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Therefore, it is necessary to search for new drug candidates. In the present paper, the use of plant extracts is highlighted. Babassu oil and Copaiba oil resin have several therapeutic properties. We investigated the in vitro effects of two nanoemulsions containing oil extracted from Babassu (Orbignya speciosa) nuts (called SNEDDS-18) and\/or oil resin extracted from Copaiba trunk (Copaifera langsdorffii) (called SNEDDS-18\/COPA) on cultured human eutopic endometrium stromal cells from endometrial biopsies of patients without (CESC) and with (EuESC) endometriosis as well as human stromal cells from biopsies of endometriotic lesions (EctESC). Methods: CESC, EuESC, and EctESC were taken and treated with SNEDDS-18 and SNEDDS-18\/COPA to evaluate their effects on cytotoxicity, cell morphology, proliferation, and signaling pathways. Results: After 48 h of incubation with SNEDDS-18 and SNEDDS-18\/COPA, cell viability and proliferation were inhibited, especially in EctESC. The lowest concentration of both nanoemulsions reduced cell viability and proliferation and broke down the cytoskeleton in EctESCs. After 24 h of treatment a decrease in IL-1, TNF-\u03b1, and MCP-1 was observed, as well as an increase in IL-10 production. Conclusions: Both nanoemulsions can affect endometriotic stromal cell behaviors, thus revealing two potential candidates for new phytotherapeutic agents for the management of endometriosis.<\/jats:p>","DOI":"10.3390\/ph15111414","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T02:24:53Z","timestamp":1668565493000},"page":"1414","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Copaiba Oil Resin Exerts an Additive Effect to Babassu Oil on Behavioral Changes in Human Endometriotic Cell Cultures"],"prefix":"10.3390","volume":"15","author":[{"given":"Julianna Henriques da","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Instituto de Ci\u00eancias Biom\u00e9dicas, Programa de Pesquisa em Biologia Celular e do Desenvolvimento, Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia Coli Louvisse de","family":"Abreu","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Faculdade de Farm\u00e1cia, Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Hospital Universit\u00e1rio Moncorvo Filho, Instituto de Ginecologia, Rio de Janeiro 20.211-340, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia Yelimar Palmero","family":"Quintana","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Instituto de Ci\u00eancias Biom\u00e9dicas, Programa de Pesquisa em Biologia Celular e do Desenvolvimento, Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-6653","authenticated-orcid":false,"given":"Eliane Gouv\u00eaa de Oliveira","family":"Barros","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Instituto de Ci\u00eancias Biom\u00e9dicas, Programa de Pesquisa em Biologia Celular e do Desenvolvimento, Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia de Moraes","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Instituto de Ci\u00eancias Biom\u00e9dicas, Programa de Pesquisa em Descoberta de F\u00e1rmacos, Laborat\u00f3rio de Farmacologia dor e da Inflama\u00e7\u00e3o, Rio de Janeiro 21.941-90, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-1204","authenticated-orcid":false,"given":"Bruno","family":"Pontes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Instituto de Ci\u00eancias Biom\u00e9dicas, Programa de Pesquisa em Biologia Celular e do Desenvolvimento, Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria Pereira de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Faculdade de Farm\u00e1cia, Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio Mendes","family":"Cabral","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Faculdade de Farm\u00e1cia, Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-6745","authenticated-orcid":false,"given":"Patricia Dias","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Instituto de Ci\u00eancias Biom\u00e9dicas, Programa de Pesquisa em Descoberta de F\u00e1rmacos, Laborat\u00f3rio de Farmacologia dor e da Inflama\u00e7\u00e3o, Rio de Janeiro 21.941-90, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Eurico","family":"Nasciutti","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Instituto de Ci\u00eancias Biom\u00e9dicas, Programa de Pesquisa em Biologia Celular e do Desenvolvimento, Rio de Janeiro 21.941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/ije\/dyx252","article-title":"Racial\/ethnic differences in the epidemiology of ovarian cancer: A pooled analysis of 12 case-control studies","volume":"47","author":"Peres","year":"2018","journal-title":"Int. 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