{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:18:06Z","timestamp":1789651086969,"version":"4.0.0"},"reference-count":67,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Progranulin (PGRN) is a glycoprotein formed by 593 amino acids encoded by the GRN gene. It has an important role in immunity and inflammatory response, as well as in tissue recovery. Its role in musculoskeletal inflammatory diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and intervertebral disc degeneration disease (IVDD), is, nowadays, an important target to investigate. The objective of this review is to systematically sum up all the recent findings concerning PGRN as a target in the development and resolution of the inflammatory diseases. PubMed was examined with the terms combinations (Progranulin) AND (Lupus Erythematosus, Systemic), (Progranulin) AND (Arthritis, Rheumatoid), and (Progranulin) AND (Intervertebral Disc Degeneration). PubMed was examined with the terms combinations (Atsttrin) AND (Lupus Erythematosus, Systemic), (Atsttrin) AND (Arthritis, Rheumatoid), and (Atsttrin) AND (Intervertebral Disc Degeneration). Moreover, research through Web of Science was performed searching the same items. The inclusion criteria were: studies whose main topic were progranulin, or atsttrin, with emphasis on the three selected diseases. On the other hand, the exclusion criteria were studies that only focused on diseases not related to RA, lupus or IVDD, in addition to the previous published literature reviews. Since few results were obtained, we did not filter by year. The records assessed for eligibility were 23, including all the studies with the information in state of art of progranulin and its capability to be a potential target or treatment for each one of the selected diseases. As these results are descriptive and not clinical trials, we did not perform risk of bias methods. Within these results, many studies have shown an anti-inflammatory activity of PGRN in RA. PGRN levels in serum and synovial fluids in RA patients were reported higher than controls. On the other hand, serum levels were directly correlated with SLE disease activity index, suggesting an important role of PGRN as a player in the progression of inflammatory diseases and a therapeutical approach for the recovery. This review has some limitations due to the small number of studies in this regard; therefore, we highlight the importance and the necessity of further investigation. No external funding was implicated in this systematical review.<\/jats:p>","DOI":"10.3390\/ph15121544","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T01:56:06Z","timestamp":1670896566000},"page":"1544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Progranulin in Musculoskeletal Inflammatory and Degenerative Disorders, Focus on Rheumatoid Arthritis, Lupus and Intervertebral Disc Disease: A Systematic Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-2219","authenticated-orcid":false,"given":"Mar\u00eda","family":"Gonz\u00e1lez-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"SERGAS (Servizo Galego de Saude), and IDIS (Instituto de Investigaci\u00f3n Sanitaria de Santiago), NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago University Clinical 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line","volume":"268","author":"Zhou","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1073\/pnas.89.5.1715","article-title":"Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains","volume":"89","author":"Bhandari","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.tins.2014.04.003","article-title":"Progranulin in neurodegenerative disease","volume":"37","author":"Petkau","year":"2014","journal-title":"Trends Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"20356","DOI":"10.1038\/srep20356","article-title":"The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1","volume":"6","author":"Abella","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"154796","DOI":"10.1016\/j.cyto.2019.154796","article-title":"Role of progranulin in adipose tissue innate immunity","volume":"125","author":"Schmid","year":"2020","journal-title":"Cytokine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1177\/002215540004800713","article-title":"Cellular localization of gene expression for progranulin","volume":"48","author":"Daniel","year":"2000","journal-title":"J. Histochem. Cytochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nsb0996-747","article-title":"The hairpin stack fold, a novel protein architecture for a new family of protein growth factors","volume":"3","author":"Hrabal","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.atherosclerosis.2009.02.017","article-title":"Progranulin expression in advanced human atherosclerotic plaque","volume":"206","author":"Kojima","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1110\/ps.073295308","article-title":"Structure dissection of human progranulin identifies well-folded granulin\/epithelin modules with unique functional activities","volume":"17","author":"Tolkatchev","year":"2008","journal-title":"Protein Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1189\/jlb.0812429","article-title":"Insights into the role of progranulin in immunity, infection, and inflammation","volume":"93","author":"Jian","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.immuni.2011.01.018","article-title":"Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling","volume":"34","author":"Park","year":"2011","journal-title":"Immunity"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Suh, H.S., Choi, N., Tarassishin, L., and Lee, S.C. (2012). Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (mmp-12). PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035115"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1128\/MCB.01775-07","article-title":"Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding","volume":"28","author":"Butler","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1152\/ajplung.00221.2013","article-title":"Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD","volume":"306","author":"Ungurs","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0092-8674(02)01141-8","article-title":"Conversion of Proepithelin to Epithelins","volume":"111","author":"Zhu","year":"2002","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"568","DOI":"10.5551\/jat.3921","article-title":"HDL\/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins","volume":"17","author":"Okura","year":"2010","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103241","DOI":"10.1016\/j.jri.2020.103241","article-title":"Secretory leukocyte protease inhibitor and progranulin as possible regulators of cervical remodeling in pregnancy","volume":"143","author":"Samejima","year":"2021","journal-title":"J. Reprod. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.2741\/4274","article-title":"Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity","volume":"19","author":"Tian","year":"2014","journal-title":"Front. Biosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.1199214","article-title":"The growth factor progranulin binds to tnf receptors and is therapeutic against inflammatory arthritis in mice","volume":"332","author":"Tang","year":"2011","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-1-4939-0669-7_14","article-title":"A Solid-Phase Assay for Studying Direct Binding of Progranulin to TNFR and Progranulin Antagonism of TNF\/TNFR Interactions","volume":"1155","author":"Tian","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jaut.2015.05.002","article-title":"The molecular basis for development of proinflammatory autoantibodies to progranulin","volume":"61","author":"Thurner","year":"2015","journal-title":"J. Autoimmun."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Liu, C., Li, X.X., Gao, W., Liu, W., and Liu, D.S. (2014). Progranulin-Derived Atsttrin Directly Binds to TNFRSF25 (DR3) and Inhibits TNF-Like Ligand 1A (TL1A) Activity. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0092743"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00296-015-3372-4","article-title":"Serum progranulin irrelated with Breg cell levels, but elevated in RA patients, reflecting high disease activity","volume":"3","author":"Chen","year":"2016","journal-title":"Rheumatol. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1096\/fj.201601134R","article-title":"Foxo4-and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis","volume":"31","author":"Fu","year":"2017","journal-title":"FASEB J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"106090","DOI":"10.1016\/j.intimp.2019.106090","article-title":"Recent advances in the study of progranulin and its role in sepsis","volume":"79","author":"Tian","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"21115","DOI":"10.1038\/srep21115","article-title":"Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner","volume":"6","author":"Mundra","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/S0140-6736(20)32340-0","article-title":"Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Cieza","year":"2020","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1007\/s10753-014-9911-4","article-title":"Increased serum GP88 (Progranulin) concentrations in rheumatoid arthritis","volume":"37","author":"Yamamoto","year":"2014","journal-title":"Inflammation"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"0300060520971459","DOI":"10.1177\/0300060520971459","article-title":"Serum progranulin level is associated with disease activity following orthopedic surgery in rheumatoid arthritis patients","volume":"48","author":"Kong","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cyto.2016.08.007","article-title":"Progranulin: A key player in autoimmune diseases","volume":"101","author":"Jian","year":"2018","journal-title":"Cytokine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/978-1-4939-8559-3_20","article-title":"Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-inflammatory Activity of Progranulin in Inflammatory Arthritis","volume":"1806","author":"Wei","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Wei, F., Zhang, Y., Zhao, W., Yu, X., and Liu, C.J. (2014). Progranulin facilitates conversion and function of regulatory T cells under inflammatory conditions. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0112110"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaut.2012.10.003","article-title":"Progranulin antibodies in autoimmune diseases","volume":"42","author":"Thurner","year":"2013","journal-title":"J. Autoimmun."},{"key":"ref_35","first-page":"94","article-title":"Progranulin-autoantibodies in sera of rheumatoid arthritis patients negative for rheumatoid factor and anti-citrullinated peptide antibodies","volume":"38","author":"Assmann","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"740357","DOI":"10.1155\/2015\/740357","article-title":"Progranulin is associated with disease activity in patients with rheumatoid arthritis","volume":"2015","author":"Cerezo","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejr.2018.07.004","article-title":"Potential value of serum progranulin as an activity biomarker in rheumatoid arthritis patients: Relation to musculoskeletal ultrasonographic evaluation","volume":"41","author":"Fouad","year":"2019","journal-title":"Egypt. Rheumatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbrc.2019.08.092","article-title":"miR-138 activates NF-\u03baB signaling and PGRN to promote rheumatoid arthritis via regulating HDAC4","volume":"519","author":"Shao","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10067-016-3467-7","article-title":"Serum progranulin levels in Hispanic rheumatoid arthritis patients treated with TNF antagonists: a prospective, observational study","volume":"36","author":"Johnson","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"ref_40","first-page":"215","article-title":"Growth factor progranulin blocks tumor necrosis factor-\u03b1-mediated inhibition of osteoblast differentiation","volume":"15","author":"Wang","year":"2016","journal-title":"Genet. Mol. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.joca.2012.05.003","article-title":"Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA","volume":"20","author":"Lai","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1002\/art.27491","article-title":"Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein","volume":"62","author":"Guo","year":"2010","journal-title":"Arthritis Rheumatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.molmed.2017.05.006","article-title":"Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective","volume":"23","author":"Moulton","year":"2017","journal-title":"Trends Mol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New insights into the immunopathogenesis of systemic lupus erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"R244","DOI":"10.1186\/ar4087","article-title":"Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity","volume":"14","author":"Tanaka","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/jir.2019.0047","article-title":"Progranulin Mediates Proinflammatory Responses in Systemic Lupus Erythematosus: Implications for the Pathogenesis of Systemic Lupus Erythematosus","volume":"40","author":"Jing","year":"2020","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cyto.2018.08.002","article-title":"Adipokine interactions promote the pathogenesis of systemic lupus erythematosus","volume":"111","author":"Chougule","year":"2018","journal-title":"Cytokine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1746-1596-8-88","article-title":"Expression level of the growth factor progranulin is related with development of systemic lupus erythematosus","volume":"8","author":"Qiu","year":"2013","journal-title":"Diagn. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ruiz-Fern\u00e1ndez, C., Francisco, V., Pino, J., Mera, A., Gonz\u00e1lez-Gay, M.A., G\u00f3mez, R., Lago, F., and Gualillo, O. (2019). Molecular relationships among obesity, inflammation and intervertebral disc degeneration: Are adipokines the common link?. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20082030"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-021-00713-z","article-title":"A new immunometabolic perspective of intervertebral disc degeneration","volume":"18","author":"Francisco","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1007\/s10753-018-0828-1","article-title":"Progranulin Is Positively Associated with Intervertebral Disc Degeneration by Interaction with IL-10 and IL-17 Through TNF Pathways","volume":"41","author":"Wang","year":"2018","journal-title":"Inflammation"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"9102","DOI":"10.1038\/srep09102","article-title":"Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice","volume":"5","author":"Zhao","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"523","DOI":"10.5966\/sctm.2014-0200","article-title":"Intra-articular transplantation of atsttrin-transduced mesenchymal stem cells ameliorate osteoarthritis development","volume":"4","author":"Xia","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s13075-017-1485-8","article-title":"Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models","volume":"19","author":"Wei","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"577572","DOI":"10.3389\/fcell.2020.577572","article-title":"Atsttrin Promotes Cartilage Repair Primarily Through TNFR2-Akt Pathway","volume":"8","author":"Wei","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/adhm.201500211","article-title":"3D-Printed Atsttrin-Incorporated Alginate\/Hydroxyapatite Scaffold Promotes Bone Defect Regeneration with TNF\/TNFR Signaling Involvement","volume":"4","author":"Wang","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.pharmthera.2011.10.003","article-title":"Progranulin: a growth factor, a novel TNFR ligand and a drug target","volume":"133","author":"Liu","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"109692","DOI":"10.18632\/oncotarget.22766","article-title":"Progranulin derived engineered protein Atsttrin suppresses TNF-\u03b1-mediated inflammation in intervertebral disc degenerative disease","volume":"8","author":"Ding","year":"2017","journal-title":"Oncotarget"},{"key":"ref_59","first-page":"62","article-title":"Distinctive roles of tumor necrosis factor receptor type 1 and type 2 in a mouse disc degeneration model","volume":"31","author":"Wang","year":"2021","journal-title":"J. Orthop. Transl."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1186\/1742-2094-10-105","article-title":"The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment","volume":"10","author":"Egashira","year":"2013","journal-title":"J. Neuroinflamm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1093\/brain\/awv079","article-title":"Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke","volume":"138","author":"Kanazawa","year":"2015","journal-title":"Brain"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/ki.2014.403","article-title":"Progranulin protects against renal ischemia\/reperfusion injury in mice","volume":"87","author":"Zhou","year":"2015","journal-title":"Kidney Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"540794","DOI":"10.1155\/2012\/540794","article-title":"Prevention of lps-induced acute lung injury in mice by progranulin","volume":"2012","author":"Guo","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/jcmm.12756","article-title":"Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock","volume":"20","author":"Yu","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/s41598-020-80940-8","article-title":"Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice","volume":"11","author":"Murakoshi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_66","first-page":"2438","article-title":"Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin","volume":"118","author":"Kessenbrock","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.clim.2011.09.005","article-title":"Towards the next generation of anti-TNF drugs","volume":"141","author":"Sfikakis","year":"2011","journal-title":"Clin. Immunol."}],"container-title":["Pharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8247\/15\/12\/1544\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:39:54Z","timestamp":1760146794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8247\/15\/12\/1544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":67,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["ph15121544"],"URL":"https:\/\/doi.org\/10.3390\/ph15121544","relation":{},"ISSN":["1424-8247"],"issn-type":[{"value":"1424-8247","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,12]]}}}