{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:48:34Z","timestamp":1762508914181,"version":"build-2065373602"},"reference-count":79,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T00:00:00Z","timestamp":1672444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Patanjali Research Foundation Trust, Haridwar, India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Ulcerative colitis (UC) is an inflammatory bowel disease that affects the patients\u2019 colorectal area culminating in an inflamed \u2018leaky gut.\u2019 The majority of UC treatments only provide temporary respite leading to its relapse. Therefore, this study investigated the efficacy of the enteric-coated \u2018Cologrit\u2019 (EC) tablet in alleviating UC-like inflammation. Cologrit is formulated using polyherbal extracts that have anti-inflammatory qualities according to ancient Ayurveda scriptures. Phytochemical profiling revealed the presence of gallic acid, rutin, ellagic acid, and imperatorin in Cologrit formulation. Cologrit treatment decreased inflammation in LPS-induced transformed THP-1 macrophages, and TNF-\u03b1-stimulated human colorectal (HT-29) cells through the modulation of NF\u03baB activity, IL-6 production, and NF\u03baB, IL-1\u03b2, IL-8, and CXCL5 mRNA expression levels. Cologrit also lessened human monocytic (U937) cell adhesion to HT29 cells. Methacrylic acid-ethylacrylate copolymer-coating of the enteric Cologrit tablets (EC) supported their dissolution, and the release of phytochemicals in the small intestine pH 7.0 environment in a simulated gastrointestinal digestion model. Small intestine EC digestae effectively abridged dextran sodium sulfate (2.5% w\/v)-induced cell viability loss and oxidative stress in human colon epithelial Caco-2 cells. In conclusion, the enteric-coated Cologrit tablets demonstrated good small intestine-specific phytochemical delivery capability, and decreased UC-like inflammation, and oxidative stress through the regulation of TNF-\u03b1\/NF\u03baB\/IL6 signaling axis.<\/jats:p>","DOI":"10.3390\/ph16010063","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T03:50:32Z","timestamp":1672631432000},"page":"63","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Enteric-Coated Cologrit Tablet Exhibit Robust Anti-Inflammatory Response in Ulcerative Colitis-like In-Vitro Models by Attuning NF\u03baB-Centric Signaling Axis"],"prefix":"10.3390","volume":"16","author":[{"given":"Acharya","family":"Balkrishna","sequence":"first","affiliation":[{"name":"Drug Discovery and Development Division, Patanjali Research Institute, Uttarakhand, Haridwar 249 405, India"},{"name":"Department of Allied and Applied Sciences, University of Patanjali, Patanjali Yog Peeth, Uttarakhand, Haridwar 249 405, India"},{"name":"Patanjali Yog Peeth (UK) Trust, 40 Lambhill Street, Kinning Park, Glasgow G41 1AU, UK"},{"name":"Vedic Acharya Samaj Foundation Inc., NFP 21725 CR 33, Groveland, FL 34736, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5819-4050","authenticated-orcid":false,"given":"Rani","family":"Singh","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Division, Patanjali Research Institute, Uttarakhand, Haridwar 249 405, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Gohel","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Division, Patanjali Research Institute, Uttarakhand, Haridwar 249 405, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0038-7941","authenticated-orcid":false,"given":"Sagar","family":"Arora","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Division, Patanjali Research Institute, Uttarakhand, Haridwar 249 405, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-6934","authenticated-orcid":false,"given":"Rishabh","family":"Dev","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Division, Patanjali Research Institute, Uttarakhand, Haridwar 249 405, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-9807","authenticated-orcid":false,"given":"Kunal","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Division, Patanjali Research Institute, Uttarakhand, Haridwar 249 405, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurag","family":"Varshney","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Division, Patanjali Research Institute, Uttarakhand, Haridwar 249 405, India"},{"name":"Department of Allied and Applied Sciences, University of Patanjali, Patanjali Yog Peeth, Uttarakhand, Haridwar 249 405, India"},{"name":"Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi 110 067, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat. 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