tropicalis and C. albicans. Regarding its effect on micromorphology, the oil was also able to inhibit the filaments in all strains. In combination with antibiotics, the oil potentiated the drug\u2019s action by reducing the MIC against E. coli and S. aureus. It can be concluded that the essential oil of A. confertus has potential against pathogenic fungi and bacteria, making it a target for the development of an antimicrobial drug.<\/jats:p>","DOI":"10.3390\/ph15101275","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:31:01Z","timestamp":1666053061000},"page":"1275","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chemical Composition and Antimicrobial Potential of Essential Oil of Acritopappus confertus (Gardner) R.M.King &amp; H.Rob. (Asteraceae)"],"prefix":"10.3390","volume":"15","author":[{"given":"Rafael Pereira","family":"da Cruz","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Walber Gon\u00e7alves","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-8366","authenticated-orcid":false,"given":"D\u00e9bora Od\u00edlia Duarte","family":"Leite","sequence":"additional","affiliation":[{"name":"Northeast Biotechnology Network, Postgraduate Program in Biotechnology, State University of Cear\u00e1, Fortaleza 60740-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Kelly Gomes","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Northeast Biotechnology Network, Postgraduate Program in Biotechnology, State University of Cear\u00e1, Fortaleza 60740-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0966-9750","authenticated-orcid":false,"given":"Jos\u00e9 Weverton","family":"Almeida-Bezerra","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimundo Luiz Silva","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1zia Fernandes Galv\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2081-8304","authenticated-orcid":false,"given":"Jos\u00e9 Jailson Lima","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Department of Botany, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrielle Rodrigues","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Federal University of Cariri, Barbalha 63180-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna","family":"Mori","sequence":"additional","affiliation":[{"name":"CECAPE College, Av. Padre C\u00edcero, Juazeiro do Norte 63024-015, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-2164","authenticated-orcid":false,"given":"Pablo Antonio Maia","family":"de Farias","sequence":"additional","affiliation":[{"name":"CECAPE College, Av. Padre C\u00edcero, Juazeiro do Norte 63024-015, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":false,"given":"Henrique Douglas Melo","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5898-1257","authenticated-orcid":false,"given":"Maria Flaviana Bezerra","family":"Morais-Braga","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5063-1236","authenticated-orcid":false,"given":"Marcello","family":"Iriti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, Universit\u00e0 degli Studi di Milano, via G. Celoria 2, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Galberto Martins","family":"da Costa","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3901-6758","authenticated-orcid":false,"given":"Fab\u00edola Fernandes Galv\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2147\/IDR.S238811","article-title":"Prevalence and some possible mechanisms of colistin resistance among multidrug-resistant and extensively drug-resisant Pseudomonas aeruginosa infect","volume":"13","author":"Masoud","year":"2020","journal-title":"Drug Resist."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Serweci\u0144ska, L. 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