{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:37:51Z","timestamp":1792460271502,"version":"4.5.0"},"reference-count":99,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Center, Poland","award":["2017\/25\/B\/NZ7\/02741"],"award-info":[{"award-number":["2017\/25\/B\/NZ7\/02741"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>The aim of the study was to investigate the effect of baicalein or Scutellaria baicalensis root extract interaction with methyldopa in pregnant spontaneously hypertensive rats (SHR) at the pharmacodynamic, molecular, and biochemical levels. The rats, after confirming pregnancy, received baicalein (200 mg\/kg\/day, p.o.) and extract (1000 mg\/kg\/day, p.o.), in combination with methyldopa (400 mg\/kg\/day; p.o.), for 14 consecutive days, 1 h before blood pressure and heart rate measurements. In the heart and placenta from mothers after giving birth to their offspring, mRNA expression of factors related to inflammatory processes (TNF-\u03b1, Il-1\u03b2, IL-6) and vascular diseases (TGF-\u03b2, HIF-1\u03b1, VEGF, PlGF) was measured. Levels of markers of oxidative stress (superoxide dismutase and malondialdehyde) in the placenta and indicators of myocardial damage (troponin cTnC and cTnI, creatine kinase, myoglobin, and lactate dehydrogenase) in the heart were also assessed. Baicalein co-administered with methyldopa was associated with reduced blood pressure, especially during the first three days. The interactions were more pronounced for such factors as TGF-\u03b2, HIF-1\u03b1, VEGF, and PlGF than TNF-\u03b1, Il-1\u03b2, and IL-6. Combined application of baicalein and extract with methyldopa may be of value in the development of a new antihypertensive medication intended for patients suffering from preeclampsia or pregnancy-induced hypertension.<\/jats:p>","DOI":"10.3390\/ph15111342","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T09:01:42Z","timestamp":1667120502000},"page":"1342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combined Effects of Methyldopa and Baicalein or Scutellaria baicalensis Roots Extract on Blood Pressure, Heart Rate, and Expression of Inflammatory and Vascular Disease-Related Factors in Spontaneously Hypertensive Pregnant Rats"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3295-2789","authenticated-orcid":false,"given":"Micha\u0142","family":"Szulc","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-0689","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Kujawski","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-6523","authenticated-orcid":false,"given":"Przemys\u0142aw \u0141.","family":"Miko\u0142ajczak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Pozna\u0144, Poland"},{"name":"Department of Pharmacology and Phytochemistry, Institute of Natural Fibres and Medicinal Plants\u2014National Research Institute, Kolejowa 2, 62-064 Plewiska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bogacz","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants\u2014National Research Institute, Kolejowa 2, 62-064 Plewiska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlena","family":"Wolek","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants\u2014National Research Institute, Kolejowa 2, 62-064 Plewiska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"G\u00f3rska","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants\u2014National Research Institute, Kolejowa 2, 62-064 Plewiska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-4746","authenticated-orcid":false,"given":"Kamila","family":"Czora-Poczwardowska","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2305-3116","authenticated-orcid":false,"given":"Marcin","family":"O\u017carowski","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants\u2014National Research Institute, Wojska Polskiego 71b, 60-630 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8164-9914","authenticated-orcid":false,"given":"Agnieszka","family":"Gryszczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Phytochemistry, Institute of Natural Fibres and Medicinal Plants\u2014National Research Institute, Kolejowa 2, 62-064 Plewiska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7533-3078","authenticated-orcid":false,"given":"Justyna","family":"Baraniak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Phytochemistry, Institute of Natural Fibres and Medicinal Plants\u2014National Research Institute, Kolejowa 2, 62-064 Plewiska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-6680","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Kania-Dobrowolska","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Phytochemistry, Institute of Natural Fibres and Medicinal Plants\u2014National Research Institute, Kolejowa 2, 62-064 Plewiska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1738-953X","authenticated-orcid":false,"given":"Artur","family":"Adamczak","sequence":"additional","affiliation":[{"name":"Department of Breeding and Botany of Useful Plants, Institute of Natural Fibres and Medicinal Plants\u2014National Research Institute, Kolejowa 2, 62-064 Plewiska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Iwa\u0144czyk-Skalska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, \u015awi\u0119cickiego 6, 60-781 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-6802","authenticated-orcid":false,"given":"Pawe\u0142 P.","family":"Jagodzi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, \u015awi\u0119cickiego 6, 60-781 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogus\u0142aw","family":"Czerny","sequence":"additional","affiliation":[{"name":"Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University in Szczecin, \u017bo\u0142nierska 48, 70-204 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kami\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics and Traumatology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Uzar","sequence":"additional","affiliation":[{"name":"Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University in Szczecin, \u017bo\u0142nierska 48, 70-204 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Seremak-Mrozikiewicz","sequence":"additional","affiliation":[{"name":"Division of Perinatology and Women\u2019s Diseases, Poznan University of Medical Sciences, Polna 33, 60-535 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bpobgyn.2011.01.006","article-title":"Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy","volume":"25","author":"Hutcheon","year":"2011","journal-title":"Best Pract. 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